Zhang Chao, M.D.

Position:Vice Chair of Ultrasound Medicine

Department:Ultrasound Medicine

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Ultrasound interventional therapy and the application of contrast-enhanced ultrasound; ultrasonic cavitation with targeted microbubble therapy on tumor.

Professional Highlights

Professional Appointments

Member, Youth Committee, Ultrasound Committee, Chinese Medical Doctor Association 

Member, Editorial Board, Journal of Clinical Ultrasound


Education Experience

Research Summary

Publications

Anti-tumor efficacy of ultrasonic cavitation is potentiated by concurrent delivery of anti-angiogenic drug in colon cancer, Cancer Letters 347(2014)105-113.

Relationship between Enhanced Intensity of Contrast Enhanced Ultrasound and Microvessel Density of Aortic Atherosclerostic Plaque in Rabbit Model. PLoS ONE 2014; 9:e92445.

Characteristics of VEGFR2-targeted lipid microbubbles contrast-enhanced ultrasound in nude mice with subcutaneous colonic carcinoma xenografts compared with lipid microbubbles. Chinese Journal of Ultrasonography, 2014,23(6): 531-534

Evaluation of the effect of endostar on neovascularization within rabbits of abdominal aortic atherosclerotic plaque using contrast-enhanced ultrasonography. Chinese Journal of Ultrasonography, 2014,23(3): 254-257

Evaluation of the effect of endostatin on neovascularization in the carotid soft plaques in patients with small cell lung cancer using contrast-enhanced ultrasound. Chinese Journal of Ultrasonography, 2014,23(1): 20-23

Improvement of left ventricular systolic function after acidic fibroblast growth factor delivered by using ultrasound-targeted microbubble destruction in diabetic cardiomyopathy in ratspreliminary experimental study. Chinese Journal of Ultrasonography,2013,22(12):1070-1074

Assessement of left ventricular diastolic function in patients with early type 2 diabetes mellitus by wave intensity. Chinese Journal of Ultrasonography, 2013,22(5): 379-382

Protective effect of aFGF delivery by ultrasound-targeted microbubble destruction on left ventricular function in diabetic cardiomyopathy rats. Chinese Journal of Pathophysiology .2013, 29( 8):1387-1392.

Application of Contrast Enhanced Ultrasonography in Gallbladder Occupying Lesions. Journal of Medical Research. 2013,40(1):166-168.

Correlation between Strain and Elasticity of Common Carotid Artery in Healthy Adults by Ultrasonography. Chinese General Practice. 2013,16(3):348-349

A pilot study on Lauren classification of advanced gastric carcinoma using virtual touch tissue quantification. Chinese Journal of Ultrasonography. 2012, 21(1): 31-34.

Detection of the texture of carotid soft plaques in patients with cerebral infarction using acoustic radiation forceimaging. Chinese Journal of Ultrasonography. 2011,20(12):1033-1035

Conformance assessment in measuring intimamedia thickness of common carotid arteries with QIMT by different operators. Journal of China Clinic Medical Imaging. 2011,22(9):670-672

Pilot study of acoustic radiation force impulse imaging for clinical pathological typing of advanced gastric cancer. Chinese Journal of Ultrasonography. 2011,20(12):1040-1042

The value of ultrasonography in the diagnosis of extragastrointestinal stromal tumors. Journal of China Clinic Medical Imaging. 2010,21(6):438-439.

Ultrasonographic observation of fetal adrenal cystic lesions.Chinese Journal of Ultrasonography. 2009,18(4):323-325

Evaluation of contrast-enhanced ultrasound in the diagnosis of vesicoureteral reflux in children. Chinese Journal of Ultrasonography. 2008,17(1):49-51

Fetal and pediatric ultrasonography, People's Medical Publishing House, May 2008, secretary of chief editor.

The Diagnosing and Typing Value of Echocardiography in The Patients With Triatriatum. Chinese Journal of Ultrasound In Medicine.2005,21(8):625-626.


Current Program

Study of neovascularization within carotid atherosclerotic plaques using contrast enhanced ultrasound. Funding Source: Science and Technology Department of Zhejiang Province.

Assessment of neovascularization within carotid plaques usingcontrast enhanced ultrasound combined with vector velocity imaging. Funding Source: Natural Science Foundation of Zhejiang.

Inhibition of tumor angiogenesis by ultrasonic cavitation and biological targeting therapy. Funding Source: National Natural Science Foundation of China.

Therapeutic effect of VEGFR2 targeted microbubbles combined with focused and targeted acoustic radiation on hypovasculartumor in pancreas. Funding Source: National Natural Science Foundation of China.

Targeted tumor therapy by low frequency focused ultrasound mediated microbubble cavitation. Funding Source: Major Scientific and Technological Project of Zhejiang Province.

Prevention and mechanism of diabetic cardiomyopathy by target aFGF using heparinized nanomicrobubbles. Funding Source: National Natural Science Foundation of China.



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