Position：Vice Chair of Gastrointestinal Surgery, Vice Chair of General Surgery
Department：Gastrointestinal Surgery
Medical School：Charité-Universitätsmedizin Berlin, Germany
Academic Rank：Chief Physician
Gastrointestinal tumors, hernia.
Outstanding Achievements for Higher Education Institutions of the Ministry of Education, First Prize
Deputy Head, Translational Medicine Professional Group of the Fourth Committee of the Anorectal Physician Branch of the Chinese Medical Doctor Association, 2019-present
Committee Member, Xenotransplantation Group of the Seventh Committee of the Chinese Society of Organ Transplantation, 2016-present
Committee Member, The First Committee of the Youth Committee of the Clinical Precision Medicine Professional Committee of the Chinese Medical Doctor Association, 2017-2020
Dr. Gong's research team focuses on the treatment effects of BET protein inhibitors on heart transplantation and liver diseases. He reported that BET protein inhibitors can prolong cardiac allograft survival by potentiating myocardiac autophagy through the LKB1-AMPK-ULK1 signaling pathway and inhibiting the subsequent release of inflammatory cytokines. Dr. Gong revealed a key mechanism of that BET protein inhibitors mediates PD-L1 expression on the plasma membrane by affecting the expression of Rab8A. His team revealed the crucial role of the YAP/TAZ–Notch1–NICD axis in liver regeneration.
Kong Deqiang, Liu Chen, Miao Xiaolong, et al. Current Statuses of Molecular Targeted and Immune Checkpoint Therapies in Hepatocellular Carcinoma. American Journal of Cancer Research, 2020,10(5): 1522-1533.
Chen Juntao, Miao Xiaolong, Liu Chen, et al. BET protein inhibition prolongs cardiac transplant survival via enhanced myocardial autophagy. Transplantation. 2020 May 18. Online ahead of print.
Liu Chen, Cheng Xiawei, Chen Juntao, et al. Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration. Theranostics, 2019,9(13): 3840-3852.
Cheng Xiawei; Ma Xiuling, Ding Xianming, et al. Pacer mediates the function of class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17. Molecular Cell, 2017,65(6): 1029-1043.
Heart transplantation. Funding Source: Outstanding Youth Science Foundation Project, National Science Foundation of China (81522006).
Exploratory research on achievement of a significant prolongation of mice cardiac allograft survival by blockade of BRD4 signaling pathway. Funding Source: National Natural Science Foundation of China (81870306).
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