Yu Lina, M.D.

Position:Vice Chair of Anesthesiology


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Clinical / Research Interests

Cardiovascular, geriatric and critical patient anesthesia.

Professional Highlights

Zhejiang Scientific and Technological Progress Award, First Prize

Professional Appointments

Member, Standing Committee, Anesthesiology Branch, Zhejiang Society of Neuroscience

Education Experience

Research Summary


Wu Y, Chen C, Chen M, Qian K, Lv X, Wang H, Jiang L, Yu L, Zhuo M, Qiu S. The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice.Nat Commun. 2020 Jan 31;11(1):640. 

Ren J, Liu N, Sun N, Zhang K, Yu L*. Mesenchymal Stem Cells and their Exosomes: Promising Therapeutics for Chronic Pain. Curr Stem Cell Res Ther. 2019;14(8):644-653.

Xu L, Shen J, Yu L, Sun J, McQuillan PM, Hu Z, Yan M. Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells. Brain Res Bull. 2018 Jun;140:291-298.

 Yan W, Xiong Y, Yao Y, Zhang FJ, Yu LN, Yan M. Continuous intravenous infusion of remifentanil improves the experience of parturient undergoing repeated cesarean section under epidural anesthesia, a prospective, randomized study. BMC Anesthesiol. 2019 Dec 30;19(1):243.

Gao Y, Sun N, Wang L, Wu Y, Ma L, Hong J, Ren J, Zhu B, Yu L, Yan M. Bioinformatics Analysis Identifies p53 as a Candidate Prognostic Biomarker for Neuropathic Pain. Front Genet. 2018 Aug 31;9:320.

Xu L, Shen J, Yu L, Sun J, Yan M. Autophagy is involved in sevoflurane-induced developmental neurotoxicity in the developing rat brain. Brain Res Bull. 2018 Jun;140:226-232.

Yu LN#, Sun LH, Wang M, Wang LJ, Wu Y, Yu J, Wang WN, Zhang FJ, Li X, Yan M. EphrinB-EphB Signaling Induces Hyperalgesia through ERK5/CREB Pathway in Rats. Pain Physician, 2017 May;20(4): E563-E574. 

Yu LN#, Sun LH#, Wang M, Yan M*, Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (erk5) pathway in pathological pain, J Zhejiang Univ Sci B, 2016 Oct.;17(10):733-741. 

Xie J, Xiao D, Zhao J, Hu N, Bao Q, Jiang L, Yu L*. Mesoporous Silica Particles as a Multifunctional Delivery System for Pain Relief in Experimental Neuropathy. Adv Healthc Mater. 2016 May; 5(10): 1213-21.  (*corresponding author)

Xie J, Xiao D, Xu Y, Zhao J, Jiang L, Hu X, Zhang Y, Yu L*, Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2, Oncotarget, 2016 Feb 9; 7(6): 6436-47. (*corresponding author)

Sun K, Xing T, Zhang F, Liu Y, Li W, Zhou Z, Fang L, Yu L, Yan M*, Perioperative Transcutaneous Electrical Acupoint Stimulation for Postoperative Pain Relief Following Laparoscopic Surgery: A Randomized Controlled Trial, Clin J Pain, 2016 Jul 19. 

Zhang DX, Jiang S, Yu LN, Zhang FJ, Zhuang Q, Yan M*, The effect of sevoflurane on the cognitive function of rats and its association with the inhibition of synaptic transmission, Int J Clin Exp Med, 2015 Nov 15; 8(11): 20853-60. 

Zhou X, Zhang C, Wang Y, Yu L, Yan M*, Preoperative Acute Normovolemic Hemodilution for Minimizing Allogeneic Blood Transfusion: A Meta-Analysis, Anesth Analg, 2015 Dec; 121(6): 1443-55. 

Zhou X, Wang Y, Zhang C, Wang M, Zhang M, Yu L, Yan M*, The Role of Dopaminergic VTA Neurons in General Anesthesia, PLoS One, 2015 Sep 23;10(9):e0138187. 

Zhou X, Zhang C, Wang M, Yu L, Yan M*, Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials, PLoS One, 2015 Aug 19;10(8):e0136091. 

Fang L#, Li X#, Zhong Y, Yu J, Yu L, Dai H, Yan M*, Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats, J Neurochem, 2015 Oct;135(2):431-40. 

Shi QY, Zhang SJ, Liu L, Chen QS, Yu LN, Zhang FJ, Yan M*, Sevoflurane promotes the expansion of glioma stem cells through activation of hypoxia-inducible factors in vitro, Br J Anaesth, 2015 May;114(5):825-30.

Zhou ZF#, Xia CZ#, Wu M, Yu LN, Yan GZ, Ren QS, Hu CX, Yan M*, Comparison of three methods for the confirmation of laryngeal mask airway placement in female patients undergoing gynecologic surgery, Ultrasound Med Biol, 2015 May;41(5):1212-20.

Zhou XL, Wang Y, Zhang CJ, Yu LN, Cao JL, Yan M*, PKA is required for the modulation of spinal nociceptive information related to EphrinB–EphB signaling in mice, Neuroscience, 2015;284:546-554.

Current Program

The mechanism of MOR gene methylation involving in the loss of morphine analgesia under neuropathic pain condition. Funding Source: National Natural Science Foundation of China.

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