Yan Min, M.D.

Position:Chair of Anesthesiology


Medical School:Kiel University School of Medicine, Germany

Academic Rank:Chief Physician, Professor


Clinical / Research Interests

Cardiovascular surgery anesthesia, difficult airway management, critical treatment of severe patients, and diagnosis and treatment of acute and chronic pain.

Professional Highlights

Zhejiang Scientific and Technological Award, First Prize   

Zhejiang Medical and Health Science and Technology Award, First Prize

Zhejiang Medical and Health Innovation Award, First Prize

Professional Appointments

Member, American Society of Anesthesiologists

Editorial Board Member, Chinese Journal of Anesthesiology

Editorial Board Member, Chinese Journal of Pain Medicine

Editorial Board Member, International Journal of Anesthesia and Resuscitation Journal of Anesthesia and Perioperative Medicine 

Editorial Board Member, Journal of Clinical Anesthesia

Editorial Board Member, Pain clinic Journal

Editorial Board Member, Pain Section of Medical Reference 

Reviewer, Journal of Pharmaceutical 

Reviewer, Sciences Brain Research

Reviewer, Acta Pharmacologica Sinica

Reviewer, Journal of Zhejiang University-Science B 

Reviewer, Chinese Medicine Journal

Reviewer, Cell Proliferation

Reviewer, National Medical Journal of China 

Reviewer, Chinese Journal of Emergency Medicine 

Reviewer, Zhejiang Medicine Journal

Education Experience

Research Summary

Epigenetic regulation of the peripheral nervous system in chronic neuropathic pain.

Impact of combined 137 Cs with thermotherapy on tumor cells and red blood cells in perioperative  autotransfusion for patients with tumor.

Impact and mechanism of isorhamnetin on revascularization following ischemic brain injury in diabetic rats.

Investigation of an anti-infectious, subcutaneous pump for epidural analgesia postoperatively.

Rational transfusion in clinical practice: A retrospective multicenter study.

Role of mitochondrial permeablity transition pore and PI3K/AKI in perioperative cardioprotection of sevoflurane postcondition.


Gao Y, Sun N, Wang L, Wu Y, Ma L, Hong J, Ren J, Zhu B, Yu L, Yan M. Bioinformatics Analysis Identifies p53 as a Candidate Prognostic Biomarker for Neuropathic Pain. Frontiers In Genetics.2018.9: (Corresponding author)Xu L,Shen J,Yu L,Sun J,Yan M,Autophagy is involved in sevoflurane-induced developmental neurotoxicity in the developing rat brain. Brain Research  Bulletin.2018.140:226-232. (Corresponding author)

Yu J,Li X,Matei N, McBride D, Tang J, Yan M, Zhang JH. Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats .Experimental Neurology. 2018.307 :12–23

Xu L, Shen J, Yu L, Sun J, McQuillan PM, Hu Z, Yan M. Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells. Brain Research Bulletin 140 (2018) 291-298

Xing XF, Zhou ZF, Zhang FJ, Yan M. The Effect of Early Use of Supplemental Therapy on Preventing Postherpetic Neuralgia: A Systematic Review and Meta-analysis. Pain Physician.2017.20(6):471-486.

Sun K, Hong F, Wang Y, Agopian VG, Yan M. Busuttil RW,Steadman RH,Xia VW.Venovenous Bypass is Associated With a Lower Incidence of Acute Kidney Injury After Liver Transplantation in Patients With Compromised Pretransplant Renal Function.Anesth Analg. 2017.125(5):1463-1470.

Shi X, Doycheva DM, Xu L, Tang J, Yan M, Zhang JH. Sestrins: A New Kid for Stroke .Treatment?Current Drug Delivery, 2017.14(6):797-806.

Zhang FJ, Yang JT, Tang LH, Wang WN, S K, MY, Kanhar Ghulam Muhammad, Zheng YF, Yan M. Effect of X-Ray Irradiation on Hepatocarcinoma Cells and Erythrocytes in Salvaged Blood.Scientific Reports 7 (2017): 7995.

Shi X, Xu L, Doycheva DM, Tang J, Yan M, Zhang JH. Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups. J Cereb Blood Flow Metab. 2017. 37(4): 1447-1460.

Sun K, Xing T, Zhang F, Liu Y, Li W, Zhou Z, Fang L, Yu L, Yan M. Perioperative Transcutaneous Electrical Acupoint Stimulation for Postoperative Pain Relief Following Laparoscopic Surgery: A Randomized Controlled Trial. Clin J Pain. 2017. 33(4): 340-347.

Zhou ZF, Jia XP, Sun K, Zhang FJ, Yu LN, Xing T, Yan M. Mild volume acute normovolemic hemodilution is associated with lower intraoperative transfusion and postoperative pulmonary infection in patients undergoing cardiac  surgery  --  a  retrospective,  propensity  matching  study.  BMC  Anesthesiol.  2017. 17(1):13.

Xu L, Shen J, Yan M. The effect of pressure-controlled inverse ratio ventilation on lung protection in obese patients undergoing gynecological laparoscopic surgery. J Anesth. 2017.

Yu LN, Sun LH, Wang M, Wang LJ, Wu Y, Yu J, Wang WN, Zhang FJ, Li X, Yan M. EphrinB-EphB Signaling Induces Hyperalgesia through ERK5/CREB Pathway in Rats. Pain Physician. 2017. 20(4): E563-E574.

Dong H, Zhang FJ, Wang FY, Wang YY, Guo J, Kanhar GM, Chen J, Liu J, Zhou C, Yan M, Chen X. Simultaneous on-line monitoring of propofol and sevoflurane in balanced anesthesia by direct resistive heating gas chromatography. J Chromatogr A. 2017. 1506: 93-100.

Zhao W, Ge X, Sun K, Agopian VG, Wang Y, Yan M, Busuttil RW, Steadman RH, Xia VW. Acute respiratory distress syndrome after orthotopic liver transplantation. Journal of critical care. 2016;31:163-167.

Zhou Q-h, Zhu B, Wei C-n, Yan M. Abdominal girth and vertebral column length can adjust spinal anesthesia for lower limb surgery, a prospective, observational study. BMC anesthesiology. 2016;16.

Shi X, Xu L, Doycheva DM, Tang J, Yan M, Zhang JH. Sestrin2, as a negative feedback regulator of mtor provides neuroprotection by activation ampk phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups. Journal of Cerebral Blood Flow & Metabolism. 2016:0271678X16656201.

Shi X, Doycheva DM, Xu L, Tang J, Yan M, Zhang JH. Sestrin2 induced by hypoxia inducible protects the blood-brain barrier via inhibiting vegf after severe hypoxic-ischemic injury in neonatal rats. Neurobiology of disease. 2016;95:111-121.

Wang YJ, Zuo ZX, Zhang M, Feng ZH, Yan M, Li XY. The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg 2016.

Shi QY, Zhang SJ, Liu L, Chen QS, Yu LN, Zhang FJ, Yan M. Sevoflurane promotes the expansion of glioma stem cells through activation of hypoxia-inducible factors in vitro. British journal of anaesthesia. 2015;114:825-830.

Zhou XL, Zhang CJ, Wang Y, Wang M, Sun LH, Yu LN, Cao JL, Yan M. Ephrinb-ephb signaling regulates spinal pain processing via pkcgamma. Neuroscience. 2015;307:64-72.

Fang L, Li X, Zhong Y, Yu J, Yu L, Dai H, Yan M. Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats. Journal of neurochemistry. 2015;135:431-440.

Zhou XL, Wang Y, Zhang CJ, Yu LN, Cao JL, Yan M. Cox-2 is required for the modulation of spinal nociceptive information related to ephrinb/ephb signalling. European journal of pain. 2015;19:1277-1287.

Zhou XL, Wang Y, Zhang CJ, Yu LN, Cao JL, Yan M. Pka is required for the modulation of spinal nociceptive information related to ephrinb–ephb signaling in mice. Neuroscience. 2015;284:546-554.

Zhou XL, Yu LN, Wang Y, Tang LH, Peng YN, Cao JL, Yan M. Increased methylation of the mor gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain. Mol Pain. 2014;10:51.

Xia WS, Peng YN, Tang LH, Jiang LS, Yu LN, Zhou XL, Zhang FJ, Yan M. Spinal ephrinb/ephb signalling contributed to remifentanil-induced hyperalgesia via nmda receptor. European journal of pain. 2014;18:1231-1239.

Chen X, Zhang XL, Liu L, Chen Y, Piao MY, Zhang FJ, Wu WD, Zhong YB, Sun K, Zou YC, Zhang X, Wang D, Wang P, Yan M. Gas chromatograph-surface acoustic wave for quick real-time assessment of blood/exhaled gas ratio of propofol in humans. British journal of anaesthesia. 2014;113:807-814.

Zhu YM, Wang CC, Chen L, Qian LB, Ma LL, Yu J, Zhu MH, Wen CY, Yu LN, Yan M. Both pi3k/akt and erk1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats. Brain research. 2013;1494:1-8.

Ma L-L, Zhang F-J, Kong F-J, Qian L-B, Ma H, Wang J-A, Yan M. Hypertrophied myocardium is refractory to sevoflurane-induced protection with alteration of reperfusion injury salvage kinase/glycogen synthase kinase 3β signals. Shock. 2013;40:217-221.

Ma LL, Zhang FJ, Qian LB, Kong FJ, Sun JF, Zhou C, Peng YN, Xu HJ, Wang WN, Wen CY, Zhu MH, Chen G, Yu LN, Liu XB, Wang JA, Yan M. Hypercholesterolemia blocked sevoflurane-induced cardioprotection against ischemia-reperfusion injury by alteration of the mg53/risk/gsk3beta signaling. International journal of cardiology. 2013;168:3671-3678.

Huang B, Sun K, Zhu Z, Zhou C, Wu Y, Zhang F, Yan M. Oximetry-derived perfusion index as an early indicator of ct-guided thoracic sympathetic blockade in palmar hyperhidrosis. Clinical Radiology. 2013;68:1227-1232.

Zhang F, Ding T, Yu L, Zhong Y, Dai H, Yan M. Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the i2 imidazoline receptor-pi3k/akt pathway in rat c6 glioma cells. The Journal of pharmacy and pharmacology. 2012;64:120-127.

Zhou Q, Xiao W, An E, Zhou H, Yan M. Effects of four different positive airway pressures on right internal jugular vein catheterisation. European Journal of Anaesthesiology. 2012;29:223-228.

Zhang FJ, Ma LL, Wang WN, Qian LB, Yang MJ, Yu J, Chen G, Yu LN, Yan M. Hypercholesterolemia abrogates sevoflurane-induced delayed preconditioning against myocardial infarct in rats by alteration of nitric oxide synthase signaling. Shock. 2012;37:485-491.

Gong M, Chen G, Zhang XM, Xu LH, Wang HM, Yan M. Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats. Acta Anaesthesiologica Scandinavica. 2012;56:601-607.

Yan M, Dai H, Ding T, Dai A, Zhang F, Yu L, Chen G, Chen Z. Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells. Neurochemistry International. 2011;58:549-557.

Zheng Z, Yang M, Zhang F, Yu J, Wang J, Ma L, Zhong Y, Qian L, Chen G, Yu L, Yan M. Gender-related difference of sevoflurane postconditioning in isolated rat hearts: Focus on phosphatidylinositol-3-kinase/akt signaling. Journal of Surgical Research. 2011;170:e3-e9.

Wang J-K, Yu L-N, Zhang F-J, Yang M-J, Yu J, Yan M, Chen G. Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via pi3k/akt pathway. Brain research. 2010;1357:142-151.

Chen G, He CX, Xu DH, Liu L, Zhang FJ, Xu JY, Zheng CH, Gao JQ, Yan M. Composite microspheres induce the sustained release and the control of the initial release of water soluble drugs. Die Pharmazie. 2009;64:284-286.

Zhang F, Chen G, Chen C, Yan M. Sevoflurane postconditioning converts persistent ventricular fibrillation into regular rhythm. European Journal of Anaesthesiology. 2009;26:766-771.

He W, Zhang FJ, Wang SP, Chen G, Chen CC, Yan M. Postconditioning of sevoflurane and propofol is associated with mitochondrial permeability transition pore. Journal of Zhejiang University. Science. B. 2008;9:100-108.

Yan M, Chen C, Zhang F, Chen G. Lidocaine abolishes the myocardial protective effect of sevoflurane post-conditioning. Acta Anaesthesiol Scand. 2008;52:111-116.

Chen G, Yan M, Lu QH, Gong M. Effects of two different hydroxyethyl starch solutions (hes200/0.5 vs. Hes130/0.4) on the expression of platelet membrane glycoprotein. Acta Anaesthesiologica Scandinavica. 2006;50:1089-1094.

Yan M, Chen G, Fang L-l, Liu Z-m, Zhang X-l. Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: Neopterin and interleukin-2. Journal of Zhejiang University SCIENCE. 2005;6B:49-52. 

Current Program

The research of the molecular mechanism of IL-6 in regulating the methylation of the promoter of Mu opioid receptor gene in DRG induced by peripheral nerve injury. Funding Source: National Natural Science Foundation of China.

Molecular mechanism of methylation silencing of Mu opioid receptor gene in DRG caused by peripheral nerve injury in mice. Funding Source: Natural Science Foundation of Zhejiang.

Establishment of precision medicine system for acute pain in perioperative period Based on artificial intelligence. Funding Source: Health Commission of Zhejiang Province.

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