Hu Xinyang, M.D., Ph.D.

Position:Vice Hospital President


Medical School:Zhejiang University School of Medicine, China

Academic Rank:ProfessorChief Physician


Clinical / Research Interests

Dr. Hu’s research interests including investigations of therapeutic targets and underlying mechanisms on myocardial infarction and heart failure. Her team focus on two aspects of studies: 1) Stem cells therapy for heart failure and myocardial infarction from rodents to non-human primates. 2) Discovering novel therapeutic targets (eg. Flavin Containing Monooxygenase 2) on their advantages towards myocardial infarction and heart failure. She acquired Youth Chang Jiang Scholars Program as well as Outstanding Youth Science Foundation during her career and has published 56 articles on renowned journals like Circulation Research, Stem Cells etc.

Professional Highlights

Team Award of the 18th China Young Women Scientists Award, 2023 

Teaching achievements of Zhejiang Province(Rank 3 th), 2016

Best Manuscript Award of Circulation Research, 2016 

National Science and Technology Award (Rank 7 th), 

Zhejiang Province Science and Technology Award (Rank 5 th), 2008

Professional Appointments

Fellow, American College of Cardiology, 2018

Fellow, European Society of Cardiology

Membership, American Heart Association, 2014

Member, The second Professional Committee of Vascular Medicine Commitee, Chinese Society of Pathophysiology, 2021

Member, Youth Committee of the 11 th Committee of the Cardiovascular Society, Chinese Medical Association, 2019

Member, The 8th Youth Committee, Medical Science Research and Management Branch, Chinese Medical Association, 2019

Committee Membership, Chinese Translational Medicine of ISHR, 2014

Associate Editor, Journal of Cellular and Molecular Medicine (JCMM), 2019-present

Editorial Member, Circulation Research, 2020-present

Editorial Member, Molecular Cardiology of China, 2017-present

Education Experience

Research Summary


Koo BK # , Hu X # , Kang J, Zhang J, Jiang J, Hahn JY, Nam CW, Doh JH, Lee BK, Kim W, Huang J, Jiang F, Zhou H, Chen P, Tang L, Jiang W, Chen X, He W, Ahn SG, Yoon MH, Kim U, Lee JM, Hwang D, Ki YJ, Shin ES, Kim HS, Tahk SJ, Wang J*; FLAVOUR Investigators. Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI. N Engl J Med. 2022 Sep 1;387(9):779-789. doi: 10.1056/NEJMoa2201546. PMID: 36053504.

Ni C, Chen Y, Xu Y, Zhao J, Li Q, Xiao C, Wu Y, Wang J, Wang Y, Zhong Z, Zhang L, Wu R, Liu Q, Wu X, Ke C, Zhu W, Chen J, Huang J, Wang Y, Wang J, Hu X. Flavin Containing Monooxygenase 2 Prevents Cardiac Fibrosis via CYP2J3-SMURF2 Axis. Circ Res. 2022 Jul 5:101161CIRCRESAHA122320538. doi: 10.1161/CIRCRESAHA.122.320538. Epub ahead of print. PMID: 35861735.

Ding H # , Ding J # , Liu Q # , Lin J, He M, Wu X, Chen X, Xiao C, Ren T, Zhu Y, Gao C*, Hu X*, Wang J*. Mesenchymal stem cells encapsulated in a reactive oxygen species-scavenging and O2-generating injectable hydrogel for myocardial infarction treatment. Chemical Engineering Journal. 2022;433(2):133511.

Wu R, Hu W, Chen H, Wang Y, Li Q, Xiao C, Fan L, Zhong Z, Chen X, Lv K, Zhong S, Shi Y, Chen J, Zhu W, Zhang J, Hu X*, Wang J*. A Novel Human Long Noncoding RNA SCDAL Promotes Angiogenesis through SNF5-Mediated GDF6 Expression. Adv Sci. 2021 Sep;8(18):e2004629.

Hua S, Zhong S, Hamed A, He J, Zhong D, Zhang D, Chen X, Qian J, Hu X*, Zhou M * . Simultaneous Deep Tracking of Stem Cells by Surface Enhanced Raman Imaging Combined with Single-Cell Tracking by NIR-II Imaging in Myocardial Infarction. Advanced Functional Materials. 2021,2100468.

Li Q # , Xu Y # , Lv K # , Wang Y, Zhong Z, Xiao C, Zhu K, Ni C, Wang K, Kong M, Li X, Fan Y, Zhang F, Chen Q, Li Y, Li Q, Liu C, Zhu J, Zhong S, Wang J, Chen Y, Zhao J, Zhu D, Wu R, Chen J, Zhu W, Yu H, Ardehali R, Zhang JJ * , Wang J * , Hu X* . Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates. Sci Transl Med. 2021 Mar 10;13(584): eabb0202.

Zhang L # , Liu G # , Lv K # , Xin J, Wang Y, Zhao J, Hu W, Xiao C, Zhu K, Zhu L, Nan J, Feng Y, Zhu H, Chen W, Zhu W, Zhang J, Wang J, Wang B*, Hu X*. Surface-Anchored Nanogel Coating Endows Stem Cells with Stress Resistance and Reparative Potency via Turning Down the Cytokine-Receptor Binding Pathways. Adv Sci. 2021 Jan 6;8(3):2003348.

Lv K # , Li Q # , Zhang L, Wang Y, Zhong Z, Zhao J, Lin X, Wang J, Zhu K, Xiao C, Ke C, Zhong S, Wu X, Chen J, Yu H, Zhu W, Li X, Wang B, Tang R, Wang J, Huang J*, Hu X*. Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction. Theranostics. 2019 Oct 11;9(24):7403-7416.

Hu X # , Zhang J # , Lee JM, Chen Z, Hwang D, Park J, Shin ES, Nam CW, Doh JH, Chen S, Yang J, Tanaka N, Kuramitsu S, Matsuo H, Takashima H, Akasaka T, Koo BK, Wang J*. Prognostic impact of diabetes mellitus and index of microcirculatory resistance in patients undergoing fractional flow reserve-guided revascularization. Int J Cardiol. 2019 Nov 5. pii: S0167-5273(19)31281-1.

Xiao C, Wang K, Xu Y, Hu H, Zhang N, Wang Y, Zhong Z, Zhao J, Li Q, Zhu D, Ke C, Zhong S, Wu X, Yu H, Zhu W, Chen J, Zhang J, Wang J*, Hu X*. Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b. Circ Res. 2018 Aug 16; 123(5): 564-578.

Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu XY*, Wang JA*. Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates. Circ Res. 2018 Mar 30;122(7):958-969. (Co-corresponding author).

Wang K # , Jiang Z, Webster KA, Chen JH, Hu HX, Zhou Y, Zhao J, Wang LH, Wang YC, Zhong ZW, Ni C, Li QJ, Xiang C, Zhang L, Wu RR, Zhu W, Yu H, Hu X*, Wang JA*. Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Transl Med. 2017 Jan;6(1):209-222. (Co-corresponding author).

Hu X # , Yang H, Zhu Y, Wang J*, Dong E*. Chinese Basic Cardiovascular Research in Transition. Circ Res. 2016;118(12):1876-9.

Hu X # , Xu Y#, Zhong Z, Wu Y, Zhao J, Wang Y, Cheng H, Kong M, Zhang F, Chen Q, Sun J, Li Q, Jin J, Li Q, Chen L, Wang C, Zhan H, Fan Y, Yang Q, Yu L, Wu R, Liang J, Zhu J, Wang Y, Jin Y, Lin Y, Yang F, Jia L, Zhu W, Chen J, Yu H, Zhang J*, Wang J*. A Large-scale Investigation of Hypoxia-preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-human Primates: Paracrine Activity Without Remuscularization. Circ Res. 2016 Mar 18;118(6):970-83.

Hu X # , Chen P # , Wu Y, Wang K, XuY , Chen H , ZhangL, Wu R, Webster KA,Yu H, Zhu W*, Wang JA*. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016;34(7):1846-58.

Hu X #*, Zhang L # , Jin J, Zhu W, Xu Y, Wu Y, Wang Y, Chen H, Webster KA, Chen H, Yu H, Wang JA*. Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells. 2015 Jun;33(6):1850-62. (Co-corresponding author).

Hu X #, Huang X, Yang Q, Wang L, Sun J, Zhan H, Lin J, Pu Z, Jiang J, Sun Y, Xiang M, Liu X, Xie X, Yu X, Chen Z, Tse HF, Zhang J, Wang JA*. Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial. Int J Cardiol. 2015 Apr 1;184:446-51.

Hu X #, Wu R # , Jiang Z, Wang L, Chen P, Zhang L, Yang L, Wu Y, Chen H, Chen H, Xu Y, Zhou Y, Huang X, Webster KA, Yu H*, Wang JA*. Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells. 2014 Oct;32(10):2702-13.

Hu X # , Wu R # , Shehadeh LA, Zhou Q, Jiang C, Huang X, Zhang L, Gao F, Liu X, Yu H, Webster KA*, Wang JA*. Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. BMC Genomics. 2014 Apr 23; 15: 303.

Xu Y # , Hu X # , Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J*, Wang J*. Preconditioning via angiotensin type 2 receptor activation improves therapeutic efficacy of bone marrow mononuclear cells for cardiac repair. PLoS One. 2013 Dec 10;8(12): e82997. (Co-first author).

Xu Y # , Hu X # , Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J*, Wang JA*. Transplantation ofpreconditioned bone marrow mononuclear cells by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells. Int J Cardiol. 2013 Oct 9;168(4):4551-4.(Co-first author)

Current Program

PI, Basic and Translational Research on Myocardial Injury and Repair, National Natural Science Foundation of China, 2023-2027

PI, FMO2 regulates pathological cardiac hypertrophy through mitochondria related endoplasmic reticulum, National Natural Science Foundation of China, 2021-2024

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