Wu Xianguo, M.S.

Department:Clinical Laboratory Medicine

Medical School:Fujian Medical University, China

Academic Rank:Associate Chief Technician


Clinical / Research Interests

Clinical hematology; tumor targeting therapy.

Professional Highlights

Zhejiang Scientific and Technological Progress Award, Third Prize

Professional Appointments

Member, Zhejiang Immunology Society, 2005-present

Member, Microbiology and Immunity Branch of Zhejiang Medical Association, 2018-present

Education Experience

Jin S, Wu XG. Aspirin inhibits colon cancer cell line migration through regulating epithelial-mesenchymal transition via Wnt signaling. Oncol Lett. 2019 May;17(5):4675-4682. (Corresponding author)

Wu D, Wu P, Wu X, Ye J, Ni C, Huang J. Ex Vivo Expanded Human Circulating Vδ1 γδT Cells Exhibit Favorable Therapeutic Potential for Colon Cancer. Oncoimmunology. 2015 Jan 22;4(3):e992749. (Co-first author)

Wu P, Wu D, Ni C, Ye J, Chen W, Hu G, Wang Z, Wang C, Zhang Z, Xia W, Chen Z, Wang K, Zhang T, Xu J, Han Y, Zhang T, Wu X, Wang J, Gong W, Zheng S, Qiu F, Yan J, Huang J. γδT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity. 2014 May 15;40(5):785-800.

Ni C, Wu P, Wu X, Zhang T, Liu Y, Wang Z, Zhang S, Qiu F, Huang J. Thymosin alpha1 enhanced cytotoxicity of iNKT cells against colon cancer via upregulating CD1d expression. Cancer Lett. 2014 Oct 7. pii: S0304-3835(14)00574-6.

Wang K, Wu XG, Wang JW, Huang J. Cancer stem cell theory: therapeutic implications for nanomedicine. Int J Nanomedicine., Int J Nanomedicine. 2013;8:899-908.

Ye J, Wu X, Wu D, Wu P, Ni C, Zhang Z, Chen Z, Qiu F, Xu J, Huang J.miRNA-27b targets vascular endothelial growth factor C to inhibit tumor progression and angiogenesis in colorectal cancer.PLoS One. 2013 Apr 12;8(4):e60687. (Co-first author)

Research Summary

IL-8 induced dedifferentiation model of colorectal cancer cells and screening of cell surface markers. Funding Source: Natural Science Foundation of Zhejiang.

Construction of matrine / CPT-11 dual drug delivery system and evaluation of its antitumor effect. Funding Source: Natural Science Foundation of Zhejiang.

Establishment of EMT platform for dynamic monitoring of colorectal cancer by laser confocal microscope. Funding Source: Scientific Research Project of Zhejiang Provincial Department of Science and Technology.


Publications

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