Huang Man, M.D., Ph.D.

Position:Chair of General ICU, Vice Chair of Lung Transplant

Department:General ICU

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Multiple Organ Dysfunction Syndrome

Perioperative management of lung transplantation

Pathogenesis and therapy of Sepsis Associated Encephalopathy

Artificial Intelligence applied in critical care medicine

Acute Kidney Injury and blood purification in critical care medicine

Professional Highlights

Professional Appointments

Ph. D. Supervisor at Zhejiang University School of Medicine

Chairman, Neurosurgery Critical Care Branch, Zhejiang Society for Neuroscience

Vice Chairman, Professional Committee of Critical Care Medicine, China Medical Women's Association

Chairman, Neurosurgery Critical Care Branch, Zhejiang Society for Neuroscience

Member, Extracorporeal Life Support Committee, Chinese Medical Association

Member, Shock and Sepsis Committee, Chinese Research Hospital Association

Member, Critical Care Medicine Sub-Committee, Chinese Society of Gerontology

Editorial board member, Chinese Journal of Emergency Medicine

Education Experience

2010.09-2013.09, Zhejiang University School of Medicine, Doctor Degree in Neurology

2002.09-2005.12, Zhejiang University School of Medicine, Master Degree  in Neurology

1989.09-1994.06, Wenzhou Medical University, Bachelor degree

Research Summary

Publications

Intensive care unit-acquired weakness: Recent insights. J Intensive Med. 2023 Aug 30;4(1):73-80.

Su J, Huang M. Recurrent malignant hyperthermia after scoliosis correction surgery. World J Emerg Med. 2024;15(1):70-72.

Prediction of successful weaning from renal replacement therapy in critically ill patients based on machine learning. Ren Fail. 2024 Dec;46(1):2319329. 

Chasing the landscape for intrahospital transmission and evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae. Sci Bull (Beijing). 2023 Dec 15;68(23):3027-3047.

Cross-Hospital Sepsis Early Detection via Semi-Supervised Optimal Transport With Self-Paced Ensemble. IEEE J Biomed Health Inform. 2023 Jun;27(6):3049-3060.

Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung. Cell Discov. 2023 Sep 26;9(1):98.

Ceftazidime/Avibactam for the Treatment of Carbapenem-Resistant Pseudomonas aeruginosa Infection in Lung Transplant Recipients. Infect Drug Resist. 2023 Apr 15;16:2237-2246.

Prevalence and clinical significance of potential drug-drug interactions among lung transplant patients. Front Pharmacol. 2024 Feb 6;15:1308260. 

China Lung Transplantation Alliance; National Lung Transplantation Expert Group for COVID-19. Lung transplantation during the outbreak of Coronavirus Disease 2019 in China. J Thorac Cardiovasc Surg. 2022 Jan;163(1):326-335.e6.

Active surveillance of carbapenem-resistant gram-negative bacteria to guide antibiotic therapy: a single-center prospective observational study. Antimicrob Resist Infect Control. 2022 Jun 22;11(1):89.

Ceftazidime/Avibactam versus Polymyxin B in the Challenge of Carbapenem-Resistant Pseudomonas aeruginosa Infection. Infect Drug Resist. 2022 Feb 25;15:655-667.

Early Prediction of Carbapenem-resistant Gram-negative Bacterial Carriage in Intensive Care Units Using Machine Learning. 2022 Mar 26;S2213-7165(22)00074-1.

Severe acute kidney injury predicting model based on transcontinental databases: a single-centre prospective study. BMJ Open. 2022 Mar 3;12(3):e054092.

Efferocytosis and Its Role in Inflammatory Disorders. Front Cell Dev Biol. 2022 Feb 25;10:839248.

Application of mngs to describe the clinical and microbial characteristics of severe burn a tanker explosion at a tertiary medical center: a retrospective study patients following. BMC Infect Dis. 2021 Oct 21;21(1):1086.

The Effect and Regulatory Mechanism of High Mobility Group Box-1 Protein on Immune Cells in Inflammatory Diseases. Cells. 2021 Apr 28;10(5):1044.

IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome. Mediators Inflamm. 2021 Dec 17;2021:6370911.

Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4 + CD25 + regulatory T cells. J Cell Mol Med. 2020 Jan;24(2):2027-2039.

Current Program

The potential role and its mechanism of interleukin-36 regulating autophagy in the immune function of regulatory T cells in sepsis. Funding Source: National Natural Science Foundation of China (81873946), 2019-2022.

The potential role and its mechanism of IL-36β regulating ERS-XBP1 pathway in the immune function of dendritic cells in septic mice. Funding Source: Natural Science Foundation of Zhejiang (LY20H150011), 2020-2022.


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