Chen Yiding, M.D., Ph.D.

Position:Chair of Breast Surgery

Department:Breast Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician 


Appointment

Clinical / Research Interests

Benign and malignant breast disease, especially breast reconstruction and oncoplastic.

Professional Highlights

Zhejiang Scientific and Technological Progress Award, Zhejiang Provincial Government, First Prize, 2008

Excellent Young Member of the Zhejiang Preventive Medical Association, 2011

Excellent Young Scholar of Zhejiang University College of Medicine, 2009

Excellent Young Teacher of Zhejiang University College of Medicine, 2009


Professional Appointments

Member, Zhejiang Anti-Cancer Association, 2000-present

Member, Committee of Zhejiang Medical Society, 2004-present

Associate Member, American Association for Cancer Research, 2006-present

Member, American Society of Clinical Oncology, 2012-present

Education Experience

2016.11-2017.2 Visiting scholar, Plastic surgery, UC Davis Medical Center, USA

2005.11-2006.12 Postdoctoral, Oncology, Long Island Jewish Medical Center of Einstein Medical school,  USA

2000.9- 2004.6 Ph.D., M.D., Oncology, Medical College of Zhejiang University, PR China

1994.9- 1997.7 Master Degree of Medical Science, Oncology, Medical College of Zhejiang University, PR China

1989.9- 1994.7 Bachelor of medicine, Zhejiang Medical University, PR China

Research Summary

1. Research on basic and translational in breast carcinoma. 

2. Research on hereditary breast cancer. 

3. Research on GeneChip Technology and Bioinformatics in Cancer. 

4. Principal Investigator in clinical research in breast cancer.


Publications

Wu SJ, Qi LN, Chen HH, Zhang K, He JP, Guo XN, Shen L, Zhou YX, Zhong X, Zheng S, Zhou JJ, Chen YD. Functional assessment of missense variants of uncertain significance in the cancer susceptibility gene PALB2. NPJ Breast Cancer 2022 Jul 8(1):86. (Corresponding author) 

Chen HH, Wu SJ, Hu J, Zhang K, Hu KM, Lu YX, He JP, Pan T, Chen YD. Prognostic Models for Nonmetastatic Triple-Negative Breast Cancer Based on the Pretreatment Serum Tumor Markers with Machine Learning. J Oncol. 2021 May 2021: 6641421. (Corresponding author)

Liu Y, Wang HL, Wang X, Liu JQ, Li JJ, Wang X, Zhang Y, Bai ZG, Zhou QH, Wu Y, Shen Y, Weng XL, Liu FT, Guo JC, Di LJ, Gires O, Zhang ZT, Chen YD, Wang HX. Prevalence and reclassification of BRCA1 and BRCA2 variants in a large, unselected Chinese Han breast cancer cohort. J Hematol Oncol. 2021 Jan 14: 18. (Corresponding author) 

Zhou JJ, Wang HL, Fu FM, Li ZW, Feng QJ, Wu WZ, Liu Y, Wang C, Chen YD. Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing. Cancer 2020 Mar 126: 3202-3208. (Corresponding author)

Zhou JJ, Zhu X, Wu SJ, Guo JX, Zhang K, Xu CJ, Chen HH, Jin YX, Sun YT, Zheng S, Chen YD. Epithelial-mesenchymal transition status of circulating tumor cells in breast cancer and its clinical relevance. Cancer Biol Med. 2020 17: 169-180. (Corresponding author) 

Wu SJ, Zhou JJ, Zhang K, Chen HH, Luo M, Lu YX, Sun YT, Chen YD. Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management. Front Oncol. 2020 Feb 10: 301. (Corresponding author)

Wu SJ, Guo XY, Zhou JJ, Zhu X, Chen HH, Zhang K, Lu YX, Chen YD. High expression of UNC5B enhances tumor proliferation, increases metastasis, and worsens prognosis in breast cancer. Aging (Albany NY) 2020 Sept 12: 17079-17098. (Corresponding author)

Ye S, Ding YF, Jia WH, Liu XL, Feng JY, Zhu Q, Cai SL, Yang YS, Lu QY, Huang XT, Yang JS, Jia SN, Ding GP, Wang YH, Zhou JJ, Chen YD, Yang WJ. SET Domain-Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence. Cancer Res. 2019 Sep 79: 4729-4743. 

Zhou JJ, Chen QS, Zou YH, Zheng S, Chen YD. Stem Cells and Cellular Origins of Mammary Gland: Updates in Rationale, Controversies, and Cancer Relevance. Stem Cells Int. 2019 Jan 2019: 4247168. (Corresponding author) 

Zhou JJ, Chen Q, Zou Y, Chen HH, Qi LN, Chen YD. Stem Cells and Cellular Origins of Breast Cancer: Updates in the Rationale, Controversies, and Therapeutic Implications. Front Oncol. 2019 Aug 9 : 820. (Corresponding author)

Deng M, Chen HH, Zhu X, Luo M, Zhang K, Xu CJ, Hu KM, Cheng P, Zhou JJ, Zheng S, Chen YD. Prevalence and clinical outcomes of germline mutations in BRCA1/2 and PALB2 genes in 2769 unselected breast cancer patients in China. Int J Cancer. 2019 Sep 15;145(6):1517-1528. (Corresponding au

Chen H, Lu W, Zhang Y, Zhu X, Zhou J, Chen Y. A Bayesian network meta-analysis of the efficacy of targeted therapies and chemotherapy for treatment of triple-negative breast cancer. Cancer Med. 2018 Dec 7. 8: 383-399. (Corresponding author)

Zhu X, Chen H, Yang Y, Xu C, Zhou J, Zhou J, Chen Y. Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members - RECQL, BLM, WRN, RECQL4, and RECQL5 - in patients with breast cancer. Cancer Manag Res. 2018 Dec 5 10:6649-6668. (Corresponding author) 

Xue Y, Lai L, Lian W, Tu X, Zhou J, Dong P, Su D, Wang X, Cao X, Chen Y, Wang Q. SOX9/FXYD3/Src axis is critical for ER+ breast cancer stem cell function. Mol Cancer Res. 2018 Sep 11. 

Dong LF, Xu SY, Long JP, Wan F, Chen YD. Role of number of sentinel nodes in predicting non-sentinel node metastasis in breast cancer. J Int Med Res. 2018 Feb;46(2):828-835. (Corresponding author)

Kong N, Deng M, Sun XN, Chen YD, Sui XB. Polydopamine-Functionalized CA-(PCL-ran-PLA) Nanoparticles for Target Delivery of Docetaxel and Chemo-photothermal Therapy of Breast Cancer. Front Pharmacol. 2018 Feb 21;9:125. doi: 10.3389/fphar.2018.00125. eCollection 2018. (Corresponding author) 

Zhang K, Zhou J, Zhu X, Luo M, Xu C, Yu J, Deng M, Zheng S, Chen Y. Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer. Breast Cancer Res Treat. 2017 Dec;166(3):865-873. (Corresponding author) 

Dong LF, Xu SY, Long JP, Wan F, Chen YD. RNA-Sequence Analysis Reveals Differentially Expressed Genes (DEGs) in Patients Exhibiting Different Risks of Tumor Metastasis. Med Sci Monit. 2017 Jun 11;23:2842-2849. (Corresponding author) 

Dong LF, Xu SY, Long JP, Wan F, Chen YD. Right metastatic occult breast cancer two years after surgery of left breast cancer: a case report and review of the literature. European Journal of Gynaecological Oncology. 2017,4,635-637 (Corresponding author) 

Xu W, Hu Y, He X, Li J, Pan T, Liu H, Wu X, He H, Ge W, Yu J, Wei Q, Zheng S, Zhang S, Chen Y. Serum profiling by mass spectrometry combined with bioinformatics for the biomarkers discovery in diffuse large B-cell lymphoma. Tumour Biol. 2014 Nov 20. [Epub ahead of print] 

Current Program

Study on the pathogenicity and drug sensitivity of PALB2 variant p.L24F in Chinese breast cancer population. National Natural Science Foundation of China (82072900).

Preclinical and multicenter basket clinical study of multi-kinase inhibitor TT-00420. Funding Source: National Science and Technology Major Project of China (2018ZX 09301047-001).

Establishing Chemopreventive model and finding intermediate biomarkers of rat colon carcinogenesis based on plasma proteomics. Funding Source: National Natural Science Foundation of China (30500598).

Role of the SNCG and it's inhibitor in Kinase singaling transduction pathway of the breast cancer. Funding Source: National Natural Science Foundation of China (30973465).

Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the JNK pathway. Funding Source: National Natural Science Foundation of China (81071879).


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