Guo Yi, M.D., Ph.D.

Position:Vice Chair of General Practice, Vice Chair of International Medicine Department

Department:General Practice and Health Management Center

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

The diagnosis and treatment of epilepsy, especially for epilepsy pregnancy management, management of epilepsy with depression, drug therapy and presurgical evaluation of refractory epilepsy.

Professional Highlights

Professional Appointments

Member, Epilepsy Comorbidity Commission, China Association Against Epilepsy, 2017-present


Education Experience

Research Summary

Identification of epileptic and psychogenic non-epileptic seizures based on semiology. 

Optimization of drug therapy for epilepsy during pregnancy.

Exploration of 5-HT mechanism of epilepsy and depression comorbidity

Publications

Zheng Y, Ding X, Guo Y, et al. Multidisciplinary management improves anxiety, depression, medication adherence, and quality of life among patients with epilepsy in eastern China: A prospective study. Epilepsy Behav. 2019;100(Pt A):106400. 

Yao L, Cai M, Chen Y, Shen C, Shi L, Guo Y. Prediction of antiepileptic drug treatment outcomes of patients with newly diagnosed epilepsy by machine learning. Epilepsy Behav. 2019;96:92-97.

Wang Y, Xu C, Xu Z, et al. Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy [published correction appears in Neuron. 2017 Aug 30;95(5):1221]. Neuron. 2017;95(1):92-105.e5.

Guo Y, Ding XY, Lu RY, et al. Depression and anxiety are associated with reduced antiepileptic drug adherence in Chinese patients. Epilepsy Behav. 2015;50:91-95.

Guo Y, Chen ZM, Zhang YX, et al. Reliability and validity of the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E). Epilepsy Behav. 2015;45:225-228.

Yang Y, Guo Y, Kuang Y, et al. Serotonin 1A receptor inhibits the status epilepticus induced by lithium-pilocarpine in rats. Neurosci Bull. 2014;30(3):401-408.


Current Program

The role of ventral hippocampus-nucleus accumbens glutamatergic pathway in the formation of depression in temporal lobe epilepsy. Funding Source: National Natural Science Foundation of China (81871010).

The role of raphe nuclei-entorhinal cortex serotoninergic pathway in the epileptogenesis of temporal lobe epilepsy. Funding Source: National Natural Science Foundation of China (81471316).

Role of serotonin 1A receptor in the epileptogenesis of temporal lobe epilepsy. Funding Source: National Natural Science Foundation of China (81000556).
 

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