Hu Xun, Ph.D.

Position:Vice Chair of Clinical Research Center, Vice Chair of Pathology

Department:Clinical Research Center, Pathology

Medical School:Institute of Psychiatry, King's College London, UK

Academic Rank:Professor


Clinical / Research Interests

Professional Highlights

First Prize of the Natural Science Award of the Ministry of Education of China (2nd position, Certificate No.: 2007-035), 2008             


Professional Appointments

Deputy Chairman, the Clinical Data and Human Resource Biobank Branch of the Research Hospital Association, 2018-2023

Standing Committee Member, the Biobank Branch of China Medical Biotechnology Association, 2017-2021

National Membership of Chinese Expert Group on Human Genetic Resources Management, 2017-Present


Education Experience

Bachelor of Science, Department of Modern Chemistry of Chengdu University of Science and Technology, 1979-1983

Master of Science, Institute of Atomic and Molecular Physics of Chengdu University of Science and Technology, 1989-1992

PhD Student (Part-time), Division of Molecular Genetics of Institute of Psychiatry of King's College London, 1998-2006

Research Summary

Publications

Qin W, Xu G, Tai PWL, Wang C, Luo L, Li C, Hu X, Xue J, Lu Y, Zhou Q, Wei Q, Wen T, Hu J, Xiao Y, Yang L, Li W, Flotte TR, Wei Y, Gao G. Large-scale molecular epidemiological analysis of AAV in a cancer patient population. Oncogene. 2021 Apr;40(17):3060-3071. doi: 10.1038/s41388-021-01725-5

Zhang X, Liu Y, Dai L, Shi G, Deng J, Luo Q, Xie Q, Cheng,L, Li C, Lin Y, Wang Q, Fan P, Zhang H, Su X, Zhang,S, Yang Y, Hu X, Gong Q, Yu D, Zheng L, Deng H. BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells. Oncogene. 2021;40(8): 1516–1530. Published online 2021 Jan 15.doi:10.1038/s41388-020-01627-y.

Dai M, Wu Y, Tang Y, Yue W, Hao Y, Zhang Y, Tan L, Deng W, Chen Q, Yang G, Lu T, Wang L, Yang F, Zhang F, Yang J, Li K, Lv L, Tan Q, Zhang H, Ma X, Li L, Wang C, Ma X, Zhang D, Yu H, Zhao L, Ren H, Wang Y, Hu X, Zhang G, Du X, Wang Q, Li T. Longitudinal trajectory analysis of antipsychotic response in patients with schizophrenia: 6-week, randomised, open-label, multicentre clinical trial. BJPsych Open. 2020 Nov;6(6): e126.Published online 2020 Oct 22. doi: 10.1192/bjo.2020.105

Tang Y, Zhang Y, and Hu X. Identification of Potential Hub Genes Related to Diagnosis and Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma via Integrated Bioinformatics Analysis. BioMed Research International 2020 https://doi.org/10.1155/2020/4251761 (CORRESPONDED)

Lin A, Zhang X, Liu Y, Hu X. New Coronavirus (nCoV) acute respiratory tract infection clinical feature data tool. Chinese Medical Biotechnology. 2020.15(2) 125-132 (Chinese Journal, CORRESPONDED)

Liu Y , Zhang X, Lin A, Hu X. New Coronavirus disease (COVID-19) test guidance document of Ontario Public Health Bureau (PHO) laboratory. Chinese Medical Biotechnology. 2020.15(2) 133-135 (Chinese Journal , CORRESPONDED)

Lin A, Zhang X, Liu Y, Hu X. Covid-19 laboratory biosafety related to sample processing - interim guidance document from CDC. Chinese Medical Biotechnology. 2020.15(2) 136-138 (Chinese Journal, CORRESPONDED)

Liu Y , Zhang X, Lin A, Hu X. A Guidance on Biosafety and biological hazards for the requirements of a biobank. Chinese Medical Biotechnology. 2020.15(2) 139-143 (Chinese Journal, CORRESPONDED)

Zhang Y, Wang Q, Reynolds GP, Yue W, Deng W, Yan H, Tan L, Wang C, Yang G, Lu T, Wang L,  Zhang F, Yang J, Li K, Lv L, Tan Q, Li Y, Yu H, Zhang H, Ma X, Yang F, Li L , Chen Q, Wei W, Zhao L,  Wang H, Li X, Guo W, Hu X , Tian Y, Ren H, Ma X, Coid J, Zhang D, Li T. Metabolic Effects of 7 Antipsychotics on Patients With Schizophrenia: A Short-Term, Randomized, Open-Label, Multicenter, Pharmacologic Trial. J Clin Psychiatry, 2020 Mar 24;81(3):19m1278

Yuan X, Ou R, Hou Y, Chen X, Cao B, Hu X and Shang H. Extra-Cerebellar Signs and Non-motor Features in Chinese Patients With Spinocerebellar Ataxia Type 3. Frontiers in Neurology, February 2019;10:1-6.

Zhang Y, Ren H, Wang Q, Deng W, Yue W, Yan H, Tan L, Chen Q, Yang G, Lu T, Wang L, Zhang F, Yang J, Li K, Lv L, Tan Q, Zhang H, Ma X, Yang F, Li L, Wang C, Zhang D, Zhao L, Wang H, Li X, Guo W, Hu X, Tian Y, Ma X, Li T. Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance. Sci China Life Sci. 2019 Apr;62(4):535-543. doi: 10.1007/s11427-018-9489-x.

Ni P, Tian Y, Gu X, Yang L, Wei J, Wang Y, Zhao L, Zhang Y, Zhang C, Li L, Tang X, Ma X, Hu X, Li T. Plasma neuropeptides as circulating biomarkers of multifactorial schizophrenia. Compr Psychiatry. 2019 Oct;94:152114. doi: 10.1016/j.comppsych.2019.152114.

Lin Y, Li M, Zhou Y, Deng W, Ma X, Wang Q, Guo W, Li Y, Jiang L, Hu X, Zhang N, Li T. Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia. Neurosci Bull. 2019 Aug;35(4):688-696. doi: 10.1007/s12264-019-00348-x.

Zhao L, Wang H, Zhang Y, Wei J, Ni P, Ren H, Li G, Wang Q, Reynolds GP, Yue W, Deng W, Yan H, Tan L, Chen Q, Yang G, Lu T, Wang L, Zhang F, Yang J, Li K, Lv L, Tan Q, Li Y, Yu H, Zhang H, Ma X, Yang F, Li L, Wang C, Wang H, Li X, Guo W, Hu X, Tian Y, Ma X, Coid J, Zhang D, Chen C, Li T. Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia. Neurosci Bull. 2019 Dec;35(6):1102-1105. doi: 10.1007/s12264-019-00432-2.

Xu Y, Fan P, Hu X. Key problems and solutions of biobank construction, West China Medical Journal. 2018, 33(6):651-4 (Chinese Journal, CORRESPONDED)

Wang Q, Wu H, Yue W, Yan H, Tan L, Deng W, Chen Q, Yang G, Lu T, Wang L, Zhang F, Yang J, Li K, Lv L, Tan Q, Zhang H, Ma X, Yang F, Li L, Wang C, Ma X, Zhao L, Wang Y, Hu X, Zhang D, Sham P* and Li T*. The Chinese Antipsychotics Pharmacogenomics Consortium, Effect of Damaging Rare Mutations in Synapse-related Gene-sets on Response to Short-term Antipsychotic Medication in Chinese Patients with Schizophrenia: A Randomized Clinical Trial. JAMA Psychiatry. 2018 Dec;75(12):1261-1269. (IF=16.642)

Chen B, Liu S, Gan L, Wang J, Hu B, Xu H, Tong R, Yang H, Cristina I, Xue J, Hu X and Lu Y. FGFR1 signaling potentiates tumor growth and predicts poor prognosis in esophageal squamous cell carcinoma patients. Cancer Biol Ther. 2018 Jan 2;19(1):76-86. doi: 10.1080/15384047.2017.1394541.

Liang S, Vega R, Kong X, Deng W, Wang Q, Ma X, Li M, Hu X, Greenshaw AJ, Greiner R, Li T. Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features. Neuroscience Bulletin. 2018 April,; 34(2):312–320.

Liang S, Brown M, Deng W, Wang Q, Ma X, Li M, Hu X, Juhas M, Li X, Greiner R, Greenshaw A, Li T.. Convergence and divergence of neurocognitive patterns in schizophreniaand depression. Schizophrenia Research. 2018; 192:327-334 .

Xu Y, Tan W, Hu X, Yang Z, Fan P, Zhang S, Xi J, Wang Y. Investigation of Mutations in the exon 3 of hepatocellular carcinoma related gene CTNNB1. West China Medical Journal. 2018;V30(10):1409-12 (Chinese Journal, CORRESPONDED)


Current Program

The establishment of a pilot cohort for chronic and rare diseases study in the natural population of western China. Sichuan Province Key R&D Program (Project Number: 2019YFS0039), 2019.04-2021.03.

Construction of Chinese human genetic resources biobank cluster in West China. A sub-topic of the key biosafety technologies in the development of Chinese Human Genetic Biobank (Project Number: 2016YFC1201705), 2016.07-2018.12.

Genome-wide association analysis and pharmacogenomics research of schizophrenia. A Sub-topic of 863 Program (Project Number: 2009AA022702), 2009.10-2012.10.       

Genetic aetiology underlying alcohol use disorder in Tibetan population. National Natural Science Foundation of China (Project Number: 30870889), 2009.1-2011.12   


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