Jiang Jun, M.D.

Position:Executive Vice Chair of Cardiology

Department:Cardiology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician 


Appointment

Clinical / Research Interests

Coronary heart disease, especially PCI of complex lesions such as calcified coronary lesions, chronic total occlusion and left main;

Cardiac arrhythmia, diagnosis, medical treatment and catheter ablation.

Professional Highlights

Excellent Student Award of Zhejiang University, 1999

Science and Technology Advancement Prize of Zhejiang Prince, 2001

Excellent Teacher for Interns of School of Medicine, Zhejiang University, 2002

Excellent Staff Award of Sir Run Run Shaw Hospital, 2003

Science and Technology Advancement Prize of Zhejiang Province, 2005

Science and Technology Advancement Prize of Zhejiang Province, 2008

Science and Technology Advancement Prize of Zhejiang Province, 2020

Professional Appointments

2007 – 2009        Secretary, Zhejiang Society of Cardiac Electrophysiology and Pacing

2009 – Present      Secretary, Zhejiang Society of Cardiology

2009 – 2018        Young Member, Chinese Society of Cardiology

2009 – 2018        Young Member, Chinese Society of Heart Rhythm

2014 – Present      Committee member, Zhejiang Society of Cardiology

2016 – Present      Fellow of American College of Cardiology

2019 – Present      Standing committee member, Chinese College of Cardiovascular Physicians

2020– Present      Vice President, Zhejiang Society of Cardiology

Education Experience

Zhejiang  University     1993-1998          B.Sc.               Medicine

Zhejiang  University     1998-2000          Master in Medicine    Medicine

Zhejiang  University     2003-2007          M.D.               Internal Medicine

Research Summary

Publications

Jiang H, Yu YQ, Jiang J, et al. The effect of ATP sensitive potassium channel in ischaemic preconditioning of rat myocardium (in Chinese). Journal of Zhejiang University (Medical Sciences) 1999;28(6):241-244

Jiang J, Liang HW, Chen ZX. Nitric oxide and long-term depression (in Chinese). Journal of Zhejiang University (Medical Sciences) 2001;30(1):43-46

Guo HY, He H, Jiang J, et al. Study on the compliance of antihypertensive drugs in patients with hypertension. Chin J of Epidemiol 2001;22(6):418-420

Jiang J, Yang Q, Sun Y, et al. Application of clopidogrel in peri-percutaneous coronary angioplasty and stent implantation (in Chinese). Chin JMAP 2002;19(6):444-445

Jiang J, Wang JA, Chen XY. Radiofrequency catheter ablation autonomic nerve injury (in Chinese). Journal of Zhejiang University (Medical Sciences) 2002;31(3):195-198

Yang Q, Jiang J, Sheng X, et al. The perioperative change of echocardiogram in chemical ablation of hypertrophic obstructive cardiomyopathy(in Chinese). Prevention and Treatment of Cerebrocardiovascular Disease 2002;2(2):25-26

Guo HY, Jiang J, Zheng JX, et al. Study of the compliance of antihypertensive drugs in outpatients and inpatients with hypertension(in Chinese). Bulletin of Science and Technology 2002;18(3):247-250

Guo HY, Ding f, Jiang J, et al. The plasma level of homocysteine in patients with coronary heart disease and intervention with folic acid(in Chinese). Acta Academiae Medicinae Sinicae 2002;24(6):661

Wang JA, Jiang J. Diabetes Mellitus and β-blockade(in Chinese). Chin J of Cardiovascular Disease 2004;32(10):952-954

Jiang J, Wang JA, Li CL, et al. The protective effects of tumor necrosis factor α receptor 1 deletion on hindlimb ischemia. Chin J of Emerg Med 2006, 15(3):197-202

Wang JA, Xie XJ, He H, Sun Y, Jiang J, et al. A prospectiverandomizedcontrolled trial of autologous mesenchymal stem cells transplantation for dilated cardiomyopathy. Chin J of Cardiol 2006;34(2):107-110

Gui C, Wang JA, He AN, Chen TL, Luo RH, Jiang J, Hu XY, Xie XJ. Heregulin protects mesenchymal stem cells from serum deprivation and hypoxia-induced apoptosis. Mol Cell Biochem. 2007;305(1-2):171-8.

Jiang J, Wei L, Wang JA. Erythropoietin signal pathway is upregulated in mesenchymal stem cell during hypoxia. Chin J of Emerg Med 2007,16(7):677-682

Cui L, Jiang J, Wei L, Zhou X, Fraser JL, Snider BJ, Yu SP. Transplantation of Embryonic Stem Cells Improves Nerve Repair and Functional Recovery after Severe Sciatic Nerve Axotomy in Rats. Stem Cells. 2008;26(5):1356-65.

Zhang N, Li J, Luo R, Jiang J, Wang JA. Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy. Exp Clin Endocrinol Diabetes. 2008;116(2):104-11.

Gui C, Wang JA, He AN, Chen TL, Liu XB, Luo RH, Jiang J. Expression of heregulin and ErbB receptors in mesenchymal. Chin Med J (Engl). 2008;121(2):155-60.

Wang JA, He A, Hu X, Jiang Y, Sun Y, Jiang J, Gui C, Wang Y, Chen H. Anoxic preconditioning: A way to enhance the cardioprotection of mesenchymal stem cells. Int J Cardiol. 2008 Jan 28;

Wang JA, Chen TL, Jiang J, Shi H, Gui C, Luo RH, Xie XJ, Xiang MX, Zhang X. Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells. Acta Pharmacol Sin. 2008;29(1):74-82.

Liu XB, Jiang J, Gui C, Hu XY, Xiang MX, Wang JA. Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathway. Acta Pharmacol Sin. 2008;29(7):815-22.

Chen XF, Tang LJ, Jiang JJ, Jiang J, Hu XY, Yu WF, Wang JA. Increased levels of lipoprotein(a) in non-smoking aortic dissection patients. Clin Exp Med. 2008;8(2):123-7.

Li CL, Jiang J, Fan YQ, Fu GS, Wang JA, Fan WM. Knockout of the tumor necrosis factor a receptor 1 gene can up-regulate erythropoietin receptor during myocardial ischemia-reperfusion injury in mice. Chin Med J 2009;122(5):566-570

Jiang J, Li CL, Wei L, et al. Dual role of tumor necrosis factor α receptor 1 in a mouse model of hindlimb ischemia. Vasc Med 2009,14:37-46

Jiang J, Sun Y, Xiang MX, et al. Complex coronary lesions and rotational atherectomy: one hospital's experience.J Zhejiang Univ Sci B. 2012;13(8):645-51

Chen TL, Zhu GL, Wang JA, Wang Y, He XL, Jiang J. Apoptosis of bone marrow mesenchymal stem cells caused by hypoxia/reoxygenation via multiple pathways. Int J Clin Exp Med. 2014;7(12):4686-97.

Wang S, Dai YX, Chen LL, Jiang T, Zheng MQ, Li CG, Chen YP, Lin WH, Zhang JF, Jiang J. Effect of IL-1β, IL-8, and IL-10 polymorphisms on the development of myocardial infarction. Genet Mol Res 2015;14(4):12016-21

Hu P, Tang MY, Song WC, Jiang J, Sun Y, Liu XB, Li CL, Hu XY, Wang JA. Fractional Flow Reserve Guided Percutaneous Coronary Intervention Improves Clinical Outcome with Reduced Cost in Contemporary Clinical Practice. Chin Med J (Engl). 2015;128(15):2000-5

Zhong Z, Hu JQ, Wu XD, Sun Y, Jiang J. Myocardin-related transcription factor-A-overexpressing bone marrow stem cells protect cardiomyocytes and alleviate cardiac damage in a rat model of acute myocardial infarction. Int J Mol Med. 2015 Sep;36(3):753-9

Liu XB, Jiang JB, Zhou QJ, Pu ZX, He W, Dong AQ, Feng Y, Jiang J, Sun Y, Xiang MX, He YX, Fan YQ, Dong L, Wang JA. Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population. J Zhejiang Univ Sci B. 201;16(3):208-14.

Xie XJ, Jiang JB, Jiang J, Wang JA. Concurrent pulmonary thrombosis with systemic embolism: a case report. J Zhejiang Univ Sci B. 2014;15(9):838-44. doi: 10.1631/jzus.B1400209.

Liu M, Chen H, Jiang J, Zhang Z, Wang C, Zhang N, Dong L, Hu X, Zhu W, Yu H, Wang J. Stem cells and diabetic cardiomyopathy: from pathology to therapy. Heart Fail Rev. 2016;21(6):723-736.

Zhong Z, Hu JQ, Wu XD, Sun Y, Jiang J. Anti-apoptotic effects of myocardin-related transcription factor-A on rat cardiomyocytes following hypoxia-induced injury. Can J Physiol Pharmacol. 2016 Apr;94(4):379-87.

Wang C, Chen H, Zhu W, Xu Y, Liu M, Zhu L, Yang F, Zhang L, Liu X, Zhong Z, Zhao J, Jiang J, Xiang M, Yu H, Hu X, Lu H, Wang J. Nicotine Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells. Arterioscler Thromb Vasc Biol. 2017;37(1):53-65.

Jiang J, Hu X, Xiang M, Wang J. Heart Center of SAHZU Transforming Into an Innovative Institute. Circ Res. 2017;121(8):917-919

Wang K, Chen L, Liu L, Cui Y, Zhang X, Jiang J. The effects of atorvastatin on interventional therapy in patients with acute myocardial infarction. Minerva Med. 2019;110(2):101-106.

Jiang J, Tian NL, Cui HB, Li CL, Liu XB, Dong L, Sun Y, Chen XM, Chen SL, Xu B, Wang JA. Post-dilatation improves stent apposition in patients with ST-segment elevation myocardial infarction receiving primary percutaneous intervention: A multicenter, randomized controlled trial using optical coherence tomography. World J Emerg Med. 2020;11(2):87-92

Guo L, Liu MF, Huang JN, Li JM, Jiang J, Wang JA. Role of interleukin-15 in cardiovascular diseases. J Cell Mol Med. 2020;24(13):7094-7101.

Li J, Xie S, Guo L, Jiang J, Chen H. Irisin: linking metabolism with heart failure. Am J Transl Res. 2020;12(10):6003-6014

Li C, Song X, Zhao H, Feng L, Hu T, Zhang Y, Jiang J, Wang J, Xiang J, Sun Y. An 8-layer residual U-Net with deep supervision for segmentation of the left ventricle in cardiac CT angiography. Comput Methods Programs Biomed. 2021 Mar;200:105876

Wu X, You W, Wu Z, Wu Q, Jiang J, Yan H, Ye F, Chen S. Ticagrelor versus clopidogrel for prevention of subclinical stent thrombosis detected by optical coherence tomography in patients with drug-eluting stent implantation-a multicenter and randomized study. Platelets. 2021 Apr 3;32(3):404-412

Xu Y, Shen Y, Chen D, Zhao P, Jiang J. Efficacy and Safety of Dual Antiplatelet Therapy in Patients Undergoing Coronary Stent Implantation: A Systematic Review and Network Meta-Analysis. J Interv Cardiol. 2021 May 5;2021:9934535

Liu H, Wingert A, Wang J, Zhang J, Wang X, Sun J, Chen F, Khalid SG, Jiang J, Zheng D. Extraction of Coronary Atherosclerotic Plaques From Computed Tomography Imaging: A Review of Recent Methods. Front Cardiovasc Med. 2021 Feb 10;8:597568

Qian C, Sun Y, Jiang J. Diagnostic Values of Epicardial Adipose Tissue Thickness with Right Common Carotid Artery Elasticity and Intima-Media Thickness for Middle-Aged and Elderly Patients with Coronary Heart Disease. Int J Gen Med. 2021 Feb 25;14:633-639

Hu P, Sun Y, Li CL, Jin R, Xie Q, Jiang XJ, Wu LP, Jiang JJ, Qiu XB, Cao Y, Ji G, Wang H, Yao ZH, Li B, Xia Y, Wang JA, Jiang J. A randomized comparison of two paclitaxel-coated balloons for the treatment of in-stent restenosis: The LONGTY ISR China randomized trial (LONGTY DCB vs. SeQuent Please DCB). Catheter Cardiovasc Interv. 2021 May 1;97 Suppl 2:988-995

Dong L, Jiang W, Lu W, Jiang J, Zhao Y, Song X, Leng X, Zhao H, Wang J, Li C, Xiang J. Automatic segmentation of coronary lumen and external elastic membrane in intravascular ultrasound images using 8-layer U-Net. Biomed Eng Online. 2021 Feb 6;20(1):16

Liang T, Gao F, Jiang J, Lu YW, Zhang F, Wang Y, Liu N, Fu X, Dong X, Pei J, Cowan DB, Hu X, Wang J, Wang DZ, Chen J. Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction. Circulation. 2020 Dec;142(22):2196-2199.

Jiang J, Li F, Li CL, et al. Fractional flow reserve for coronary stenosis assessment derived from fusion of intravascular ultrasound and X-ray angiography. Quant Imaging Med Surg. 2021 Nov; 11(11): 4543–4555

Li CL, Leng XC, He JS, Xia YQ, Jiang WB, Pan YB, Dong L, Sun Y, Hu XY, Wang JA, Xiang JP, Jiang J. Diagnostic Performance of Angiography-Based Fractional Flow Reserve for Functional Evaluation of Coronary Artery Stenosis. Front Cardiovasc Med. 2021; 8: 714077

Liu HP, Wingert A, Wang XH, Zhang JH, Sun JZ, Chen F, Khalid SG, Gong YL, Xia L, Jiang J, Wang JA, Zheng DC. Consistency in Geometry Among Coronary Atherosclerotic Plaques Extracted From Computed Tomography Angiography. Front Physiol. 2021; 12: 715265.

Zhang YX, Zhang XY, Dong QC, Chen DL, Xu Y, Jiang J. Duration of Dual Antiplatelet Therapy After Implantation of Drug-Coated Balloon. Front Cardiovasc Med. 2021; 8: 762391

Jiang J, Tang LJ, Du CQ, Leng XC, He JS, Hu YM, Dong L, Sun Y, Li CL, Xiang JP, Wang JA. Diagnostic performance of AccuFFRangio in the functional assessment of coronary stenosis compared with pressure wire-derived fractional flow reserve. Quant Imaging Med Surg. 2022 Feb; 12(2): 949–958

Chen DL, Zhang YX, Yidilisi A, Xu Y, Dong QC, Jiang J. Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study. J Clin Endocrinol Metab. 2022 Jun; 107(6): e2572–e2580

Jiang J, Li C, Hu Y, Li C, He J, Leng X, Xiang J, Ge J, Wang J. A novel CFD-based computed index of microcirculatory resistance (IMR) derived from coronary angiography to assess coronary microcirculation. Comput Methods Programs Biomed. 2022 Jun;221:106897

Koo BK, Hu X, Kang J, Zhang J, Jiang J, Hahn JY, Nam CW, Doh JH, Lee BK, Kim W, Huang J, Jiang F, Zhou H, Chen P, Tang L, Jiang W, Chen X, He W, Ahn SG, Yoon MH, Kim U, Lee JM, Hwang D, Ki YJ, Shin ES, Kim HS, Tahk SJ, Wang J; FLAVOUR Investigators. Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI. N Engl J Med. 2022 Sep 1;387(9):779-789.

Ma S, Jiang J. Pulmonary vein stenosis stenting in a patient with persistent left superior vena cava after atrial fibrillation ablation. Eur Heart J. 2023 Mar 14;44(11):1000.

Jiang J, Du C, Hu Y, Yuan H, Wang J, Pan Y, Bao L, Dong L, Li C, Sun Y, Leng X, Xiang J, Tang L, Wang J. Diagnostic performance of computational fluid dynamics (CFD)-based fractional flow reserve (FFR) derived from coronary computed tomographic angiography (CCTA) for assessing functional severity of coronary lesions. Quant Imaging Med Surg. 2023 Mar 1;13(3):1672-1685

Wei QC, Chen YW, Gao QY, Ren KD, Liu YB, He F, Shi JT, Jiang J. Association of stress hyperglycemia with clinical outcomes in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention: a cohort study. Cardiovasc Diabetol. 2023 Apr 12;22(1):85

Zhang J, Hu X, Jiang J, Lu D, Guo L, Peng X, Pan Y, He W, Li J, Zhou H, Huang J, Jiang F, Pu J, Cheng Z, Yang B, Ma J, Chen P, Liu Q, Song D, Lu L, Li S, Fan Y, Meng Z, Tang L, Shin ES, Tu S, Koo BK, Wang J. Rationale and design of a comparison of angiography-derived fractional flow reserve-guided and intravascular ultrasound-guided intervention strategy for clinical outcomes in patients with coronary artery disease: a randomised controlled trial (FLAVOUR II). BMJ Open. 2023 Dec 10;13(12):e074349

Zhang J*, Jiang J*, Hu X, Sun Y, Li C, Zhu L, Gao F, Dong L, Liu Y, Shen J, Ni C, Wang K, Chen Z, Chen H, Li S, Yang S, Kang J, Hwang D, Hahn JY, Nam CW, Doh JH, Lee BK, Kim W, Huang J, Jiang F, Zhou H, Chen P, Tang L, Jiang W, Chen X, He W, Ahn SG, Yoon MH, Kim U, Lee JM, Ki YJ, Shin ES, Kim CH, Tahk SJ, Koo BK, Wang J. Sex Differences in Fractional Flow Reserve- or Intravascular Ultrasound-Guided Percutaneous Coronary Intervention. JACC Cardiovasc Interv. 2023 Oct 9;16(19):2426-2435.

Yang S, Kang J, Hwang D, Zhang J, Jiang J, Hu X, Hahn JY, Nam CW, Doh JH, Lee BK, Kim W, Huang J, Jiang F, Zhou H, Chen P, Tang L, Jiang W, Chen X, He W, Ahn SG, Yoon MH, Kim U, Lee JM, Ki YJ, Shin ES, Kim HS, Tahk SJ, Wang J, Koo BK. Physiology- or Imaging-Guided Strategies for Intermediate Coronary Stenosis. JAMA Netw Open. 2024 Jan 2;7(1):e2350036

Chen D, Yidilisi A, Zhang Y, Fang J, Zheng Y, Gao F, Li W, Zhou H, Chen Y, Lu D, Wang J, Jiang J. Fractional Flow Reserve Guided Drug-Coated Balloon Versus Drug-Eluting Stent for De Novo Non-Small Coronary Lesions.  JACC Cardiovasc Interv. 2024 Feb 13:S1936-8798(24)00313-3

Fan L, Liu J, Hu W, Chen Z, Lan J, Zhang T, Zhang Y, Wu X, Zhong Z, Zhang D, Zhang J, Qin R, Chen H, Zong Y, Zhang J, Chen B, Jiang J, Cheng J, Zhou J, Gao Z, Liu Z, Chai Y, Fan J, Wu P, Chen Y, Zhu Y, Wang K, Yuan Y, Huang P, Zhang Y, Feng H, Song K, Zeng X, Zhu W, Hu X, Yin W, Chen W, Wang J. Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans. Cell Res. 2024 Mar 15.

Wu X, Wang K, Li G, Wu J, Jiang J, Gao F, Zhu L, Xu Q, Wang X, Xu M, Chen H, Ma L, Han X, Luo N, Tu S, Wang J, Hu X. Diagnostic Performance of Angiography-Derived Quantitative Flow Ratio in Complex Coronary Lesions. Circ Cardiovasc Imaging. 2024 Mar;17(3):e016046

Ki YJ, Kang J, Zhang J, Hu X, Jiang J, Hahn JY, Nam CW, Doh JH, Lee BK, Kim W, Huang J, Jiang F, Zhou H, Chen P, Tang L, Jiang W, Chen X, He W, Ahn SG, Yoon MH, Kim U, Hwang D, Shin ES, Kim HS, Tahk SJ, Wang J, Koo BK. Prognostic Implications of Quantitative Flow Ratio and Plaque Characteristics in Intravascular Ultrasound-Guided Treatment Strategy. JACC Cardiovasc Interv. 2024 Feb 26;17(4):461-470.

Lu D, Huang YZ, Guo HY, Zhou JG, Chen C, Wang ZR, Wang JA, He H, Wu XM, Li ZJ, Zhang L, Xian TC, Hu SJ, Zhao BW, Xu G, Jiang J. Cardiac arrhythmias, evidence-based medicine and large scale clinical trials. In: Practical diagnostic and therapeutic guideline for cardiac arrhythmias (in Chinese). Press of Fudan University, Shanghai, pp. 440-441, 2003.

Wang JA, David McFadden, Jiang J, Sheng X. Patient rounds and evaluation: an American perspective (Bilingual edition). People’s Medical Publishing House, Beijing, 2004.

Wang JA, Xiang MX, Sun Y, Jiang J, et al. Fractional flow reserve and coronary artery functional evaluation. People’s Medical Publishing House, Beijing, 2012.

Ge JB, Liu XB, Jiang J, et al. Intravascular Ultrasound. People’s Medical Publishing House, Beijing, 2018.

Current Program

Nature Science Foundation of China, “The effect of pretreatment with SCF and C-CSF on the proliferation and differentiation of marrow stromal cell”, 2002-2003

Nature Science Foundation of Zhejiang Province, “Transplantation of embryonic stem cell to treat failing heart”, 2001-2003

Zhejiang Province Science Office Emphasis Project Grant, “Developing of new stent grafts and real-time intracoronary pressure monitoring system”, 2001-2003

Zhejiang Province Young Medical Investigator Grant, “Transplantation of autologous marrow stromal cell to repair failing heart”, 2001-2003

Zhejiang Province Medical Office Emphasis Project Grant, “The effect of SCF and IGF-I on the proliferation and differentiation of marrow stromal cell”, 2003-2005

Nature Science Foundation of China, “The role of Tie2/Ang1 signal pathway on the survival and paracrine ability of Mesenchymal stem cell”, 2007-2009

Scientific plan of Zhejiang Province, “The effect of central aortic pressure on the prognosis in patients with hypertension”, 2009-2011

Nature Science Foundation of China, “The role of mast cell in cardiac rupture after acute myocardial infarction”, 2012-2014

Nature Science Foundation of China, “The role of interleukin 15 in cardiac rupture after acute myocardial infarction”, 2016-2019

Scientific plan of Zhejiang Province, “Multi parameter noninvasive early diagnosis of coronary microvascular disease”, 2020-2022

Nature Science Foundation of China, “The role and mechanism of GRP94 dependent protein quality control in the outcome of acute myocardial infarction in mice”, 2022-2025

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