Wu Yulian, M.D., Ph.D.

Position:Chair of General Surgery

Department:General Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor  


Appointment

Clinical / Research Interests

Standard extended R0 lymphonectomy for advanced pancreatic cancer;

Tumor markers in hepatic, biliary, pancreatic and gastric cancers;

Surgical pancreatic diseases and pancreatic, Islet and islet stem cell transplantation;

RFA in treatment of various solitary tumors.


Professional Highlights

Professional Appointments

Vice Chair, Surgery Committee, Zhejiang Medical Association

Vice Chair, Transplantation Committee, Zhejiang Medical Association

Vice Chair, Gastric Cancer Comittee, Zhejiang Anti-Cancer Association

Associate Director, Surgery Institute of Zhejiang University

Associate Director, Surgery Department of Zhejiang University 

Member, Surgical Committee of Zhejiang, China, 1996-present: 

Member, Transplantation Committee of Zhejiang, China, 1998-present

Member, Editorial Board, Experimental Surgery of China, 1998-present

Member, Editorial Board, World Journal of Gastroenterology (WJG), 2003-present


Education Experience

Research Summary

Publications

Kang M, Qin W, Buya M, Dong X, Zheng W, Lu W, Chen J, Guo Q and Wu Y*. VNN1, a potential biomarker for pancreatic cancer-associated new-onset diabetes, aggravates paraneoplastic islet dysfunction by increasing oxidative stress. Cancer letters. 2016; 373(2):241-250. 

Zhang Y, Yang B, Liu Y, Qin W, Li C, Wang L, Zheng W and Wu Y*. Effective mRNA Inhibition in PANC-1 Cells in Vitro Mediated via an mPEG-SeSe-PEI Delivery System. Biol Pharm Bull. 2016 May 1;39(5):680-8.

Tang K, Lu W, Qin W and Wu Y*. Neoadjuvant therapy for patients with borderline resectable pancreatic cancer: A systematic review and meta-analysis of response and resection percentages. Pancreatology. 2016; 16(1):28-37. 

Han B, Cai H, Chen Y, Hu B, Luo H, Wu Y* and Wu J. The role of TGFBI (betaig-H3) in gastrointestinal tract tumorigenesis. Molecular cancer. 2015; 14:64. 

Qin W, Li C, Zheng W, Guo Q, Zhang Y, Kang M, Zhang B, Yang B, Li B, Yang H and Wu Y*. Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells. Oncotarget. 2015; 6(37):39839-39854. 

Cai H, Yang B, Xu Z, Zhang B, Xu B, Li X, Wu P, Chen K, Rajotte RV, Wu Y* and Rayat GR. Cyanidin-3-O-glucoside enhanced the function of syngeneic mouse islets transplanted under the kidney capsule or into the portal vein. Transplantation. 2015; 99(3):508-514. 

Li C, Liu DR, Li GG, Wang HH, Li XW, Zhang W, Wu Y* and Chen L. CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway. World journal of gastroenterology. 2015; 21(20):6215-6228

Kang M, Dong X, Lu W, Wu Y*. Vanin-1 as A Biomarker for Pancreatic Cancer Associated New-onset Diabetes Has Been Proven in Clinical and Laboratory Research. PANCREAS. 2014;43(8): 1374-1374. 

Yang B, Cai H, Qin W, Zhang B, Zhai C, Jiang B, Wu Y*. Bcl-2-functionalized ultrasmall superparamagnetic iron oxide nanoparticles coated with amphiphilic polymer enhance the labeling efficiency of islets for detection by magnetic resonance imaging.Int J Nanomedicine. 2013;8:3977-90. 

Zhang B,Yang B,Zhai C,Jiang B,Wu Y*, The role of exendin-4-conjugated superparamagnetic iron oxide nanoparticles in beta-cell-targeted MRI. Biomaterials 2013, 34, 5843-52.

Kang, M.; Jiang, B.; Xu, B.; Lu, W.; Guo, Q.; Xie, Q.; Zhang, B.; Dong, X.; Chen, D.; Wu Y*., Delta like ligand 4 induces impaired chemo-drug delivery and enhanced chemoresistance in pancreatic cancer. Cancer Lett 2013, 330, 11-21.

Zhang, B.; Buya, M.; Qin, W.; Sun, C.; Cai, H.; Xie, Q.; Xu, B.; Wu Y*., Anthocyanins from Chinese Bayberry Extract Activate Transcription Factor Nrf2 in beta Cells and Negatively Regulate Oxidative Stress-Induced Autophagy. J Agric Food Chem 2013, 61, 8765-72.

Lu, W. J.; Xu, B.; Gao, S. L.; Dong, X.; Zhang, B.; Wu, Y. L*., Enucleation of benign or borderline pancreatic head tumors adjacent to the common pancreatic duct. Pancreas 2012, 41, 336-7. 

Chen, Y.; Kang, M.; Lu, W.; Guo, Q.; Zhang, B.; Xie, Q.; Wu Y*, DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer. J Cancer Res Clin Oncol 2012, 138, 1463-74. 

Zhang, B.; Jiang, B.; Chen, Y.; Huang, H.; Xie, Q.; Kang, M.; Zhang, H.; Zhai, C.; Wu, Y*., Detection of viability of transplanted beta cells labeled with a novel contrast agent - polyvinylpyrrolidone-coated superparamagnetic iron oxide nanoparticles by magnetic resonance imaging. Contrast Media Mol Imaging 2012, 7, 35-44.  

Dong, X.; Zhang, B.; Kang, M. X.; Chen, Y.; Guo, Q. Q.; Wu Y*., Analysis of pancreatic fistula according to the International Study Group on Pancreatic Fistula classification scheme for 294 patients who underwent pancreaticoduodenectomy in a single center. Pancreas 2011, 40, 222-8.

Zhang, B.; Kang, M.; Xie, Q.; Xu, B.; Sun, C.; Chen, K.; Wu Y*, Anthocyanins from Chinese bayberry extract protect beta cells from oxidative stress-mediated injury via HO-1 upregulation. J Agric Food Chem 2011, 59, 537-45. 

Zhai C, Z. H., Du N, Chen B, Huang H, Wu Y*, Yang D, One-Pot Synthesis of Biocompatible CdSe/CdS Quantum Dots and Their Applications as Fluorescent Biological Labels. Nanoscale Res Lett 2011, 6, 31.  

Tang, Z.; Fang, H.; Kang, M.; Zhang, B.; Dong, X.; Chen, X.; Xu, J.; Chen, J.; Wu Y*., Percutaneous radiofrequency ablation for liver tumors: Is it safer and more effective in low-risk areas than in high-risk areas? Hepatol Res 2011, 41, 635-40.    

Huang, H.; Dong, X.; Kang, M. X.; Xu, B.; Chen, Y.; Zhang, B.; Chen, J.; Xie, Q. P.; Wu Y*., Novel blood biomarkers of pancreatic cancer-associated diabetes mellitus identified by peripheral blood-based gene expression profiles. Am J Gastroenterol 2010, 105, 1661-9.  

Chen, B.; Zhang, H.; Zhai, C.; Du, N.; Sun, C.; Xue, J.; Yang, D*.; Huang, H.; Zhang, B.; Xie, Q.; Wu Y*., Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficient contrast agents for multimodal cellular imaging. J Mater Chem 2010, 20, 9895-9902. 

Guo, Q.; Kang, M.; Zhang, B.; Chen, Y.; Dong, X.; Wu Y*., Elevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes. J Cancer Res Clin Oncol 2010, 136, 1627-31. 

Dong, X.; Zhan, Y. C.; Jiang, R. Y.; Xie, Q. P.; Peng, J. P.; Wang, J.; Gao, S. L.; Wu Y*., The potential effect of proteasome inhibitor PS-341 on severe acute pancreatitis detected by positron emission tomography in ICR mice. J Surg Res 2010, 162, 193-202. 

Zhang, B.; Gao, S.; Chen, Y.; Wu Y*, Primary yolk sac tumor arising in the pancreas with hepatic metastasis: a case report. Korean J Radiol 2010, 11, 472-5. 

Zhang, B.; Xie, Q. P.; Gao, S. L.; Fu, Y. B.; Wu Y*, Pancreatic somatostatinoma with obscure inhibitory syndrome and mixed pathological pattern. J Zhejiang Univ Sci B 2010, 11, 22-6. 

Xie QP, Huang H, Xu B, Dong X, Gao SL, Zhang B, Wu YL: Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation. 2009 Jun; 77(5):483-91. 

Guo Q, Chen Y, Zhang B, Kang M, Xie Q, Wu Y*, Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition. Biochem Pharmacol. 2009 Jun 1; 77(11):1674-83. 

Guo Q, Zhang B, Dong X, Xie Q, Guo E, Huang H, Wu Y*, Elevated levels of plasma fibrinogen in patients with pancreatic cancer: possible role of a distant metastasis predictor.Pancreas. 2009 Apr; 38(3):e75-9. 

Huang H, Xie Q, Kang M, Zhang B, Zhang H, Chen J, Zhai C, Yang D, Jiang B, Wu Y*, Labeling transplanted mice islet with polyvinylpyrrolidone coated superparamagnetic iron oxide nanoparticles for in vivo detection by magnetic resonance imaging. Nanotechnology. 2009 Sep 9; 20(36):365101.  

Wu Y, Guo E, Yu J, Xie Q.: High DcR3 expression predicts stage pN2-3 in gastric cancer. Am J Clin Oncol. 2008 Feb; 31(1):79-83. 

Zhiyu Tang, Yulian Wu, Shunlian Gao, Hongwei Shen. Effects of the proteasome inhibitor Bortezomib on gene expression profiles of pancreatic cancer cells. Journal of surgical research, J Surg Res. 2008 Mar; 145(1):111-23. 

Xin Dong, Shunliang Gao, Qiuping Xie, Lin Xu, Yuanliang Xu, Yulian Wu; In situ high-volume modified continuous closed and/or open lavage for infected necrotizing pancreatitis, Pancreas. 2008 Jan; 36(1):44-9. 

Enqi Guo, Lirong Chen, Qiuping Xie, Jian Chen, Zhiyu Tang, Yulian Wu; Serum HDL-C as a potential biomarker for nodal stages in gastric cancer. ASO, 2007; 14: 2528-2534.

Yulian Wu, Enqi Guo, Junxiu Yu, Qiuping Xie; High DcR3 expression predicts stage pN2-3 in Gastric cancer. Am J Clin Oncol, 2007; 30:000-000. 

Xin Dong, Shunliang Gao, Qiuping Xie, Lin Xu, Yuanliang Xu, Yulian Wu; In situ high-volume modified continuous closed and/or open lavage for infected necrotizing pancreatitis. Pancreas. 2008 Jan;36(1):44-9.

Zhiyu Tang, Enqi Guo, Haichao Yan, Qiuping Xie, Jian’an Lian, Yulian Wu; Risk factors for infectious morbidity in gallbladder cancer patients treated surgically. Hepatogastro -enterology, 2007; 54: 22-27. 

Zhiyu Tang, Yulian Wu, Shunlian Gao, Hongwei Shen. Effects of the proteasome inhibitor Bortezomib on gene expression profiles of pancreatic cancer cells. J Surg Res. 2008 Mar;145(1):111-23.

Yulian Wu, Hai Chao Yan, Lirong Chen et al. Extended Appleby’s Operation for Pancreatic Cancer Involving Celiac Axis. Journal of Surgical Oncology 2007; 96: 442-446 

Yulian Wu ,Zhe Tang, Heqing Fang et al. High Operative risk of cool-tip radiofrequency ablation for unresectable pancreatic head cancer. JSO 2006; 94(5):392-5. 

Yulian Wu, Jian Chen, Junxiu Yu et al. A practical scoring system based upon ROC analysis for evaluating potential lymph nodes metastasis during gastric surgery. JSO 2006; 93(7):534-40. 

Yan HC, Wu YL, Chen LR, Gao Sl et al. Resection of non-cystic adenocarcinoma in pancreatic body and tail. WJG 2006; 21(35):5726-8 

Wu YL, Yan HC, Chen LR, Chen J, Gao SL, Li JT.: Pancreatic benign schwannoma treated by simple enucleation: case report and review of literature. Pancreas. 2005 Oct; 31(3):286-8. 

Wu Y, Junxiu Yu, Bing Xu: Safe major abdominal operations: Hepatotectomy, Gastrectomy and Pancreatectomy in eld patients. WJG 10(13):1995-1997, 2004 

Wu YL, Peng CH, Sheng HW: Expression of exon 13 from the Ki-67 gene in human cells and tissues by digoxigenin-labelled mRNA in situ hybridization. CMJ 2001; 114:48-53

Guang Yu, Jianning Mao, Yulian Wu, Hongyu Luo and Jiangping Wu et al.Ephrin-B1 is critical in T-cell development. J Biol Chem. 2006 Apr 14; 281 

Yu G, Mao J, Wu Y, Luo H, Wu J.: EPHRIN-B1 is critical in T-cell development and thymocyte TCR signaling strength J Biol Chem. 2006; (281)15:10222-10229.

Wu Y, B. Han, H. Luo, G. Shi, and J. Wu. Dipeptide boronic acid (DPBA), a novel proteasome inhibitor, prevents islet allograft rejection. Transplantation 2004; 78: 360-366. 

Yu G, Luo H, Wu Y, Wu J. EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J Biol Chem. 2004 Dec 31; 279(53):55531-9. 

Shi G, Wu Y, Zhang J, Wu J.: Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo. J Immunol. 2003 Oct 1; 171(7):3407-14. 

Wu Y, Han B, Sheng H, Lin M, Moore PA, Zhang J, Wu J: Clinical significance of detecting elevated serum DcR3/TR6/M68 in malignant tumor patients. Int J Cancer 2003 Jul 10; 105(5):724-32.

Wu Y, Han B, Luo H, Roduit R, Salcedo TW, Zheng G Zhang J, Wu J: DcR3/TR6 Effectively Prevents Islet Primary Non-function after Transplantation Diabetes 2003 Sep; 52(9):2279-86. 

Yu G, Luo H, Wu Y, Wu J.: Ephrin B2 Induces T Cell Costimulation.J Immunol. 2003 Jul 1; 171(1):106-114. 

Yu G, Luo H, Wu Y, Wu J.: Mouse ephrinB3 augments T-cell signaling and responses to T-cell receptor ligation. J Biol Chem. 2003 Nov 21; 278(47):47209-16. 

Luo H, Yu G, Wu Y, Wu J.: EphB6 crosslinking results in costimulation of T cells. J Clin Invest. 2002 Oct; 110(8): 1141-50. J Clin Invest. 2002 Oct; 110(8): 1141-50.

Luo H, Wu YL, Wan X, Qi S, Chen H, Wu J: A proteasome inhibitor effectively prevents mouse heart allograft rejection Transplantation 72 (2):196-202, 2001.

Luo H, Wan X, Wu YL, and Wu J. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. J.Immunol. 167 (3):1362-1370, 2001. 

Wu YL, Luo HY, Kanaan N and Wu JP: The proteasome controls the protein level Ki67 in human pancreatic cancer cells J Cellular Biochemistry 2000; 76:596-604


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