Position:Chair of General Surgery
Department:General Surgery, HPB Surgery
Medical School:Zhejiang University School of Medicine, China
Academic Rank:Professor
Standard extended R0 lymphonectomy for advanced pancreatic cancer;
Tumor markers in hepatic, biliary, pancreatic and gastric cancers;
Surgical pancreatic diseases and pancreatic, Islet and islet stem cell transplantation;
RFA in treatment of various solitary tumors.
Vice Chair, Surgery Committee, Zhejiang Medical Association
Vice Chair, Transplantation Committee, Zhejiang Medical Association
Vice Chair, Gastric Cancer Comittee, Zhejiang Anti-Cancer Association
Associate Director, Surgery Institute of Zhejiang University
Associate Director, Surgery Department of Zhejiang University
Member, Surgical Committee of Zhejiang, China, 1996-present:
Member, Transplantation Committee of Zhejiang, China, 1998-present
Member, Editorial Board, Experimental Surgery of China, 1998-present
Member, Editorial Board, World Journal of Gastroenterology (WJG), 2003-present
Kang M, Qin W, Buya M, Dong X, Zheng W, Lu W, Chen J, Guo Q and Wu Y*. VNN1, a potential biomarker for pancreatic cancer-associated new-onset diabetes, aggravates paraneoplastic islet dysfunction by increasing oxidative stress. Cancer letters. 2016; 373(2):241-250.
Zhang Y, Yang B, Liu Y, Qin W, Li C, Wang L, Zheng W and Wu Y*. Effective mRNA Inhibition in PANC-1 Cells in Vitro Mediated via an mPEG-SeSe-PEI Delivery System. Biol Pharm Bull. 2016 May 1;39(5):680-8.
Tang K, Lu W, Qin W and Wu Y*. Neoadjuvant therapy for patients with borderline resectable pancreatic cancer: A systematic review and meta-analysis of response and resection percentages. Pancreatology. 2016; 16(1):28-37.
Han B, Cai H, Chen Y, Hu B, Luo H, Wu Y* and Wu J. The role of TGFBI (betaig-H3) in gastrointestinal tract tumorigenesis. Molecular cancer. 2015; 14:64.
Qin W, Li C, Zheng W, Guo Q, Zhang Y, Kang M, Zhang B, Yang B, Li B, Yang H and Wu Y*. Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells. Oncotarget. 2015; 6(37):39839-39854.
Cai H, Yang B, Xu Z, Zhang B, Xu B, Li X, Wu P, Chen K, Rajotte RV, Wu Y* and Rayat GR. Cyanidin-3-O-glucoside enhanced the function of syngeneic mouse islets transplanted under the kidney capsule or into the portal vein. Transplantation. 2015; 99(3):508-514.
Li C, Liu DR, Li GG, Wang HH, Li XW, Zhang W, Wu Y* and Chen L. CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway. World journal of gastroenterology. 2015; 21(20):6215-6228
Kang M, Dong X, Lu W, Wu Y*. Vanin-1 as A Biomarker for Pancreatic Cancer Associated New-onset Diabetes Has Been Proven in Clinical and Laboratory Research. PANCREAS. 2014;43(8): 1374-1374.
Yang B, Cai H, Qin W, Zhang B, Zhai C, Jiang B, Wu Y*. Bcl-2-functionalized ultrasmall superparamagnetic iron oxide nanoparticles coated with amphiphilic polymer enhance the labeling efficiency of islets for detection by magnetic resonance imaging.Int J Nanomedicine. 2013;8:3977-90.
Zhang B,Yang B,Zhai C,Jiang B,Wu Y*, The role of exendin-4-conjugated superparamagnetic iron oxide nanoparticles in beta-cell-targeted MRI. Biomaterials 2013, 34, 5843-52.
Kang, M.; Jiang, B.; Xu, B.; Lu, W.; Guo, Q.; Xie, Q.; Zhang, B.; Dong, X.; Chen, D.; Wu Y*., Delta like ligand 4 induces impaired chemo-drug delivery and enhanced chemoresistance in pancreatic cancer. Cancer Lett 2013, 330, 11-21.
Zhang, B.; Buya, M.; Qin, W.; Sun, C.; Cai, H.; Xie, Q.; Xu, B.; Wu Y*., Anthocyanins from Chinese Bayberry Extract Activate Transcription Factor Nrf2 in beta Cells and Negatively Regulate Oxidative Stress-Induced Autophagy. J Agric Food Chem 2013, 61, 8765-72.
Lu, W. J.; Xu, B.; Gao, S. L.; Dong, X.; Zhang, B.; Wu, Y. L*., Enucleation of benign or borderline pancreatic head tumors adjacent to the common pancreatic duct. Pancreas 2012, 41, 336-7.
Chen, Y.; Kang, M.; Lu, W.; Guo, Q.; Zhang, B.; Xie, Q.; Wu Y*, DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer. J Cancer Res Clin Oncol 2012, 138, 1463-74.
Zhang, B.; Jiang, B.; Chen, Y.; Huang, H.; Xie, Q.; Kang, M.; Zhang, H.; Zhai, C.; Wu, Y*., Detection of viability of transplanted beta cells labeled with a novel contrast agent - polyvinylpyrrolidone-coated superparamagnetic iron oxide nanoparticles by magnetic resonance imaging. Contrast Media Mol Imaging 2012, 7, 35-44.
Dong, X.; Zhang, B.; Kang, M. X.; Chen, Y.; Guo, Q. Q.; Wu Y*., Analysis of pancreatic fistula according to the International Study Group on Pancreatic Fistula classification scheme for 294 patients who underwent pancreaticoduodenectomy in a single center. Pancreas 2011, 40, 222-8.
Zhang, B.; Kang, M.; Xie, Q.; Xu, B.; Sun, C.; Chen, K.; Wu Y*, Anthocyanins from Chinese bayberry extract protect beta cells from oxidative stress-mediated injury via HO-1 upregulation. J Agric Food Chem 2011, 59, 537-45.
Zhai C, Z. H., Du N, Chen B, Huang H, Wu Y*, Yang D, One-Pot Synthesis of Biocompatible CdSe/CdS Quantum Dots and Their Applications as Fluorescent Biological Labels. Nanoscale Res Lett 2011, 6, 31.
Tang, Z.; Fang, H.; Kang, M.; Zhang, B.; Dong, X.; Chen, X.; Xu, J.; Chen, J.; Wu Y*., Percutaneous radiofrequency ablation for liver tumors: Is it safer and more effective in low-risk areas than in high-risk areas? Hepatol Res 2011, 41, 635-40.
Huang, H.; Dong, X.; Kang, M. X.; Xu, B.; Chen, Y.; Zhang, B.; Chen, J.; Xie, Q. P.; Wu Y*., Novel blood biomarkers of pancreatic cancer-associated diabetes mellitus identified by peripheral blood-based gene expression profiles. Am J Gastroenterol 2010, 105, 1661-9.
Chen, B.; Zhang, H.; Zhai, C.; Du, N.; Sun, C.; Xue, J.; Yang, D*.; Huang, H.; Zhang, B.; Xie, Q.; Wu Y*., Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficient contrast agents for multimodal cellular imaging. J Mater Chem 2010, 20, 9895-9902.
Guo, Q.; Kang, M.; Zhang, B.; Chen, Y.; Dong, X.; Wu Y*., Elevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes. J Cancer Res Clin Oncol 2010, 136, 1627-31.
Dong, X.; Zhan, Y. C.; Jiang, R. Y.; Xie, Q. P.; Peng, J. P.; Wang, J.; Gao, S. L.; Wu Y*., The potential effect of proteasome inhibitor PS-341 on severe acute pancreatitis detected by positron emission tomography in ICR mice. J Surg Res 2010, 162, 193-202.
Zhang, B.; Gao, S.; Chen, Y.; Wu Y*, Primary yolk sac tumor arising in the pancreas with hepatic metastasis: a case report. Korean J Radiol 2010, 11, 472-5.
Zhang, B.; Xie, Q. P.; Gao, S. L.; Fu, Y. B.; Wu Y*, Pancreatic somatostatinoma with obscure inhibitory syndrome and mixed pathological pattern. J Zhejiang Univ Sci B 2010, 11, 22-6.
Xie QP, Huang H, Xu B, Dong X, Gao SL, Zhang B, Wu YL: Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation. 2009 Jun; 77(5):483-91.
Guo Q, Chen Y, Zhang B, Kang M, Xie Q, Wu Y*, Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition. Biochem Pharmacol. 2009 Jun 1; 77(11):1674-83.
Guo Q, Zhang B, Dong X, Xie Q, Guo E, Huang H, Wu Y*, Elevated levels of plasma fibrinogen in patients with pancreatic cancer: possible role of a distant metastasis predictor.Pancreas. 2009 Apr; 38(3):e75-9.
Huang H, Xie Q, Kang M, Zhang B, Zhang H, Chen J, Zhai C, Yang D, Jiang B, Wu Y*, Labeling transplanted mice islet with polyvinylpyrrolidone coated superparamagnetic iron oxide nanoparticles for in vivo detection by magnetic resonance imaging. Nanotechnology. 2009 Sep 9; 20(36):365101.
Wu Y, Guo E, Yu J, Xie Q.: High DcR3 expression predicts stage pN2-3 in gastric cancer. Am J Clin Oncol. 2008 Feb; 31(1):79-83.
Zhiyu Tang, Yulian Wu, Shunlian Gao, Hongwei Shen. Effects of the proteasome inhibitor Bortezomib on gene expression profiles of pancreatic cancer cells. Journal of surgical research, J Surg Res. 2008 Mar; 145(1):111-23.
Xin Dong, Shunliang Gao, Qiuping Xie, Lin Xu, Yuanliang Xu, Yulian Wu; In situ high-volume modified continuous closed and/or open lavage for infected necrotizing pancreatitis, Pancreas. 2008 Jan; 36(1):44-9.
Enqi Guo, Lirong Chen, Qiuping Xie, Jian Chen, Zhiyu Tang, Yulian Wu; Serum HDL-C as a potential biomarker for nodal stages in gastric cancer. ASO, 2007; 14: 2528-2534.
Yulian Wu, Enqi Guo, Junxiu Yu, Qiuping Xie; High DcR3 expression predicts stage pN2-3 in Gastric cancer. Am J Clin Oncol, 2007; 30:000-000.
Xin Dong, Shunliang Gao, Qiuping Xie, Lin Xu, Yuanliang Xu, Yulian Wu; In situ high-volume modified continuous closed and/or open lavage for infected necrotizing pancreatitis. Pancreas. 2008 Jan;36(1):44-9.
Zhiyu Tang, Enqi Guo, Haichao Yan, Qiuping Xie, Jian’an Lian, Yulian Wu; Risk factors for infectious morbidity in gallbladder cancer patients treated surgically. Hepatogastro -enterology, 2007; 54: 22-27.
Zhiyu Tang, Yulian Wu, Shunlian Gao, Hongwei Shen. Effects of the proteasome inhibitor Bortezomib on gene expression profiles of pancreatic cancer cells. J Surg Res. 2008 Mar;145(1):111-23.
Yulian Wu, Hai Chao Yan, Lirong Chen et al. Extended Appleby’s Operation for Pancreatic Cancer Involving Celiac Axis. Journal of Surgical Oncology 2007; 96: 442-446
Yulian Wu ,Zhe Tang, Heqing Fang et al. High Operative risk of cool-tip radiofrequency ablation for unresectable pancreatic head cancer. JSO 2006; 94(5):392-5.
Yulian Wu, Jian Chen, Junxiu Yu et al. A practical scoring system based upon ROC analysis for evaluating potential lymph nodes metastasis during gastric surgery. JSO 2006; 93(7):534-40.
Yan HC, Wu YL, Chen LR, Gao Sl et al. Resection of non-cystic adenocarcinoma in pancreatic body and tail. WJG 2006; 21(35):5726-8
Wu YL, Yan HC, Chen LR, Chen J, Gao SL, Li JT.: Pancreatic benign schwannoma treated by simple enucleation: case report and review of literature. Pancreas. 2005 Oct; 31(3):286-8.
Wu Y, Junxiu Yu, Bing Xu: Safe major abdominal operations: Hepatotectomy, Gastrectomy and Pancreatectomy in eld patients. WJG 10(13):1995-1997, 2004
Wu YL, Peng CH, Sheng HW: Expression of exon 13 from the Ki-67 gene in human cells and tissues by digoxigenin-labelled mRNA in situ hybridization. CMJ 2001; 114:48-53
Guang Yu, Jianning Mao, Yulian Wu, Hongyu Luo and Jiangping Wu et al.Ephrin-B1 is critical in T-cell development. J Biol Chem. 2006 Apr 14; 281
Yu G, Mao J, Wu Y, Luo H, Wu J.: EPHRIN-B1 is critical in T-cell development and thymocyte TCR signaling strength J Biol Chem. 2006; (281)15:10222-10229.
Wu Y, B. Han, H. Luo, G. Shi, and J. Wu. Dipeptide boronic acid (DPBA), a novel proteasome inhibitor, prevents islet allograft rejection. Transplantation 2004; 78: 360-366.
Yu G, Luo H, Wu Y, Wu J. EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J Biol Chem. 2004 Dec 31; 279(53):55531-9.
Shi G, Wu Y, Zhang J, Wu J.: Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo. J Immunol. 2003 Oct 1; 171(7):3407-14.
Wu Y, Han B, Sheng H, Lin M, Moore PA, Zhang J, Wu J: Clinical significance of detecting elevated serum DcR3/TR6/M68 in malignant tumor patients. Int J Cancer 2003 Jul 10; 105(5):724-32.
Wu Y, Han B, Luo H, Roduit R, Salcedo TW, Zheng G Zhang J, Wu J: DcR3/TR6 Effectively Prevents Islet Primary Non-function after Transplantation Diabetes 2003 Sep; 52(9):2279-86.
Yu G, Luo H, Wu Y, Wu J.: Ephrin B2 Induces T Cell Costimulation.J Immunol. 2003 Jul 1; 171(1):106-114.
Yu G, Luo H, Wu Y, Wu J.: Mouse ephrinB3 augments T-cell signaling and responses to T-cell receptor ligation. J Biol Chem. 2003 Nov 21; 278(47):47209-16.
Luo H, Yu G, Wu Y, Wu J.: EphB6 crosslinking results in costimulation of T cells. J Clin Invest. 2002 Oct; 110(8): 1141-50. J Clin Invest. 2002 Oct; 110(8): 1141-50.
Luo H, Wu YL, Wan X, Qi S, Chen H, Wu J: A proteasome inhibitor effectively prevents mouse heart allograft rejection Transplantation 72 (2):196-202, 2001.
Luo H, Wan X, Wu YL, and Wu J. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. J.Immunol. 167 (3):1362-1370, 2001.
Wu YL, Luo HY, Kanaan N and Wu JP: The proteasome controls the protein level Ki67 in human pancreatic cancer cells J Cellular Biochemistry 2000; 76:596-604