Chen Weiping, M.D.


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Clinical / Research Interests

Arthroplasty (hip, knee, shoulder) for arthritis and osteonecrosis of the femeral head; sports medicine for hip, knee, shoulder joint.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Osteoarthritis (OA), including pathogenesis of OA, signaling pathway in OA especially about Wnt, Notch pathway, adipokines in OA, new agents for treatment of OA, etc.


Chen WP, Hu ZN, Jin LB et al.Licochalcone A Inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-Catenin Signaling Pathways in Rat Chondrocytes. Cell Physiol Biochem. 2017,43(3) 937~944.

Chen WP, Jin GJ, Yan Xiong et al. Rosmarinic acid down-regulates NO and PGE2 expression via MAPK pathway in rat chondrocytes. J Cell Mol Med.2017, 10(3).

Chen WP, Xiong Y, Hu PF et al. Baicalein Inhibits MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes, Cell Physiol Biochem, 2015, 36(1):325-333. 

Chen WP, Yang ZG, Hu PF et al. Acacetin inhibits expression of matrix metalloproteinases via a MAPK-dependent mechanism in fibroblast-like synoviocytes, J Cell Mol Med, 2015,19(8):1910-1915.

Chen WP, Xiong Y, Shi YX et al. Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes, Int Immunopharmacol, 2014, 19(1):174-177. 

Chen WP, Wu LD*. Chlorogenic acid suppresses interleukin-1β-induced inflammatory mediators in human chondrocytes, Int J Clin Exp Pathol,2014, 7(12):8797-8801.

Chen WP, Yu C, Hu PF, Bao JP et al. Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis, Acta Biochim Pol, 2012, 59(4):537-541.

Chen WP, Hu PF, Bao JP et al. Morin exerts antiosteoarthritic properties: an in vitro and in vivo study, Exp Biol Med (Maywood), 2012, 237(4):380-386.

Chen WP, Wang YL, Tang JL et al. Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes, Int Immunopharmacol,2012, 12(2):447-452. 

Chen WP, Tang JL, Bao JP et al. Effects of diallyl sulphide in chondrocyte and cartilage in experimental osteoarthritis in rabbit, Phytother Res, 2011, 25(3):351-356. 

Chen WP, Tang JL, Bao JP et al. Anti-arthritic effects of chlorogenic acid in interleukin-1β-induced rabbit chondrocytes and a  rabbit osteoarthritis model, Int Immunopharmacol, 2011, 11(1): 23-28.

Chen WP, Bao JP, Tang JL et al. Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis, Rheumatol Int, 2011, 31(10): 1325-1331. 

Chen WP, Bao JP, Feng J et al. Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis, Clin Chem Lab Med, 2010,48(8):1141-1145.

Chen WP, Tang JL, Bao JP et al. Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis, Exp Biol Med (Maywood), 2010, 235(12):1425-1431.

Chen WP, Bao JP, Hu PF,  et al. Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis, Mol Biol Rep, 2010,37(8):3967-3972.  

Huang LJ, Chen WP*. Astaxanthin ameliorates cartilage damage in experimental osteoarthritis, Mod Rheumatol, 2015, 25(5): 768-77.

Current Program

The role and mechanism of interaction between EGFR and Notch signaling pathway on cartilage degradation in osteoarthritis. Funding Source: Natural Science Foundation of Zhejiang Province.

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