Ding Kefeng, M.D., Ph.D.

Position:Vice Hospital President, Interim Chair of Colorectal Surgery

Department:Colorectal Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor, Chief Physician 


Appointment

Clinical / Research Interests

Colorectal cancer, laparoscopic surgery, tumor metastasis, tumor Screening, and cohort study.

Professional Highlights

Provincial Award for Science and Technology Innovation, Second Prize

Professional Appointments

Vice Chairman, Colorectal Cancer Committee, Chinese Anti-Cancer Association

Chairman, Surgical Committee of Colorectal Cancer Committee, Chinese Medical Doctor Association

Chairman, Colorectal Cancer Committee of Zhejiang Anti-Cancer Association

Past Chairman, Tumor Anti-Metastasis Committee of Zhejiang Anti-Cancer Association

Vice Chairman, Surgical Oncology Committee of Zhejiang Medical Association 

Education Experience

Research Summary

Publications

Tang Yang, Hang Zhiheng, Wang Zhanhuai, Xiao Qian, Liu Yue, Ge Xiaoxu, Wei Jingsun, Zheng Shu, Ding Kefeng. Increased RAB31 Expression in Cancer-Associated Fibroblasts Promotes Colon Cancer Progression Through HGF-MET Signaling. Front. Oncol, 23 September 2020.

Jiafeng Wang, Xuefei Zhou, Huifang Wang, Qian Xiao, Kefeng Ding, Xue Dong, Shufeng Xu, Bo Shen, Jihong Sun, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Youqing Shen. Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability. Biomaterials 2020, May 31; 255:120156. 

Jicheng Wu, Shen Hu, Lihong Zhang, Jinxia Xin, Chongran Sun, Liquan Wang, Kefeng Ding, Ben WangTumor circulome in the liquid biopsies for cancer diagnosis and prognosis. Theranostics  2020; 10(10):4544-4556.

Yinuo Tan, Yeting Hu, Qian Xiao, Yang Tang, Haiyan Chen, Jinjie He, Liubo Chen, Kai Jiang, Zhanhuai Wang, Ying Yuan, Kefeng Ding. Silencing of brain-expressed X-linked 2 (BEX2) promotes colorectal cancer metastasis through the Hedgehog signaling pathway. Int. J Bio Sci. 2020; 16(2): 228-238.

Lu W, Fu DL, Kong XX, Huang ZH, Hwang M, Zhu YS, Chen LB, Jiang K, Li XL, Wu YH, Li J, Yuan Y, Ding KF. FOLFOX treatment response prediction in metastatic or recurrent colorectal cancer patients via machine learning algorithms. Cancer Medicie. 2020 Feb;9(4):1419-1429.

Jun Li, Xiang-Xing Kong, Jiao-Jiao Zhou, Yong-Mao Song, Xue-Feng Huang, Gen-Hai Li, Xiao-Jiang Ying, Xiao-Yu Dai, Min Lu, Kai Jiang, Dong-Liang Fu, Xin-Lin Li, Jin-Jie He, Jian-Wei Wang, Li-Feng Sun, Dong Xu, Jing-Yan Xu, Min Chen, Yu Tian, Jing-Song Li, Min Yan, Ying Yuan and Ke-Feng Ding. Fast-track multidisciplinary treatment versus conventional treatment for colorectal cancer: a multicenter, open-label randomized controlled study.  BMC Cancer. 2019.

Zhang M, Ding K. Adult congenital megacolon with acute fecal obstruction and diabetic nephropathy: A case report. Exp Ther Med. 2019 Oct;18(4):2726-2730.

Tan Y, Fu D, Li D, Kong X, Jiang K, Chen L, Yuan Y, Ding K. Predictors and Risk Factors of Pathologic Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Population-Based Analysis. Front Oncol. 2019 Jun 13;9:497.

M Hwang, D Wang, WC Jiang, X Pan, DL Fu, KS Hwang, Kefeng Ding. An Adaptive Regularization Approach to Colonoscopic Polyp Detection using a Cascaded Structure of Encoder-Decoders. Int J Fuzzy Syst. 2019.

Wang Z, Ye Y, Hu Y, Han S, Sun L, Xu D, Ding K. Extent of enhancement on multiphase contrast-enhanced CT images is a potential prognostic factor of stage I-III colon cancer. Eur Radiol. 2019 Mar;29(3):1114-1123.

Jiang K, Jiao Y, Liu Y, Fu D, Geng H, Chen L, Chen H, Shen X, Sun L, Ding K. HNF6 promotes tumor growth in colorectal cancer and enhances liver metastasis in mouse model. J Cell Physiol. 2019 Apr;234(4):3675-3684.

Chen L, Jiang K, Chen H, Tang Y, Zhou X, Tan Y, Yuan Y, Xiao Q, Ding K. Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway. Cancer Manag Res. 2018 Dec 20;11:95-105.

Kong X, Li J, Cai Y, Tian Y, Chi S, Tong D, Hu Y, Yang Q, Li J, Poston G, Yuan Y, Ding K.  A modified TNM staging system for non-metastatic colorectal cancer based on nomogram analysis of SEER database. BMC Cancer. 2018 Jan 8;18(1):50.

Jiao Y, He J, Li J, Xu D, Ding K. Associated vessel heteromorphosis in laparoscopic complete mesocolic excision and solutions to intraoperative hemorrhage.  Chinese Journal of Gastrointestinal Surgery. 2018 Mar 25;21(3):259-266.

Zhan X, Sun X, Hong Y, Wang Y, Ding K.Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone. Biomed Res Int. 2017;2017:3809464. 

Zhanhuai Wang, Yinuo Tan, Wei Yu, Shu Zheng, Suzhan Zhang, Lifeng Sun, Kefeng Ding. Small role with big impact: miRNAs as communicators in the cross-talk between cancer-associated fibroblasts and cancer cells. Int J Biol Sci. 2017; 13(3): 339–348.

Haiyan Chen, Qian Xiao, Yeting Hu, Liubo Chen, Kai Jiang, Yang Tang, Yinuo Tan, Wangxiong Hu, Zhanhuai Wang, Jinjie He, Yue Liu, Yibo Cai, Qi Yang, Kefeng Ding. ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138. J Exp Clin Cancer Res. 2017; 36: 78. Published online 2017 Jun 12. doi: 10.1186/s13046-017-0548-7.

Yue Liu, Jinjie He, Jinghong Xu, Jun Li, Yurong Jiao, Dikai Bei, Yeting Hu, Haiyan Chen, Qian Xiao, Kefeng Ding. Neuroendocrine differentiation is predictive of poor survival in patients with stage II colorectal cancer. Oncol Lett, 2017, 13: 2230-2236.

Yeting Hu, Qian Xiao, Haiyan Chen, Jinjie He, Yinuo Tan, Yue Liu, Zhanhuai Wang, Qi Yang, Xiangfeng Shen, Yu Huang, Ying Yuan, Kefeng Ding. BEX2 promotes tumor proliferation in colorectal cancer. Int J Biol Sci , 2017; 13(3):286-294.

Jun Li, Cheng-Hao Yi, Ye-Ting Hu, Jin-Song Li, Ying Yuan, Su-Zhan Zhang, Shu Zheng, and Ke-Feng Ding. TNM staging of colorectal cancer should be reconsidered according to weighting of the T stage: Verification based on a 25-year follow-up. Medicine. 2016, Feb;95(6).

Tan Y, Li X, Chen H, Hu Y, Jiang M, Fu J, Yuan Y, Ding K.Hormone receptor status may impact the survival benefit of surgery in stage iv breast cancer: a population-based study.  Oncotarget. 2016 Oct 25;7(43):70991-71000.

Chenghao Yi, Yanqing Huang, Xing Yu, Xiaofen Li, Shu Zheng, Kefeng Ding, Jinghong Xu. Pathological distributions and implications of KARS and BRAF mutations in a Chinese population with colorectal cancer precursor lesions. Oncotarget, 2016 Mar 29; 7(13): 17265-74.

Chen H, Cai Y, Liu Y, He J, Hu Y, Xiao Q, Hu W, Ding K. Incidence, surgical treatment, and prognosis of anorectal melanoma from 1973 to 2011: A population-based SEER analysis. Medicine. 2016 Feb;95(7):e2770.

Xu D, Song R, Wang G, Jeyabal PV, Weiskoff AM, Ding K, Shi ZZ. Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop.Oncotarget. 2016 Jan 19;7(3):3427-39.

Yi-bo Cai, Hai-yan Chen, Jin-jie He, Ye-ting Hu, Qi Yang, Liu-bo Chen, Qian Xiao and Ke-feng Ding. The role of surgical intervention in primary colorectal lymphoma: A SEER population-based analysis. Oncotarget, 2016 Nov 1;7(44):72263-72275.

Li J, Liu Y, Xu JH, Xu ZP, Zheng S, Ding KF. Expression of hepatocyte growth factor and c-Met is characteristic of α-fetoprotein-producing colorectal adenocarcinoma: A report of three cases. Oncol Lett. 2016 Jan;11(1):731-734.

Xu D, Jiao Y, Ding K. Integrative management of operation, perioperative rehabilitation and postoperative adjuvant chemotherapy in elderly patients with colorectal carcinoma. Chinese Journal of Gastrointestinal Surgery. 2016 May;19(5):507-10. Review. Chinese.

Kong X, Li J, Ding K. Key points and difficulties in implementing enhanced recovery after surgery of colorectal cancer.  Chinese Journal of Gastrointestinal Surgery. 2016 Mar;19(3):260-1. Chinese.

Haiyan Chen, Zhujing Shen, Yeting Hu, Qian Xiao, Dikai Bei, Xiangfeng Shen, Kefeng Ding. Association between MutL homolog 1 polymorphisms and the risk of colorectal cancer: a meta-analysis. J Cancer Res Clin Oncol. 2015, 141(12):2147-2158.

Chen H, Hu Y, Xiang W, Cai Y, Wang Z, Xiao Q, Liu Y, Li Q, Ding K. Prognostic significance of matrix metalloproteinase 7 immunohistochemical expression in colorectal cancer: a meta-analysis. Int J Clin Exp Med. 2015 15;8(3):3281-90. 

Xu D, Li J, Song Y, Zhou J, Sun F, Wang J, Duan Y, Hu Y, Liu Y, Wang X, Sun L, Wu L, Ding Kefeng. Laparoscopic surgery contributes more to nutritional and immunologic recovery than fast-track care in colorectal cancer. World J Surg Oncol. 2015 Feb 4;13(1):18.

LF SUN, JJ HE, SJ YU, JH XU, JW WANG, JL, YM SONG, KF DING, S ZHENG. Transsacral excision with pre-operative imatinib mesylate treatment and approach for gastrointestinal stromal tumors in the rectum: A report of two cases. Oncology Letters. 2014, 8: 1455-1460.

Yue Liu,  Jinghong Xu,  Yurong Jiao,  Yeting Hu,  Chenghao Yi,  Qiong Li,  Zhou Tong, Xiaowei Wang, Lifeng Hu, Qian Xiao, Jun Li, and Kefeng Ding. Neuroendocrine Differentiation Is a Prognostic Factor for Stage II Poorly Differentiated Colorectal Cancer. BioMed Res Int, 2014. 

Jun Li, Yue Liu, Jian-Wei Wang, Yang Gao, Ye-Ting Hu, Jin-Jie He, Xiu-Yan Yu, Han-Guang Hu, Ying Yuan, Su-Zhan Zhang, Ke-Feng Ding. Oxaliplatin-Based Adjuvant Chemotherapy without Radiotherapy Can Improve the Survival of Locally-Advanced Rectal Cancer. Plos one. 2014.

Tan Y, Fu J, Li X, Yang J, Jiang M, Ding K, Xu J, Li J, Yuan Y. A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in china. PLoS One. 2015 Mar 19;10(3).

Jun Li, Bao-Cai Guo, Li-Rong Sun, Jian-Wei Wang, Xian-Hua Fu, Su-Zhan Zhang, Graeme Poston, Ke-Feng Ding. TNM staging of colorectal cancer should be reconsidered by T stage weighting. World Journal of Gastroenterology. 2014 May 7; 20(17): 5104-5112.

Xiao Q, Hu YT, Liu Y, Wang ZH, Geng HT, Hu LF, Xu DY, Wang K, Zheng L, Zheng S, Ding KF. BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. Plos one. 2014. 

Wang ZH, Ding KF, Yu JK, Zhai XH, Ruan SQ, Wang SW, Zhu YL, Zheng S, Zhang SZ. Proteomic analysis of primary colon cancer-associated fibroblasts using the SELDI-ProteinChip platform. J Zhejiang Univ Sci B. 2012; 13: 159-167.

JJ HE, KF DING, L ZHENG, JH XU, J LI, YL WU, LF SUN, DE ZHOU and S ZHENG. Adenosquamous carcinoma of the uncinate process of the pancreas with synchronous gastrointestinal stromal tumor of the stomach: Case report and review of the literature. Oncol  Letters2012, 4: 1191-1194.

Zhou JJ, Li J, Ying XJ, Song YM, Chen R, Chen G, Min Y, Ding KF. Fast Track Multi-Discipline Treatment (FTMDT trial) Versus Conventional Treatment In Colorectal Cancer - The Design of A Prospective Randomized Controlled Study. BMC Cancer. 2011;11:494-505.

Li J, Wang JW, Zheng S, Zhang SZ, Ding KF. Influences of Laparoscopic Resection on Expressions of Metastasis Genes in Colorectal Cancer: Report of Microarray Analysis and Literature Review. Hepatogastroenterology. 2011;12:1975-1982.

Ding KF, Ying XJ, Li J, Li G, Chen ZL, Wang ZH, Lv K, Zhou JJ, Ma YY, Zhang SZ. The interim analysis of an open nonrandomized prospective study comparing laparoscopic surgery with XELOX chemotherapy and open surgery with mFOLFOX6 chemotherapy for resectable colorectal cancer. Annals of Oncology. 2010;21:220.

Li J, Chen R, Xu YQ, Wang XC, Zheng S, Zhang SZ, Ding KF. Impact of a laparoscopic resection on the quality of life in rectal cancer patients: results of 135 patients. Surg Today. 2010;10: 917-922. 

Ding KF, Su YY, Pang LR, Lu Q, Wang ZH, Zhang SZ, Zheng S, Mao JS, Zhu YL. Inhibition of apoptosis by down-regulation of hBex1, a novel mechanism, contributes to the chemoresistance of Bcr/Abl+ leukemic cells. Carcinogenesis. 2009; 30:35-42.

Ding KF, Chen R, Zhang JL, Li J, Xu YQ, Lv L, Wang XC, Sun LF, Wang JW, Zheng S, Zhang SZ. Laparoscopic surgery for the curative treatment of rectal cancer: results of a Chinese three-center case–control study. Surg Endosc. 2009,23:854–861.

Sun LF, Ye HL, Zhou QY, Ding KF, Qiu PL, Deng YC, Zhang SZ, Zheng S. A giant hemolymphangioma of the pancreas in a 20-year-old girl: a report of one case and review of the literature. World J Surg Oncol. 2009; 18:31-33.

Zhou S, Wei H, Ding KF. A Rare Case of Metachronous Bilateral Angiosarcoma of the Breast. Breast Care  2009; 4:405-407. 

Ge WT, Hu HG, Ding KF, Sun LF, Zheng S. Protein interaction analysis of ST14 domains and their point and deletion mutants. J Biol Chem. 2006;281:7406-7412.

Ding KF, Sun LF, Ge WT, Su ZZ, Zheng S. Expression and purification of  ST14, a tumor metastasis-related protein, and its activity assay. FEBS J. 2005;272: 352-352. 

Ding KF, Sun LF, Ge WT, Hu HG, Zhang SZ, Zheng S. Effect of SNC19/ST14 gene overexpression on invasion of colorectal cancer cells. World J Gastroenterol. 2005;36:5651-5654.9. 

Akio Yamaguchi, Kefeng Ding, Masanori Maehara, Takanori Goi and Gizo Nakagawara. Expression of nm23-H1 Gene and Sialyl Lewis X Antigen in Breast Cancer. Oncology, 1998, 55:357-362. 

Kefeng Ding, Akio Yamaguchi, Takanori Goi, Masanori Maehara and. Gizo Nakagawara. Lectin-histochemical Reactivity of Sialic Acid in Breast Cancer and Its Relationship to Prognosis Using limulus polyphemus agglutinin.  Int J Oncology, 1997,10:759-763.

Current Program

Study Comparing Conventional and Fast Track Multi-Discipline Treatment Interventions for Colorectal Cancer. ClinicalTrials.gov Identifier: NCT01080547.

Randomized Trial of Promary Surgery Followed Selective Radiochemotherapy for Rectal Cacncer With MRI Negative CRM (PSSR). ClinicalTrials.gov Identifier: NCT02121405.

Trial Evaluating Surgery With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinometestasis. ClinicalTrials.gov Identifier: NCT02179489.

Study Comparing Pursestring Wound Closure vs Conventional Closure to Reverse Stoma of Colorectal Cancer Patients (PURSE). Clinical Trail gov Identifier: NCT02564224.

Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis. Clinical Trail gov Identifier: NCT02453490.

Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in China (CLEAR-C). Clinical Trail gov Identifier: NCT04287335.

Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type mCRC Patients (ALTER-C-002). Clinical Trail gov Identifier: NCT04080843.

ePRO for Adjuvant Therapy of Gastric and Colorectal Adenocarcinoma. Clinical Trail gov Identifier: NCT04069455.


 

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