Research Faculty Back
Chen Zhihua
Position Researcher
Department Respiratory Medicine
Medical School
Clinical Interests
molecular mechanisms, prevention and treatment involved in the pathogenesis of chronic inflammatory airway diseases, such as asthma, chronic obstructive pulmonary disease (COPD), environmental particulate matter and lung diseases, molecular mechanisms of airway epithelial injury, and novel animal models for COPD.
Professional Highlights
Young Investigator Award, 2005, Society for Free Radical Research Japan.
Guangji Potential Scholar, 2010, 2nd Affiliated Hospital of Zhejiang University School of Medicine
Professional Appointments
Member, Asthma Committee of Chinese Thoracic Society
Member, Respiratory Committee of Chinese Association for Physiological Sciences
Current Program
1.Project of Chinese National Programs for Fundamental Research and Development (973 Program), 2015CB553405
Zhi-Hua Chen, (PI), 2015 ~ 2019, ¥5,200,000
Airway epithelial injury and genomic instability induced by environmental particular matter.
2.General Program, NSFC, 81670031
Zhi-Hua Chen (PI), 2017~2020, ¥1,050,000
A novel mouse model for COPD based on cigarette smoking-induced and elastin-mediated autoimmune response.
3.General Program, NSFC, 81370142
Zhi-Hua Chen (PI), 2014~2017, ¥850,000
Role of mTOR in cigarette smoking induced airway epithelial injury.
4.Key Program, NSFC, 81130001
Zhi-Hua Chen (2nd PI), 2012~2016, ¥2,800,000
Molecular Mechanisms of HDAC2 and Inflammasomes in Synergistic Regulation of Th17 and Neutrophilic Inflammation in Chronic Airway Diseases
Yue Hu, Jian Lou, Yuan-Yuan Mao, Tian-Wen Lai, Li-Yao Liu, Chen Zhu, Chao Zhang, Juan Liu, Yu-Yan Li, Fan Zhang, Wen Li, Song-Min Ying, Zhi-Hua Chen*, Hua-Hao Shen*. Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury. Autophagy, 2016, in press.
Zhou JS, Zhao Y, Zhou HB, Wang Y, Wu YF, Li ZY, Xuan NX, Zhang C, Hua W, Ying SM, Li W, Shen HH, Chen ZH*. Autophagy Plays an Essential Role in Cigarette Smoke-Induced Expression of MUC5AC in Airway Epithelium. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1042-52. doi: 10.1152/ajplung.00418.2015. 
Xia LX, Hua W, Jin Y, Tian BP, Qiu ZW, Zhang C, Che LQ, Zhou HB, Wu YF, Huang HQ, Lan F, Ke YH, Lee JJ, Li W, Ying SM, Chen ZH*, Shen HH*. Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2. Cell Death Dis. 2016 Apr 7;7:e2175. doi: 10.1038/cddis.2016.74.
Zhang C, Zhang LH, Wu YF,Lai TW, Wang HS, Xiao H, Che LQ, Ying SM, Li W, Chen ZH*, Shen HH*. Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a merine model of chronic asthma. Sci Rep.2016 Feb 10;6:21515.
Chen ZH, Wu YF, Wang PL, Wu YP, Li ZY, Zhao Y, Zhou JS, Zhu C, Cao C, Mao YY, Xu F, Wang BB, Cormier S, Ying SM, Li W, Shen HH. Autophagy Is Essential for Ultrafine Particle-Induced Inflammation and Mucus Hyperproduction in Airway Epithelium. Autophagy, 2016;12(2):297-311. doi: 10.1080/15548627.2015.1124224.
Hu Y, Liu J, Wu YF, Lou J, Mao YY, Shen HH, Chen ZH*.mTOR and autophagy in regulation of acute lung injury: a review and perspective. Microbes Infect. 2014 Sep;16(9):727-34. doi: 10.1016/j.micinf.2014.07.005.
Chen ZH, Cao JF, Zhou JS, Liu H, Che LQ, Mizumura K, Li W, Choi AM, Shen HH. Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L1016-25.
Chen ZH, Wang PL, Shen HH*. Asthma research in China: A five-year review. Respirology. 18 (3):10-9, 2013.
Chen ZH, Shen HH*. Moving forward: Respirology supplement on chronic airway inflammation research in China. Respirology. 2013 Nov;18 Suppl 3:2-3.
Chen ZH, Shen HH. You can control your asthma if appropriately managed. Indian J Med Res 135, May 2012, pp 267-269.
Li W, Liu H, Zhou JS, Cao JF, Zhou XB, Choi AM, Chen ZH*, Shen HH*. Caveolin-1 regulates expressions of antioxidant enzymes via interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2). J. Biol. Chem. Apr 30, 2012£¨287(25):20922-30.
Chen ZH, Niki E. Two faces of lipid peroxidation products: the -Yin and Yang- principles of oxidative stress. J. Exp. Integr. Med. 2011; 1(4): 215-219.
Chen ZH, Lam HC, Jin Y, Kim HP, Cao J, Lee SJ, Ifedigbo E, Parameswaran H, Ryter SW, Choi AMK. Autophagy Protein LC3B Activates Extrinsic Apoptosis During Cigarette-Smoke Induced Emphysema. Proc. Natl. Acad. Sci. USA. 2010, 107: 18880-18885.
Chen ZH, Kim HP, Sciurba FC, Lee SJ, Feghali-Bostwick C, Stolz DB, Dhir R, Landreneau RJ, Schuchert MJ, Yousem SA, Nakahira K, Pilewski JM, Lee JS, Zhang Y, Ryter SW, Choi AMK. Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS ONE 2008, 3, e3316.
Chen ZH, Kim HP, Ryter S, Choi AMK. Identifying targets for COPD treatment through gene expression analyses. Int. J. COPD, 2008, 3, 359-370.
Chen ZH Saito Y, Yoshida Y, Noguchi N, Niki E. Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation. Biofactors, 2008, 33, 1-11.
Chen ZH, Saito Y, Yoshida Y, Niki E. Effect of oxygen concentration on free radical-induced cytotoxicity. Biosci Biotechnol Biochem. 2008, 72, 1491-1497.
 Chen ZH*, Yoshida Y, Saito Y, Sekine A, Noguchi N, Niki E. Induction of adaptive response and enhancement of PC12 cell tolerance by 7-Hydroxycholesterol and 15-deoxy-delta12,14-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. J. Biol. Chem., 2006, 281, 14440-14445.
Chen ZH*, Yoshida Y, Saito Y, Noguchi N, Niki E. Adaptive response induced by lipid peroxidation products in cell cultures. FEBS Lett. 2006, 580, 479-483.
Chen ZH*, Niki E. 4-hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects? IUBMB Life 2006, 58, 372-373.
Chen ZH*, Saito Y, Yoshida Y, Sekine A, Noguchi N, Niki E. 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2. J. Biol. Chem. 2005, 280, 41921-41927.
Chen ZH*, Yoshida Y, Saito Y, Niki E. Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage. Neurosci. Lett. 2005, 383, 256-259.
Chen ZH, Na HK, Hurh YJ, Surh YJ. 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK. Toxicol. Appl. Pharmacol. 2005, 208, 46-56.
Chen ZH, Hurh YJ, Na HK, Kim JH, Chun YJ, Kim DH, Kang KS, Cho MH, Surh YJ. Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Carcinogenesis 2004, 25, 2005-2013.
Hurh YJ#, Chen ZH#, Na HK, Han SY, Surh YJ. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J. Toxicol. Environ. Health A. 2004, 67, 1939-1953.
Chen ZH, Zhou B, Yang L, Wu LM, Liu ZL. Antioxidant activity of green tea polyphenols against lipid peroxidation inhibited by lipid-soluble radicals in micelles. J. Chem. Soc. Perkin Trans. 2, 2001, 1835-1839.
click here to update your profile