Position：Vice Hospital President, Vice Chair of Gastroenterology
Medical School：Massachusetts General Hospital, Harvard Medical School (Postdoc), USA
Academic Rank：Professor, Chief Physician
Early diagnosis of premalignancy or early cancer in esophagus, stomach and colon, and endoscopic therapy including EMR, ESD, ESE, FER.
Endoscopic therapy of gastroesophageal varies in liver cirrhosis.
Study on microenvironment of the development colorectal cancers, epigenetic regulation of GI cancers.
Zhejiang Professional Award for Scientific and Technological Innovation, First Prize
Member, Chinese Gastroenterology Association, 2014-present
Vice Chair, Zhejiang Gastroenterology Medical Association, 2013-present
Member, American Gastroenterology Association, 2010-present
Zhao GF, Xue M, Hu YY, Chen SJ, Wang LJ*. How common the diagnosis of gastric low grade dysplasia will be upgraded by endoscopic resection: a meta-analysis. Plos One 2015;10(7):e0132699.
Hu YY, Lian QW, Lin ZH, Zhong J,Xue M, Wang LJ*. Diagnostic performance of magnifying narrow-band imaging for early gastric cancer: A meta-analysis. World J Gastroenterol. 2015;21(25):7884-94.
Xue M, Chen XQ, Shi LH, Si JM, Wang LJ*, Chen SJ. Small bowel capsule endoscopy in patients with unexplained chronic abdominal pain or diarrhea: a systemic review. Gastrointestinal Endoscopy 2015;81(1):186-93.
Wang L, Gala M, Yamamoto M, Pino MS, Kikuchi H, Shue DS, Shirasawa S, Austin TR, Lynch MP, Rueda BR, Zukerberg LR, Chung DC. Adrenomedullin is a therapeutic target in colorectal cancer. Int J Cancer 2014; 134:2041-50.
Wang LJ, Chen SJ, Xue M, Zhong J, Wang X, Gan LH, Lam EKY, Liu X, Zhang JB, Zhou TH, Yu J, Jin HC, Si JM. Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis. Molecular Medicine 2012;18:389-400.
Zhong J, Chen SJ, Xue M, Du Q, Cai JT, Jin HC, Si JM, Wang LJ*. ZIC1 modulates cell-cycle distributions and cell migration though regulation of Sonic hedgehog, PI3K and MAPK signaling pathways in gastric cancer. BMC Cancer 2012, 12:290.
Gan LH, Chen SJ, Zhong J, Wang X, Lam EKY, Liu X, Zhang JB, Zhou TH, Yu J, Si JM, Wang LJ*, Jin HC. ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer. PLoS ONE 2011;6(2):e16916.
Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X, Wang LJ*. Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. Tumor Biol 2011; 32: 729-735.
Wang LJ, Wang X, Wang XJ, Pan J, Liu HQ, Zhang SJ, Lin XY, Lam EKY, Cui Y, Yu J, Jin HC. Klotho is silenced through promoter hypermethylation in gastric cancer. Am J Cancer Res 2011;1(1):111-119.
Wang LJ, Gala M , Yamamoto M , Pino MS , Shue DS , Shirasawa S , Zukerberg LR , Chung DC. Adrenomedullin is a novel K-RAS target gene that regulates cellular invasion and angiogenesis in hypoxia. Gastroenterology 2011;140(5): S163.
Chen SJ, Zhong J, Zhou QY, Lu XF, Wang LJ*. The Regenerating Ia gene is overexpressed in atrophic gastritis rats with hypergastrinemia. Gastroenterol Res Pract 2011;2011:403956. Epub 2011 Sep 22.
Zhong J, Chen Y, Wang LJ. Irreformable hyponatremia：a case report of pituitary dysfunction with liver cirrhosis. Chin Med J 2011; 124(14):2234-2236.
Zhou QY, Lu XF, Gan LH, Chen SJ, Zhou TH, Wang LJ*, Si JM. Role of REG Iα in gastric carcinogenesis: gastrin-associated proliferative and anti-apoptotic activities. Mol Med Rep 2010; 3: 999-1005.
Wang LJ, Jin HC, Wang X, Lam EKY, Zhang JB, Liu X, Yu J, Chan FKL, Si JM, Sung JJY. ZIC1 is downregulated through promoter hypermethylation in gastric cancer. Biochem Biophys Res Commun 2009; 379(4):959-63.
Wang LJ, Zhou QY, Chen Y, Chen SJ, Xu M, Zhu FS, Si JM. Muscovite reverses gastric gland atrophy and intestinal metaplasia by promoting cytoprotection and cell proliferation in rats with atrophic gastritis. Digestion 2009 ;79(2):79-91.
Sun LM, Si JM, Chen SJ, Liu WL, Zhao L, Wang LJ. The establishment and clinical appliance of technique of mucosa marking targeting biopsy. Hepatogastroenterology 2009; 56:59-62.
Zhao Y, Wang LJ, Si JM. Hookworm infection causing chronic anemia identified during a procedure for acute gastrointestinal bleeding: a case report. Cases Journal 2009; 2:105.
Chen MY, Cai JT, Du Q, Wang LJ. Sarcoidosis of spleen presenting with solitary thrombopenia. Eur J Intern Med. 2009;20(1):e12.
Chen Y, Chen Y, Liu WL, Zhou TH, Cai JT, Du Q, Wang LJ, Wu JG, Si JM. Therapeutic effects of rectal administration of muscovite on experimental colitis in rats. J Gastroenterol Hepatol. 2009;24(5):912-919.
Zhao Y, Zhou T, Li A, Yao H, He F, Wang LJ, Si JM. A potential role of collagens expression in distinguishing between premalignant and malignant lesions in stomach. Anatomic Records. 2009;292(5):692-700.
Chen SJ, Wang LJ*, Zhu Q, Cai JT, Chen T, Si JM. Effect of H pylori infection and its eradication on hyperammo-nemia and hepatic encephalopathy in cirrhotic patients. World J Gastroenterol 2008;14(12):1914-8.
Zhu FS, Si JM, Wang LJ, Wang DF, Chen P. Effect of mica monomer powder on chief and parietal cells as well as G and D cells in gastric mucosa of chronic atrophic gastritis in rats. Chin J Integr Med 2008 ;14(2):111-6
Wang LJ, Chen SJ, Chen Z, Cai JT, Si JM. Morphological and pathologic changes of experimental chronic atrophic gastritis (CAG) and the regulating mechanism of protein expression in rats. Journal of Zhejiang University SCIENCE 2006;7(8):634-640.
Si JM, Sun LM, Fan YJ, Wang LJ. Trial of a novel endoscopic tattooing biopsy forceps on animal model. World J Gastroenterol 2005;11(12):1859-1861.
Si JM, Wang LJ, Sun LM, Dai N. Irritable bowel syndrome consulters in Zhejiang province: the symptoms pattern, predominant bowel habit subgroups and quality of life. World J Gastroenterol 2004;10(7):1059-1064.
Si JM, Wang LJ, Chen SJ, Zhao L, Dai N. Quality of life and cost-effectiveness of combined therapy for reflux esophagitis. Journal of Zhejiang University SCIENCE 2003;4(5):602-606.