Wu Pin, M.D., Ph.D.

DepartmentThoracic Surgery

Medical SchoolZhejiang University School of Medicine, China

Academic RankAssociate Chief Physician


Appointment

Clinical / Research Interests

The minimally invasive surgical treatment of pulmonary nodule, lung cancer, esophagus cancer, mediastinal tumor and other thoracic diseases.

Dr. Wu is especially proficient at uniportal VATS surgical treatment of pulmonary nodules, including Ground Glass Opacity (GGO) nodules.

Professional Highlights

Zhejiang Scientific and Technological Progress Award, First Prize

Chinese Medical Science and Technology Award

Young Investigator Award of Institut Mérieux, France


Professional Appointments

Vice Chairman, Youth Committee, Zhejiang Provincial Committee of Clinical Immunology

Associate Editor, Frontiers in Immunology


Education Experience

Research Summary

Dr. Wu is a Principle Investigator in the Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province. In Wu's laboratory, one area of focus is the elucidation of the role of unconventional T cells, such as γδT cells and TRMs, in tumor microenvironment, as well as immune regulatory pathways that affect unconventional T cell function and differentiation.

Publications

Zhixing Hao, Mingjie Lin, Feng Du, Zhongwei Xin, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Pin Wu, Systemic immune dysregulation correlate with clinical features of early NSCLC. Frontiers in Immunology, 2022, 12: 754138.

Wu P, Zhao L, Chen Y, Xin Z, Lin M, Hao Z, Chen X, Chen D, Wu D, Chai Y. CD38 identifies pre-activated CD8+ T cells which can be reinvigorated by anti-PD-1 blockade in human lung cancer. Cancer Immunol Immunother 2021;70(12):3603-16 doi 10.1007/s00262-021-02949-w.

Chen Y, Xin Z, Huang L, Zhao L, Wang S, Cheng J, Wu P, Chai Y. CD8(+) T Cells Form the Predominant Subset of NKG2A(+) Cells in Human Lung Cancer. Front Immunol 2019;10:3002 doi 10.3389/fimmu.2019.03002.

Hu G, Wu P, Cheng P, Zhang Z, Wang Z, Yu X, Shao X, Wu D, Ye J, Zhang T, Wang X, Qiu F, Yan J, Huang J. Tumor-infiltrating CD39(+)gammadeltaTregs are novel immunosuppressive T cells in human colorectal cancer. Oncoimmunology 2017;6(2):e1277305 doi 10.1080/2162402X.2016.1277305.

Wu D, Wu P, Qiu F, Wei Q, Huang J. Human gammadeltaT-cell subsets and their involvement in tumor immunity. Cell Mol Immunol 2017;14(3):245-53 doi 10.1038/cmi.2016.55.

Wu D, Wu P, Wu X, Ye J, Wang Z, Zhao S, Ni C, Hu G, Xu J, Han Y, Zhang T, Qiu F, Yan J, Huang J. Ex vivo expanded human circulating Vdelta1 gammadeltaT cells exhibit favorable therapeutic potential for colon cancer. Oncoimmunology 2015;4(3):e992749 doi 10.4161/2162402X.2014.992749.

Wu P, Wu D, Ni C, Ye J, Chen W, Hu G, Wang Z, Wang C, Zhang Z, Xia W, Chen Z, Wang K, Zhang T, Xu J, Han Y,   Zhang T, Wu X, Wang J, Gong W, Zheng S, Qiu F, Yan J, Huang J. gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity 2014;40(5):785-800 doi 10.1016/j.immuni.2014.03.013.



Current Program

National Natural Science Foundation of China (81572800 and 82073141).

Fundamental Research Funds for the Central Universities (2019QNA7025).

Natural Science Foundation of Zhejiang Province (LR22H160006 and LY15H160041).


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