Departments & Centers
Doctors Back
Shen Huahao M.D Ph.D
Position£º Chair of Respiratory Medicine
Department£º Respiratory Medicine
Medical School
Academic Rank
Clinical Interests
Pathogenesis of asthma, especially immunological and pathophysiological mechanism involved, pulmonary infection, critical care in respiratory including respiratory failure and rare respiratory diseases.
Professional Highlights
Second Prize of National Science and Technology Progress Award, 2013;
First Prize of Science and Technology Progress Award, Ministry of Education, 2012;
Second Prize of Chinese Medical Science and Technology Award, CMA, 2012;
First Prize of Zhejiang Province Science and Technology Progress Award, 2010;
Professional Appointments
Professor of Yangtze River Scholars Program
Distinguished Young Scientist, the National Natural Science Foundation of China
Vice President, Chinese Thoracic Society (CTS), Chinese Medical Association
Chair, Asthma Committee of Chinese Thoracic Society
Vice President, Chinese Respiratory Physician Association
Education Experience
Postdoctoral Fellow & Senior Research Associate, Mayo Clinic Scottsdale, USA.
Research Fellow, Department of Medicine, McMaster University, Canada.
Ph.D., Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Current Program
Major Program, NSFC, 81490532
Huahao Shen (PI), 2015~2019, ¥2,760,000
Key factors in regulation of inflammation in acute lung injury
International Cooperative Key Program, NSFC, 81420108001
Huahao Shen (PI), 2015~2019, ¥3,000,000
Molecular mechanisms of eosinophils in regulation of chronic airway diseases and lung carcinogenesis
Key Program, NSFC, 81130001
Huahao Shen (PI), 2012~2016, ¥2,800,000
Molecular Mechanisms of HDAC2 and Inflammasomes in Synergistic Regulation of Th17 and Neutrophilic Inflammation in Chronic Airway Diseases

Sheroy Minocherhomji, Songmin Ying, Victoria A. Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W. Mankouri, *Huahao Shen, *Ying Liu, and *Ian D. Hickson*. Replication Stress Activates DNA Repair Synthesis in Mitosis. Nature. 2015. DOI:10.1038/Nature16139 . IF 41.45
Zhi-Hua Chen , Yin-Fang Wu, Ping-Li Wang, Yan-Ping Wu, Zhou-Yang Li, Yun Zhao, Jie-Sen Zhou, Chen Zhu, Chao Cao, Yuan-Yuan Mao, Feng Xu, Bei-Bei Wang, Stephania A Cormier, Song-Min Ying, *Wen Li, *Hua-Hao Shen. Autophagy Is Essential for Ultrafine Particle-Induced Inflammation and Mucus Hyperproduction in Airway Epithelium. Autophagy. 2016 Feb;12(2):297-311. doi: 10.1080/15548627.2015.1124224. IF 11.75
Chao Cao, Tianwen Lai, A Miao, Hongbin Zhou, Zaichun Deng, Songmin Ying, Zhihua Chen, Wen Li, *Huahao Shen. Smoking-promoted oxidative DNA damage response is highly correlated to lung carcinogenesis. Oncotarget 2016 Mar 1. doi: 10.18632/oncotarget.7810. [Epub ahead of print] IF 6.36
Che, L., Jin, Y., Zhang, C., Lai, T., Zhou,H., Xia, L., Tian, B., Zhao, Y., Liu, J., Wu, Y., Wu, Y., Du, J., Li, W., Ying,S., Chen, Z., and *Shen, H. 2016. Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade. Scientific reports 6: 18680  IF 5.578
Xia LX, Hua W, Jin Y, Tian BP, Qiu ZW, Zhang C, Che LQ, Zhou HB, Wu YF, Huang HQ, Lan F, Ke YH, Lee JJ, Li W, Ying SM, Chen ZH, *Shen HH. Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2. Cell Death Dis. 2016 Apr 7;7:e2175. doi: 10.1038/cddis.2016.74. IF 5.014
Zhou JS, Zhao Y, Zhou HB, Wang Y, Wu YF, Li ZY, Xuan NX, Zhang C, Hua W, Ying SM, Li W, Shen HH, *Chen ZH. Autophagy Plays an Essential Role in Cigarette Smoke-Induced Expression of MUC5AC in Airway Epithelium. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1:ajplung.00418.2015. doi: 10.1152/ajplung.00418.2015. [Epub ahead of print] IF 4.08
Zhang C, Zhang LH, Wu YF, Lai TW, Wang HS, Xiao H, Che LQ, Ying SM, Li W, Chen ZH,  *Huahao Shen. Suhuang antitussive capsule attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma. Sci Rep. 2016 Feb 10;6:21515. doi: 10.1038/srep21515.  IF 5.578
Zhengqiang Bao, Chao Cao, Xinwei Geng, Baoping Tian, Yanping Wu, Chao Zhang, Zhihua Chen, Wen Li, *Huahao Shen, *Songmin Ying. Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis. Oncotarget. 2016 Feb 16;7(7):7629-39. doi: 10.18632/oncotarget.5367.  IF 6.359
Chao Cao, Wen Li, *Huahao Shen. Reduced-Nicotine Cigarettes: A Double-edged Sword (To the Editor). N Engl J Med. 2016,374(4):394-395.  IF 55.873
Chao Cao , Yinfang Wu , Zhiwei Xu , Dan Lv , Chao Zhang , Tianwen Lai , Wen Li, *Huahao Shen. The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research. Sci Rep. 2015 Nov 10;5:16461. doi: 10.1038/srep16461.  IF 5.578
Xing M, Wang X, Palmai-Pallag T, Shen H, Helleday T, Hickson ID, *Ying S.Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget. 2015 Nov 10;6(35):37638-46. doi: 10.18632/oncotarget.5497.  IF 6.359
Hua W, Liu H, Xia LX, Tian BP, Huang HQ, Chen ZY, Ju ZY, Li W, Chen ZH, *Shen HH. Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice. Respirology. 2015 Oct;20(7):1055-65. doi: 10.1111/resp.12554. Epub 2015 Jun 4.   IF 3.345
Tianwen Lai, Shaobin Wang, Zhiwei Xu, Chao Zhang, Yun Zhao, Yue Hu, Chao Cao, Songmin Ying, Zhihua Chen, Wen Li, Bin Wu, *Huahao Shen. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis. Scientific Reports. 2015 Aug 14;5:9548. doi: 10.1038/srep09548.  IF 5.578
Zhou H, Hua W, Jin Y, Zhang C, Che L, Xia L, Zhou J, Chen Z, Li W, *Shen HH. Tc17 Cells Are Associated with Cigarette Smoke-Induced Lung Inflammation and Emphysema. Respirology. 2015 Apr;20(3):426-33. doi: 10.1111/resp.12486. Epub 2015 Feb 11. IF 3.345

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