Position：Vice Chair of Clinical Laboratory Medicine
Department：Clinical Laboratory Medicine
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Associate Chief Technician
Clinical blood, body fluid test, laboratory test automation and information management.
Mechanism and evaluation of matrine in the treatment of colorectal cancer, Zhejiang Scientific and Technological Progress Award, Third Prize of, 2012.
Study on mutation characteristics, biological characteristics and clinical significance of genes related to gastrointestinal adenocarcinoma, Zhejiang Scientific and Technological Progress Award, Third Prize of, 2005.
Member, Chinese Society of Immunology
Member, Clinical Immunology Committee, Zhejiang Immune Society
Member, Management Team, Zhejiang Provincial Laboratory Medicine Branch
Clinical data show that aspirin has the effect of reducing tumor metastasis, but it is not clear whether the effect can affect the EMT program. Epithelial mesenchymal transition(EMT) is closely related to post-translational modifications such as transcription factor acetylation, which is the first step in colorectal cancer and other tumor metastasis. Dr. Jin's research uses the TGF-β induced EMT model established by himself to study the molecular mechanism of aspirin acetylation key transcription factors and their inhibition on colorectal cancer cell by Transwell, cellular immunofluorescence analysis, qRTPCR, Western blot, siRNA interference,immunoprecipitation (IP). In summary, his study indicates that Aspirin can affect the occurrence of tumor cell EMT by regulating the acetylation and nucleation behavior of ZEB1, thereby inhibiting the colon cancer cell migration ability.
SHENGHANG JIN and XIANGUO WU. Aspirin inhibits colon cancer cell line migration through regulating epithelial-mesenchymal transition via Wnt signaling. Oncol Lett, 17: 4675-4682, 2019.
Shenghang Jin, Minjin Wu, Hanqin Cao, et al. p27kip1 Upregulated by hnRNPC1⁄2 Antagonizes CagA (a Virulence Factor of Helicobacter pylori) Mediated Pathogenesis. Helicobacter, 2012.17: 140–147.
Huang, Jian; Jin Sheng-hang; Zhang Shu-zhan, et al. Mutational studies of adenomatous polyposis coli gene in carcinomas form patients with hereditary non-polyposis colorectal. Chinese Journal of Medical Genetics, 2003, 20(3):196-199.
Natural Science Foundation of Zhejiang (LY15H160037)
Zhejiang Provincial Department of Education (Y201330050)
88 Jiefang Road,Shangcheng District Hangzhou,China, 310009
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