Liu Daren, M.D., Ph.D.

Department:HPB Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

Professional Highlights

Zhejiang Scientific and Technological Progress Award, Second Prize, 2015 

Zhejiang Scientific and Technological Progress Award, Third Prize, 2013 

Hangzhou Scientific and Technological Progress Award, Third Prize, 2012


Professional Appointments

Secretary-General, Evidence-Based Medicine Group, Abdominal Oncology Professional Committee, Chinese Society of Medical Education 

Member, Pancreatic Diseases Branch, China Association For the Promotion of International Medical and Health Exchanges


Education Experience

Research Summary

The mechanism of metastasis of gastric cancer and liver cancer 

The novel therapeutic methods of these malignancies such as molecular targeted therapy

Publications

Liu D, Li X, Chen C, Li C, Zhou C, Zhang W, Zhao J, Fan J, Cheng K, Chen L.Target-specific?delivery?of?oxaliplatin?to HER2-positive gastric cancer cells?in vivo?using?oxaliplatin-au-fe3o4-herceptin nanoparticles.Oncol Lett. 2018 May;15(5):8079-8087. 

Yu YQ, Wang L, Jin Y, Zhou JL, Geng YH, Jin X, Zhang XX, Yang JJ, Qian CM, Zhou DE, Liu DR, Peng SY, Luo Y, Zheng L, Li JT. Identification of serologic biomarkers for predicting microvascular invasion in hepatocellular carcinoma. Oncotarget. 2016 Mar 29;7(13):16362-71. 

Liu D, Li C, Trojanowicz B, Li X, Shi D, Zhan C, Wang Z, Chen L. CD97 promotion of gastric carcinoma lymphatic metastasis is exosome dependent, Gastric Cancer, 2016, 19(3): 754-766

Zhang WD, Liu DR, Wang P, Zhao JG, Wang ZF, Chen LI. Clinical treatment of gastrinoma: A case report and review of the literature. Oncol Lett. 2016 May;11(5):3433-3437. 

Zhang WD, Liu DR, Que RS, Zhou CB, Zhan CN, Zhao JG, Chen LI. Management of retroperitoneal liposarcoma: A case report and review of the literature. Oncol Lett. 2015 Jul;10(1):405-409. 

Li C, Liu DR, Li GG, Wang HH, Li XW, Zhang W, Wu YL, Chen L. CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway. World J Gastroenterol. 2015 May 28;21(20):6215-28.

Zhang WD, Liu DR, Feng CC, Zhou CB, Zhan CN, Que RS, Chen L. Management of differentiated thyroid carcinoma with bone metastasis: a case report and review of the Chinese literature.J Zhejiang Univ Sci B. 2014 Dec;15(12):1081-7. 

Li C, Liu DR, Ye LY, Huang LN, Jaiswal S, Li XW, Wang HH, Chen L. HER-2 overexpression and survival in colorectal cancer: a meta-analysis. J Zhejiang Univ Sci B. 2014 Jun;15(6):582-9. 

Weng WH, Liu DR, Feng CC, Que RS. Colonic interposition between the liver and left diaphragm - management of Chilaiditi syndrome: A case report and literature review. Oncol Lett. 2014 May;7(5):1657-1660. 

Liu D, Shi D, Xu Y, Cao L. Management of perivascular epithelioid cell tumor of the liver: A case report and review of the literature. Oncol Lett. 2014 Jan;7(1):148-152. 

Liu DR, Li C, Li C. Management of giant intermuscular lipoma of hips: A case report and review of literature. Molecular and clinical oncology 2013; 1:369-372.

Li GG, Li L, Li C, Ye LY, Li XW, Liu DR, Bao Q, Zheng YX, Xiang DP, Chen L, Chen J. Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells. World J Gastroenterol. 2013 Jul 28;19(28):4486-94.

Wang H, Tang AM, Liu D, Li G, Ye L, Li X, Li C, Chen L. Renoprotective activity of sivelestat in severe acute pancreatitis in rats. Exp Ther Med. 2013 Jul;6(1):29-32. 

Ye LY, Liu DR, Li C, Li XW, Huang LN, Ye S, Zheng YX, Chen L. Systematic review of laparoscopy-assisted versus open gastrectomy for advanced gastric cancer. J Zhejiang Univ Sci B 2013 Jun;14(6):468-78.

Fan JQ, Liu DR, Li C, Chen G. Phlegmonous gastritis after esophagectomy: a case report. World J Gastroenterol. 2013 Feb 28;19(8):1330-2.

Ye LY, Wang JJ, Liu DR, Ding GP, Cao LP. Management of giant ovarian teratoma: A case series and review of the literature. Oncol Lett. 2012 Oct;4(4):672-676.

Liu D, Trojanowicz B, Ye L, Li C, Zhang L, Li X, Li G, Zheng Y, Chen L. The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma. PLoS One. 2012;7(6):e39989. 

Ding GP, Cao LP, Liu DR, Que RS. Saline conducted electric coagulation (SCEC): original experience in experimental hepatectomy. J Zhejiang Univ Sci B. 2012 Mar;13(3):186-91. 

Ding GP, Cao LP, Liu J, Liu DR, Que RS, Zhu LH, Zhou YM, Mao KJ, Hu JA. Assessment of 188Re marked anti MHC class II antibody by peripheral blood mononuclear cells stimulated by donor alloantigen. Chin Med J (Engl) 2011; 124:2512-2516.

Liu D, Trojanowicz B, Radestock Y, Fu T, Hammje K, Chen L, Hoang-Vu C. Role of CD97 isoforms in gastric carcinoma. Int J Oncol. 2010; 36(6):1401-1408.

Cao L, Wang L, Wang G, Liu D, Yu J, Que R, Xie D. Evaluation of the effectiveness of a chemoprevention model of pancreatic adenocarcinoma using protein chip technology. Int J Oncol 2010; 37:1515-1520.

Liu D, Chen L. Management of the Total Bowel Diverticular Disease. Hepatogastroenterology 2009; 56:1679-1682.

Zhang X, Liu D, Wu D, Zhu C, Ye J, Wang K, Peng L, Zhuo G. Effect of salvia miltiorrhizae on the expressions of TLR4 protein in the liver of rats with SAP or OJ. Inflammation 2009; 32(3):151-162.

Liu D, Cao L, Yu J, Que R, Jiang W, Zhou Y, Zhu L. Diagnosis of pancreatic adenocarcinoma using protein chip technology. Pancreatology 2009; 9:127-135. 

Cao L, Liu D. Diagnosis and treatment of pancreatoblastoma in China. Pancreas 2007; 34:92-95.


Current Program

Establishment of multimodal traceable multifunctional nano-probe and assessment of its role in the therapy of microvascular invasion of hepatocellular carcinoma. Funding Source: Natural Science Foundation of Zhejiang.

The establishment of oxaliplatin release, MRI traceable, nano complex Au-USPIO and its role in the treatment of CD97 positive gastric cance. Funding Source: Natural Science Foundation of Zhejiang.

The establishment of bio-therapy model of pancreatic cancer and the expression profile of exosome microRNA. Funding Source: Natural Science Foundation of Zhejiang.

The therapeutic effect of CD97iso metastatic gastric carcinoma. Funding Source: Zhejiang Medical Health Science and Technology Plan. 

The modification mechanism of CD97iso in pre-metastatic niche establishment of gastric carcinoma. Funding Source: National Natural Science Foundation of China.

The role of CD97iso in the pre-metastatic niche establishment of gastric cancer. Funding Source: Funding Source: Research Fund for the Doctoral Program of Higher Education of China.

The establishment of MRI targeted, Paclitaxel released USPIO and its therapeutic value in EGFR/HER2 positive gastric carcinoma. Funding Source: National Natural Science Foundation of China. 

The construction of MRI tracing paclitaxel relaeased USPIO and its role in HER2 positive gastric carcinoma. Funding Source: Zhejiang Provincial Department of Science Technology Department.

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