Wu Lidong, M.D., Ph.D.

Position:Vice Chair of Orthopedics


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Clinical / Research Interests

Hip and knee joint surgery, special for total joint arthroplasty for osteoarthritis, rheumatoid arthritis, developmental dysplasia of hips, old Perthes disease, high riding congenital hip dislocation, avascular necrosis of femoral head, and hip and knee sports medicine. 

Professional Highlights

Zhejiang Scientific and Technological Award, First Prize

Professional Appointments

Member, Joint Surgery Committee, Chinese Society of Orthopaedic, Chinese Medical Association 

Executive Member, Chinese Knee Society

Member, Joint Surgery Committee, Chinese Medical Doctor Association (CMDA)

Chair, Youth Work Committee, Orthopedics Institute, Chinese Association of Integrative Medicine 

Education Experience

Research Summary

Basic and clinical research of osteoarthritis and cartilage repair; material and biomechanical study of joint replacement.


H Qu, J Li, L Wu, W Chen. Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. Mol Med Rep. 2016 Sep;14(3):2423-30.

X Zhou, X Lin, Y Xiong, L Jiang, W Li, J Li, L Wu. Chondroprotective effects of palmatine on osteoarthritis in vivo and in vitro: A possible mechanism of inhibiting the Wnt/β-catenin and Hedgehog signaling pathways. Int Immunopharmacol. 2016 May;34:129-38.

Kai Huang, Jia-peng Bao, Gavin James Jennings, Li-dong Wu. The disease-modifying effect of dehydroepiandrosterone in different stages of experimentally induced osteoarthritis: a histomorphometric study. BMC Musculoskelet Disord. 2015 Jul 31;16:178. 

Y Zhong, Y Huang, MB Santoso, LD Wu. Sclareol exerts anti-osteoarthritic activities in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model. Int J Clin Exp Pathol. 2015 Mar 1;8(3):2365-74. 

WP Chen, Y Xiong, PF Hu, JP Bao, LD Wu. Baicalein Inhibits MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes. Cell Physiol Biochem. 2015;36(1):325-33.

WP Chen, ZG Yang, PF Hu, JP Bao, LD Wu. Acacetin inhibits expression of matrix metalloproteinases via a MAPK-dependent mechanism in fibroblast-like synoviocytes. J Cell Mol Med. 2015 Aug;19(8):1910-5.

X Zhou, M Yishake, J Li, L Jiang, L Wu, R Liu, N Xu. Genetic susceptibility to prosthetic joint infection following total joint arthroplasty: A systematic review. Gene. 2015 May 25;563(1):76-82.

Wei-Ping Chen, Li-Dong Wu. Chlorogenic acid suppresses interleukin-1β-induced inflammatory mediators in human chondrocytes. Int J Clin Exp Pathol. 2014 Dec 1;7(12):8797-801. .

JP Bao, LF Jiang, WP Chen, PF Hu, LD Wu. Expression of vaspin in the joint and the levels in the serum and synovial fluid of patients with osteoarthritis. Int J Clin Exp Med. 2014 Oct 15;7(10):3447-53.

J Li, XD Zhou, KH Yang, TD Fan, WP Chen, LF Jiang, JP Bao, LD Wu, Y Xiong. Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo. Int Immunopharmacol. 2014 Nov;23(1):85-91.

J Bao, L Jiang, J Li, W Chen, P Hu, L Wu. Visceral adipose tissue-derived serine protease inhibitor inhibits interleukin-1β-induced catabolic and inflammatory responses in murine chondrocytes. Mol Med Rep. 2014 Oct;10(4):2191-7.

Wei-Ping Chen, Yan Xiong, Yong-Xiang Shi, Peng-Fei Hu, Jia-Peng Bao, Li-Dong Wu. Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes. Int Immunopharmacol. 2014 Mar;19(1):174-7.

WJ Li, LP Tang, Y Xiong, WP Chen, XD Zhou, QH Ding, LD Wu. A possible mechanism in DHEA-mediated protection against osteoarthritis. Steroids. 2014;89:20-6. 

L Jiang, J Bao, X Zhou, Y Xiong, L Wu. Increased serum levels and chondrocyte expression of nesfatin-1 in patients with osteoarthritis and its relation with BMI, hsCRP, and IL-18. Mediators Inflamm. 2013;2013:631251.

XD Zhou, LD Wu. Reply to comment on Zhou et al.: Do we really need closed-suction drainage in total hip arthroplasty? A meta-analysis. Int Orthop. 2013 Dec;37(12):2531-2.

X Zhou, W Qian, J Li, P Zhang, Z Yang, W Chen, L Wu. Who are at risk for thromboembolism after arthroplasty? A systematic review and meta-analysis. Thromb Res. 2013 Nov;132(5):531-6.

X Zhou, L Jin, X Yan, L Jiang, W Li, L Wu. Do we really need closed-suction drainage in total hip arthroplasty? A meta-analysis. Int Orthop. 2013 Nov;37(11):2109-18. 

XD Zhou, LJ Tao, J Li, LD Wu. Do we really need tranexamic acid in total hip arthroplasty? A meta-analysis of nineteen randomized controlled trials. Arch Orthop Trauma Surg. 2013 Jul;133(7):1017-27.

W Li, L Tang, X Yan, X Zhou, L Wu.The chondroprotective effects of dehydroepiandrosterone probably exerted by its conversion to estradiol. J Steroid Biochem Mol Biol. 2013 Mar;134:15-22.

W Li, L Tang, X Yan, X Zhou, L WuEffectiveness and Safety of Tranexamic Acid in Reducing Blood Loss in Total Knee Arthroplasty: A Meta-Analysis, J Bone Joint Surg Am. 2012,3;94(13):1153-9.

WP Chen, C Yu, PF Hu, JP Bao, JL Tang, LD Wu. Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis. Acta Biochim Pol. 2012;59(4):537-41.           

WP Chen, YL Wang, JL Tang, PF Hu, JP Bao, LD Wu. Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes. Int Immunopharmacol. 2012 Feb;12(2):447-52.

WP Chen, PF Hu, JP Bao, LD Wu. Morin exerts antiosteoarthritic properties: an in vitro and in vivo study. Exp Biol Med (Maywood). 2012 Apr;237(4):380-6.

Xiang Gao, Rong-xin He, Shi-gui Yan, Li-dong Wu. Dermatitis associated with chromium following total knee arthroplasty. J Arthroplasty. 2011 Jun;26(4):665.

Peng-fei Hu, Yi Chen, Peng-fei Cai, Li-feng Jiang, Li-dong Wu. Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis. Mol Biol Rep. 2011 Aug;38(6):4225-30. 

PF Hu, WP Chen, JL Tang, JP Bao, LD Wu. Protective Effects of Berberine in an Experimental Rat Osteoarthritis Model. Phytother Res. 2011 Jun;25(6):878-85.

K Huang, C Zhang, XW Zhang, JP Bao, LD Wu. Effect of dehydroepiandrosterone on aggrecanase expression in articular cartilage in a rabbit model of osteoarthritis. Mol Biol Rep. 2011 Jun;38(5):3569-72. 

WP Chen, JL Tang, JP Bao, PF Hu, ZL Shi, LD Wu. Anti-arthritic effects of chlorogenic acid in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model. Int Immunopharmacol. 2011 Jan;11(1):23-8. 

Wei‐Ping Chen, Jing‐Li Tang, Jia‐Peng Bao, Peng‐Fei Hu, Chong Yu, Zhong‐Li Shi, Li‐Dong Wu. Effects of diallyl sulphide in chondrocyte and cartilage in experimental osteoarthritis in rabbit. Phytother Res. 2011 Mar;25(3):351-6.

PF Hu, JL Tang, WP Chen, JP Bao, LD Wu. Increased apelin serum levels and expression in human chondrocytes in osteoarthritic patients. Int Orthop. 2011 Sep;35(9):1421-6. 

PF Hu, JP Bao, LD Wu. The emerging role of adipokines in osteoarthritis: a narrative review. Mol Biol Rep. 2011 Feb;38(2):873-8.

WP Chen, JP Bao, JL Tang, PF Hu, LD Wu. Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. Rheumatol Int. 2011 Oct;31(10):1325-31.

JP Bao, WP Chen, LD Wu. Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis. Mol Biol Rep. 2011 Jun;38(5):2879-85.

X Gao, ZJ Xu, RX He, SG Yan, LD Wu. A preliminary report of patellofemoral arthroplasty in isolated patellofemoral arthritis. Chin Med J (Engl). 2010 Nov;123(21):3020-3.

WP Chen, JL Tang, JP Bao, LD Wu. Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis. Exp Biol Med (Maywood). 2010 Dec;235(12):1425-31.

Peng-Fei Hu, Wei-Ping Chen, Jing-Li Tang, Jia-Peng Bao, Li-Dong Wu. Apelin plays a catabolic role on articular cartilage: in vivo and in vitro studies. Int J Mol Med. 2010 Sep;26(3):357-63.

WP Chen, JP Bao, J Feng, PF Hu, ZL Shi, LD Wu. Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis. Clin Chem Lab Med. 2010 Aug;48(8):1141-5.

WP Chen, JP Bao, PF Hu, J Feng, LD Wu. Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. Mol Biol Rep. 2010 Dec;37(8):3967-72. 

JP Bao, WP Chen, J Feng, PF Hu, ZL Shi, LD Wu. Leptin plays a catabolic role on articular cartilage. Mol Biol Rep. 2010 Oct;37(7):3265-72.

H Kai, LD Wu. Suppression of aggrecanase: a novel protective mechanism of dehydroepiandrosterone in osteoarthritis? Mol Biol Rep. 2010 Mar;37(3):1241-5.

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