Chen Yiding, M.D., Ph.D.

Position:Chair of Breast Surgery

Department:Breast Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician 


Appointment

Clinical / Research Interests

Benign and malignant breast disease, especially breast reconstruction and oncoplastic.

Professional Highlights

Zhejiang Scientific and Technological Progress Award, Zhejiang Provincial Government, First Prize, 2008

Excellent Young Member of the Zhejiang Preventive Medical Association, 2011

Excellent Young Scholar of Zhejiang University College of Medicine, 2009

Excellent Young Teacher of Zhejiang University College of Medicine, 2009


Professional Appointments

Member, Zhejiang Anti-Cancer Association, 2000-present

Member, Committee of Zhejiang Medical Society, 2004-present

Associate Member, American Association for Cancer Research, 2006-present

Member, American Society of Clinical Oncology, 2012-present

Education Experience

Postdoctoral program, Oncology, Long Island Jewish Medical Center of Einstein Medical school, United States, 2005-2006

Research Summary

1. Research on basic and translational in breast carcinoma. 

2. Research on hereditary breast cancer. 

3. Research on GeneChip Technology and Bioinformatics in Cancer. 

4. Principal Investigator in clinical research in breast cancer.


Publications

Zhou JJ, Chen Q, Zou Y, Chen HH, Qi LN, Chen YD.  Stem Cells and Cellular Origins of Breast Cancer: Updates in the Rationale, Controversies, and Therapeutic Implications. Frontiers in Oncology, August 2019; 9 : 820. (Corresponding author)

Deng M, Chen HH, Zhu X, Luo M, Zhang K, Xu CJ, Hu KM, Cheng P, Zhou JJ, Zheng S, Chen YD.. Prevalence and clinical outcomes of germline mutations in BRCA1/2 and PALB2 genes in 2769 unselected breast cancer patients in China. Int J Cancer. 2019 Sep 15;145(6):1517-1528. (Corresponding author)

Chen H, Lu W, Zhang Y, Zhu X, Zhou J, Chen Y. A Bayesian network meta-analysis of the efficacy of targeted therapies and chemotherapy for treatment of triple-negative breast cancer. Cancer Med. 2018 Dec 7. doi: 10.1002/cam4.1892. [Epub ahead of print] (Corresponding author)

Zhu X, Chen H, Yang Y, Xu C, Zhou J, Zhou J, Chen Y. Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members - RECQL, BLM, WRN, RECQL4, and RECQL5 - in patients with breast cancer. Cancer Manag Res. 2018 Dec 5;10:6649-6668. doi: 10.2147/CMAR.S185769. eCollection 2018. (Corresponding author)

Xue Y, Lai L, Lian W, Tu X, Zhou J, Dong P, Su D, Wang X, Cao X, Chen Y, Wang Q. SOX9/FXYD3/Src axis is critical for ER+ breast cancer stem cell function. Mol Cancer Res. 2018 Sep 11. pii: molcanres.0610.2018. doi: 10.1158/1541-7786.MCR-18-0610. [Epub ahead of print] 

Dong LF, Xu SY, Long JP, Wan F, Chen YD. Role of number of sentinel nodes in predicting non-sentinel node metastasis in breast cancer. J Int Med Res. 2018 Feb;46(2):828-835. (Corresponding author)

Kong N, Deng M, Sun XN, Chen YD, Sui XB. Polydopamine-Functionalized CA-(PCL-ran-PLA) Nanoparticles for Target Delivery of Docetaxel and Chemo-photothermal Therapy of Breast Cancer. Front Pharmacol. 2018 Feb 21;9:125. doi: 10.3389/fphar.2018.00125. eCollection 2018. (Corresponding author)

Zhang K, Zhou J, Zhu X, Luo M, Xu C, Yu J, Deng M, Zheng S, Chen Y. Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer. Breast Cancer Res Treat. 2017 Dec;166(3):865-873. (Corresponding author) 

Dong LF, Xu SY, Long JP, Wan F, Chen YD. RNA-Sequence Analysis Reveals Differentially Expressed Genes (DEGs) in Patients Exhibiting Different Risks of Tumor Metastasis. Med Sci Monit. 2017 Jun 11;23:2842-2849. (Corresponding author)

Dong LF, Xu SY, Long JP, Wan F, Chen YD. Right metastatic occult breast cancer two years after surgery of left breast cancer: a case report and review of the literature. European Journal of Gynaecological Oncology. 2017,4,635-637 (Corresponding author) 

Xu W, Hu Y, He X, Li J, Pan T, Liu H, Wu X, He H, Ge W, Yu J, Wei Q, Zheng S, Zhang S, Chen Y. Serum profiling by mass spectrometry combined with bioinformatics for the biomarkers discovery in diffuse large B-cell lymphoma. Tumour Biol. 2014 Nov 20. [Epub ahead of print] 

Shao Y, Wang B, Shi D, Miao S, Manivel P, Krishna R, Chen Y, Eric Shi Y. Synuclein gamma protects HER2 and renders resistance to Hsp90 disruption. Mol Oncol. 2014 Dec;8(8):1521-31 (Corresponding author)

Liang W, Miao S, Zhang B, He S, Shou C, Manivel P, Krishna R, Chen Y, Shi YE. Synuclein γ protects Akt and mTOR and renders tumor resistance to Hsp90 disruption. Oncogene. 2014 Jun 23;0. doi: 10.1038/onc.2014.126. [Epub ahead of print] (Corresponding author)

Qian X, Chen Y, Wan F. Granular cell tumor of the breast during lactation: A case report and review of the literature. Oncol Lett. 2014 Dec;8(6):2565-2568.

Chen X, Ye G, Zhang C, Li X, Chen Y, Xie X, Zheng H, Cao Y, Wu K, Ni D, Tang J, Wei Z, Shen K. Superior outcome after neoadjuvant chemotherapy with docetaxel, anthracycline, and cyclophosphamide versus docetaxel plus cyclophosphamide: results from the NATT trial in triple negative or HER2 positive breast cancer. Breast Cancer Res Treat. 2013 Dec;142(3):549-58.

Zhou J, Huang Y, Li L, Zhu L, Zhang D, Zhang S, Chen Y. Identification of two novel,alternatively spliced mRNA transcripts of human follicle-stimulating hormone receptor. Molecular Reproduction and Development 2013.80(11):916-923(Corresponding author)

Zhou J, Chen Y, Huang Y, Long J, Wan F, Zhang S. Serum folliclestimulating hormone level is associated with human epidermal growth factor receptor type 2 and Ki67 expression in postmenopausal females with breast cancer. Oncology Letters 2013,6(4): 1128-1132.

Zhou J, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y. Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway. Anti-Cancer Drugs 2013, 24(9):928~936. (Corresponding author)

Wan F, Dong L, Zhang F, Wang Y, Chen F, Ni S, Chen Y, Long J. Clinical study of the relationship between g-synuclein and the response of neoadjuvant chemotherapy in breast cancer. Journal of International Medical Research 2013;41(3):743-53.

Li L, Zhou J, Qian XJ and Chen Y. Meta-analysis on the possible association between in vitro fertlilization and cancer risk. Int J Gynecol cancer. 2013 ;23(1):16-24. (Corresponding author)

Wu J, Chen Y, Yu JK, Shi XL, Gu W.  Analysis of urinary proteomic patterns for type 2 diabetic nephropathy by ProteinChip. Diabetes Res Clin Pract. 2011;91(2):213-9.

Shi YE, Chen Y, Dackour R, Potters L, Wang Z and Liu YE. Synuclein gamma stimulates membrane initiated estrogen signaling by chaperoning ER-36, a variant of ER-. American J Pathology,.2010,177:964-73. (Co-first Author)

Chen Y, Chen F, Xie P, Qiu P, Zhou J, Deng Y. Combined Oxidized Cellulose and Cyanoacrylate Glue in the Management of Severe Presacral Bleeding.  Surgery Today. 2009, 39:1016~1017. (First Author)

Wang H, Ge J, Chen L, Xie P, Chen F, Chen Y. Melanocytic Malignant Peripheral Nerve Sheath Tumor of the Male Breast. Breast care. 2009,4:460-462. (Corresponding author)

Zhou Y, Liu Y, Cao J, Zeng, G, Shen C, Li Y, Zhou M, Chen Y, Pu W, Potters L, Shi E. Vitexins, Nature-Derived Lignan Compounds, Induce Apoptosis and Suppress Tumor Growth. Clinical Cancer Research. 2009,15:5161-5170.

Gu W, Zhou L, Shan P, Chen Y. Analysis of Urinary Proteomic Patterns for Diabetic Nephropathy by ProteinChip. Proteomics. 2008, 2:744–750. (Corresponding author)

Wu K, Quan Z, Weng Z, Li F, Zhang Y, Yao X, Chen Y, Budman D, Goldberg ID, Shi YE. Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis Breast Cancer Research and Treatment. 2007;101:259-67.

Guo J, Shou C, Meng L, Jiang B, Dong B, Yao L, Xie Y, Zhang J, Chen Y, Budman DR, Shi YE. Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. International Journal of Cancer. 2007;121:1296-305.

Chen Y, Zheng S, Yu J,Hu X. Artificial Neural Networks Analysis of SELDI Mass Spectra of Serum Protein Pattern Distinguishes Colorectal Cancer from Healthy Population. Clinical Cancer Research 2004.10: 8380-8385. (First Author)

Chen Y, Zheng S, Yu J, Hu X.  Development of serum biomarker model and its application in colorectal cancer diagnosis.  Journal of Tumor Marker Oncology 2004,19: 251-258. (First Author)

Yu J, Chen Y, Zheng S, . An integrated approach utilizing Proteomics and bioinformatics to detect colorectal cancer. World J Gastroenterol, 2004, 10: 3127-3131.


Current Program

Preclinical and multicenter basket clinical study of multi-kinase inhibitor TT-00420. Funding Source: National Science and Technology Major Project of China (2018ZX 09301047-001).

Establishing Chemopreventive model and finding intermediate biomarkers of rat colon carcinogenesis based on plasma proteomics. Funding Source: National Natural Science Foundation of China (30500598).

Role of the SNCG and it's inhibitor in Kinase singaling transduction pathway of the breast cancer. Funding Source: National Natural Science Foundation of China (30973465).

Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the JNK pathway. Funding Source: National Natural Science Foundation of China (81071879).


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