Departments & Centers
Leadership Back
Wang Jian'an M.D Ph.D FACC
Position£º Hospital President; Chair of Heart Center
Department£º Cardiology
Medical School
Academic Rank
Professor of Medicine
Clinical Interests
Basic and clinical research on the coronary heart diseases
Basic and clinical application research of mesenchymal stem cells
Professional Highlights
2013 Science and Technology Advancement Prize of Zhejiang Province, First Place
2012 National Prize for Progress in Science and Technology of China, Second Place
2008 Science and Technology Advancement Prize of Zhejiang Province, First Place
2005 Science and Technology Advancement Prize of Zhejiang Province, Second Place
2005 Science and Technology Advancement Prize of Zhejiang Province Dept. of Education
Second Place
2004 Chinese Medical Science and Technology Prize, Third Place
2002 Science and Technology Advancement Prize of Zhejiang Province, Third Place
2001 Science and Technology Advancement Prize of Zhejiang Province, Second Place
2000 Excellent Natural Science Article Prize of Zhejiang Province, First Place
2000 Excellent Natural Science Article Prize of Zhejiang Province, Second Place
Professional Appointments
Fellow of American College of Cardiology
Vice chief Committee Member of Chinese Society of Cardiovascular Diseases
Committee Member of Chinese Electrophysiology and Cardiac Pacing Association
Committee Member of Chinese Association of Cardiologist
Chairman of Zhejiang Provincial Cardiology Association
Past Chairman of Zhejiang Electrocardiophysiology and Pacing Association
Chairman of Zhejiang Cardiologist Association
Chairman of Zhejiang Cardiology Intervention Quality Control Center
Chairman of Zhejiang Cardiology Intervention Specialist Committee
Director of Zhejiang Key Laboratory of Cardiology
Education Experience
Advanced Training in Interventional Cardiology, Loma Linda Medical Center, USA
Advanced Training in Cardiology, Queen Mary Hospital,Hongkong
Research Summary
Dr.Wang's reseach focuses on the coronary heart diseases and mesenchymal stem cells, characteristics and
mechanisms of its effectiveness to the ischemic heart diseases.
Hu X, Xu Y, Zhong Z, Wu Y, Zhao J, Wang Y, Cheng H, Kong M, Zhang F, Chen Q, Sun J, Li Q, Jin J, Li Q, Chen L, Wang C, Zhan H, Fan Y, Yang Q, Yu L, Wu R, Liang J, Zhu J, Wang Y, Jin Y, Lin Y, Yang F, Jia L, Zhu W, Chen J, Yu H, Zhang J, Wang J. A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates: Paracrine Activity Without Remuscularization. Circ Res. 2016 Mar 18;118(6):970-983.
Hu X, Zhang L, Jin J, Zhu W, Xu Y, Wu Y, Wang Y, Chen H, Webster KA, Chen H, Yu H, Wang J. Heparanase released from mesenchymal stem cells activates intergrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells. 2015;33(6):1850-62.
Liu XB , Jiang JB, Zhou QJ, Pu ZX, He W, Dong AQ, Feng Y, Jiang J, Sun Y, Xiang MX, He YX, Fan YQ, Dong L, Wang J. Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population. Journal of  Zhejiang University. Science. B. 2015;16(3):208-14.
Hu X, Huang X, Yang Q, Wang L, Sun J, Zhan H, Lin J, Pu Z, Jiang J, Sun Y, Xiang M, Liu X, Xie X, Yu X, Chen Z, Tse HF, Zhang J, Wang J. Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial. International Journal of Cardiology. 2015 25;184C:446-451.
Liu X,Chen H,Zhu W,Chen H,Hu X,Jiang Z,Xu Y,Zhou Y,Wang K,Wang L,Chen P,Hu H,Wang C,Zhang N,Ma Q,Huang M,Hu D,Zhang L,Wu R,Wang Y,Xu Q,Yu H,Wang J.Transplantation of SIRT1 engineered aged MSCs improves cardiac function in a rat myocardial infarction model. The Journal of Heart and Lung Transplantation. 2014;33(10):1083-92.
Chen H,Liu X,Zhu W,Chen H,Hu X,Jiang Z,Xu Y,Wang L,Zhou Y,Chen P,Zhang N,Hu D, Zhang L,Wang Y,Xu Q,Wu R,Yu H,Wang J. SIRT1 Ameliorates Age-Related Senescence of Mesenchymal Stem Cells Via Modulating Telomere Shelterin. SIRT1 Ameliorates Age-Related Senescence of Mesenchymal Stem Cells Via Modulating Telomere Shelterin. Frontiers in Aging Neuroscience. 2014;6:103.
Hu X,Wu R,Jiang Z,Wang L,Chen P,Zhang L,Yang L,Wu Y,Chen H,Chen H,Xu Y,Zhou Y, Huang X,Webster KA, Yu H, Wang J. Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells. 2014;32(10):2702-13.
Hu X,Wu R,Shehadeh LA,Zhou Q,Jiang C,Huang X,Zhang L,Gao F,Liu X,Yu H,Webster KA,Wang J.Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells.BMC Genomics. 2014 23;15(1):303.
Chen H,Liu X,Chen H,Cao J,Zhang L,Hu X,Wang J.Role of SIRT1 and AMPK in mesenchymal stem cells differentiation.Ageing Research Reviews.2014; 13: 55-64.
Zhang Z,Wang J,Xu Y,Jiang Z,Wu R,Wang L,Chen P,Hu X,Yu H. Menstrual blood derived mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to mesenchymal transition in myocardial infarction. International Journal of Cardiology. 2013;168(2):1711-4.
Xu Y,Hu X,Wang L,Jiang Z,Liu X,Yu H,Zhang Z,Chen H,Chen H,Steinhoff G,Li J,Wang J. Transplantation of preconditioned bone marrow mononuclear cells by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells. International Journal of Cardiology. 2013  9;168(4):4551-4.
Chen H,Wang J,Xiang MX,Lin Y,He A,Jin CN,Guan J,Sukhova GK,Libby P,Wang J,Shi GP. Cathepsin S-Mediated Fibroblast Trans-Differentiation Contributes to Left Ventricular Remodeling After Myocardial Infarction. Cardiovascular Research. 2013;100(1):84-94.
Jiang Z,Hu X,Yu H,Xu Y,Wang L,Chen H,Chen H,Wu R,Zhang Z, Xiang C,Webster KA,Wang J. Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms. Journal of Cellular and Molecular Medicine. 2013;17(10):1247-60.
Ma LL,Zhang FJ,Qian LB,Kong FJ,Sun JF,Zhou C,Peng YN,Xu HJ,Wang WN,Wen CY,Zhu MH,Chen G,Yu LN,Liu XB,Wang J,Yan M. Hypercholesterolemia blocked sevoflurane-induced cardioprotection against ischemia-reperfusion injury by alteration of the MG53/RISK/GSK3β signaling. International Journal of Cardiology. 2013;9;168(4):3671-8. 
Liu XB,Wang J. Update of transcatheter valve treatment. Journal of Zhejiang     University. Science. B. 2013;14(8):670-75.
Wang J. Progress and challenges in the cardiovascular field. Journal of Zhejiang University. Science. B. 2012;13(8):587-88.
Liu XB,Chen H,Chen HQ,Zhu MF,Hu XY,Wang YP,Jiang Z,Xu YC, Xiang MX,Wang J. Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation. Journal of Zhejiang University. Science. B. 2012;13(8):616-23.
Xie X,Wang Y,Zhang S,Zhang G,Xu Y,Bi H,Daugherty A,Wang J. Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis. The Journal of Nutritional Biochemistry. 2012;23(6):549-56.
Pan XH, Zhang SZ, Chen HQ, Xiang MX, Wang J. Spuriously high B-type natriuretic peptide level caused by human antimouse antibodies. Annals of Internal Medicine. 2011 20;155(6):407-8.¡¡
Wang Y,Hu X,Xie X,He A,Liu X,Wang J. Effects of mesenchymal stem cells on matrix metalloproteinase synthesis in cardiac fibroblasts. Experimental Biology and Medicine. 2011;236(10):1197-204.
Wang WX,Hu XY,Xie XJ,Liu XB,Wu RR,Wang YP,Gao F,Wang J.Nerve growth factor induces cord formation of mesenchymal stem cell by promoting proliferation and activating the PI3K/Akt signaling pathway. Acta Pharmacologica Sinica. 2011;32(12):1483-90.
Wang J,Chen WA,Wang Y,Zhang S,Bi H,Hong B,Luo Y,Daugherty A,Xie X. Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Atherosclerosis. 2011;217(1):90-6.
Hu X,Wei L,Taylor TM,Wei J,Zhou X, Wang J,Yu SP.Hypoxic Preconditioning Enhances Bone Marrow Mesenchymal Stem Cell Migration via Kv2.1 Channel and FAK Activation. American Journal of Physiology:Cell Physiology.  2011;301(2):C362-72.
Hu XY,Wang WX,Yu MJ,Liu XB,Wu RR,Gao F,Huang X,Cao J, Xie XJ,Wang J. Tongxinluo promotes mesenchymal stem cell tube formation in vitro. Journal of Zhejiang University. Science. B. 2011;12(8):644-51.
Wang J. Advances in cardiovascular disease: how far is the summit? Journal of Zhejiang University. Science. B.2010;11(8):547.
Gao F,Hu XY,Xie XJ,Xu QY,Wang YP,Liu XB,Xiang MX,Sun Y, Wang J. Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. Journal of Zhejiang University. Science. B. 2010;11(8):608-17.
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