Xiong Yan, M.D., Ph.D.

Department:Orthopedics

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

Sports medicine and joint reconstruction surgery. Especially in knee, shoulder and hip arthroscopy surgery, hip and knee joint preservation surgery.

Professional Highlights

Professional Appointments

Member, Youth Committee, Upper extremity Group, Sports Medicine Branch, Chinese Medical Association

Member, Hip Preservation Group, Orthopedic Branch, Chinese Medical Doctor Association

Member, Bone and Joint Branch, Chinese Geriatrics Society

Member of Joint Group, Orthopaedic Society, Zhejiang Medical Association

Education Experience

Research Summary

Publications

Y. Xiong#, J. Ran#, L. Xu, Z. Tong, M.S. Adel Abdo, C. Ma, K. Xu, Y. He, Z. Wu, Z. Chen, P. Hu, L. Jiang, J. Bao, W. Chen, L. Wu. Reactivation of NR4A1 Restrains Chondrocyte Inflammation and Ameliorates Osteoarthritis in Rats, Frontiers in cell and developmental biology 8 (2020) 158. 

L. Jiang#, K. Xu#, J. Li, X. Zhou, L. Xu, Z. Wu, C. Ma, J. Ran, P. Hu, J. Bao, L. Wu*, Y. Xiong*. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats, Aging 12(2) (2020) 1760-1777. 

J. Bao, Z. Chen, L. Xu, L. Wu, Y. Xiong*. Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis, Aging 12(6) (2020) 5152-5167. 

L. Xu#, K. Xu#, Z. Wu#, Z. Chen, Y. He, C. Ma, S.A.A. Moqbel, J. Ran, C. Zhang, L. Wu, Y. Xiong*. Pioglitazone attenuates advanced glycation end products-induced apoptosis and calcification by modulating autophagy in tendon-derived stem cells, Journal of cellular and molecular medicine 24(3) (2020) 2240-2251. 

L. Xu#, Z. Wu#, Y. He, Z. Chen, K. Xu, W. Yu, W. Fang, C. Ma, S.A. AbdoMoqbel, J. Ran*, Y. Xiong*, L. Wu*, MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis, Osteoarthritis and cartilage  2020 May 13;S1063-4584(20)30997-3. 

J. Ran#, C. Ma#, K. Xu#, L. Xu, Y. He, S.A.A. Moqbel, P. Hu, L. Jiang, W. Chen, J. Bao, Y. Xiong*, L. Wu*. Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways, Drug design, development and therapy 12 (2018) 1195-1204.

J. Luo, Y. Xiong, P.F. Fu, E.C. Li, L. Qu, X. Fan, Z.J. Cai, A.F. Lin. Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment, Journal of Zhejiang University. Science. B 20(6) (2019) 488-495.

Chen WP, Jin GJ, Xiong Y, Hu PF, Bao JP, Wu LD. Rosmarinic acid down-regulates NO and PGE2 expression via MAPK pathway in rat chondrocytes . J. Cell. Mol. Med., 2017.

Zhou X, Lin X, Xiong Y, Jiang L, Li W, Li J, Wu L. Chondroprotective effects of palmatine on osteoarthritis in vivo and in vitro: A possible mechanism of inhibiting the Wnt/β-catenin and Hedgehog signaling pathways. Int. Immunopharmacol., 2016, 34: 129-38.

Chen WP, Xiong Y, Hu PF, Bao JP, Wu LD. Baicalein Inhibits MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes. Cell. Physiol. Biochem., 2015, 36(1): 325-33.

Jin Li,Xin-die Zhou, Kong-he Yang, Teng-di Fan, Wei-ping Chen, Li-feng Jiang, Jia-peng Bao, Li-dong Wu(*), Yan Xiong(*). Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo,International Immunopharmacology,2014,23(1):85-91. 

Yan-Xiong, Chen, Wei-Ping, Tang, Jing-Li, Bao, Jia-Peng, Hu, Peng-Fei, Wu, Li-Dong. Salvianolic acid B inhibits matrix metalloproteinases by NF-kappa B signaling in rabbit chondrocytes, African Journal of Pharmacy and Pharmacology, 2012,6(11):840-847.

Xiong, Y, Yang, H J, Feng, J, Shi, Z L, Wu, L D. Effects of alendronate on the proliferation and osteogenic differentiation of MG-63 cells.,Journal of International Medical Research,2009,37(2):407-416.

Wu LD, Xiong Y(*), Yu HC. Effects of rhBMP-2 on cortical strut allograft healing to the femur in revision total hip arthroplasties: an experimental study. Int Orthop. 2007;31(5):605-11.

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