Publications

Ke C#, Xiao C, Li J, Wu X, Zhang Y, Chen Y, Sheng S, Fu Z, Wang L, Ni C, Zhao J, Shi Y, Wu Y, Zhong Z, Nan J, Zhu W, Chen J, Wu R*, Hu X*. FMO2 ameliorates nonalcoholic fatty liver disease by suppressing ER-to-Golgi transport of SREBP1. Hepatology. 2023 Oct 24. doi: 10.1097/HEP.0000000000000643. Epub ahead of print. PMID: 37874228.

Wu R#, Hu X*, Wang J*. Current optimized strategies for stem cell-derived extracellular vesicle/exosomes in cardiac repair. J Mol Cell Cardiol. 2023 Nov;184:13-25. doi: 10.1016/j.yjmcc.2023.09.006. Epub 2023 Oct 4. PMID: 37801756.

Koo BK#, Hu X*, Kang J#, Zhang J, Jiang J, Hahn JY, Nam CW, Doh JH, Lee BK, Kim W, Huang J, Jiang F, Zhou H, Chen P, Tang L, Jiang W, Chen X, He W, Ahn SG, Yoon MH, Kim U, Lee JM, Hwang D, Ki YJ, Shin ES, Kim HS, Tahk SJ, Wang J*; FLAVOUR Investigators. Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI. N Engl J Med. 2022 Sep 1;387(9):779-789. doi: 10.1056/NEJMoa2201546. PMID: 36053504.

Ni C#, Chen Y#, Xu Y, Zhao J, Li Q, Xiao C, Wu Y, Wang J, Wang Y, Zhong Z, Zhang L, Wu R, Liu Q, Wu X, Ke C, Zhu W, Chen J, Huang J, Wang Y, Wang J, Hu X*. Flavin Containing Monooxygenase 2 Prevents Cardiac Fibrosis via CYP2J3-SMURF2 Axis. Circ Res. 2022 Jul 5:101161CIRCRESAHA122320538. doi: 10.1161/CIRCRESAHA.122.320538. Epub ahead of print. PMID: 35861735.

Ding H#, Ding J#, Liu Q#, Lin J, He M, Wu X, Chen X, Xiao C, Ren T, Zhu Y, Gao C*, Hu X*, Wang J*. Mesenchymal stem cells encapsulated in a reactive oxygen species-scavenging and O2-generating injectable hydrogel for myocardial infarction treatment. Chemical Engineering Journal. 2022;433(2):133511.

Tao Y#, Liu Q#, Wu R#, Xiao C, Ni C, Wang K, Hu W, Zhong Z, Zhao J, Li Q, Zhu D, Zhong S, Yu H, Zhu W, Chen J, Hu X*, and Wang J*. Long noncoding RNA LUCAT1 enhances the survival and therapeutic effects of mesenchymal stromal cells post-myocardial infarction. Molecular Therapy Nuclear Acids. 2021 Dec 11;27:412-436.

Wu R#, Hu W#, Chen H, Wang Y, Li Q, Xiao C, Fan L, Zhong Z, Chen X, Lv K, Zhong S, Shi Y, Chen J, Zhu W, Zhang J, Hu X*, Wang J*. A Novel Human Long Noncoding RNA SCDAL Promotes Angiogenesis through SNF5-Mediated GDF6 Expression. Advanced Science. 2021 Sep;8(18):e2004629.

Hua S#, Zhong S#, Hamed A#, He J#, Zhong D, Zhang D, Chen X, Qian J, Hu X*, Zhou M*. Simultaneous Deep Tracking of Stem Cells by Surface Enhanced Raman Imaging Combined with Single-Cell Tracking by NIR-II Imaging in Myocardial Infarction. Advanced Functional Materials. 2021,2100468.

Li Q#, Xu Y#, Lv K#, Wang Y, Zhong Z, Xiao C, Zhu K, Ni C, Wang K, Kong M, Li X, Fan Y, Zhang F, Chen Q, Li Y, Li Q, Liu C, Zhu J, Zhong S, Wang J, Chen Y, Zhao J, Zhu D, Wu R, Chen J, Zhu W, Yu H, Ardehali R, Zhang JJ*, Wang J*, Hu X*. Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates. Sci Transl Med. 2021 Mar 10;13(584):eabb0202.

Zhang L#, Liu G#, Lv K#, Xin J, Wang Y, Zhao J, Hu W, Xiao C, Zhu K, Zhu L, Nan J, Feng Y, Zhu H, Chen W, Zhu W, Zhang J, Wang J, Wang B*, Hu X*. Surface-Anchored Nanogel Coating Endows Stem Cells with Stress Resistance and Reparative Potency via Turning Down the Cytokine-Receptor Binding Pathways. Advanced Science. 2021 Jan 6;8(3):2003348.

Wu X#, Wu B, He W#, Wang X, Wang K, Yan Z, Cheng Z, Huang Y, Zhang W, Chen R, Liu J, Wang J, Hu X*. Expanding the coronary tree reconstruction to smaller arteries improves the accuracy of FFRCT. Eur Radiol. 2021 Dec;31(12):8967-8974.

Hu X#, Zhang J#, Lee JM, Chen Z, Hwang D, Park J, Shin ES, Nam CW, Doh JH, Chen S, Yang J, Tanaka N, Kuramitsu S, Matsuo H, Takashima H, Akasaka T, Koo BK, Wang J*. Prognostic impact of diabetes mellitus and index of microcirculatory resistance in patients undergoing fractional flow reserve-guided revascularization. Int J Cardiol. 2020;307:171-175.

Lv K#, Li Q#, Zhang L, Wang Y, Zhong Z, Zhao J, Lin X, Wang J, Zhu K, Xiao C, Ke C, Zhong S, Wu X, Chen J, Yu H, Zhu W, Li X, Wang B, Tang R, Wang J, Huang J*, Hu X*. Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction. Theranostics. 2019 Oct 11;9(24):7403-7416.

Xiao C#, Wang K, Xu Y, Hu H, Zhang N, Wang Y, Zhong Z, Zhao J, Li Q, Zhu D, Ke C, Zhong S, Wu X, Yu H, Zhu W, Chen J, Zhang J, Wang J*, Hu X*. Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b. Circulation Research. 2018 Aug 16; 123(5): 564-578.

Wu R#, Hu X*, Wang J*. Concise Review: Optimized Strategies for Stem Cell-Based Therapy in Myocardial Repair: Clinical Translatability and Potential Limitation. Stem Cells. 2018 Apr;36(4):482-500. doi: 10.1002/stem.2778.

Zhu K#, Wu Q#, Ni C#, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang H*, Hu X*, Wang JA*. Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates. Circ Res. 2018 Mar 30;122(7):958-969. doi: 10.1161/CIRCRESAHA.117.311578.

Wang K#, Jiang Z, Webster KA, Chen JH, Hu HX, Zhou Y, Zhao J, Wang LH, Wang YC, Zhong ZW, Ni C, Li QJ, Xiang C, Zhang L, Wu RR, Zhu W, Yu H, Hu X*, Wang JA*. Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Transl Med. 2017 Jan;6(1):209-222.

Hu X#, Yang H, Zhu Y, Wang J*, Dong E*. Chinese Basic Cardiovascular Research in Transition. Circulation Research. 2016;118(12):1876-9.

Hu X#, Xu Y#, Zhong Z, Wu Y, Zhao J, Wang Y, Cheng H, Kong M, Zhang F, Chen Q, Sun J, Li Q, Jin J, Li Q, Chen L, Wang C, Zhan H, Fan Y, Yang Q, Yu L, Wu R, Liang J, Zhu J, Wang Y, Jin Y, Lin Y, Yang F, Jia L, Zhu W, Chen J, Yu H, Zhang J*, Wang J*. A Large-scale Investigation of Hypoxia-preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-human Primates: Paracrine Activity Without Remuscularization. Circulation Research. 2016 Mar 18;118(6):970-83.

Hu X#, Chen P# , Wu Y, Wang K, XuY , Chen H , ZhangL, Wu R, Webster KA,Yu H, Zhu W*, Wang JA*. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016;34(7):1846-58.

Hu X#*, Zhang L#, Jin J, Zhu W, Xu Y, Wu Y, Wang Y, Chen H, Webster KA, Chen H, Yu H, Wang JA*. Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells. 2015 Jun;33(6):1850-62.

Hu X#, Huang X, Yang Q, Wang L, Sun J, Zhan H, Lin J, Pu Z, Jiang J, Sun Y, Xiang M, Liu X, Xie X, Yu X, Chen Z, Tse HF, Zhang J, Wang JA*. Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial. Int J Cardiol. 2015 Apr 1;184:446-51.

Hu X#, Wu R#, Jiang Z, Wang L, Chen P, Zhang L, Yang L, Wu Y, Chen H, Chen H, Xu Y, Zhou Y, Huang X, Webster KA, Yu H*, Wang JA*. Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells. 2014 Oct;32(10):2702-13.

Hu X#, Wu R#, Shehadeh LA, Zhou Q, Jiang C, Huang X, Zhang L, Gao F, Liu X, Yu H, Webster KA*, Wang JA*. Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. BMC Genomics. 2014 Apr 23;15:303.

Xu Y#, Hu X#, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J*, Wang J*. Preconditioning via angiotensin type 2 receptor activation improves therapeutic efficacy of bone marrow mononuclear cells for cardiac repair. PLoS One. 2013 Dec 10;8(12):e82997.

Xu Y#, Hu X#, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J*, Wang JA*. Transplantation of preconditioned bone marrow mononuclear cells  by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells. Int J Cardiol. 2013 Oct 9;168(4):4551-4.

Hu X#, Wang WX, Yu MJ, Liu XB, Wu RR, Gao F, Huang X, Cao J, Xie XJ, Wang JA*. Tongxinluo promotes mesenchymal stem cell tube formation in vitro. J Zhejiang Univ Sci B. 2011 Aug;12(8):644-51.

Hu X#, Wei L#, Taylor TM, Wei J, Zhou X, Wang JA*, Yu SP. Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation. Am J Physiol Cell Physiol. 2011 Aug;301(2):C362-72.

Hu X#, Yu SP, Fraser JL, Lu Z, Ogle ME, Wang JA, Wei L*. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg. 2008 Apr;135(4):799-808. doi: 10.1016/j.jtcvs. 2007.07.071. PMID: 18374759.

Hu X#, Wang J*, Chen J, Luo R, He A, Xie X, Li J. Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction. Eur J Cardiothorac Surg. 2007 Mar;31(3):438-43.