Huang Jian, M.D., Ph.D.

Position:Executive Vice Hospital President

Department:Breast Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor, Chief Physician


Appointment

Clinical / Research Interests

Early diagnosis and surgical management of breast cancer, especially precise localization of non-palpable tumor using breast clip and early prediction of neo-adjuvant chemotherapy response by breast-specific molecular imaging.


Professional Highlights

Zhejiang Natural Science Award, First Prize

Professional Appointments

Member, Editor Board of National Guideline for Breast Cancer Screening, Early Diagnosis and Treatment  

Member, Chinese Society of Breast Surgery

Standing Committee Member, Breast Cancer Committee, Chinese Cancer Society

Standing Committee Member, Breast Cancer Committee, Chinese Society of Clinical Oncology

Chairman, Breast Cancer Committee, Zhejiang Cancer Society

Editor, Translational Breast Cancer Research


Education Experience

Research Summary

Explore the key regulatory mechanisms for tumor microenvironment remodeling and their novel intervention targets, especially in breast cancer; discover novel tumor-related immune cell subsets like γδT and neutriphil , develop potential immune and targeted therapies based on tumor immuno-metablic suppressive microenvironment and translate into clinical practice.


Publications

Ni C, Fang QQ, Chen WZ, Jiang JX, Jiang Z, Ye J, Zhang T, Yang L, Meng FB, Xia WJ, Zhong M, Huang J (Corresponding author). Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells. Signal Transduct Target Ther. 2020 Apr 29;5(1):41.

Huang Q, Chen Z, Cheng P, Jiang Z, Wang Z, Huang Y, Yang C, Pan J, Qiu F, Huang J (Corresponding author). LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation. Cancer Lett. 2019 Jul 28;455:36-47.

Chen Z, Li W, Qiu F, Huang Q, Jiang Z, Ye J, Cheng P, Low C, Guo Y, Yi X,Chen W, Yu Y, Han Y, Wu J, Jin S, Kong D, Huang J (Corresponding author). Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer. Theranostics. 2018 Aug 7;8(16):4447-4461.

Hu G, Wu P, Cheng P, Zhang Z, Wang Z, Yu X, Shao X, Wu D, Ye J, Zhang T, WangX, Qiu F, Yan J, Huang J (Corresponding author). Tumor-infiltrating CD39 Tregs are novel immunosuppressive T cells in human colorectal cancer. Oncoimmunology. 2017 Jan 6;6(2):e1277305.

Chen W, Jiang J, Xia W, Huang J (Corresponding author).Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective. J Immunol Res. 2017;2017:1073947.

Zhang Z, Zhu Y, Wang Z, Zhang T, Wu P, Huang J (Corresponding author). Yin-yang effect of tumor infiltrating B cells in breast cancer: From mechanism to immunotherapy. Cancer Lett. 2017 (1)393:1-7.

Wu D, Wu P, Qiu F, Wei Q, Huang J (Corresponding author). Human γδT-cell subsets and their involvement in tumor immunity. Cell Mol Immunol. 2017 Mar;14(3):245-253.

Yu X, Hu G, Zhang Z, Qiu F, Shao X, Wang X, Zhan H, Chen Y, Deng Y, Huang J (Corresponding author).Retrospective and comparative analysis of (99m)Tc-Sestamibi breast specific gamma imaging versus mammography, ultrasound, and magnetic resonance imaging for the detection of breast cancer in Chinese women. BMC Cancer. 2016 Jul 11;16:450

Wu D, Wu P, Wu X, Ye J, Wang Z, Zhao S, Ni C, Hu G, Xu J, Han Y, Zhang T, Qiu F, Yan J, Huang J (Corresponding author). Ex vivo expanded human circulating Vδ1 γδT cells exhibit favorable therapeutic potential for colon cancer. Oncoimmunology. 2015 Jan 22;4(3):e992749.

Zhang Z, Yu X, Wang Z, Wu P, Huang J (Corresponding author)..Anthracyclines potentiate anti-tumor immunity: A new opportunity for chemoimmunotherapy. Cancer Lett. 2015 Dec 28;369(2):331-5.

Wu P, Wu D, Ni C, Ye J, Chen W, Hu G, Wang Z, Wang C, Zhang Z, Xia W, Chen Z,Wang K, Zhang T, Xu J, Han Y, Zhang T, Wu X, Wang J, Gong W, Zheng S, Qiu F, Yan J, Huang J (Corresponding author). γδT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity. 2014 May 15;40(5):785-800. (Cover paper)

Yan J, Huang J (Corresponding author). Innate γδT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells. Oncoimmunology. 2014 Aug 3;3(8):e953423.


Current Program

γδT cells heterogeneity mediating dysbacteriosis promotes immunosupressive microenvironment and the progression of colorectal cancer. Funding Source: Key Program, National Natural Science Foundation of China. 

Key mechanism of novel aging neutrophils in promoting the reconstitution of immune microenvironment before lung metastasis of breast cancer. Funding Source:  National Natural Science Foundation of China.

Role and mechanism of novel human CD39 + γδ Treg cells in promoting the formation of immunosuppressive microenvironment in colorectal cancer. Funding Resource: International/Regional Exchange and Cooperative Project, National Natural Science Foundation of China.

Development of antitumor peptide vaccine with novel immune adjuvant. Funding Source: National Major Scientific and Technological Special Project for New Drugs Development.

Molecular mechanism of selective clearance of colorectal cancer stem cells by acetylation of ALDH1 with aspirin. Funding Source:  National Natural Science Foundation of China.

Key molecular mechanism of novel LYRM2 in promoting stemness of colorectal cancer cell. Funding Source: National Natural Science Foundation of China.

Development of humanized CD73 therapeutic antibody and evaluation of its antitumor effect. Funding Source: Zhejiang Provincial Department of Science and Technology.


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