Chen Qixin, M.D., Ph.D.


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Clinical / Research Interests

Basic research: spinal cord injuries, intervertebral disc degeneration;

Clinical research: surgical treatment for spine deformity, especially with minimal invasive approach.

Professional Highlights

Professional Award for Science and Technology Innovation of Zhejiang Province, Second Prize

Professional Award for Science and Technology Innovation of Zhejiang Province, Third Prize

Professional Appointments

Member, AO Spine

Member, Society of Lateral Access Surgery

Standing Committee Member, Spine and Spinal Cord Injury Committee, Chinese Association of Rehabilitation Medicine

Past Chairman, Spine and Spinal Cord Committee, Zhejiang Association of Rehabilitation Medicine

Head, Zhejiang Spine Surgery Society

Education Experience

Research Summary


Duraplasty of PHBV/PLA/Col membranes promote axonal regeneration by inhibiting NLRP3 complex and M1 macrophage polarization in rats with spinal cord injury. FASEB J. 2020; Jul 20.

Osmolarity controls the differentiation of adipose-derived stem cells into nucleus pulposus cells via histone demethylase KDM4B. Mol Cell Biochem. 2020 Jun 27.

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury. Cell Death Dis. 2020 Jun 8;11(6):439.

Cervical Flexion Osteotomy through One-Stage Posterior-Anterior-Posterior Approach for Cervical Extension Deformity in Ankylosing Spondylitis: A Novel Surgical Technique. Orthop Surg. 2020 Jun;12(3):1005-1009.

Overexpression of the transcription factors OCT4 and KLF4 improves motor function after spinal cord injury. CNS Neurosci Ther. 2020 May 25

Transplantation strategies for spinal cord injury based on microenvironment modulation. Curr Stem Cell Res Ther. 2020 Apr 21.

Radiographic and clinical outcome of lateral lumbar interbody fusion for extreme lumbar spinal stenosis of Schizas grade D: a retrospective study. BMC Musculoskelet Disord. 2020 Apr 20;21(1):259.

Does Lateral Lumbar Interbody Fusion Decrease the Grading of Lenke-Silva Classification and Determine the Optimal Fusion Level in Severe Adult Degenerative Scoliosis? World Neurosurg. 2020 Jul;139:e335-e344.

The biomechanical study of a modified lumbar interbody fusion-crenel lateral interbody fusion (CLIF): a three-dimensional finite-element analysis. Comput Methods Biomech Biomed Engin. 2020 Jul;23(9):548-555.

An injectable recombinant human milk fat globule-epidermal growth factor 8-loaded copolymer system for spinal cord injury reduces inflammation through NF-κB and neuronal cell death. Cytotherapy. 2020 Apr;22(4):193-203.

Scar Tissue-Targeting Polymer Micelle for Spinal Cord Injury Treatment. Small. 2020 Feb;16(8):e1906415.

Magnetic Resonance Imaging Research of Thoracic Inlet Parameters in the Cervical and Cervicothoracic Spine in Degenerative Cervical Spondylosis. World Neurosurg. 2020 Apr;136:e586-e592.

Micro Fragmented Adipose Tissue Promotes the Matrix Synthesis Function of Nucleus Pulposus Cells and Regenerates Degenerated Intervertebral Disc in a Pig Model. Cell Transplant. Jan-Dec 2020;29:963689720905798.

Stem Cell Transplantation: A Promising Therapy for Spinal Cord Injury. Curr Stem Cell Res Ther. 2020;15(4):321-331.

lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration. Stem Cell Res Ther. 2019 Nov 21;10(1):344.

Magnetic Resonance Imaging Study of Oblique Corridor and Trajectory to L1-L5 Intervertebral Disks in Lateral Position. World Neurosurg. 2020 Feb;134:e616-e623.

Small Molecule-Based Strategy Promotes Nucleus Pulposus Specific Differentiation of Adipose-Derived Mesenchymal Stem Cells. Mol Cells. 2019 Sep 30;42(9):661-671.

An injectable heparin-Laponite hydrogel bridge FGF4 for spinal cord injury by stabilizing microtubule and improving mitochondrial function. Theranostics. 2019 Sep 21;9(23):7016-7032.

The technical note and approach related complications of modified lateral lumbar interbody fusion. J Clin Neurosci. 2019 Aug;66:182-186.

Intradiscal Injection of Induced Pluripotent Stem Cell-Derived Nucleus Pulposus-Like Cell-Seeded Polymeric Microspheres Promotes Rat Disc Regeneration. Stem Cells Int. 2019 May 2;2019:6806540.

Reassessment System and Staged Surgical Strategy with Minimally Invasive Techniques for Treatment of Severe Adult Spinal Deformities. World Neurosurg. 2019 Jun;126:e860-e868.

Integration of mesenchymal stem cell sheet and bFGF-loaded fibrin gel in knitted PLGA scaffolds favorable for tendon repair. J Mater Chem B. 2019 Apr 7;7(13):2201-2211.

Sustained release of GDF5 from a designed coacervate attenuates disc degeneration in a rat model. Acta Biomater. 2019 Mar 1;86:300-311.

The Application of Neural Stem/Progenitor Cells for Regenerative Therapy of Spinal Cord Injury. Curr Stem Cell Res Ther. 2019;14(6):495-503.

Identification of the key genes and long non‑coding RNAs in ankylosing spondylitis using RNA sequencing. Int J Mol Med. 2019 Mar;43(3):1179-1192.

Wogonin mitigates intervertebral disc degeneration through the Nrf2/ARE and MAPK signaling pathways. Int Immunopharmacol. 2018 Dec;65:539-549.

Enhanced recovery care versus traditional care following laminoplasty: A retrospective case-cohort study. Medicine (Baltimore). 2018 Nov;97(48):e13195.

PHBV/PLA/Col-Based Nanofibrous Scaffolds Promote Recovery of Locomotor Function by Decreasing Reactive Astrogliosis in a Hemisection Spinal Cord Injury Rat Model. J Biomed Nanotechnol. 2018 Nov 1;14(11):1921-1933.

Injectable decellularized nucleus pulposus-based cell delivery system for differentiation of adipose-derived stem cells and nucleus pulposus regeneration. Acta Biomater. 2018 Nov;81:115-128.

The Influence of Hyperosmolarity in the Intervertebral Disc on the Proliferation and Chondrogenic Differentiation of Nucleus Pulposus-Derived Mesenchymal Stem Cells. Cells Tissues Organs. 2018;205(3):178-188. 

Does the Access Angle Change the Risk of Approach-Related Complications in Minimally Invasive Lateral Lumbar Interbody Fusion? An MRI Study. J Korean Neurosurg Soc. 2018 Jun 26. 

A modified surgical technique of lateral lumbar interbody fusion. Chinese Journal of Orthopaedics. 2018; 38 (4) :212-219. [Chinese]

Minimally invasive surgery for the severe degenerative lumbar scoliosis: two stage protocol. Zhonghua Yi Xue Za Zhi. 2018 Jul 3;98(25):1996-2001. [Chinese] 

FoxA2 regulates the type II collagen-induced nucleus pulposus-like differentiation of adipose-derived stem cells by activation of the Shh signaling pathway. FASEB J. 2018 Jun 11.

Facet angle and its importance on joint violation in percutaneous pedicle screw fixation in lumbar vertebrae: A retrospective study. Medicine (Baltimore). 2018 Jun;97(22).

Genipin-cross-linked type II collagen scaffold promotes the differentiation of adipose-derived stem cells into nucleus pulposus-like cells. J Biomed Mater Res A. 2018 May;106(5):1258-1268.

Genipin cross-linked type II collagen/chondroitin sulfate composite hydrogel-like cell delivery system induces differentiation of adipose-derived stem cells and regenerates degenerated nucleus pulposus. Acta Biomater. 2018 Apr 15;71:496-509.

Radiological manifestations and surgical outcome of combined upper cervical cord compression and cervical ossification of the posterior longitudinal ligament with a minimum 2-year follow-up. Medicine (Baltimore). 2017 Nov;96(45): e8332.

Combined upper cervical canal stenosis and cervical ossification of the posterior longitudinal ligament resulting in myelopathy: A case series and literature review. J Clin Neurosci. 2017 Nov; 45:270-275. 

A case report of atypical long segmental thoracic hypertrophic pachymeningitis with ossification Medicine (Baltimore). 2017 Jan;96(1): e5841. 

Posterior arthrodesis of C1-C3 for the stabilization of multiple unstable upper cervical fractures with spinal cord compromise: A case report and literature review of ligamentum flavum and literature review. Eur Spine J. 2017 May;26 (Suppl 1):202-206. 

Idiopathic intracranial hypertension occurred after spinal surgery: report of two rare cases and systematic review of the literature. Eur Spine J. 2017 May;26(Suppl 1):9-16.

Computer Simulation of Two-level Pedicle Subtraction Osteotomy for Severe Thoracolumbar Kyphosis in Ankylosing Spondylitis. Indian J Orthop. 2017 Nov-Dec;51(6):666-671. 

Clinical outcome of laminoplasty for cervical ossification of the posterior longitudinal ligament with K-line (-) in the neck neutral position but K-line (+) in the neck extension position: A retrospective observational study. Medicine (Baltimore). 2017 Jun;96(22) :e6964.

Three-dimensional scaffold of type II collagen promotes the differentiation of adipose-derived stem cells into a nucleus pulposus-like phenotype. J Biomed Mater Res A. 2016 Jul;104(7):1687-93.

Proportion of collagen type II in the extracellular matrix promotes the differentiation of human adipose-derived mesenchymal stem cells into nucleus pulposus cells. Biofactors. 2016 Mar-Apr;42(2):212-23.

TGF-β3 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK/ERK signaling. Growth Factors. 2015;33(5-6):326-36. 

BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype. Int J Mol Sci. 2015 Aug 27;16(9):20344-59. 

Morphometric measurement of the lumbosacral spine for minimally invasive cortical bone trajectory implant using computed tomography. Eur Spine J. 2016 Mar;25(3):870-6.

The potential of chondrogenic pre-differentiation of adipose-derived mesenchymal stem cells for regeneration in harsh nucleus pulposus microenvironment. Exp Biol Med (Maywood). 2016 Dec;241(18):2104-2111.

Cervical total disc replacement is superior to anterior cervical decompression and fusion: a meta-analysis of prospective randomized controlled trials. PLoS One. 2015 Mar 30;10(3) :e 0117826.

Motion preservation in type II odontoid fractures using temporary pedicle screw fixation: a preliminary study. Eur Spine J. 2015 Apr;24(4):686-93. 

Roles of FGF-2 and TGF-beta/FGF-2 on differentiation of human mesenchymal stem cells towards nucleus pulposus-like phenotype. Growth Factors. 2015 Feb;33(1):23-30. 

Clinical Guideline for Treatment of Symptomatic Thoracic Spinal Stenosis. Orthop Surg. 2015 Aug;7(3):208-12. 

Stromal cell-derived factor-1 and its receptor CXCR4 are upregulated expression in degenerated intervertebral discs. Int J Med Sci. 2014 Jan 11;11(3):240-5. 

Nucleus pulposus mesenchymal stem cells in acidic conditions mimicking degenerative intervertebral discs give better performance than adipose tissue-derived mesenchymal stem cells. Cells Tissues Organs. 2014;199(5-6):342-52. 

Dual release of dexamethasone and TGF-β3 from polymeric microspheres for stem cell matrix accumulation in a rat disc degeneration model. Acta Biomater. 2013 Dec;9(12):9423-33. 

Influence of hypoxia in the intervertebral disc on the biological behaviors of rat adipose- and nucleus pulposus-derived mesenchymal stem cells. Cells Tissues Organs. 2013;198(4):266-77. 

Potential of co-culture of nucleus pulposus mesenchymal stem cells and nucleus pulposus cells in hyperosmotic microenvironment for intervertebral disc regeneration. Cell Biol Int. 2013 Aug;37(8):826-34. 

Regulatory role of hypoxia inducible factor in the biological behavior of nucleus pulposus cells. Yonsei Med J. 2013 Jul;54(4):807-12. 

Posterolateral lumbar fusion versus transforaminal lumbar interbody fusion for the treatment of degenerative lumbar scoliosis. J Clin Neurosci. 2013 Sep;20(9):1241-5.

Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc.  J Transl Med. 2012 Mar 16; 10:49. 

Clinical application of a new plate fixation system in open-door laminoplasty. Orthopedics. 2012 Feb 17;35(2): e 225-31. 

Fabrication of a Layered Microstructured Polymeric Microspheres as a Cell Carrier for Nucleus Pulposus Regeneration. J Biomater Sci Polym Ed. 2012;23(18):2287-302. 

Decreased sleep duration: a risk of progression of degenerative lumbar scoliosis. Med Hypotheses. 2012 Feb;78(2):244.

Elevated local TGF-β1 level predisposes a closed bone fracture to tuberculosis infection. Med Hypotheses. 2012 Sep;79(3):400-2.

Acidic pH conditions mimicking degenerative intervertebral discs impair the survival and biological behavior of human adipose-derived mesenchymal stem cells. Exp Biol Med (Maywood). 2012 Jul;237(7):845-52. 

Learning curve of thoracic pedicle screw placement using the free-hand technique in scoliosis: how many screws needed for an apprentice? Eur Spine J. 2012 Jun;21(6):1151-6.

The relationship between low pH in intervertebral discs and low back pain: a systematic review. Arch Med Sci. 2012 Dec 20;8(6):952-6. 

Dual delivery for stem cell differentiation using dexamethasone and bFGF in/on polymeric microspheres as a cell carrier for nucleus pulposus regeneration. J Mater Sci Mater Med. 2012 Apr;23(4):1097-107.

Surgery is an effective and reasonable treatment for degenerative scoliosis: a systematic review. J Int Med Res. 2012;40(2):399-405.

Kümmell's disease, an uncommon and complicated spinal disorder: a review. J Int Med Res. 2012;40(2):406-14.

The effect of injection volume on disc degeneration in a rat tail model. Spine (Phila Pa 1976). 2011 Jul 15;36(16): E1062-9.

Rhein: a potential biological therapeutic drug for intervertebral disc degeneration. Med Hypotheses. 2011 Dec;77(6):1105-7.

Ion channel blockers and spinal cord injury. J Neurosci Res. 2011 Jun;89(6):791-801. 

Posterior-only approach with selective segmental TLIF for degenerative lumbar scoliosis. J Spinal Disord Tech. 2011 Jul;24(5):308-12. 

An unusual high-pressure injection injury involving the cervical spinal cord. J Bone Joint Surg Br. 2011 Aug;93(8):1140-2.

Decreases in fluid shear stress due to microcracks: a possible primary pathogenesis of Kümmell's disease. Med Hypotheses. 2011 Nov;77(5):897-9. 

Transforaminal lumbar interbody fusion with one cage and excised local bone. Arch Orthop Trauma Surg. 2010 May;130(5):591-7.

Endplate degeneration may be the origination of the vacuum phenomenon in intervertebral discs. Med Hypotheses. 2010 Aug;75(2):169-71.

Spinal cord decompression reduces rat neural cell apoptosis secondary to spinal cord injury. J Zhejiang Univ Sci B. 2009 Mar;10(3):180-7. 

Unilateral transforaminal lumbar interbody fusion: a review of the technique, indications and graft materials. J Int Med Res. 2009 May-Jun;37(3):908-17.

A simple disc degeneration model induced by percutaneous needle puncture in the rat tail. Spine (Phila Pa 1976). 2008 Aug 15;33(18):1925-34.

The treatment of concomitant odontoid fracture and lower cervical spine injuries. Spine (Phila Pa 1976). 2008 Sep 1;33(19): E693-8. 

Surgical treatment of 40 patients with thoracic ossification of the ligamentum flavum.  J Neurosurg Spine. 2006 Mar;4(3):191-7.

Laminoplasty with foraminotomy for coexisting cervical myelopathy and unilateral radiculopathy: a preliminary report. Spine (Phila Pa 1976). 1996 Jan 15;21(2):196-202.

Postoperative bone re-growth in lumbar spinal stenosis. A multivariate analysis of 48 patients. Spine (Phila Pa 1976). 1994 Oct 1;19(19):2144-9.

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