Ye Zhaoming, M.D., Ph.D.

Position:Chair of Orthopaedics

Department:Orthopedics

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor, Chief Physician

Appointment

Clinical / Research Interests

Diagnosis and surgical treatment of musculoskeletal tumors, especially limb salvage and biological reconstruction after pelvic tumor resection.

Professional Highlights

Qiushi Distinguished Physician of Zhejiang University 

Professional Appointments

Chairman, Orthopedic Branch of Zhejiang Medical Association

Chairman, Bone and Soft Tissue Branch of Zhejiang Anticancer Association

Standing member, Orthopedic Branch of the Chinese Medical Doctor Association

Vice Chairman, The First Committee of Orthopedic Oncology Society

Deputy Director, Sarcoma Committee, Chinese anti-Cancer Association

Deputy Chief Editor, World Journal of Emergency Medicine

Editorial Board Member, Orthopaedic Surgery

Education Experience

Research Summary

Immunotherapy of musculoskeletal tumors;

Multi-omics studies of musculoskeletal tumors (including imaging, pathology, proteomics;

Engineering and product development of bone induction and intelligent antibacterial active bone implantation devices.


Publications

Zhang Y, Sun H, Huang F, Chen Y, Ding X, Zhou C, Wu Y, Zhang Q, Ma X, Wang J,Yue R, Shen L, Sun X, Ye Z. The chromatin remodeling factor Arid1a cooperateswith Jun/Fos to promote osteoclastogenesis by epigenetically upregulatingSiglec15 expression. J Bone Miner Res. 2024 Mar 11:zjae042.

Zhang J, Zhu X, Li H, Li B, Sun L, Xie T, Zhu T, Zhou H, Ye Z. Corrigendum to"Piperine inhibits proliferation of human osteosarcoma cells via G2/M phasearrest and metastasis by suppressing MMP-2/-9 expression" [Int. Immunopharmacol.24(1) (2015) 50-58]. Int Immunopharmacol. 2024 Mar 10;129:111493.

Zhou H, Zhang W, Li H, Xu F, Yinwang E, Xue Y, Chen T, Wang S, Wang Z, Sun H,Wang F, Mou H, Yao M, Chai X, Zhang J, Diarra MD, Li B, Zhang C, Gao J, Ye Z.Osteocyte mitochondria inhibit tumor development via STING-dependent antitumorimmunity. Sci Adv. 2024 Jan 19;10(3):eadi4298.

Zhang W, Zhou H, Li H, Mou H, Yinwang E, Xue Y, Wang S, Zhang Y, Wang Z, ChenT, Sun H, Wang F, Zhang J, Chai X, Chen S, Li B, Zhang C, Gao J, Ye Z. Cancercells reprogram to metastatic state through the acquisition of plateletmitochondria. Cell Rep. 2023 Dec 26;42(12):113464.

Zhang W, Zhou H, Li H, Mou H, Yinwang E, Xue Y, Wang S, Zhang Y, Wang Z, ChenT, Sun H, Wang F, Zhang J, Chai X, Chen S, Li B, Zhang C, Gao J, Ye Z. Cancercells reprogram to metastatic state through the acquisition of plateletmitochondria. Cell Rep. 2023 Sep 26;42(9):113147.

Xu H, Luo H, Chen J, Chen G, Yu X, Ye Z. BMP-2 releasing mineral-coatedmicroparticle-integrated hydrogel system for enhanced bone regeneration. FrontBioeng Biotechnol. 2023 Aug 10;11:1217335.

Shao Z, Chen L, Zhang Z, Wu Y, Mou H, Jin X, Teng W, Wang F, Yang Y, Zhou H,Xue Y, Eloy Y, Yao M, Zhao S, Cui W, Yu X, Ye Z. KERS-Inspired NanostructuredMineral Coatings Boost IFN-γ mRNA Therapeutic Index for Antitumor Immunotherapy.Adv Mater. 2023 Dec;35(51):e2304296.

Chen L, Shao Z, Zhang Z, Teng W, Mou H, Jin X, Wei S, Wang Z, Eloy Y, ZhangW, Zhou H, Yao M, Zhao S, Chai X, Wang F, Xu K, Xu J, Ye Z. An On-DemandCollaborative Innate-Adaptive Immune Response to Infection Treatment. Adv Mater.2024 Apr;36(15):e2304774.

Wang F, Ye Y, Zhang Z, Teng W, Sun H, Chai X, Zhou X, Chen J, Mou H, Eloy Y,Jin X, Chen L, Shao Z, Wu Y, Shen Y, Liu A, Lin P, Wang J, Yu X, Ye Z. PDGFR inPDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a TemporalManner. Research (Wash D C). 2023 May 5;6:0086.

Wang S, Li H, Chen T, Zhou H, Zhang W, Lin N, Yu X, Lou Y, Li B, Yinwang E,Wang Z, Wang K, Xue Y, Qu H, Lin P, Sun H, Teng W, Mou H, Chai X, Cai Z, Ye Z.Human γδ T cells induce CD8+ T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK. Cancer ImmunolImmunother. 2023 Jun;72(6):1803-1821.

Chen T, Xue Y, Wang S, Lu J, Zhou H, Zhang W, Zhou Z, Li B, Li Y, Wang Z, LiC, Eloy Y, Sun H, Shen Y, Diarra MD, Ge C, Chai X, Mou H, Lin P, Yu X, Ye Z.Enhancement of T cell infiltration <i>via</i> tumor-targeted Th9 cell deliveryimproves the efficacy of antitumor immunotherapy of solid tumors. Bioact Mater.2022 Dec 5;23:508-523.

Wang Z, Li B, Li S, Lin W, Wang Z, Wang S, Chen W, Shi W, Chen T, Zhou H,Yinwang E, Zhang W, Mou H, Chai X, Zhang J, Lu Z, Ye Z. Metabolic control ofCD47 expression through LAT2-mediated amino acid uptake promotes tumor immuneevasion. Nat Commun. 2022 Oct 23;13(1):6308.

Mou H, Qu H, Li B, Wang S, Li H, Li X, Zhang W, Teng W, Zhang Z, Wang K,Wang F, Sun H, Chen L, Zhang J, Jin X, Wang C, Huang X, Lin N, Ye Z. Can"domino" therapy effectively treat the infection around the prosthesis after thelimb salvage surgery of bone tumor? - A study of sequential therapy. Int J Surg.2022 May;101:106630.

Lin P, Xue Y, Mu X, Shao Y, Lu Q, Jin X, Yinwang E, Zhang Z, Zhou H, Teng W,Sun H, Chen W, Shi W, Shi C, Zhou X, Jiang X, Yu X, Ye Z. Tumor Customized 2DSupramolecular Nanodiscs for Ultralong Tumor Retention and Precise PhotothermalTherapy of Highly Heterogeneous Cancers. Small. 2022 May;18(21):e2200179.

Zhou X, Chen J, Sun H, Wang F, Wang Y, Zhang Z, Teng W, Ye Y, Huang D, ZhangW, Mo X, Liu A, Lin P, Wu Y, Tao H, Yu X, Ye Z. Spatiotemporal regulation ofangiogenesis/osteogenesis emulating natural bone healing cascade forvascularized bone formation. J Nanobiotechnology. 2021 Dec 14;19(1):420.

Zhang Y, Chen Y, Sun H, Zhang W, Zhang L, Li H, Huang X, Yang J, Ye Z.SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates GlucocorticoidInduced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis. FrontCell Dev Biol. 2021 Jun 24;9:693079.

Huang X, Huang D, Zhu T, Yu X, Xu K, Li H, Qu H, Zhou Z, Cheng K, Wen W, YeZ. Sustained zinc release in cooperation with CaP scaffold promoted boneregeneration via directing stem cell fate and triggering a pro-healing immunestimuli. J Nanobiotechnology. 2021 Jul 12;19(1):207.

Zhang Z, Wang Y, Teng W, Zhou X, Ye Y, Zhou H, Sun H, Wang F, Liu A, Lin P,Cui W, Yu X, Wu Y, Ye Z. An orthobiologics-free strategy for synergisticphotocatalytic antibacterial and osseointegration. Biomaterials. 2021Jul;274:120853.

Li GQ, Wang YK, Zhou H, Jin LG, Wang CY, Albahde M, Wu Y, Li HY, Zhang WK,Li BH, Ye ZM. Application of Immune Infiltration Signature and Machine LearningModel in the Differential Diagnosis and Prognosis of Bone-Related Malignancies.Front Cell Dev Biol. 2021 Apr 15;9:630355.

Wang Y, Teng W, Zhang Z, Zhou X, Ye Y, Lin P, Liu A, Wu Y, Li B, Zhang C,Yang X, Li W, Yu X, Gou Z, Ye Z. A trilogy antimicrobial strategy for multipleinfections of orthopedic implants throughout their life cycle. Bioact Mater.2020 Dec 10;6(7):1853-1866.

Gu Z, Zhou Y, Cao C, Wang X, Wu L, Ye Z. TFAP2C-mediated LINC00922 signalingunderpins doxorubicin-resistant osteosarcoma. Biomed Pharmacother. 2020Sep;129:110363.

Chen T, Guo J, Cai Z, Li B, Sun L, Shen Y, Wang S, Wang Z, Wang Z, Wang Y,Zhou H, Cai Z, Ye Z. Th9 Cell Differentiation and Its Dual Effects in TumorDevelopment. Front Immunol. 2020 May 20;11:1026.

Wang Z, Wang Z, Li B, Wang S, Chen T, Ye Z. Innate Immune Cells: A Potentialand Promising Cell Population for Treating Osteosarcoma. Front Immunol. 2019 May16;10:1114.

Wu Y, Xu L, Yang P, Lin N, Huang X, Pan W, Li H, Lin P, Li B, Bunpetch V,Luo C, Jiang Y, Yang D, Huang M, Niu T, Ye Z. Survival Prediction in High-gradeOsteosarcoma Using Radiomics of Diagnostic Computed Tomography. EBioMedicine.2018 Aug;34:27-34.

Wang Z, Wang Z, Li S, Li B, Sun L, Li H, Lin P, Wang S, Teng W, Zhou X, YeZ. Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on OsteosarcomaCells <i>via</i> the NKG2DL-NKG2D Axis. Front Immunol. 2018 Jun 1;9:1239.

Li B, Wang Z, Wu H, Xue M, Lin P, Wang S, Lin N, Huang X, Pan W, Liu M, YanX, Qu H, Sun L, Li H, Wu Y, Teng W, Wang Z, Zhou X, Chen H, Poznansky MC, Ye Z.Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating TumorProgression and the Immune Response In Osteosarcoma. Cancer Res. 2018 Jul15;78(14):3938-3953.

Zhang J, Huang Y, Shao H, Bi Q, Chen J, Ye Z. Grape seed procyanidin B2inhibits adipogenesis of 3T3-L1 cells by targeting peroxisome proliferator-activated receptor γ with miR-483-5p involved mechanism. Biomed Pharmacother.2017 Feb;86:292-296.

Wang Z, Li B, Ren Y, Ye Z. T-Cell-Based Immunotherapy for Osteosarcoma:Challenges and Opportunities. Front Immunol. 2016 Sep 14;7:353.

Wang SD, Li HY, Li BH, Xie T, Zhu T, Sun LL, Ren HY, Ye ZM. The role ofCTLA-4 and PD-1 in anti-tumor immune response and their potential efficacyagainst osteosarcoma. Int Immunopharmacol. 2016 Sep;38:81-9.

Liu M, Sun LL, Li YJ, Li HY, Zhang J, Li BH, Ye ZM. Trastuzumab enhanced thecytotoxicity of Vγ9Vδ2 T cells against zoledronate-sensitized osteosarcomacells. Int Immunopharmacol. 2015 Sep;28(1):160-7.

Wang S, Li H, Ye C, Lin P, Li B, Zhang W, Sun L, Wang Z, Xue D, Teng W, ZhouX, Lin N, Ye Z. Valproic Acid Combined with Zoledronate Enhance γδ T CellMediated Cytotoxicity against Osteosarcoma Cells the Accumulation ofMevalonate Pathway Intermediates. Front Immunol. 2018 Feb 27;9:377.

Zheng K, Yu XC, Hu YC, Wang Z, Wu SJ, Ye ZM; Giant Cell Tumor Group of China(GTOC). How to Fill the Cavity after Curettage of Giant Cell Tumors around theKnee? A Multicenter Analysis. Chin Med J (Engl). 2017 Nov 5;130(21):2541-2546.

Li Z, Xu Q, Peng H, Cheng R, Sun Z, Ye Z. IFN-γ enhances HOS and U2OS celllines susceptibility to γδ T cell-mediated killing through the Fas/Fas ligandpathway. Int Immunopharmacol. 2011 Apr;11(4):496-503.

Zhang J, Zhu X, Li H, Li B, Sun L, Xie T, Zhu T, Zhou H, Ye Z. Piperineinhibits proliferation of human osteosarcoma cells via G2/M phase arrest andmetastasis by suppressing MMP-2/-9 expression. Int Immunopharmacol. 2015Jan;24(1):50-8.

Teng W, Zhang Z, Wang Y, Ye Y, Yinwang E, Liu A, Zhou X, Xu J, Zhou C, SunH, Wang F, Zhang L, Cheng C, Lin P, Wu Y, Gou Z, Yu X, Ye Z. Iodine ImmobilizedMetal-Organic Framework for NIR-Triggered Antibacterial Therapy on OrthopedicImplants. Small. 2021 Sep;17(35):e2102315.

Li B, Li G, Yan X, Zhu D, Lin PP, Wang Z, Qu H, He X, Fu Y, Zhu X, Lin P,Zhang J, Li X, Dai H, Chen H, Poznansky MC, Lin N, Ye Z. Fresh Tissue Multiomics Profiling Reveals Immune Classification and Suggests ImmunotherapyCandidates for Conventional Chondrosarcoma. Clin Cancer Res. 2021 Dec1;27(23):6543-6558.

Current Program

Musculoskeletal system repair materials and implanted instruments, and engineering techniques for surface modification. Funding Source: National Key R&D Program of China. 

The role and mechanism of PCSK9 mediated ferroptosis of T cells in MDSC induced by high lactic acid microenvironment of osteosarcoma.Funding Source: National Natural Science Foundation of China.

The role of γδ T cells as novel antigen-presenting cells in inducing anti-osteosarcoma immune response and the mechanism of antigen presentation. Funding Source: National Natural Science Foundation of China.

Research and application of 3D printing integrated manufacturing technology for personalized medical aids. Funding Source: Key R&D Project of Zhejiang Provincial Department of Science and Technology.

Anti-osteosarcoma effect and mechanism of a novel tumor vaccine with porous nano-silicon loaded antigen presented by γδ T cells. Funding Source: Zhejiang Provincial Medicine and Health Science and Technology Project.

Demethylation therapy induces CTA-specific γδ T cells to recognize the osteosarcoma and its mechanisms. Funding Source: Natural Science Foundation of Zhejiang.

Basic research of adoptive transferring αβ TCR gene transfection γδ T cells for osteosarcoma. Funding Source: National Natural Science Foundation of China.

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