Departments & Centers
Leadership Back
Wu Zhiying M.D, Ph.D
Position£º Vice President
Department£º Neurology
Medical School
Academic Rank
Professor of Neurology
Clinical Interests
Screening of causative genes, analyzing genotype-phenotype correlations and understanding molecular pathogenesis of neurological disorders.
Professional Highlights
Associate Group Leader, Neurogenetics Research Group, Neurology Division of Chinese Medical Association
Winner of National Outstanding Youth Science Foundation in 2011
China Young Women Scientists’ Award in 2012

Yao Y#, Cui X#, Al-Ramahi I#, Sun X#, Li B, Hou J, Difiglia M, Palacino J, Wu ZY*,Ma L*, Botas J*, Lu B*. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. Elife, 2015; 4: e05449.
Xu M, Wu ZY*. Huntington disease in Asia. Chinese Medical Journal, 2015, 128: 1815-1819.
Cheng Q, He SQ, Gao D, Lei B, Long X, Liang HF, Zhu P, Jin JF, Tang B, Tomlinson S, Wu ZY*, Chen XP*. Early Application of Auxiliary Partial Orthotopic Liver Transplantation in Murine Model of Wilson Disease. Transplantation, 2015 May 25. [Epub ahead of print]
Zhu M, Dong Y, Ni W, Wu ZY*. Defective roles of ATP7B missense mutations in cellular copper tolerance and copper excretion. Mol Cell Neurosci, 2015, 67: 31-36.
Ni W, Chen S, Qiao K, Wang N, Wu ZY*. Genotype-phenotype correlation in Chinese patients with spinal and bulbar muscular atrophy. PLOS ONE, 2015, 10(3):e0122279.
Yang P, Xu M, Liu ZJ, Tao QQ, Lu SJ, Li HL, Guo QH, Sun YM, Wu ZY*. Genetic association of CUGBP2 and DNMBP with Alzheimer’s disease in the Chinese Han population. Current Alzheimer Research, 2015, 12: 228-232.
Dong Y, Wu JJ, Wu ZY*. Identification of 46 CAG repeats within PPP2R2B as probably the shortest pathogenic allele for SCA12. Parkinsonism Relat Disord, 2015, 21:398-401. 
Lu HP, Gan SR, Chen S, Li HF, Liu ZJ, Ni W, Wang N, Wu ZY*. Intermediate-length polyglutamine in ATXN2 is a possible risk factor among Eastern Chinese patients with amyotrophic lateral sclerosis. Neurobiol Aging, 2015, 36(3): 1603.e11-14.
Dong Y, Shi SS, Chen S, Ni W, Zhu M, Wu ZY*. The discrepancy between absence of copper deposition and presence of neuronal damage in brain of Atp7b-/- mice. Metallomics, 2015, 7(2): 283-288.
Zhuang JC, Huang ZY, Zhao GX, Yu H, Li ZX, Wu ZY*. Variants of CYP27B1 are associated with both multiple sclerosis and neuromyelitis optica patients in Han Chinese population. Gene, 2015, 557(2):236-239.
Li HL, Yang P, Liu ZJ, Sun YM, Lu SJ, Tao QQ, Guo QH, Wu ZY*. Common variants at Bin1 are associated with sporadic Alzheimer's disease in the Han Chinese population. Psychiatr Genet, 2015, 25(1):21-25. 
Liu ZJ, Sun YM, Ni W, Dong Y, Shi SS, Wu ZY*. Clinical features of Chinese patients with Huntington’s disease carrying CAG repeats beyond 60 within HTT gene. Clin Genet, 2014, 85:189-193.
Jiang H, Sun YM, Hao Y, Yan YP, Chen K, Xin SH, Tang YP, Li XH, Jun T, Chen YY, Liu ZJ, Wang CR, Li H, Pei Z, Shang HF, Zhang BR, Gu WH, Wu ZY*, Tang BS, Burgunder JM*, Chinese HD Network. Huntingtin gene CAG repeat numbers in Chinese patients with Huntington's disease and controls. Eur J Neurol, 2014, 21(4):637-642.
Tao QQ, Sun YM, Liu ZJ, Ni W, Yang P, Li HL, Lu SJ, Wu ZY*. A variant within FGF1 is associated with Alzheimer's disease in the Han Chinese population. Am J Med Genet B, 2014, 165(2):131-136.
Tao QQ, Sun YM, Liu ZJ, Yang P, Li HL, Lu SJ, Wu ZY*. Lack of association between CALHM1 p.P86L variation and Alzheimer's disease in the Han Chinese population. Neurobiol Aging, 2014, 35(8):1956.e13-14. 
Lu SJ, Li HL, Sun YM, Liu ZJ, Yang P, Wu ZY*. Clusterin variants are not associated with southern Chinese patients with Alzheimer's disease. Neurobiol Aging, 2014, 35(11): 2656.e9-11. 
Liu ZJ, Li HF, Tan GH, Tao QQ, Ni W, Cheng XW, Xiong ZQ, Wu ZY*. Identify mutation in amyotrophic lateral sclerosis cases using HaloPlex target enrichment system. Neurobiol Aging, 2014, 35(12):2881.e11-15.
Liu QB, Li ZX, Zhao GX, Yu H, Wu ZY*. No association between the identified multiple sclerosis non-MHC risk loci and neuromyelitis optica. Neurosci Bul, 2014, 30(6):1036-1044.
Li HF, Chen WJ, Ni W, Wu ZY*. Paroxysmal kinesigenic dyskinesia and myotonia congenita in the same family: coexistence of a PRRT2 mutation and two CLCN1 mutations. Neurosci Bull, 2014, 30(6): 1010-1016. 
Liu Y, Zhao G, Yu H, Lyu C, Li Z, Wu Z*. Differentiation of neuromyelitis optica from multiple sclerosis in a cohort from the mainland of China. Chin Med J (Engl), 2014, 127(18):3213-3218. 
Zhu M, Tao Y, He Q, Gao H, Song F, Sun YM, Li HL, Wu ZY*, David Saffen*. A common GSAP promoter variant contributes to Alzheimer’s disease liability. Neurobiol Aging, 2014, 35(11): 2656.e1-7.
Cai PP, Wang HX, Zhuang JC, Liu QB, Zhao GX, Li ZX*, Wu ZY*. Variants of autophagy-related gene 5 are associated with neuromyelitis optica in the Southern Han Chinese population. Autoimmunity, 2014; 47(8): 563–566.
Tao QQ, Chen Y, Liu ZJ, Sun YM, Yang P, Lu SJ, Xu M, Dong QY, Yang JJ*, Wu ZY*. Associations between apolipoprotein Egenotypes and serum levels of glucose, cholesterol, and triglycerides in a cognitively normal aging Han Chinese population. Clin Interv Aging, 2014, 9: 1063-1067.
Zhou Q, Ni W, Dong Y, Wang N, Gan SR*, Wu ZY*. The Role of Apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful. PLOS One, 2014, 9(11): e111356.
Li HF, Ni W, Xiong ZQ, Xu JF, Wu ZY*. PRRT2 c.649dupC mutation derived from de novo in paroxysmal kinesigenic dyskinesia. CNS Neurosci Ther, 2013, 19(1):61-65. 
Ni W, Dong QY, Zhang Y, Wu ZY*. Zinc monotherapy and a low-copper diet are beneficial in patients with Wilson disease after liver transplantation. CNS Neurosci Ther, 2013, 19(11):905-907.
Yang P, Sun YM, Liu ZJ, Tao QQ, Li HL, Lu SJ, Wu ZY*. Association study of ABCA7 and NPC1 polymorphisms with Alzheimer’s disease in Chinese Han ethnic population. Psychiatr Genet, 2013, 23(6): 268. 
Li HF, Chen WJ, Ni W, Wang KY, Liu GL, Wang N, Xiong ZQ, Xu J, Wu ZY*. PRRT2 mutation correlated with phenotype of paroxysmal kinesigenic dyskinesia and drug response. Neurology, 2013, 80(16):1534-1535. 
Dong Y, Sun YM, Ni W, Gan SR, Wu ZY*. Chinese patients with spinocerebellar ataxia type 3 presenting with rare clinical symptoms. J Neurol Sci, 2013, 324(1-2):167-171
Dong Y, Sun YM, Liu ZJ, Ni W, Shi SS, Wu ZY*. Chinese patients with Huntington’s disease initially presenting with spinocerebellar ataxia. Clin Genet, 2013, 83(4):380-383.
Li HL, Lu SJ, Sun YM, Guo QH, Sadovnick AD, Wu ZY*. The LRRK2 R1628P varianrt plays a protect role in Han Chinese population with Alzheimer’s diseases. CNS Neurosci Ther, 2013, 19(4):207-215.
Zhu M, Ni W, Dong Y, Wu ZY*. EGFP tags affect cellular localization of ATP7B mutants. CNS Neurosci Ther, 2013, 19(5): 346-351.
Niu YF, Ni W, Wu ZY*. ABCD1 mutations and phenotype distribution in Chinese patients with X-linked adrenoleukodystrophy. Gene, 2013, 522(1): 117-120.
Chen WJ*, Yao XP, Zhang QJ, Ni W, He J, Li HF, Liu XY, Zhao GX, Murong SX, Wang N, Wu ZY*. Novel SLC20A2 mutations identified in Southern Chinese patients with idiopathic basal ganglia calcification. Gene, 2013, 529(1): 159-162. 
Zhao GX, Liu Y, Li ZX, Lv CZ, Traboulsee A, Sadovnick AD, Wu ZY*. Variants in the promoter region of CYP7A1 are associated with neuromyelitis optica but not with multiple sclerosis in the Han Chinese population. Neurosci Bull, 2013, 2013, 29(5): 525-530.
Sun YM, Li HL, Guo QH, Wu P, Hong Z, Lu CZ, Wu ZY*. The polymorphism of the ATP-binding cassette transporter 1 gene modulates Alzheimer’s disease risk in Chinese Han ethnic population. Am J Geriatr Psychiatry, 2012, 20(7): 603-611. 
Shi SS, Lin Y, Zhao GX, Gan SR, Wu ZY*. A Chinese pedigree with a homozygote for CAG repeats of Huntington's disease. Psychiatr Genet, 2012, 22(1): 53-54.
Zhang Y, Huang JJ, Wang ZQ, Wang N, Wu ZY*. Value of muscle enzymes measurement in evaluating different neuromuscular diseases. Clin Chim Acta, 2012, 413(3-4):520-524.
Gan SR, Ni W, Zhao GX, Wu ZY*. Clinical and molecular analyses of a Chinese spinocerebellar ataxia type 7 family that includes infantile-onset cases. Neurology Asia, 2012, 17(2) : 121-126. 
Wang ZQ, Chen XJ, Murong SX, Wang N, Wu ZY*. Molecular analysis of 51 unrelated pedigrees with late-onset multiple acyl-CoA dehydrogenation deficiency (MADD) in southern China confirmed the most common ETFDH mutation and high carrier frequency of c.250G>A. J Mol Med, 2011, 89(6): 569-576. 
Chen WJ, Lin Yu, Xiong ZQ, Wei W, Ni W, Tan GH, Guo SL, He J, Chen YF, Zhang QJ, Li HF, Lin Yi, Murong SX, Xu J, Wang N*, Wu ZY*. Exome sequencing identifies truncating mutations in the PRRT2 gene that cause paroxysmal kinesigenic dyskinesia. Nature Genetics, 2011, 43(12): 1252-1255.
Cai B, Lin Y, Xue XH, Fang L, Wang N*, Wu ZY*. TAT-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice. Exp Neurol, 2011, 227(1): 224-231. 
Wang ZQ, Wang N, van der Maarel S, Murong SX, Wu ZY*. Distinguishing the 4qA and 4qB variants is essential for the diagnosis of facioscapulohumeral muscular dystrophy in the Chinese population. Eur J Hum Genet, 2011, 19(1): 64-69.
Li HL, Shi SS, Guo QH, Ni W, Dong Y, Liu Y, Sun YM, Wang B, Lu SJ, Hong Z, Wu ZY*. PICALM and CR1 variants are not associated with sporadic Alzheimer’s disease in Chinese patients. J Alzheimers Dis, 2011, 25(1):111-117.
Wang N, Xue XH, Lin Y, Fang L, Murong SX, Wu ZY*. The R219K polymorphism in the ATP-binding cassette transporter 1 gene has a protective effect on atherothrombotic cerebral infarction in Chinese Han ethnic population. Neurobiol Aging, 2010, 31(4): 647-653.
Xiong HL, Wang JY, Sun YM, Wu JJ, Chen Y, Qiao K, Zheng QJ, Zhao GX, Wu ZY*. Association between novel TARDBP mutations and Chinese patients with amyotrophic lateral sclerosis. BMC Med Genet, 2010, 11:8.
Gan SR, Shi SS, Wu JJ, Wang N, Zhao GX, Weng ST, Murong SX, Lu CZ, Wu ZY*. High frequency of Machado-Joseph disease identified in Southeastern Chinese kindreds with spinocerebellar ataxia. BMC Med Genet, 2010, 11:47. 
Gan SR, Zhao K, Wu ZY*, Wang N, Murong SX. Chinese patients with Machado-Joseph disease presenting with complicated hereditary spastic paraplegia. Eur J Neurol, 2009, (8):953-956.
Zhao ZH, Chen WZ, Wu ZY*, Wang N*, Zhao GX, Chen WJ, Murong SX. A novel mutation in the senataxin gene identified in a Chinese patient with sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Sc, 2009, 10(2): 118-122.
Wu ZY*, Lin Y, Chen WJ, Zhao GX, Xie H, Murong SX, Wang N. Molecular analyses of GCH-1, TH and parkin genes in Chinese dopa- responsive dystonia families. Clin Genet, 2008, 74(6): 513-521. 
Lin Y, Fang L, Xue XH, Murong SX, Wang N*, Wu ZY*. Association between Ngb polymorphisms and ischemic stroke in the Southern Chinese Han population. BMC Med Genet, 2008, 9: 110.
Xue XH, Wang N, Lin Y, Zhao GX, Fang L, Murong SX, Wu ZY*. Novel mutation in the ABCA1 gene identified in a Chinese patient with dementia and atherothrombotic cerebral infarction. Dement Geriatr Cogn Disord, 2008, 26 (3): 234-238.
Wu ZY*, Zhao GX, Chen WJ,Wang N, Wan B, Lin MT, Murong SX, Yu L. Mutation analysis of 218 Chinese patients with Wilson disease revealed no correlation between the canine copper toxicosis gene MURR1 and Wilson disease. J Mol Med, 2006, 84(5): 438-442.
Wu ZY*, Wang ZQ, Murong SX, Wang N. FSHD in Chinese population: Characteristics of translocation and genotype-phenotype correlation. Neurology, 2004, 63(3): 581-583.
Wu ZY*, Lin MT, Murong SX, Wang N. Molecular diagnosis and prophylactic therapy for presymptomatic Chinese patients with Wilson disease. Arch Neurol, 2003, 60(5): 737-741.
Wu ZY*, Wang N, Lin MT, Fang L, Murong SX. Mutation analysis and the correlation between genotype and phenotype of Arg778Leu mutation in Chinese patients with Wilson disease. Arch Neurol, 2001, 58 (6): 971-976.
Xu H#, Wu ZY#, Fang F, Guo L, Chen D, Xi Chen J, Stern D, Taylor GA, Jiang H, Shidu Yan S*. Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. FASEB J, 2010, 24(5):1583-1592. (#Co-first)
Chen WJ#, Wu ZY#, Lin MT, Su JF, Lin Y, Murong SX, Wang N*. Molecular analysis and prenatal prediction of spinal muscular atrophy in Chinese patients by the combination of restriction fragment length polymorphism analysis, denaturing high-performance liquid chromatography, and linkage analysis. Arch Neurol, 2007, 64(2): 225-231. (#Co-first)
Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu ZY, Pei G*. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol, 2009, 10(12): 1229-1231.
Yan SS*, Wu ZY, Zhang HP, Furtado G, Chen X, Yan SF, Schmidt AM, Brown C, Stern A, LaFailie J, Chess L, Stern D, Jiang H. Suppressipn of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med, 2003, 9(3): 287-293.

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