Hu Xinyang, M.D., Ph.D.

Position:Vice Hospital President, Director of Science and Research Department

Department:Cardiology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:ProfessorChief Physician

Appointment

Clinical / Research Interests

Percutaneous coronary intervention, especially the functional and imaging guided interventional surgery.

Professional Highlights

Zhejiang Science and Technology Award, First Prize 

Zhejiang Teaching Achievement Award, Third Prize

Best Manuscript Award of Circulation Research

State Scientific and Technological Progress Award, Seventh Place

Zhejiang Science and Technology Award, Fifth Place

Professional Appointments

Associate Editor, Journal of Cellular and Molecular Medicine (JCMM), 2019-present

Editorial Committee Member, Molecular Cardiology of China, 2017-present

Education Experience

Research Summary

Publications

Lv K, Li Q, Zhang L, Wang Y, Zhong Z, Zhao J, Lin X, Wang J, Zhu K, Xiao C, Ke C, Zhong S, Wu X, Chen J, Yu H, Zhu W, Li X, Wang B, Tang R, Wang J, Huang J*, Hu X*. Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction. Theranostics. 2019 Oct 11;9(24):7403-7416.

Xiao C, Wang K, Xu Y, Hu H, Zhang N, Wang Y, Zhong Z, Zhao J, Li Q, Zhu D, Ke C, Zhong S, Wu X, Yu H, Zhu W, Chen J, Zhang J, Wang J*, Hu X*. Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b. Circulation Research. 2018 Aug 16; 123(5): 564-578.

Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu X*, Wang JA*. Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates. Circ Res. 2018 Mar 30;122(7):958-969. (Co-corresponding author) 

Wang K#, Jiang Z, Webster KA, Chen JH, Hu HX, Zhou Y, Zhao J, Wang LH, Wang YC, Zhong ZW, Ni C, Li QJ, Xiang C, Zhang L, Wu RR, Zhu W, Yu H, Hu X*, Wang JA*. Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Transl Med. 2017 Jan;6(1):209-222. (Co-corresponding author) 

Hu X#, Yang H, Zhu Y, Wang J*, Dong E*. Chinese Basic Cardiovascular Research in Transition. Circulation Research. 2016;118(12):1876-9.

Hu X#, Xu Y#, Zhong Z, Wu Y, Zhao J, Wang Y, Cheng H, Kong M, Zhang F, Chen Q, Sun J, Li Q, Jin J, Li Q, Chen L, Wang C, Zhan H, Fan Y, Yang Q, Yu L, Wu R, Liang J, Zhu J, Wang Y, Jin Y, Lin Y, Yang F, Jia L, Zhu W, Chen J, Yu H, Zhang J*, Wang J*. A Large-scale Investigation of Hypoxia-preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-human Primates: Paracrine Activity Without Remuscularization. Circulation Research. 2016 Mar 18;118(6):970-83.

Hu X#, Chen P# , Wu Y, Wang K, XuY , Chen H , ZhangL, Wu R, Webster KA,Yu H, Zhu W*, Wang JA*. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016;34(7):1846-58.

Hu X#*, Zhang L#, Jin J, Zhu W, Xu Y, Wu Y, Wang Y, Chen H, Webster KA, Chen H, Yu H, Wang JA*. Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells. 2015 Jun;33(6):1850-62. (Co-corresponding author)

Hu X#, Huang X, Yang Q, Wang L, Sun J, Zhan H, Lin J, Pu Z, Jiang J, Sun Y, Xiang M, Liu X, Xie X, Yu X, Chen Z, Tse HF, Zhang J, Wang JA*. Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial. Int J Cardiol. 2015 Apr 1;184:446-51.

Hu X#, Wu R#, Jiang Z, Wang L, Chen P, Zhang L, Yang L, Wu Y, Chen H, Chen H, Xu Y, Zhou Y, Huang X, Webster KA, Yu H*, Wang JA*. Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells. 2014 Oct;32(10):2702-13.

Hu X#, Wu R#, Shehadeh LA, Zhou Q, Jiang C, Huang X, Zhang L, Gao F, Liu X, Yu H, Webster KA*, Wang JA*. Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem  cells. BMC Genomics. 2014 Apr 23;15:303.

Xu Y#, Hu X#, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J*, Wang J*. Preconditioning via angiotensin type 2 receptor activation improves therapeutic efficacy of bone marrow mononuclear cells for cardiac repair. PLoS One. 2013 Dec 10;8(12):e82997.(Co-first author)

Xu Y#, Hu X#, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J*, Wang JA*. Transplantation of preconditioned bone marrow mononuclear cells  by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells. Int J Cardiol. 2013 Oct 9;168(4):4551-4. (Co-first author)

Hu X#, Wang WX, Yu MJ, Liu XB, Wu RR, Gao F, Huang X, Cao J, Xie XJ, Wang JA*. Tongxinluo promotes mesenchymal stem cell tube formation in vitro. J Zhejiang Univ Sci B. 2011 Aug;12(8):644-51.

Hu X#, Wei L#, Taylor TM, Wei J, Zhou X, Wang JA*, Yu SP. Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation. Am J Physiol Cell Physiol. 2011 Aug;301(2):C362-72.

Hu X#, Yu SP, Fraser JL, Lu Z, Ogle ME, Wang JA, Wei L*. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg. 2008 Apr;135(4):799-808. doi: 10.1016/j.jtcvs. 2007.07.071. PMID: 18374759

Hu X#, Wang J*, Chen J, Luo R, He A, Xie X, Li J. Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction. Eur J Cardiothorac Surg. 2007 Mar;31(3):438-43.


Current Program

Translational study of hypoxia-preconditioned stem cell-derived exosomes for heart failure. Funding Source: Key Research and Development Program of Zhejiang Province.

The effect of hPSCs differentiated cardiovascular pregenitor cells and functional cells on infarcted myocardium repair. Funding Source: National Key Research and Development Program of China.

The effect and mechanism of Flavin-containing monooxidase (FMO2)on myocyte survival. Funding Source: National Natural Science Foundation of China.

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