Xie Xiaojie, M.D., Ph.D.

Department:Cardiology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Diagnosis and treatment of cardiovascular diseases, including coronary heart disease, heart failure, cardiomyopathy, aortic aneurysm, arrhythmia, hypertension, hyperlipidemia, etc.;

Basic and clinical research on atherosclerosis and aneurysms. 


Professional Highlights

Quality Education Award of Zhejiang University, Second Prize

Excellent Teacher, Chinese Standard Training Program of Resident

Chinese Medical Science and Technology Award, Third Prize

Zhejiang Scientific and Technological Progress Award, First Prize

ATVB (Arteriosclerosis, Thrombosis, and Vascular Biology) Travel Awards for Young Investigators


Professional Appointments

Fellowship, Royal College of Physicians (FRCP)

Fellowship, American College of Cardiology (FACC)

Fellowship, Zhejiang College of Cardiology (FZCC)

Instructor, BLS, ACLS&EP, American Heart Association

Member, Chinese Society of Cardiology, Cardiac Rehabilitation

Member, Chinese Society of Cardiac Electrophysiology and Pacing

Member, Chinese Society of Cardiology

Member, Zhejiang Rehabilitation Society

Member, Zhejiang Medical Association

Member, National Medical Examination Center of China


Education Experience

Research Summary

Publications

Yang FK, Bao QY, Wang Z, Ma MH, Shen JL, Ye FM, Xie XJ#. Sex-Specific Genetically Predicted Iron Status in relation to 12 Vascular Diseases: A Mendelian Randomization Study in the UK Biobank. BioMed Research International, 2020;8.

Wang Z, Yang FK, Ma MH, Bao QY,  Shen JL, Ye FM, Xie XJ#. The impact of growth differentiation factor 15 on the risk of cardiovascular diseases: two-sample Mendelian randomization study. BMC Cardiovasc Disord. 2020;20(1):462.

Shen JL, Xie XJ#. Insight into the Pro-inflammatory and Profibrotic Role of Macrophage in Heart Failure With Preserved Ejection Fraction. J Cardiovasc Pharmacol. 2020;76(3):276-285.

Xie XJ, Tang BY, Deng YJ, Feng L, Zhang LN, Feng TT, Wu ZY*. An overview of the reform and satisfaction rate of online teaching during COVID-19 pandemic. Chinese Higher Medical Education. 2020;5.

Tang BY, Xie XJ*, Kang YX, Shi MM, Wu YC, Zhang LN, Feng TT, Wu ZY. Practice and explore of elaborate management model for medical trainees under COVID-19 pandemic. Chinese Higher Medical Education. 2020;5.

Xie XJ, Kang YX, Zhang FJ, Peng J, Tang BY, Wang K. Integration Practice and Explore of resident and specialist training program. Chinese Postgraduate Medical Education. 2019; 3(3):238-242.

Xie XJ, Feng JB, Zhang FJ, Yan ML, Wu YC, Peng J, Wang K, Wang JA*. The application of intelligent educational administration system on management of standardized residency training program. Chinese Higher Medical Education. 2019;8:49-50.

Huang XF, Zhang SZ, You YY, Zhang N, Lu H, Daugherty A, Xie XJ*. Ginkgo biloba extracts prevent aortic rupture in angiotensin II-infused hypercholesterolemic mice. Acta Pharmacol Sin. 2019;40:192-8.

Howatt DA#, Dajee M#, Xie X#, Moorleghen J, Rateri DL, Balakrishnan A, Da Cunha V, Johns DG, Gutstein DE, Daugherty A, Lu H*. Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms. Circ J. 2017;81(6):888-90。

Zhang N, Xie X, Wang JA. Multifunctional protein: cardiac ankyrin repeat protein. J Zhejiang Univ Sci B. 2016;17(5):333-4.

Tie C, Gao K, Zhang N, Zhang S, Shen J, Xie X*, Wang JA*. Ezetimibe Attenuates Atherosclerosis Associated with Lipid Reduction and Inflammation Inhibition. PLoS One. 2015;10(11):e0142430.

Xie XJ, Jiang JB, Jiang J, Wang JA*. Concurrent pulmonary thrombosis with systemic embolism: a case report. J Zhejiang Univ Sci B. 2014;15(9):838-44.

Zhang N, Xie X, Chen H, Chen H, Yu H, Wang JA*. Stem cell-based therapies for atherosclerosis: perspectives and ongoing controversies. Stem Cells Dev. 2014 1;23(15): 1731-40.

Xie X, Lu H, Moorleghen J, Howatt D, Rateri D, Cassis L, Daugherty A*. Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice. PLoS ONE 2012;7(9):e46411.

Xie X, Wang YF, Zhang SZ, Zhang GD, Xu YC, Bi HH, Daugherty A, Wang JA*. Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis. J Nutr Biochem. 2012;23(6):549-56. 

Wang JA, Chen WA, Wang YF, Zhang SZ, Bi HH, Hong B, Luo YQ, Daugherty A, Xie X*. Statins exert differential effects on angiotensin II- induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Atherosclerosis. 2011;217(1):90-6.

Gao F, Hu XY, Xie XJ, Xu QY, Wang YP, Liu XB, Xiang MX, Sun Y, Wang JA*. Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways.J Zhejiang Univ Sci B. 2010;11(8):608-17.

Chen XF, Wang JA*, Lin XF, Tang LJ, Yu WF, Chen H, Xie XJ, Jiang JJ, Peng XH. Diabetes mellitus: is it protective against aortic root dilatation? Cardiology. 2009;112(2):138-43. 

Chen XF, Wang JA*, Hou J, Gui C, Tang LJ, Chen XQ, Xie XJ, Jiang JJ, Cai JF, Chen HS, Lu HS, Chen H. Extracellular matrix metalloproteinase inducer (EMMPRIN) is present in smooth muscle cells of human aneurysmal aorta and is induced by angiotensin II in vitro. Clin Sci (Lond). 2009;116(11):819-26.

Chen TL, Wang JA*, Shi H, Gui C, Luo RH, Xie XJ, Xiang MX, Zhang X, Cao J. Cyclosporin A pre-incubation attenuates hypoxia/reoxygenation -induced apoptosis in mesenchymal stem cells. Scand J Clin Lab Invest. 2008:1-9。

Wang JA, Chen TL*, Jiang J, Shi H, Gui C, Luo RH, Xie XJ, Xiang MX, Zhang X. Hypoxic preconditioning attenuates hypoxia/reoxygenation- induced apoptosis in mesenchymal stem cells. Acta Pharmacol Sin. 2008, 29(1):74-82. 

Hu X, Wang J*, Chen J, Luo R, He A, Xie X, Li J. Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction. Eur J Cardiothorac Surg. 2007; 31(3):438-43.

Gui C, Wang JA*, He AN, Chen TL, Luo RH, Jiang J, Hu XY, Xie XJ. Heregulin protects mesenchymal stem cells from serum deprivation and hypoxia-induced apoptosis. Mol Cell Biochem. 2007;305 (1-2):171-8.

Wang JA*, Luo RH, Zhang X, Xie XJ, Hu XY, He AN, Chen J, Li JH. Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction. J Zhejiang Univ Sci B. 2006;7(8): 641-7.

Xie XJ, Wang JA*, Cao J, Zhang X. Differentiation of bone marrow mesenchymal stem cells induced by myocardial medium under hypoxic conditions. Acta Pharmacol Sin. 2006;27(9): 1153-8.

Wang JA*, Xie XJ. Stem cells transplantation on dilated cardiomyopathy. Zhonghua Xin Xue Guan Bing Za Zhi, 2006(3):200-1.

Wang JA*, Xie XJ, He H, Sun Y, Jiang J, Luo RH, Fan YQ, Dong L. A Prospective, randomized, controlled trial of autologous mesenchymal stem cells transplantation for dilated cardiomyopathy. Zhonghua Xin Xue Guan Bing Za Zhi. 2006;34(2):107-10.

Wang JA*, Xie XJ, Sun Y, He H, Jiang CY, Zhou BQ, Luo RH, Dong L. Clinical investigation of autologous mesenchymal stem cells transplantation on patients with post-myocardial infarction and heart dysfunction. Zhonghua Ji Zhen Yi Xue Za Zhi, 2005(14):996-9.



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