Research
Research Faculty Back
Dai Haibin
Position Vice Chair of Pharmacy
Department Pharmacy
Medical School
Zhejiang%20University%20School%20of%20Medicine%2C%20Zhejiang%2C%20China
Academic Rank
Chief Pharmacist
Clinical Interests
Focus on understanding the roles of Annexin A2 in ischemic brain damage, insight into molecular mechanisms of glycation in diabetes enhancing ischemic stroke injury, and developing anti-AGE agents for treating stroke accompanied by diabetes 
Professional Highlights
2016 National Excellent Clinical Pharmacist: Chinese Medical Association Clinical Pharmacy Branch 
2015 First Prize of Natural Science in Zhejiang Province: New target and significance of drug therapy for ischemic brain injury (2015-Z-001-R04)
2015, First Prize, Zhejiang Provincial Pharmaceutical Science and Technology Award.
Eighteenth SERVIER young pharmacological workers, Chinese Pharmacological Society, 2014.
Professional Appointments
Member of Editor Board of Chinese Journal of Modern Applied Pharmacy 
Member of Editor Board of Chinese Journal of Hospital Pharmacy 
Membersof Neuropsychopharmacology branch of Chinese Pharmacological Society
Education Experience
1993.9-1998.6   Department of pharmacology, China Pharmaceutical University, Bachelor Degree.
2003.9-2008.6   Department of pharmacology,School of Medicine, Zhejiang University,  Ph.D.
Current Program
1. The role and mechanism of HDAC9 in ischemic brain injury, NSFC, 2015
2. The role of complement C3 in cerebral ischemia injury and its effect on TLR2/4 signaling pathway in diabetic patients, NSFC, 2013
Publications
Hu Y, Ping Y, Li L, Xu H, Yan X, Dai H. A retrospective study of risk factors for carbapenem-resistant Klebsiella pneumoniae acquisition among ICU patients. J Infect Dev Ctries. 2016 Mar 31;10(3):208-13.
Li W, Chen Z, Yan M, He P, Chen Z, Dai H*. The protective role of Isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen glucose deprivation. J Neurochem. 2016 Feb;136(3):651-9.
Zhang J, Wu G, Dai H*. The matricellular protein CCN1 regulates TNF-α induced vascular endothelial cell apoptosis. Cell Biol Int. 2016 Jan;40(1):1-6.
Fang L, Li X, Zhong Y, Yu J, Yu L, Dai H*, Yan M*. Autophagy protects Human Brain Microvascular Endothelial Cells against Methylglyoxal-induced Injuries: in parallel with Cerebral Ischemic Model in Diabetic Rats. J Neurochem. 2015 135(2):431-40.
Zhang S, Hu Y, Huang Y, Xu H, Wu G, Dai H*. Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer. Oncol Lett. 2015 Jun;9(6):2572-2576. 
Xu H, He Y, Xu L, Yan X, Dai H*. Trends and patterns of five antihypertensive drug classes between 2007 and 2012 in China using hospital prescription data. Int J Clin Pharmacol Ther. 2015 Jun;53(6):430-7. 1.223

Zhang X, Yuan Y, Jiang L, Zhang J, Gao J, Shen Z, Zheng Y, Deng T, Yan H, Li W, Hou WW, Lu J, Shen Y, Dai H, Hu WW, Zhang Z, Chen Z. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014 Oct 1;10(10):1801-13.
Cai H, Dai H, Hu Y, Yan X, Xu H. Pharmacist care and the management of coronary heart disease: a systematic review of randomized controlled trials. BMC Health Serv Res. 2013 Nov 4;13(1):461.
Hu Y, Li L, Li W, Xu H, He P, Yan X, Dai H*. Combination antibiotic therapy versus monotherapy for Pseudomonas aeruginosa bacteraemia: A meta-analysis of retrospective and prospective studies. Int J Antimicrob Agents. 2013.42: 492–496.
Li W, Xu H, Hu Y, He P, Ni Z, Xu H, Zhang Z, Dai H*. Edaravone Protected Human Brain Microvascular Endothelial Cells from Methylglyoxal-Induced Injury by Inhibiting AGEs/RAGE/Oxidative Stress. PLoS ONE. 2013. 8(9): e76025. 
Li W, Liu J, He P, Ni Z, Hu Y, Xu H, Dai H*. Hydroxysafflor yellow A protects methylglyoxal-induced injury in the cultured human brain microvascular endothelial cells. Neurosci Lett. 2013. 549:146–150.
Dai H*, Yu Z, Fan X, Liu N, Yan M, Chen Z, Lo EH, Hajjar KA, Wang X*. Dysfunction of annexin A2 contributes to hyperglycemia-induced loss of human endothelial cell surface fibrinolytic activity. Thromb Haemost. 2013 Mar 21;109(6): 1070-8.
Xu H, Cai H, Qian Z, Xu G, Yan X, Dai H*. Dosing practice of low molecular weight heparins and its efficacy and safety in cardiovascular inpatients: a retrospective study in a Chinese teaching hospital. BMC Cardiovasc Disord. 2012 Dec 5;12(1):118
Ni Z, Zhuge Z, Li W, Xu H, Zhang Z, Dai H*. Inhibitory effects of hydroxysafflor yellow A on the formation of advanced glycation endproducts in vitro. Biol Pharm Bull. 2012;35(11):2050-3.
Hu Y, Ren J, Zhan M, Li W, Dai H*. Efficacy of rifaximin in prevention of traveler diarrhea: a meta-analysis of randomized, double-blind, placebo-controlled trials. J Travel Med. 2012;19(6):352-6.
Zhang F, Ding T, Yu L, Zhong Y, Dai H, Yan M. Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells. J Pharm Pharmacol. 2012;64(1):120-7
Fan X, Qiu J, Yu Z, Dai H, Singhal AB, Lo EH, Wang X. A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke. 2012 ;43(2):567-70 
Bie X, Chen Y, Zheng X, Dai H. The role of crocetin in protection following cerebral contusion and in the enhancement of angiogen esis in rats. Fitoterapia. 2011;82(7):997-1002.
Yan M, Dai H, Ding T, Dai A, Zhang F, Yu L, Chen G, Chen Z. Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells. Neurochem Int. 2011; 58(5):549-57.Co-first author
Fan YY, Hu WW, Dai HB, Zhang JX, Zhang LY, He P, Shen Y, Ohtsu H, Wei EQ, Chen Z. Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice. J Cereb Blood Flow Metab. 2011;31(1):305-14. Co-first author
Bie X, Han J, Dai H*. Effects of hydroxysafflor yellow A on the experimental traumatic brain injury in rats. J Asian Nat Prod Res. 2010; 12(3):239-47.
Fu Q, Dai H, He P, Hu W, Fan Y, Zhang W, Chen Z. The H3 receptor antagonist clobenpropit protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells. Pharmazie. 2010;65(4):257-60.
Dai H, Zhang Z, Zhu Y, Shen Y, Hu W, Huang Y, Luo J, Timmerman H, Leurs R, Chen Z. Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H2 receptor/cyclic AMP/protein kinase A and H3 receptor/GABA release pathways. J Neurochem 2006;96:1390-400.
Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. Eur J Pharmacol 2007;563:117-23.
Xu X, Dai H, Shi Y. Erythropoietin protects primary cultures of rat cortical neurons from hypoxia-induced toxicity through attenuating both glutamate release and NMDA receptor evoked neurotoxicity pathway. Pharmazie 2009;64:210-3. 
Fu Q, Dai H, Hu W, Fan Y, Shen Y, Zhang W, Chen Z. Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells. Cell Mol Neurobiol 2008;28:307-16.
Shen Y, Fan Y, Dai H, Fu Q, Hu W, Chen Z. Neuroprotective effect of carnosine on necrotic cell death in PC12 cells. Neurosci Lett 2007;414:145-9.
Bie X, Chen Y, Han J, Dai H, Wan H, Zhao T. Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Asia Pac J Clin Nutr 2007;16 Suppl 1:305-8.
Shen Y, Hu WW, Fan YY, Dai HB, Fu QL, Wei EQ, Luo JH, Chen Z. Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors. Biochem Pharmacol 2007;73:709-17. 
Hu W, Fan Y, Shen Y, Yang Y, Dai H, Fu Q, Chen Z. Mast cell-derived mediators protect against oxygen-glucose deprivation-induced injury in PC12 cells and neurons. Neurosci Lett 2007;423:35-40.
Gong YX, Wang HJ, Zhu YP, Zhang WP, Dai HB, Zhang SH, Wei EQ, Chen Z. Carnosine ameliorates morphine-induced conditioned place preference in rats. Neurosci Lett 2007;422:34-8.
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