Huang Man, M.D., Ph.D.

Position:Chair of General ICU, Vice Chair of Lung Transplant

Department:General ICU

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Sepsis and Multiple Organ Dysfunction Syndrome

pathogenesis and therapy of Sepsis Associated Encephalopathy

Oxidative stress injury and critical neurological diseases

Acute Kidney Injury and blood purification in critical care medicine

Perioperative management of solid organ transplantation

Professional Highlights

Professional Appointments

Ph. D. Supervisor at Zhejiang University School of Medicine

Chairman, Neurosurgery Critical Care Branch, Zhejiang Society for Neuroscience

Vice Chairman, Professional Committee of Critical Care Medicine, China Medical Women's Association

Member, Extracorporeal Life Support Committee, Chinese Medical Association

Member, Shock and Sepsis Committee, Chinese Research Hospital Association

Member, Critical Care Medicine Sub-Committee, Chinese Society of Gerontology

Editorial board member, Chinese Journal of Emergency Medicine

Education Experience

2010.09-2013.09, Zhejiang University School of Medicine, Doctor Degree in Neurology

2002.09-2005.12, Zhejiang University School of Medicine, Master Degree  in Neurology

1989.09-1994.06, Wenzhou Medical University, Bachelor degree

Research Summary

Publications

Active surveillance of carbapenem-resistant gram-negative bacteria to guide antibiotic therapy: a single-center prospective observational study. Antimicrob Resist Infect Control. 2022 Jun 22;11(1):89.

Ceftazidime/Avibactam versus Polymyxin B in the Challenge of Carbapenem-Resistant Pseudomonas aeruginosa Infection. Infect Drug Resist. 2022 Feb 25;15:655-667.

Early Prediction of Carbapenem-resistant Gram-negative Bacterial Carriage in Intensive Care Units Using Machine Learning. 2022 Mar 26;S2213-7165(22)00074-1.

Severe acute kidney injury predicting model based on transcontinental databases: a single-centre prospective study. BMJ Open. 2022 Mar 3;12(3):e054092.

Efferocytosis and Its Role in Inflammatory Disorders. Front Cell Dev Biol. 2022 Feb 25;10:839248.

Application of mNGS to describe the clinical and microbial characteristics of severe burn a tanker explosion at a tertiary medical center: a retrospective study patients following. BMC Infect Dis. 2021 Oct 21;21(1):1086.

The Effect and Regulatory Mechanism of High Mobility Group Box-1 Protein on Immune Cells in Inflammatory Diseases. Cells. 2021 Apr 28;10(5):1044.

IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome. Mediators Inflamm. 2021 Dec 17;2021:6370911.

Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4 + CD25 + regulatory T cells. J Cell Mol Med. 2020 Jan;24(2):2027-2039.

Biological functions and clinical implications of interleukin-34 in inflammatory diseases. Adv Protein Chem Struct Biol. 2020;119:39-63.

Effect of Interleukin-36β on Activating Autophagy of CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis. J Infect Dis. 2020 Oct 1;222(9):1517-1530.

Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis. Front Immunol. 2020 Jul 28;11:1558.

Metagenomic next-generation sequencing helped diagnose scrub typhus without eschar: A case report. Int J Infect Dis. 2020 Jan;90:1-4.

Feasibility and safety of total percutaneous closure of femoral arterial access sites after veno-arterial extracorporeal membrane oxygenation. Medicine (Baltimore). 2019 Nov;98(45):e17910.

Recent advances in the biology of IL-1 family cytokines and their potential roles in development of sepsis. Cytokine Growth Factor Rev. 2019 Feb;45:24-34.

Successful voriconazole treatment of Talaromyces marneffei infection in an HIV-negative patient with osteolytic lesions. J Infect Chemother. 2019 Mar;25(3):204-207.

Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection. Braz J Infect Dis. 2019 Jan - Feb;23(1):60-65.

Preemptive isolation and active surveillance in the prevention and control of nosocomial infection reduce the incidence of carbapenem resistant. Infect Dis (Lond). 2019 May;51(5):377-379.

α-Mangostin suppresses NLRP3 inflammasome activation via promoting autophagy in LPS-stimulated murine macrophages and protects against CLP-induced sepsis in mice. Inflamm Res. 2019 Jun;68(6):471-479.

How do we maximize the humanistic care of a long-range (36-day) venoarterial extracorporeal membrane oxygenation and successfully bridged to heart transplantation. J Clin Anesth. 2019 May 28;58:105-106.

Pulmonary Scedosporiosis in a patient with acute hematopoietic failure diagnosis aided by next-generation sequencing. Int J Infect Dis. 2019 Jun 3;85:114-116.

A more physiological feeding process in ICU Intermittent infusion with semi-solid nutrients (CONSORT-compliant). Medicine (Baltimore). 2018 Sep;97(36):e12173.

High-dose tigecycline for the treatment of nosocomial carbapenem-resistant Klebsiella pneumoniae bloodstream infections. Medicine (Baltimore). 2018 Feb;97(8):e9961.

Transferrin-modified liposome promotes α-mangostin to penetrate the blood–brain barrier. Nanomedicine. 2016 Feb;12(2):421-30.

Lack of Genetic Association Between TREM2 and Alzheimer's Disease in East Asian Population: A Systematic Review and Meta-Analysis. Am J Alzheimers Dis Other Demen. 2015 Sep;30(6):541-6.

Gamma-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats. Chin Med J (Engl). 2014;127(5):924-8.

The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain. J Ethnopharmacol. 2012 Aug 30;143(1):228-35.

Copeptin Is Associated with Mortality in Patients with Traumatic Brain Injury. J Trauma. 2011 Nov;71(5):1194-8.

Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic rat brain: possible involvement of Toll-like receptor 4/nuclear factor-kappa B pathway. J Ethnopharmacol. 2011 Oct 11;137(3):1462-8.

Time course of plasma microparticle concentrations after acute spontaneous basal ganglia hemorrhage. Acta Neurol Scand. 2011 Apr;123(4):280-8.

High concentrations of procoagulant microparticles in the cerebrospinal fluid and peripheral blood of patients with acute basal ganglia hemorrhage are associated with poor outcome. Surg Neurol. 2009 Nov;72(5):481-9


Current Program

The potential role and its mechanism of interleukin-36 regulating autophagy in the immune function of regulatory T cells in sepsis. Funding Source: National Natural Science Foundation of China (81873946), 2019-2022.

The potential role and its mechanism of IL-36β regulating ERS-XBP1 pathway in the immune function of dendritic cells in septic mice. Funding Source: Natural Science Foundation of Zhejiang (LY20H150011), 2020-2022.


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