Research
Research Faculty Back
Chen Lili
Position Chair of Oral Medicine Department
Department Oral Medicine
Medical School
Zhejiang%20University%20School%20of%20Medicine%2C%20Zhejiang%2C%20China
Academic Rank
Chief Physician 
Clinical Interests
Clinical research of comprehensive therapy of periodontitis and peri-implantitis; 
Basic research of mechanism of periodontal development, the relationship between periodontal disease and systemic disease.
Professional Highlights
Special Allowance Prize
Manpower Certificate of Cross-Century Academic and Technical Leader of Zhejiang Province Government (151 engineering)
The Second Prize of Science and Technology Advancement Prize of Zhejiang Province
The Third Prize of Science and Technology Advancement Prize of Zhejiang Province
Professional Appointments
Doctoral supervisor of Zhejiang University
Director of Chinese Stomatological Association
Standing Committee Member of Periodontology of Chinese Stomatological Association
Standing Director of Zhejiang Stomatological Association 
Chairman of committee of Oral Medicine of Zhejiang Stomatological Association
Standing Director of Zhejiang Association of Stomatologist
Expert peer reviewer of National Natural Science Foundation,
Member of special editorial board for “Chinese Jounal of Stomotology”
Member of editorial board for “Stomotology”
Member of editorial board for “Journal of Practical Stomatology”
Member of Asian-Pacific Society of Periodontology
Publications

Chen Lili, Wei Fen, Sun Weilian, Ding Peihui, Chen Xiaotao, Wu Yanmin, Delta12-prostaglandinJ2-nano capsule up-regulates growth factor expression and enhances bone regeneration in rats. Chinese Journal of Stomatology, 2015, 50 (3): 151-156.
Diya Zhang , Lili Chen , Shenglai Li, Lingjing Hu, Lieping Sheng, Zheng Cao, Yanmin Wu, Modulation of protease-activated receptor expression by Porphyromonasgingivalis in human gingival epithelial cells. BMC Oral Health, 2015, 15 (1):1-8.
Xiao-tao Chen, Jing-yi Tan, Li-hong Lei, Li-li Chen, Cytokine levels in plasma and gingival crevicular fluid in chronic periodontitis. American Journal of Dentistry, 2015, 28 (1):9-12.
Chen LL, Wu YM, Ren F, Sun WL, Liu J, Lei LH, Zhang J, Cao Z, Possible Socioeconomic and Oral Hygiene Behavioural Risk Factors for Self-reported Periodontal Diseases in Women of Childbearing Age in a Chinese Population. Oral Health and Preventive Dentistry, 2014, 12 (2):171-181.
Diya,Zhang , Shenglai,Li, Lingjing,Hu, Liping,Sheng, Zheng,Cao, Yanmin,Wu, Lili,Chen, Protease-activated receptors expression in gingiva in periodontal health and disease. Archives of Oral Biology, 2014, 54 (9):393-399.
Zhang Diya, Hu Lingjing, Li Shenglai, Sheng Lieping, Cao Zheng, Chen Lili, Expressions of protease-activated receptors in human gingival fibroblasts and its functions in periodontitis. Chinese Journal of Stomatology,2014,49 (1):21-26.
Chen Lili, Huang Mei, Lei Lihong, Wu Yanming,  Role of OPG/RANKL/RANK system during alveolar bone resorption and remodeling.ActaAcademiaeMedicinaeMilitarisTertiae, 2013,35 (4):288-292.
Li-li Chen, Mei Huang, Jing-yi Tan, Xiao-tao Chen, Li-hongLei, Yan-min Wu, PI3K/AKT Pathway Involvement in the Osteogenic Effects of Osteoclast Culture Supernatants on Preosteoblast Cells. Tissue Engineering -Part A., 2013, 19 (19-20):2226-2232.
Yan-min Wu, Jia Liu, Wei-lian Sun, Li-guo Chai, Xiang Xiao, Zheng Cao, Li-li Chen, Periodontal status and associated risk factors among child bearing agewomen in CixiCity of China. J Zhejiang Univ SciB,2013,14 (3): 231-239.
Lei Lihong, Huang Mei, Wu Yanmin, Chen Lili, Role of EphrinB2/EphB4 during alveolar bone resorption and remodeling. ActaAcademiaeMedicinaeMilitarisTertiae, 2013,  (21): 2331-233.
Hu Lingjing, Zhang Diya, Chen Lili, The role of gingipain R and protease activated receptors in periodontitis. International Journal of Stomatology, 2013, 40 (1): 86-89.
CHEN Li-li, WANG Kai, ZHANG Jie, WU Yan-min, Effect of the bone resorption supernatant from RAW264.7 osteoclast on the osteogenicactivity of mouse MC3T3-E1 cell.Chinese journal of stomatology, 2012, 47 (1): 32-37.
Chen LL, Wang K, Zhang J, Wu YM. Effect of the bone resorption supernatant from RAW264.7 osteoclast on the osteogenic activity of mouse MC3T3-E1 cell. Chinese Journal of Stomatology. 2012; 47(1): 32-37.
Zhang DY, Li SL, Sheng LP, Hu LJ, Chen LL. Effect of recombinant product of Porphyromonasgingivalisgingipain R in periodontitis. Chinese Journal of Stomatology. 2011; 46(z1): 22-6.
Sun WL, Chen LL, Zhang SZ, Wu YM, Ren YZ, Qin GM. Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis. Intern Med. 2011; 50(15): 1569-74.
Chen LL, Lei LH, Ding PH, Tang Q, Wu YM. Osteogenic effect of Drynariaerhizoma extracts and Naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. Arch Oral Biol. 2011 Dec; 56(12): 1655-62.
Sun WL, Xu KL, Chen LL, Yu ZS. Tuberculosis cutis orificialis with both gingival involvement and underlying pulmonary tuberculosis. Aust Dent J. 2011; Jun;56(2): 216-20.
Sun WL, Yan JL, Chen LL. Ramsay-Hunt syndrome with unilateral polyneuropathy involving cranial nerves V, VII, VIII, and XII in a diabetic patient. Quintessence Int. 2011; 42(10): 873-7.
Sun WL, Chen LL, Zhang SZ, Ren YZ, Qin GM. Changes of adiponectin and inflammatory cytokines after periodontal intervention in type 2 diabetes patients with periodontitis. Arch Oral Biol. 2010 Dec; 55(12): 970-4.
Hu QY, Chen LL, Wang RF. Traditional Chinese medicine Drynariafortunei J. Smith naringin promotes proliferation and differentiation of human periodontal ligament cells. Journal of Zhejiang University(Medical Sciences). 2010 Jan; 39(1): 79-83.
Tang Q, Wang WQ, Wang RF, Ding PH, Chen LL. Influence of Naringin on Mouse' Osteoblast MC3T3-E1 Proliferation. Journal of Zhejiang Chinese Medical University. 2010; 34(2): 171-2.
Chen LL. Treatment of tooth mobility in patients with periodontal disease. Chinese Journal of Practical Stomatology. 2010; 3(1): 4-7.
Zhuang CY, Chen LL, Sun WL, Wu YM. Correlation between levels of porphyromonasgingivalis outer membrane protein A in subgingival plaques of chronic periodontitis and periodontal lesions. Stomatology. 2009; 29(2): 81-3.
Tang Q, Wang RF, Wang WQ, Ding PH, Chen LL. Effects of DrynariafortuneiJ.Smith and naringin from drynariafortuneiJ.Smith on matrix mineralization of mouse osteoblastic cell line MC3T3-El cells. Stomatology. 2009; 29(8): 403-4,408.
Zhang DY, Chen LL, Li SL, Gu ZY, Yan J. Lipopolysaccharide (LPS) of Porphyromonasgingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS. Innate Immun. 2008 Apr; 14(2): 99-107.
Wu YM, Chen LL, Sun WL, Yan J. Effect of lipopolysaccharide of Porphyromonasgingivalis on prostaglandin E2 biosynthetic pathway in human monocytic cell strain THP-1. Chinese Journal of Stomatology. 2008 Aug; 43(8): 483-7.
Ding PH, Tang Q, Chen LL, Yan J. Therapeutic effects of Pheretimaguillelmi on rat experimental model of alveolar bone resorption and mouse osteoblastic MC3T3-E1 cells. Journal of Zhejiang University(Science Edition). 2008; 35(6): 684-9.
Chen YF, Yan J, Zhang DY, Chen LL. Effect of Porphyromonasgingivalis lipopolysaccharide on induced secretion of inflammatory cytokines by different cell lines. Journal of Zhejiang University(Medical Sciences). 2008 Nov; 37(6): 622-8.
Cao Z, Chen LL, Gong XY. Artifacts from dental metal alloys in magnetic resonance imaging. National Medical Journal of China. 2008 Jul 8; 88(26): 1855-8.
Lou XJ, Zhang DY, Yan J, Li SL, Chen LL. Diversity of Porphyromonasgingivalis lipopolysaccharide induced IL-1β,TNF-α and IL-6 levels in THP-1 cells and the associated Toll-like receptors. Chinese Journal of Microbiology and Immunology. 2008; 28(8): 717-21.
Li SL, Zhang DY, Yan J, Chen LL. Effects of Porphyromonasgingivalis lipopolysaccharide on induction of IL-1β in THP-1 and HL-60 cells and the associated signaling receptors. Journal of Modern Stomatology. 2008; 22(2): 176-9.
Shi ZJ, Yan J, Chen LL. Molecular cloning and expression of rgpA and rgpB proteinase region genes of Porphyromonasgingivalis. Stomatology. 2008; 28(7): 340-2,346.
Wu YM, Yan J, Ojcius DM, Chen LL, Gu ZY, Pan JP. Correlation between infections with different genotypes of human cytomegalovirus and Epstein-Barr virus in subgingival samples and periodontal status of patients. J ClinMicrobiol. 2007 Nov; 45(11): 3665-70.
Wu YM, Chen LL, Yan J, Zhuang CY, Gu ZY. Effect of PorphyromonasgingivalisPrtC on cytokine expression in ECV304 endothelial cells and its level in subgingival plaques from patients with chronic periodontitis. ActaPharmacol Sin. 2007 Jul; 28(7): 1015-23.
Wu YM, Yan J, Chen LL, Gu ZY. Association between infection of different strains of Porphyromonasgingivalis and Actinobacillusactinomycetemcomitans in subgingival plaque and clinical parameters in chronic periodontitis. J Zhejiang UnivSci B. 2007 Feb; 8(2): 121-31.
Zhang DY, Yan J, Li SL, Chen LL. Diversity of Porphyromonadgingivalis lipopolysaccharide induced IL-1β, TNF-α and IL-6 levels in HL-60 cells and the associated Toll-like receptors and signaling pathways. Chinese Journal of Microbiology and Immunology. 2007; 27(10): 954-9.
Lin HY, Fu BP, Chen LL. Correlation of the subgingival infection and co-infection with human cytomegalovirus and Epstein-Barr virus in chronic periodontitis with severity of the periodontal lesions. Chinese Journal of Zoonoses. 2007; 23(3): 269-73.
Zhang DY, Li SL, Chen LL. Research Development of the Relationship between Actinobacillusactinomycetemcomitans and Apoptosis in Periodontitis. International Journal of Stomatology. 2007; 34(2): 94-6.
Ding PH, Chen LL. Periodontal Regeneration by Gene Therapy. International Journal of Stomatology. 2007; 34(2): 97-9.
Wu YM, Yan J, Chen LL, Sun WL, Gu ZY. Infection frequency of Epstein-Barr virus in subgingival samples from patients with different periodontal status and its correlation with clinical parameters. J Zhejiang UnivSci B. 2006 Nov; 7(11): 876-83.
Chen LL, Sun WL, Yan J, Yu ZS. Correlation between infection of different glycoprotein B genotypes of human cytomegalovirus and human chronic periodontitis. Chinese Journal of Stomatology. 2006 Apr; 41(4): 212-5.
Jin DM, Chen LL, Yan J. Effects of IGF-I and BMP-2 combined application on promoting proliferation, differentiation and calcification of MC 3T3-E1 and NIH 3T3 cells. Journal of Zhejiang University(Medical Sciences). 2006 Jan; 35(1): 55-63.
Jin DM, Chen LL, Yan J. Effects of insulin growth factor ĘŮ and bone morphogenetic protein-2 combined application on promoting proliferation and differentiation of MC 3T3-E1 and NIH 3T3 cells. Stomatology. 2006; 26(3): 193-5
Lou YL, Chen LL, Hu MD, Ruan P, Yan J. Correlation between the level of Porphyromonasgingivalis collagenase in subgingival plaques of chronic periodontitis and the periodontal lesions. Chinese Journal of Microbiology and Immunology. 2006; 26(3): 203-7.
Wu YM, Chen LL, Yan J, Sun WL, Gu ZY. Infection frequency of Epstein-Barr virus in subgingival samples from patients with different periodontal status and its correlation with severity of periodontal lesion. National Medical Journal of China. 2005 Nov 30; 85(45): 3216-20.
Chen LL, Wu YM, Yan J, Sun WL, Sun YZ, Ojcius D. Association between coinfection of Porphyromonasgingivalis, Actinobacillusactinomycetemcomitans and Treponemadenticola and periodontal tissue destruction in chronic periodontitis. Chin Med J (Engl). 2005 Jun 5; 118(11): 915-21.
Zhan DF, Liu ZW, Xia XP, Hu JC, Chen LL, Yan J. Study on the detection of P. gingivalis, A. actinomycetemcomitans and T. denticola and the correlation between coinfections of the microbes and levels of chronic periodontitis lesion. Chinese Journal of Epidemiology. 2005 Feb; 26(2): 120-3.
Sun WL, Chen LL, Yan J, Yu ZS. Effects of IGF-II on promoting proliferation and regulating nitric oxide synthase gene expression in mouse osteoblast-like cell. J Zhejiang UnivSci B. 2005 Jul; 6(7): 699-704.
Yu ZS, Sun WL, Chen LL, Hong WL. Glycoprotein B genotype of human cytomegalovirus analysis by nPCR-RFLP. Chinese Journal of Infectious Diseases. 2005; 23(2): 91-4.
Chen LL, Wu MJ, Yan J. Mutation and expression frequency of fimA gene in Porphyromonasgingivalis isolates and inflammation-causing effect of recombinant product of the gene. Chinese Journal of Microbiology and Immunology. 2005; 25(10): 850-4.
Zhuang CY, Chen LL, Yan J, Sun WL. Cloning and expression of PorphyromonasgingivalispgmA gene encoding outer membrane protein associated with fimbria. Journal of Zhejiang University(Medical Sciences). 2004; 33(1): 41-5.
Tang Q, Chen LL, Yan J. Effects of traditional chinese medicine Drynariafortunei smith on promoting the proliferation, differentiation and calcification of mouse osteoblastic MC3T3-E1 cells. China Journal of Chinese MateriaMedica. 2004 Feb; 29(2): 164-8.
Chen LL, Tang Q, Yan J. Therapeutic effect of aqueous-extract from a traditional Chinese medical herb Drynariafortunei on rat experimental model of alveolar bone resorption. China Journal of Chinese MateriaMedica. 2004 Jun; 29(6): 549-53.
Sun WL, Chen LL, Yan J, Yu ZS. Effects of insulin-like growth factor II on regulating nitric oxide synthase gene expression in mouse osteoblast-like MC3T3-E1 cells. Chinese Journal of Stomatology. 2004 May; 39(3): 201-4.
Sun WL, Chen LL, Yan J, Yu ZS. Effects of Insulin-like Growth Factor II (IGF- II) on the Inducible Nitric Oxide Synthase Gene Expression in Mouse Osteoblast-Like Cells. Stomatology. 2004; 24(5): 274-5.
Sun WL, Wu YM, Chen LL, Yan J. Effects of IGF-ĘÚon MC3T3-E1 Cells Proliferation and Nitric Oxide Production. Bulletin of Science and Technology. 2004; 20(3): 238-40.
Yan J, Chen LL, Wu YM, Sun WL. PCR detection of Treponemadenticola in subgingival plaques and the linkage between periodontal tissue destruction and spirochete infection. Chinese Journal of Microbiology and Immunology. 2003; 23(3): 228-30.
Yan J, Chen LL, Lou YL, Zhong XZ. Investigation of HGV and TTV infection in sera and saliva from non-hepatitis patients with oral diseases. World J Gastroenterol. 2002 Oct; 8(5): 857-62.
Chen LL, Yan J, Wu YM, Genotyping of Actinobacillusactinomycetemcomitans isolated from subgingival plaques of patients with chronic periodontitis. Chinese Journal of Microbiology and Immunology. 2002; 22(5): 496-9.
Wu YM, Chen LL, Yan J. Detection of Different Genotypes of Porphyromonasgingivalis in Subgingival Plaque from Patients with Chronic Periodontitis. West China Journal of Stomatology. 2002; 20(4): 251-3.
Wu YM, Chen LL, Yan J, Tang Q, Sun WL. Detection of Porphyromonasgingivalis from subgingival plaques of patients with chronic periodontitis PCR and genotype analysis of responssible strains. Chinese Journal of Microbiology and Immunology. 2002; 22(1): 112-5.
Yan J, Chen LL, Luo YH, Mao YF, He M. High frequencies of HGV and TTV infections in blood donors in Hangzhou. World J Gastroenterol. 2001 Oct; 7(5): 637-41.
Chen LL, Yan J. Porphyromonasgingivalis lipopolysaccharide activated bone resorption of osteoclasts by inducing IL-1, TNF, and PGE. ActaPharmacol Sin. 2001 Jul; 22(7): 614-8.
Chen LL, Tang Q, Wu YM, Sun WL, Yan J. Identification of subgingival anaerobic bacteria from adult periodontitis patients and analysis of medicine sensitivity tests results of isolated strains. Journal of Microbiology. 2001; 21(4): 39-40.

click here to update your profile