Zheng Chao, M.D.

Position:Chair of Endocrinology

Department:Endocrinology

Medical School:Central South University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Mechanism and novel intervention targets of diabetic microvascular disease.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Publications

Yan, H., Zhou, Q., Wang, Y., Tu, Y., Zhao, Y., Yu, J., Chen, K., Hu, Y., Zhou, Q., Zhang, W., & Zheng, C. (2024). Associations between cardiometabolic indices and the risk of diabetic kidney disease in patients with type 2 diabetes. Cardiovascular Diabetology, 23(1), 142. https://doi.org/10.1186/s12933-024-02228-9

Ye, S., Hu, Y. P., Zhou, Q., Zhang, H., Xia, Z. Z., Zhao, S. Z., Wang, Z., Wang, S. Y., Wang, X. Y., Zhang, Y. K., Chen, Z. D., Mao, G. Y., & Zheng, C. (2023). Lipidomics Profiling Reveals Serum Phospholipids Associated with Albuminuria in Early Type 2 Diabetic Kidney Disease. ACS Omega, 8(39), 36543-36552. https://doi.org/10.1021/acsomega.3c05504

Yu, X., Wen, X., Xu, J., Zhou, Q., Chen, Y., Qu, F., He, M., Chang, H., & Zheng, C. (2024). Rapid Correction of the Hypoglycemia State in Nonhuman Primates Using a Glucagon Long-Dissolving Microneedle Patch. ACS Biomater Sci Eng. https://doi.org/10.1021/acsbiomaterials.3c01962

Zhang, Y., Wang, S., Zhou, Q., Xie, Y., Hu, Y., Fang, W., Yang, C., Wang, Z., Ye, S., Wang, X., & Zheng, C. (2024). Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis in Mice. Arterioscler Thromb Vasc Biol. https://doi.org/10.1161/atvbaha.124.320714

Chen Z, Wang Z, Hu Y, Lin H, Yin L, Kong J, Zhang Y, Hu B, Li T, Zheng X, Yang Q, Ye S, Wang S, Zhou Q, Zheng C#. ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway.Inflammation. 2023 Aug 4. doi: 10.1007/s10753-023-01882-7.

Zhao, S, Jin, D, Wang, S, Xu, Y, Li, H, Chang, Y, Ma, Y, Xu, Y, Guo, C, Peng, F, Huang, R, Lai, M, Xia, Z, Che, M, Zuo, J, Jiang, D, Zheng, C*, Mao, G*. Serum omega-6/omega-3 polyunsaturated fatty acids ratio and diabetic retinopathy: A propensity score matching based case-control study in China. EClinicalMedicine 2021; 39: 101089.

Xu Y, Wang XY, Liu H, Jin D, Song X, Wang S, Zheng C* et al. A novel clinical diagnostic marker predicting the relationship between visceral adiposity and renal function evaluated by estimated glomerular filtration rate (eGFR) in the Chinese physical examination population. Lipids Health Dis. 2023;22(1):32.

Xiaoqing Yan 1,†, Yue Su 2,3,†, Xia Fan 1,†, Hui Chen 1, Zixian Lu 1, Zijuan Liu 1, Yingjian Li 1, Mei Yi 1,Guigui Zhang 1, Chunjie Gu 1, KaiWang 4 , JiaminWu 1, Da Sun 5 , Yikai Zhang 6, Chi Zhang 3, Xiaozhen Dai 7,*and Chao Zheng,Liraglutide Improves the Angiogenic Capability of EPC and Promotes Ischemic Angiogenesis in Mice under Diabetic Conditions through an Nrf2-Dependent Mechanism,cells,2022

Chengnan Guo, Depeng Jiang, Yixi Xu, Fang Peng, Shuzhen Zhao, Huihui Li, Dongzhen Jin, Xin Xu , Zhezheng Xia, Mingzhu Che, Mengyuan Lai, Ruogu Huang, Hui Wang, Chao Zheng*, Guangyun Mao*, High-Coverage Serum Metabolomics Reveals Metabolic Pathway Dysregulation in Diabetic Retinopathy: A Propensity Score-Matched Study, Front Mol Biosci, 2022, 9:822647.

Guo, C, Xu, Y, Ma, Y, Xu, X, Peng, F, Li, HH, Jin, D, Zhao, SZ, Xia, Z, Lai, M, Che, M, Huang, R, Wang, Y, Jiang, D, Zheng, C*, Mao, G*. Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case-control study. Endocr Connect 2022.

Yikai Zhang, Shengyao Wang, Xia Chen, Zhe Wang, Xinyi Wang, Qiao Zhou, Weihuan Fang, Chao Zheng. Liraglutide  prevents high glucose induced HUVECs dysfunction via inhibition of PINK1/Parkin-dependent mitophagy. Mol Cell Endocrinol. 2022 Apr 5;545:111560. doi: 10.1016/j.mce.2022.111560. Epub 2022 Jan 13.

Zhe Wang, Zhida Chen, Xinyi Wang, Yepeng Hu, Jing Kong, Jiabin Lai, Tiekun Li, Bibi Hu, Yikai Zhang, Xianan Zheng, Xiaoxian Liu, Shengyao Wang, Shu Ye, Qiao Zhou, Chao Zheng. Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and  fibrosis via the NF-?B signaling pathway. Front Pharmacol. 2022 Aug 16;13:953004. doi: 10.3389/fphar.2022.953004. eCollection 2022.

Hang Zhang, Jing-Jing Zuo, Si-Si Dong, Yuan Lan, Chen-Wei Wu, Guang-Yun Mao, Chao Zheng. Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study [J]. J Diabetes Res. 2020 Mar 2;2020:3049098. doi: 10.1155/2020/3049098.

Tan Y#, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L. Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol. 2020 Feb 20;. doi: 10.1038/s41569-020-0339-2.

Chao zheng, Wu Luo, Lan Huang, Weihui Yu, Xueting Hu, Xinfu Guan, Yan Cai, Chunpeng Zou, Haimin Yin, Zheng Xu, Chao Zheng, and Guang Liang, Yi Wang. Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice. Cell Death Dis. 2019 Nov 7;10(11):848.

Hou X, Wang D, Zuo J, Li J, Wang T, Guo C, Peng F, Su D, Zhao L, Ye Z, ZhangH, Zheng C, Mao G*. Development and validation of a prognostic nomogram for HIV/AIDS patients who underwent antiretroviral therapy: Data from a China population-based cohort. EBioMedicine. 2019 Oct 5. pii: S2352-3964(19)30658-9. 

Luo W, Huang L, Wang J, Zhuang F, Xu Z, Yin H, Qian Y, Liang G, Zheng C, Wang Y*. Inhibition of EGFR-STAT3 attenuates cardiomyopathy in streptozotocin-induced type 1 diabetes. J Endocrinol. 2019 Sep 1;242(3):199-210. 

Su X, Xu J, Zheng C. The relationship between non-alcoholic fatty liver and skeletal muscle mass to visceral fat area ratio in women with type 2 diabetes. BMC Endocr Disord. 2019 Jul 17;19(1):76.

Tu Y, Wang L, Wei L, Xu Y, Han X, Han J, Yu H, Zheng C, Bao Y, Jia W*.Cost-Utility of Laparoscopic Roux-en-Y Gastric Bypass in Chinese Patients with Type 2 Diabetes and Obesity with a BMI ≥ 27.5 kg/m2: a Multi-Center Study with a 4-Year Follow-Up of Surgical Cohort. Obes Surg. 2019 Jul 23. 

Wang D, Jin M, Zhao X, Zhao T, Lin W, He Z, Fan M, Jin W, Zhou J, Jin L, Zheng C*, Jin H, Zhao Y, Li X, Ying L, Wang Y, Zhu G, Huang Z. FGF1(ΔHBS) ameliorates chronic kidney disease via PI3K/AKT mediated suppression of oxidative stress and inflammation. Cell Death Dis. 2019 Jun 12;10(6):464. 

Qian J, Chen X, Chen X, Sun C, Jiang Y, Qian Y, Zhang Y, Khan Z, Zhou J, Liang G, Zheng C. Kaempferol reduces K63-linked polyubiquitination to inhibit nuclear factor-κB and inflammatory responses in acute lung injury in mice. Toxicol Lett. 2019 May 15;306:53-60.

Xu J, Zhou X, Zheng C. The geriatric nutritional risk index independently predicts adverse outcomes in patients with pyogenic liver abscess. BMC Geriatr. 2019 Jan 16;19(1):14. 

Zheng C, Liu Z. Vascular function, insulin action, and exercise: an intricate interplay. Trends Endocrinol Metab. 2015 Jun;26(6):297-304. 

Li CY, Wang LX, Dong SS, Hong Y, Zhou XH, Zheng WW, Zheng C. Phlorizin Exerts Direct Protective Effects on Palmitic Acid (PA)-Induced Endothelial Dysfunction by Activating the PI3K/AKT/eNOS Signaling Pathway and Increasing the Levels of  Nitric Oxide (NO). Med Sci Monit Basic Res. 2018 Jan 8;24:1-9. 

Peng K, Pan Y, Li J, Khan Z, Fan M, Yin H, Tong C, Zhao Y, Liang G, Zheng C. 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes. Sci Rep. 2016 Nov 14;6:37160. 

Fan M, Li W, Wang L, Gu S, Dong S, Chen M, Yin H, Zheng J, Wu X, Jin J, Jiang X, Cai J, Liu P, Zheng C. Association of SLC30A8 gene polymorphism with type 2 diabetes, evidence from 46 studies: a meta-analysis. Endocrine. 2016 Aug;53(2):381-94.

Chen MD, Dong SS, Cai NY, Fan MD, Gu SP, Zheng JJ, Yin HM, Zhou XH, Wang LX, Li CY, Zheng C. Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2016 Jan 29;16:28. 

Fang Q, Wang J, Wang L, Zhang Y, Yin H, Li Y, Tong C, Liang G, Zheng C. Attenuation of inflammatory response by a novel chalcone protects kidney and heart from hyperglycemia-induced injuries in type 1 diabetic mice. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):179-91.

Zheng C, Dalla Man C, Cobelli C, Groop L, Zhao H, Bale AE, Shaw M, Duran E,Pierpont B, Caprio S, Santoro N. A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity. Obesity (Silver Spring). 2015 May;23(5):1022-9. 


Current Program

The Effect and Mechanism of GLP-1 (32-36) on Mitochondrial Glycolysis of EPCs to Improve Angiogenesis in Diabetic Ischemic Disease. 2024-2027 National Natural Science Funding of China. (82370817) PI

GLP-1 Promotes Angiogenesis in Diabetic Periphery Arterial Disease by Regulating Mitophagy and Increasing NO Secretion of Endothelial Progenitor Cells : a Mechanism Study. 2021-2024 National Natural Science Funding of China. (82070833) PI

Development and Clinical Validation of Novel Precise Diagnostic Techniques for Early Detection of Diabetic Nephropathy in Metabolic Disease Management. 2021-2023 Zhejiang Provincial Key Research and Development Program (2021C03070) PI

Clinical Trials:

A prospective, multicenter, randomized, double-blind, double-dummy, parallel controlled trial of pregabalin capsules was conducted to evaluate the efficacy and safety of HSK16149 capsules in Chinese patients with diabetic peripheral neuralgia who had a poor response to pregabalin

A multicenter, randomized, open, parallel-group Phase III clinical trial evaluating the efficacy and safety of insulin aspartate injection versus Novoril® injection in the treatment of type 2 diabetes mellitus (T2DM)

A randomized, open-label, parallel-controlled, multicenter phase III clinical study comparing the efficacy and safety of INS068 and insulin glargine in combination with insulin aspart in patients with type 1 diabetes

A multicenter post-marketing observational study evaluating the long-term drug safety of Dorzagliatin in patients with type 2 diabetes mellitus

Efficacy and safety of Qishen Yiqi Drops for diabetic kidney disease (Qi deficiency and blood stasis evidence) randomized, double-blind, multicenter, basal treatment-loaded, placebo-parallel controlled phase II clinical trial

Multi center, randomized, parallel, placebo (double-blind in group) and positive drug (open) control phase II clinical study to evaluate the effectiveness and safety of HEC88473 injection in subjects with type 2 diabetes

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