Fu Xianhua, M.D., Ph.D.

Department:Medical Oncology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

Vascular targeted therapy for malignant tumors;

Comprehensive treatment of lung cancer, breast cancer, colorectal cancer, hepatobiliary cancer, pancreatic cancer, gallbladder cancer;

Cancer pain, venous thrombosis.


Professional Highlights

Professional Appointments

Youth Committee Member, Cancer Internal Medicine Committee, Zhejiang Anti-Cancer Association

Youth Committee Member, Cancer Pain Committee, Zhejiang Anti-Cancer Association

Member, Cancer Rehabilitation Promotion Committee, Zhejiang Population and Health Association


Education Experience

Research Summary

Publications

Fu XianHua, Li Jun, Zou Yong, Hong YuRong, Fu ZhiXuan, Huang JianJin, Zhang SuZhan, Zheng Shu. Endostar enhances the antineoplastic effects of combretastatin A4 phosphate in an osteosarcoma xenograft. Cancer Letters. 2011. 312(1): 109-16.

Fu XianHua, Li Jun, Huang JianJin, Zheng Shu, Zhang SuZhan. Translational research of a novel humanized epidermal growth factor receptor-related protein: a putative inhibitor of pan-ErbB. Cancer Chemotherapy and Pharmacology. 2011. 68(6): 1373-6.

Xiang JianJie, Pan XiaoChan, Xu Jin, Fu XianHua, Wu DongPing, Zhang Yu, Shen Li, Wei QiChun. Human epidermal growth factor receptor 2 protein expression between primary breast cancer and paired asynchronous local-regional recurrences. Experimental and Therapeutic Medicine. 2011.2: 1187-1191.

Romagnoli R, Baraldi PG, Lopez Cara C, Kimatrai Salvador M, Bortolozzi R, Basso G, Viola G;Balzarini J, Brancale A, Fu XianHua, Li J, Zhang SZ, Hamel E. One-Pot Synthesis and Biological Evaluation of 2-Pyrrolidinyl-4-Amino-5-(3',4',5'-Trimethoxybenzoyl)Thiazole:an Unique Highly Active Antimicrotubule Agents. European Journal of Medicinal Chemistry. 2011.46: 6015-6024.

Romagnoli R, Baraldi PG, Salvador MK, Preti D, Aghazadeh Tabrizi M, Brancale A, Fu XianHua, Li J, Zhang SZ, Hamel E, Basso G, Bortolozzi R, Viola G. Synthesis and Evaluation of 1,5- Disubstituted Tetrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative and Antitumor Activity. Journal of Medicinal Chemistry. 2012. 55(1): 475-88.

Romagnoli R, Baraldi PG, Salvador MK, Preti D, tabrizi MA, Brancale A, Fu XianHua, Li J, Zhang SZ, Hamel E, Bortolozzi R, Porcù E, Basso G, Viola G. Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents. Journal of Medicinal Chemistry. 2012. 55(11): 5433-45.

Sun JF, Li J, Wang JW, Pan T, Zhou J, Fu XianHua, Zhang SZ. Meta-analysis of randomized controlled trials on laparoscopic gastrectomy vs. open gastrectomy for distal gastric cancer. Hepatogastroenterology. 2012. 59(118): 1699-705.

Romagnoli R, Baraldi PG, Lopez-Cara C, Delia P, Aghazadeh Tabrizi M, Balzarini J, Bassetto M, Brancale A, Fu XH, Gao Y, Li J, Zhang SZ, Hamel E, Bortolozzi R, Basso G, Viola G. Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene  Derivatives As a Novel Class of Potent Antimitotic Agents. Journal of Medicinal Chemistry. 2013. 56(22): 9296-309.

Fu Zhixuan, Song Peiming, Li Dongbo, Yi Chenghao, Chen Huarong, Ruan Suqin, Shi Zhong, Xu Wenhong, Fu XianHua, Zheng Shu.Cancer-associated fibroblasts from invasive breast cancer have an attenuated capacity to secrete collagens. international journal of oncology. 2014 Oct;45(4):1479-88.

Wei Q, Xu J, Shen L, Fu XianHua, Zhang B, Zhou X, Carlsson J. HER2 expression in primary gastric cancers and paired synchronous lymph node and liver metastases. A possible road to target HER2 with radionuclides. Tumour Biol. 2014 Jul;35(7):6319-26.

Xianhua Fu, Yin Duan, Hongdan Shen, Yong Zou, Chi Pan, Demin Lu, Jianjin Huang, Jun Li, Suzhan Zhang.Antineoplastic effects of Endostar combined with combretastatin A4 phosphate in vitro. Translational Cancer Research. 2018;7(3):578-586.


Current Program

In Vitro and in Vivo Effects and Mechanisms of Resveratrol Derivatives in Preventing Colorectal Cancer. Funding Source: National Natural Science Foundation (81402365).

Study on the Mechanism of Rac1/Cdc42 Activation in Endostatin Combined with CA4P Blocking Tumor Vascular Network. Funding Source: National Natural Science Foundation (81301890).


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