Position：Vice Chair of Oral Medicine
Department：Oral Medicine
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Chief Physician
Comprehensive treatment of moderate to severe periodontitis,including regenerative periodontal surgery; dental implants in periodontal compromised patients.
Member, Committee of Periodontology, Chinese Stomatological Association
Member, Committee of Oral Biology, Chinese Stomatological Association
Member, International Team for Implantology (ITI)
In recent years, Dr. Wu Yanmin mainly focused on the study of 15d-PGJ2, which is a lipid signaling molecule discovered for its anti-inflammation potentials. Her study group found that 15d-PGJ2 played a role in the osteoclast activity in rat alveolar bone resorption model. The 15d-PGJ2 or △12-PGJ2 nano-capsules could significantly inhibit the expression and transcription of inflammatory cytokines, as well as increase the expression of osteogenic factors such as BMP-6 and PDGF-B. The obtained results provided some scientific evidence for the application of 15d-PGJ2 and △12-PGJ2 as a host modulation drug in periodontitis induced alveolar bone resorption. Nowadays, they are investigating the regenerative potential of decellularized cell matrix derived from periodontal ligament cells combined with 15d-PGJ2 nano-particles in periodontal inflammatory niche.
Wen JH, Wu YM, Chen LL. Functions of Non-Coding RNAs in the Osteogenic Differentiation of Human Periodontal Ligament-Derived Cells. Hua Xi Kou Qiang Yi Xue Za Zhi. 2020;38(3):330-337.
Zhou LL, Liu W, Wu YM, Sun WL, Dörfer CE, Fawzy El-Sayed KM. Oral Mesenchymal Stem/Progenitor Cells: The Immunomodulatory Masters. Stem Cells Int. 2020;2020:1327405.
Huang JP, Liu JM, Wu YM, Chen LL, Ding PH. Efficacy of xenogeneic collagen matrix in the treatment of gingival recessions: A systematic review and meta-analysis. Oral Dis. 2019;25(4):996-1008.
Tan JY, Lei LH, Chen XT, Ding PH, Wu YM, Chen LL. AKT2 is involved in the IL-17A-mediated promotion of differentiation and calcification of murine preosteoblastic MC3T3-E1 cells. Mol Med Rep. 2017;16(5):5833-5840.
Tang Q, Chen LL, Wei F, Wu YM*. Effect of 15-Deoxy-Δ12,14-prostaglandin J2Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model. Chin Med J (Engl). 2017;130(3):347-356.
Wu YM, Ren F, Chen LL, et al. Possible socioeconomic and oral hygiene behavioural risk factors for self-reported periodontal diseases in women of childbearing age in a Chinese population. Oral Health Prev Dent. 2014;12(2):171-181.
Wu YM, Liu J, Sun WL, et al. Periodontal status and associated risk factors among childbearing age women in Cixi City of China. J Zhejiang Univ Sci B. 2013;14(3):231-239.
Chen LL, Huang M, Tan JY, Wu YM*. PI3K/AKT pathway involvement in the osteogenic effects of osteoclast culture supernatants on preosteoblast cells. Tissue Eng Part A. 2013;19(19-20):2226-2232.
Application of modularized complex with decellularized cell matrix derived from periodontal ligament cells and PGJ2 nano-particles in the regeneration of periodontal tissue. Funding Source: Zhejiang Provincial Department of Science and Technology.
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Zhejiang University School of Medicine
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iao_sahzu@zju.edu.cn
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