Guo Yi, M.D., Ph.D.

Position:Vice Chair of General Practice and International Medicine

Department:General Practice and Health Management Center

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

The diagnosis and treatment of epilepsy, especially the identification of epileptic seizures and psychogenic non-epileptic seizures, management of epilepsy with pregnancy, epilepsy with anxiety and depression, drug treatment and surgical evaluation of refractory epilepsy. He is also good at health management of chronic diseases of nervous system.

Professional Highlights

Professional Appointments

Youth Member, Health Management Branch, Chinese Medical Association

Youth Member, Health Management and Health Insurance Committee, Chinese Medical Doctor Association

Member, Neuroscience Committee, Chinese Research Hospital Association

Youth Member, China Association Against Epilepsy

Member, Epileptic comorbidity Committee, China Association Against Epilepsy

Member, Epilepsy community management Committee, China Association Against Epilepsy

Member, Standing committee, General Practice Branch, Zhejiang Medical Association

Education Experience

Research Summary

Identification of epileptic and psychogenic non-epileptic seizures based on semiology. 

Optimization of drug therapy for epilepsy during pregnancy.

Exploration of 5-HT mechanism of epilepsy and depression comorbidity

Publications

Yu Q, Ying YQ, Lu PP, Sun MT, Zhu ZL, Xu ZY, Guo Y. Evaluation of the knowledge, awareness, and attitudes toward epilepsy among nurses. Epilepsy Behav. 2022;136:108920.

Xu ZY, Qian P, Cai MT, Ding MP, Guo Y. Management of epilepsy in pregnancy in eastern China: A survey from the Zhejiang association against epilepsy. Front Neurol. 2022;13:1001918.

Zhang G-F, Gong W-X, Xu Z-Y-R, Guo Y. Alzheimer’s disease and epilepsy: The top 100 cited papers. Front. Aging Neurosci. 2022;14:926982.

Feng X, Guo Y, Tu H, Li S, Chen C, Sun M, Wang S, Li B, Wu X, Song Z. Temporal changes in serum uric acid and risk for metabolic syndrome: a longitudinal cohort study. Diabetol Metab Syndr. 2022;14:92.

Xu ZY, Shen CH, Cai MT, Zhang GF, Ding MP, Guo Y. Managing depression and anxiety in patients with epilepsy in eastern China: A survey of epilepsy health professionals in Zhejiang Province. Epilepsy Behav. 2022;127:108516.

Xu L, Lin W, Zheng Y, Chen J, Fang Z, Tan N, Hu W, Guo Y, Wang Y, Chen Z. An H2R-dependent medial septum histaminergic circuit mediates feeding behavior. Curr Biol. 2022;32:1937-1948.e5.

Guo Y, Xu ZY, Cai MT, Gong WX, Shen CH. Epilepsy With Suicide: A Bibliometrics Study and Visualization Analysis via CiteSpace. Front Neurol. 2022;12:823474.

Cheng H, Qi Y, Lai N, Yang L, Xu C, Wang S, Guo Y, Chen Z, Wang Y. Inhibition of hyperactivity of the dorsal raphe 5-HTergic neurons ameliorates hippocampal seizure. CNS Neurosci Ther. 2021;27:963-972.

Guo Y, Cai MT, Lai QL, Zheng Y, Shen CH, Zhang YX. Anti-Ma2 Antibody-Associated Paraneoplastic Neurological Syndromes: A Pilot Study. Brain Sci. 2021;11:1577.

Shen CH, Fang GL, Yang F, Cai MT, Zheng Y, Fang W, Guo Y, Zhang YX, Ding MP. Seizures and risk of epilepsy in anti-NMDAR, anti-LGI1, and anti-GABAB R encephalitis. Ann Clin Transl Neurol. 2020;7:1392-1399.

Guo Y, Liu Y, Ming W, Wang Z, Zhu J, Chen Y, Yao L, Ding M, Shen C. Distinguishing Focal Cortical Dysplasia From Glioneuronal Tumors in Patients With Epilepsy by Machine Learning. Front Neurol. 2020;11:548305.

Chen B, Xu C, Wang Y, Lin W, Wang Y, Chen L, Cheng H, Xu L, Hu T, Zhao J, Dong P, Guo Y, Zhang S, Wang S, Zhou Y, Hu W, Duan S, Chen Z. A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy. Nat Commun. 2020;11:923.

Wang Y, Wang Y, Xu C, Wang S, Tan N, Chen C, Chen L, Wu X, Fei F, Cheng H, Lin W, Qi Y, Chen B, Liang J, Zhao J, Xu Z, Guo Y, Zhang S, Li X, Zhou Y, Duan S, Chen Z. Direct Septum-Hippocampus Cholinergic Circuit Attenuates Seizure Through Driving Somatostatin Inhibition. Biol Psychiatry. 2020;87:843-856

Zheng Y, Ding X, Guo Y, et al. Multidisciplinary management improves anxiety, depression, medication adherence, and quality of life among patients with epilepsy in eastern China: A prospective study. Epilepsy Behav. 2019;100(Pt A):106400. 

Yao L, Cai M, Chen Y, Shen C, Shi L, Guo Y. Prediction of antiepileptic drug treatment outcomes of patients with newly diagnosed epilepsy by machine learning. Epilepsy Behav. 2019;96:92-97.

Shen CH, Zhang YX, Zheng Y, Yang F, Hu Y, Xu S, Yan SQ, Ding Y, Guo Y, Ding MP. Expression of plasma microRNA-145-5p and its correlation with clinical features in patients with refractory epilepsy. Epilepsy Res. 2019;154:21-25.


Current Program

The role of ventral hippocampus-nucleus accumbens glutamatergic pathway in the formation of depression in temporal lobe epilepsy. Funding Source: National Natural Science Foundation of China (81871010).

The role of raphe nuclei-entorhinal cortex serotoninergic pathway in the epileptogenesis of temporal lobe epilepsy. Funding Source: National Natural Science Foundation of China (81471316).

Role of serotonin 1A receptor in the epileptogenesis of temporal lobe epilepsy. Funding Source: National Natural Science Foundation of China (81000556).
 

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