Position：Chair of Ultrasound Medicine
Department：Ultrasound Medicine
Medical School：Wenzhou Medical College, China
Academic Rank：Professor, Chief Physician
Dr. Huang is engaged in ultrasound disease diagnosis and ultrasound interventional therapy for nearly 30 years, and took the lead in carrying out ultrasound-guided microwave ablation and particle implantation treatment of liver cancer, ablation treatment of thyroid nodules, ablation treatment of uterine fibroids, etc.
He is Involved in the research and development of focused ultrasound cavitation equipment/cavitation nuclear materials and related biological effects; super-resolution ultrasound imaging technology; systematic evaluation of carotid plaque stability; ultrasound radiomics, etc.
Honorary Fellow, American Institute of Ultrasound in Medicine
Director, International Contrast Ultrasound Society (ICUS)
Vice President, Ultrasound Physician Branch, Chinese Medical Doctor Association
Commitee Member, Ultrasound Medicine Branch, Chinese Medical Association
Co-Editor-in-Chief, Bio Integration
Associate Editor, Ultrasound in Medicine and Biology
Editorial Board Member, Cancer Letters
His contributions include:
1. Research and development of ultrasonic cavitation equipment/cavitation nuclear materials and related biological effects;
2. Clinical application of super-resolution ultrasound imaging technology;
3. Evaluate the stability of carotid plaque by monitoring hydrodynamics and neovascularization;
4. Preoperative evaluation of gastric cancer using oral contrast ultrasound and dual contrast-enhanced ultrasound (DCUS);
5. Application of ultrasound radiomics in disease diagnosis.
G. Wang, Y. Jiang, J. Xu, J. Shen, T. Lin, J. Chen, W. Fei, Y. Qin, Z. Zhou, Y. Shen, P. Huang*, Unraveling the Plasma Protein Corona by Ultrasonic Cavitation Augments Active-Transporting of Liposome in Solid Tumor. Adv Mater. 2023 Mar;35(9):e2207271. IF=32.086.
G. Wang, C. Zhang, Y. Jiang, Y. Song, J. Chen, Y. Sun, Q. Li, Z. Zhou, Y. Shen, P. Huang*, Ultrasonic Cavitation-Assisted and Acid-Activated Transcytosis of Liposomes for Universal Active Tumor Penetration. Adv. Funct. Mater. 2021, 31, 2102786. IF= 19.924.
G. Wang, Z. Zhou, Z. Zhao, Q. Li, Y. Wu, S. Yan, Y. Shen, P. Huang*, Enzyme-Triggered Transcytosis of Dendrimer-Drug Conjugate for Deep Penetration into Pancreatic Tumors. ACS Nano. 2020 Apr 28;14(4):4890-4904. IF=18.027.
L. He, Q. Ni, J. Mu, W. Fan, L. Liu, Z. Wang, L. Li, W. Tang, Y. Liu, Y. Cheng, L. Tang, Z. Yang, Y. Liu, J. Zou, W. Yang, O. Jacobson, F. Zhang, P. Huang*, X. Chen*, Solvent-Assisted Self-Assembly of a Metal-Organic Framework Based Biocatalyst for Cascade Reaction Driven Photodynamic Therapy. J Am Chem Soc. 2020 Apr 8;142(14):6822-6832. IF=16.383.
C. Zhang, S. Chen, Q. Li, J. Wu, F. Qiu, Z. Chen, Y. Sun, J. Luo, R.A. Bastarrachea, P.A. Grayburn, R.A. DeFronzo, Y. Liu, K. Qian, P. Huang*, Ultrasound-Targeted Microbubble Destruction Mediates Gene Transfection for Beta-Cell Regeneration and Glucose Regulation. Small. 2021 Aug;17(31):e2008177. IF=15.153.
G. Wang, B. Wu, Q. Li, S. Chen, X. Jin, Y. Liu, Z. Zhou, Y. Shen, P. Huang*, Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy. Small. 2020 Nov;16(44):e2004172. IF=15.153.
Z. Yang, Y. Dai, L. Shan, Z. Shen, Z. Wang, B.C. Yung, O. Jacobson, Y. Liu, W. Tang, S. Wang, L. Lin, G. Niu, P. Huang*, X. Chen*, Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics. Nanoscale Horiz. 2019 Mar 1;4(2):426-433. IF= 11.684.
G. Wang, Q. Li, D. Chen, B. Wu, Y. Wu, W. Tong, P. Huang*, Kidney-targeted rhein-loaded liponanoparticles for diabetic nephropathy therapy via size control and enhancement of renal cellular uptake. Theranostics. 2019 Aug 14;9(21):6191-6208. IF= 11.600.
C. Zhang, L. Xin, J. Li, J. Cao, Y. Sun, X. Wang, J. Luo, Y. Zeng, Q. Li, Y. Zhang, T. Zhang, P. Huang*, Metal-Organic Framework (MOF)-Based Ultrasound-Responsive Dual-Sonosensitizer Nanoplatform for Hypoxic Cancer Therapy. Adv Healthc Mater. 2022 Jan;11(2):e2101946. IF=11.467.
X. Wang, Z. Shi, J. Luo, Y. Zeng, L. He, L. Chen, J. Yao, T. Zhang, P. Huang*, Ultrasound improved immune adjuvant delivery to induce DC maturation and T cell activation. J Control Release. 2022 Sep;349:18-31. IF=11.092.
J. Yan, T. Zhang, J. Broughton-Venner, P. Huang*, M. Tang*, Super-Resolution Ultrasound Through Sparsity-Based Deconvolution and Multi-Feature Tracking. IEEE Trans Med Imaging. 2022 Aug;41(8):1938-1947. IF=11.037.
J. Cao, Y. Sun, C. Zhang, X. Wang, Y. Zeng, T. Zhang, P. Huang*, Tablet-like TiO2/C nanocomposites for repeated type I sonodynamic therapy of pancreatic cancer. Acta Biomater. 2021 Jul 15;129:269-279. IF=10.633.
X. Wang, J. Luo, J. Wang, J. Cao, Y. Hong, Q. Wen, Y. Zeng, Z. Shi, G. Ma, T. Zhang, P. Huang*, Catalytically Active Metal-Organic Frameworks Elicit Robust Immune Response to Combination Chemodynamic and Checkpoint Blockade Immunotherapy. ACS Appl Mater Interfaces. 2023 Feb 8;15(5):6442-6455. IF=10.383.
L. Xin, C. Zhang, J. Chen, Y. Jiang, Y. Liu, P. Jin, X. Wang, G. Wang, P. Huang*, Ultrasound-Activatable Phase-Shift Nanoparticle as a Targeting Antibacterial Agent for Efficient Eradication of Pseudomonas aeruginosa Biofilms. ACS Appl Mater Interfaces. 2022 Oct 26;14(42):47420-47431. IF=10.383.
J. Luo, J. Cao, G. Ma, X. Wang, Y. Sun, C. Zhang, Z. Shi, Y. Zeng, T. Zhang, P. Huang*, Collagenase-Loaded H-TiO2 Nanoparticles Enhance Ultrasound Imaging-Guided Sonodynamic Therapy in a Pancreatic Carcinoma Xenograft Model via Digesting Stromal Barriers. ACS Appl Mater Interfaces. 2022 Sep 14;14(36):40535-40545. IF=10.383.
C. Zhang, J. Chen, Y. Song, J. Luo, P. Jin, X. Wang, L. Xin, F. Qiu, J. Yao, G. Wang, P. Huang*, Ultrasound-Enhanced Reactive Oxygen Species Responsive Charge-Reversal Polymeric Nanocarriers for Efficient Pancreatic Cancer Gene Delivery. ACS Appl Mater Interfaces. 2022 Jan 19;14(2):2587-2596. IF=10.383.
Y. Sun, J. Cao, X. Wang, C. Zhang, J. Luo, Y. Zeng, C. Zhang, Q. Li, Y. Zhang, W. Xu, T. Zhang, P. Huang*, Hypoxia-Adapted Sono-chemodynamic Treatment of Orthotopic Pancreatic Carcinoma Using Copper Metal-Organic Frameworks Loaded with an Ultrasound-Induced Free Radical Initiator. ACS Appl Mater Interfaces. 2021 Aug 18;13(32):38114-38126. IF=10.383.
Y. Bao, J. Chen, H. Qiu, C. Zhang, P. Huang*, Z. Mao*, W. Tong*, Erythrocyte Membrane-Camouflaged PCN-224 Nanocarriers Integrated with Platinum Nanoparticles and Glucose Oxidase for Enhanced Tumor Sonodynamic Therapy and Synergistic Starvation Therapy. ACS Appl Mater Interfaces. 2021 Jun 2;13(21):24532-24542. IF=10.383.
T. Zhang, Z. Jiang, L. Chen, C. Pan, S. Sun, C. Liu, Z. Li, W. Ren, A. Wu, P. Huang*, PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia. Nano Res. 2020, Jan 13, 273–281. IF=10.383.
Q. Li, T. Jiang, C. Zhang, Y. Zhang, Z. Huang, H. Zhou, P. Huang*, A nomogram based on clinical information, conventional ultrasound and radiomics improves prediction of malignant parotid gland lesions. Cancer Lett. 2022 Feb 28;527:107-114. IF=9.756.
Experimental study on the reversal of multidrug resistance in breast cancer by ultrasound-mediated functional lipid droplet acoustodynamic therapy. Major Program of National Natural Science Foundation of China, 2022 (Grant No. 82230069)
Visual evaluation of super-resolution ultrasound imaging on the effect of ultrasound-mediated targeted CD39 nanobubble cavitation on the immune microenvironment of pancreatic cancer. Major Program of National Natural Science Foundation of China, 2020 (Grant No. 82030048)
Research on comprehensive evaluation system of carotid plaque stability based on artificial intelligence. Zhejiang Provincial Key Research and Development Program, 2019 (Grant No. 2019C03077)
Research on the Key Technology of Ultrasonic Cavitation Biological Effect Evaluation. National Key Research and Development Program of China, 2018 (Grant No. 2018YFC0115900)
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