Wang Shuang, M.D., Ph.D.

Position:Vice Chair of Neurology, Vice Director of Neurology Epilepsy Center


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Professor, Chief Physician


Clinical / Research Interests

Seizure disorders


Pharmacoresistant epilepsy


Professional Highlights

Zhejiang Scientific and Technological Innovation Award, Third Prize, 2011

Professional Appointments

Committee Member, Group of EEG and Epilepsy, Chinese Society of Neurology, Chinese Medical Association, 2020-present

Committee Member, Chinese Association Against Epilepsy, 2019-present

Vice Chair, Zhejiang Association Against Epilepsy, 2017-present

Education Experience

Research Summary

Dr. Wang is engaged in diagnosis and treatment of seizure disorders, EEG analysis and presurgical evaluation of pharmacoresistant epilepsy. His research is focused on the mechanism of epileptogenesis and probing epileptic network using neurophysiological and imaging techniques. 


Chen B, Xu C, Wang Y, Lin W, Wang Y, Chen L, Cheng H, Xu L, Hu T, Zhao J, Dong P, Guo Y, Zhang S, Wang S, Zhou Y, Hu W, Duan S, Chen Z. A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy. Nat Commun. 2020;11:923.

Wang S, et al. Direct Septum-Hippocampal Cholinergic Circuit Attenuates Seizure Through Driving Somatostatin Inhibition. Biol Psychiatry. 2019. pii:S0006-3223(19)31883-9. 

Wang S, et al. Localization value of subclinical seizures on scalp video-EEG in epilepsy presurgical evaluation. Epilepsia. 2019;60:2477-2485.

Xu C, Wang Y, Zhang S, Nao J, Liu Y, Wang Y, Ding F, Zhong K, Chen L, Ying X, Wang S,et al. Subicular pyramidal neurons gate drug resistance  in temporal lobe epilepsy. Ann Neurol. 2019;86:626-640.

Wang S, et al. Multimodal noninvasive evaluation in MRI-negative operculoinsular epilepsy. J Neurosurg. 2019:1-11.

Fang J, Jirsch J, Wang S,et al. Neurologists' attitudes toward driving among persons with epilepsy in China: A pilot electronic survey. Epilepsy Behav. 2019;94:47-51.

Chen C, Li H, Ding F, Yang L, Huang P, Wang S, et al. Alterations in the hippocampal-thalamic pathway underlying secondarily generalized tonic-clonic seizures in mesial temporal lobe epilepsy: A diffusion tensor imaging study. Epilepsia. 2019;60:121-130.

Wang S,et al. Application of MRI Post-processing in Presurgical Evaluation of Non-lesional Cingulate Epilepsy. Front Neurol. 2018 Nov 27;9:1013. 

Wang Y, Liang J, Chen L, Shen Y, Zhao J, Xu C, Wu X, Cheng H, Ying X, Guo Y, Wang S, Zhou Y, Wang Y, Chen Z. Pharmaco-genetic therapeutics targeting parvalbumin neurons attenuate temporal lobe epilepsy. Neurobiol Dis. 2018;117:149-160.

Ding Y, Zhu Y, Jiang B, Zhou Y, Jin B, Hou H, Wu S, Zhu J, Wang ZI, Wong CH, Ding M, Zhang H, Wang S, Tian M. (18)F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2018;45:1567-1572. 

Cen Z, Jiang Z, Chen Y, Zheng X, Xie F, Yang X, Lu X, Ouyang Z, Wu H, Chen S,  Yin H, Qiu X, Wang S, et al. Intronic pentanucleotide TTTCA repeat insertion in the SAMD12 gene causes familial cortical myoclonic tremor with epilepsy type 1. Brain. 2018 [In press] 

Jin B, Krishnan B, Adler S, Wagstyl K, Hu W, Jones S, Najm I, Alexopoulos A, Zhang K, Zhang J, Ding M, Wang S, Wang ZI. Automated detection of focal cortical dysplasia type II with surface-based magnetic resonance imaging postprocessing and machine learning. Epilepsia. 2018;59:982-992. 

Ji C, Zhu L, Chen C, Wang S, Zheng L, Li H. Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. Neurosci Bull. 2018;34:389-396. 

Jin B, Hu W, Ye L, Krishnan B, Aung T, Jones SE, Najm IM, Alexopoulos AV, Zhang K, Zhu J, Zhang J, Ding M, Chen Z, Wang S, Wang ZI. Small Lesion Size Is Associated with Sleep-Related Epilepsy in Focal Cortical Dysplasia Type II. Front Neurol. 2018;9:106.

Wang S, So NK, Jin B, et al. Interictal ripples nested in epileptiform discharge help to identify the epileptogenic zone in neocortical epilepsy. Clin Neurophysiol. 2017;128:945-951.

Zhou Y, Zhu L, Jin B, Wu X, Ding M, Wang S. Gelastic seizures caused by subtle focal cortical dysplasia in the inferior frontal gyrus: Three case reports. J Neurol Sci. 2017;376:140-142.

Li H, Ji C, Zhu L, Huang P, Jiang B, Xu X, Sun J, Chen Z, Ding M, Zhang M, Wang S. Reorganization of anterior and posterior hippocampal networks associated with memory performance in mesial temporal lobe epilepsy. Clin Neurophysiol. 2017;128(5):830-838.

Yang L, Li H, Zhu L, Yu X, Jin B, Chen C, Wang S, Ding M, Zhang M, Chen Z, Wang S. Localized shape abnormalities in the thalamus and pallidum are associated with secondarily generalized seizures in mesial temporal lobe epilepsy. Epilepsy Behav. 2017;70:259-264.

Wang Y, Xu C, Xu Z, Ji C, Liang J, Wang Y, Chen B, Wu X, Gao F, Wang S, Guo Y, Li X, Luo J, Duan S, Chen Z. Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy. Neuron. 2017;95:1221.

Wang S, Graf S, Xu J, et al. The incidence of peri-ictal prone position in patients with generalized convulsive seizures. Epilepsy Behav. 2016;61:158-61.

Xu C, Wang S, Wang Y, et al. A decrease of ripples precedes seizure onset in mesial temporal lobe epilepsy. Exp Neurol. 2016;284:29-37.

Jin B, So NK, Wang S. Advances of Intracranial Electroencephalography in Localizing the Epileptogenic Zone. Neurosci Bull. 2016;32:493-500 9.

Xu J, Jin B, Yan J, Wang J, Hu J, Wang Z, Chen Z, Ding M, Chen S, Wang S. Postictal generalized EEG suppression after generalized convulsive seizures: A double-edged sword. Clin Neurophysiol. 2016;127(4):2078-84.

Jin B, Wu H, Xu J, Yan J, Ding Y, Wang ZI, Guo Y, Wang Z, Shen C, Chen Z, Ding M, Wang S. Analyzing reliability of seizure diagnosis based on semiology. Epilepsy Behav. 2014;41:197-202.

Jin B, Zhao Z, Ding Y, Guo Y, Shen C, Wang Z, Tang Y, Zhu J, Ding M, Wang S. Diagnostic yield of inpatient video-electroencephalographic monitoring: experience from a Chinese comprehensive epilepsy center. Epilepsy Behav. 2014 ;34:77-80.

Wang S, Wang IZ, Bulacio JC, et al. Ripple classification helps to localize the seizure-onset zone in neocortical epilepsy. Epilepsia. 2013;54(2):370-6.

Wang S, Wu DC, Fan XN, et al. Mediodorsal thalamic stimulation is not protective against seizures induced by amygdaloid kindling in rats. Neurosci Lett. 2010;481(2):97-101.

Ding Y, Wang S, Zhang MM, et al. Fructose-1,6-diphosphate inhibits seizure acquisition in fast hippocampal kindling. Neurosci Lett. 2010;477(1):33-6.

Gao F, Wang S, Guo Y, et al. Protective effects of repetitive transcranial magnetic stimulation in a rat model of transient cerebral ischaemia: a microPET study. Eur J Nucl Med Mol Imaging. 2010;37(5):954-61.

Liu XQ, Li FC, Wang JW, Wang S. Postpartum septic sacroiliitis misdiagnosed as sciatic neuropathy. Am J Med Sci. 2010;339(3):292-5.

Ding Y, Wang S, Liu J, et al. Neuropsychiatric profiles of patients with insulinomas. Eur Neurol. 2010;63(1):48-51.

Gao F, Guo Y, Zhang H, Wang S, et al. Anterior thalamic nucleus stimulation modulates regional cerebral metabolism: an FDG-MicroPET study in rats. Neurobiol Dis. 2009;34(3):477-83.

Wang S, Hu HT, Wen SQ, et al. An insulinoma with clinical and electroencephalographic features resembling complex partial seizures. J Zhejiang Univ Sci B. 2008;9(6):496-9.

Wang S, Ding M, Wu D, et al. omega-Conotoxin MVIIA inhibits amygdaloid kindled seizures in Sprague-Dawley rats. Neurosci Lett. 2007;413(2):163-7.

Wang S, Wu JM, Cheng YS. Asymmetric cerebral lesion pattern in X-linked adrenoleukodystrophy. J Chin Med Assoc. 2006;69(8):383-6.  

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