Position：Chair of Rheumatology
Department：Rheumatology
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Chief Physician
Diagnosis and treatment of variety rheumatic diseases, especially in systemic lupus erythematosus, gout, rheumatoid arthritis, ankylosing spondylitis and idiopathic inflammatory myopathy.
Dr. Wu has been engaged in clinical, teaching, and scientific research for 37 years. She has accumulated rich clinical experience on the diagnosis and treatment of Rheumatic Diseases, such as gout, systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, Sjogren's syndrome and idiopathic inflammatory myopathy. She has been in charge of 22 research programs including two general programs of National Natural Science Foundation, two sub-project of major projects of the Science and Technology Ministry, one Key Research and Development Program of Zhejiang Province, two general programs of the Provincial Natural Science Foundation and fifteen other national and provincial-ministerial projects. She has published more than 150 papers and 50 papers in SCI-cited journals. The programs she participated in won the second prize of National Science and Technology Progress Award, the first prize of Zhejiang Provincial Science and Technology Award and the first prize of Zhejiang Provincial Science and Technology Award of Traditional Chinese Medicine.
Chair, the Rheumatology and Immunology Branch of Zhejiang Medical Doctors Association
Chair, the First Committee of Rheumatology Branch of Zhejiang Medical Association
Standing Committee Member, the Rheumatology and Immunology Branch of Chinese Medical Doctor Association
Member or Standing Committee Member, the 6th, 7th, 8th and 9th Chinese Rheumatology Society
Vice Chair, the Rheumatic Diseases Committee of Zhejiang Integrated Chinese and Western Medical society
Editorial Board Member, Chinese Journal of Rheumatology, Zhejiang Medicine, etc.
Dr. Wu specializes in clinical and basic research on gout and hyperuricemia. She focuses on the metabolic mechanism of uric acid in the intestinal tract, the related factors of hyperuricemia developing into gout and the role of intestinal flora in the pathogenesis of gout. She also study tuberculosis intervention in people with Rheumatic Disease.
Dong Y, Wang T, Wu H. Tertiary lymphoid structures in autoimmune diseases. Front Immunol. 2024 Jan 8;14:1322035. doi: 10.3389
Qi Cheng , Lijun Mou, Wenjing Su , Xin Chen , Ting Zhang , Yifan Xie , Jing Xue , Pui Y Lee ,Huaxiang Wu,Yan Du. Ferroptosis of CD163+ tissue-infiltrating macrophages and CD10+ PC+ epithelial cells in lupus nephritis. Front Immunol.. 2023 Jul 31:14:1171318. doi: 10.3389
Qi Cheng , Mo Chen , Mengdan Liu , Fangying Wang , Xin Chen , Wenjia Sun , Yan Du , Huaxiang Wu. Age-related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis. J Gene Med.2023 Sep 19:e3582. doi: 10.1002/jgm.3582.
Tong S, Zhang P, Cheng Q, Chen M, Chen X, Wang Z, Lu X, Wu H.The role of gut microbiota in gout: Is gut microbiota a potential target for gout treatment.Front Cell Infect Microbiol.2022 Nov 24;12:1051682. doi: 10.3389/fcimb.2022.1051682. eCollection 2022.PMID: 36506033
Liu L, Wang J, Zhang P, Sun W, Zhu X, Sun X, Xue J, Wu H. Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis.J Immunol Res.2022 Sep 26;2022:1886083. doi: 10.1155/2022/1886083. eCollection 2022
Cheng Q, Chen M, Liu M, Chen X, Zhu L, Xu J, Xue J, Wu H, Du Y. Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis. Cell Death Dis. 2022 Jul 14;13(7):608. doi: 10.1038/s41419-022-05065-4
Chen M, Ye C, Zhu J, Zhang P, Jiang Y, Lu X, Wu H. Bergenin as a Novel Urate-Lowering Therapeutic Strategy for Hyperuricemia. Front Cell Dev Biol. 2020 Jul 29;8:703.
Ting Zhang , Jianing Zhu, Dongyi He, Xiaowei Chen, Hongzhi Wang, Ying Zhang, Qin Xue, Weili Liu, Guangbo Xiang, Yasong Li, Zhongming Yu and Huaxiang Wu. Disease activity guided stepwise tapering or discontinuation of rhTNFR:Fc, an etanercept biosimilar, in patients with ankylosing spondylitis: a prospective, randomized, open-label, multicentric study. Ther Adv Musculoskel Dis.2020, Vol. 12: 1–14.
Du Y, Sun F, Zhou M, Wu X, Sun W, Jiang Y, Cheng Q, Chen X, Wu H, Xue J. Theexpression and clinical significance of different forms of LILRA3 in systemiclupus erythematosus. Clin Rheumatol. 2019, 38(11):3099-3107.
Wu H, Shen J, Liu L, Lu X, Xue J. Vasoactive intestinal peptide-induced tolerogenic dendritic cells attenuated arthritis in experimental collagen-induced arthritic mice. Int J Rheum Dis. 2019 Jul;22(7):1255-1262.
Zhu JN, Nie LY, Lu XY, Wu HX. Meta-analysis: compared with anti-CCP and rheumatoid factor, could anti-MCV be the next biomarker in the rheumatoid arthritis classification criteria?. Clin Chem Lab Med. 2019 Oct 25;57(11):1668-1679.
Mo Chen, Xiaoyong Lu, Ci Lu, Ning Shen, Yujie Jiang, Menglu Chen and Huaxiang Wu. Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Arthritis Res Ther. 2018 Feb 7;20(1):20.
Study on the role and mechanism of estradiol in regulating intestinal SLC2A9 in hyperuricemia, General Program of National Natural Science Foundation, NO.82071810
Research on New Technology for Diagnosis and Treatment of Dermatovenereal Diseases and Rheumatic Diseases-- Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout, 2020 Key Research and Development Program of Zhejiang Province, Zhejiang Science and Technology Department, NO. 2020C03044
Study on the intervention technology of latent tuberculosis in people with Rheumatic Disease. Study on intervention strategies in key population of Tuberculosis. Major scientific and technological projects for the prevention and treatment of major infectious diseases such as AIDS and viral hepatitis. Ministry of Science and Technology. NO.2017ZX10201302
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