Position：Vice Chair of Neurology
Department：Neurology
Medical School：Central South University Schoool of Medicine, China
Academic Rank：Chief Physician
Neurodegenerative disease
Parkinson's disease
Essential tremor
Primary familial brain calcification
Familial cortical myoclonic tremor with epilepsy
Clinical genetics
Zhejiang Scientific and Technological Progress Award, Second Prize, 2017
Zhejiang Scientific and Technological Progress Award, Third Prize, 2012
Zhejiang Scientific and Technological Progress Award, Third Prize, 2011
Chair, Precision Medicine Society of National Association of Health Industry and Enterprise Management, 2019-present
Member, Chinese Society of Neuromodulation , 2019-present
Member, Zhejiang Society of Neurology, 2018-present
Vice Chair, Hydrocephalus Group of Chinese Society of Microcirculation Neurodegenerative Diseases Committee, 2017-present
Member, Professional Committee on Parkinson's Disease and Movement Disorders of Chinese Society of Rehabilitation Medicine, 2017-present
Member, Zhejiang Society of Rare Diseases, 2017-present
Dr. Luo has dedicated to the clinical and basic research of movement disorders for decades, and achieved remarkable outcomes in improving diagnostic accuracy and elucidating the underlying mechanisms of these disorders:
(1) Identification of intronic (TTTCA)n insertion in the SAMD12 gene as the first genetic cause for familial cortical myoclonic tremor with epilepsy based on anticipation phenomenon and linkage analysis;
(2) Identification of JAM2 gene as the genetic cause for primary familial brain calcification and expanding the mutational and phenotypic spectrum of several causative genes for primary familial brain calcification and Parkinson’s disease;
(3) Identification of specific brain functional alterations of Parkinson’s disease patients with depressive disorder or rapid eye movement sleep behavior disorder, shedding new light on the physiopathogenic basis of these disorders;
(4) After finding two novel probable causative genes of Parkinson's disease and one candidate causative gene of essential tremor using homozygosity mapping, next-generation sequencing and long-read sequencing technologies, we plan to collect more patients and identify more novel causative genes for movement disorders by using multiple sequencing technologies, and perform functional studies of these newly identified causative genes;
(5) Develop better strategies for the diagnosis, differential diagnosis and treatment of typical and atypical parkinsonism with the integration of clinical, imaging, molecular genetics and artificial intelligence research.
Wang B(#), Wang J(#), Cen ZD(#), Wei W, Xie F, Chen Y, Sun HY, Hu YS, Yang DH, Lou Y, Chen XH, Ouyang ZY, Chen S, Wang HT, Wang LB, Wang S, Qiu X, Ding Y, Yin HM, Wu S, Zhang BR, Zang YF*, Luo W(*). Altered cerebello-motor network in familial cortical myoclonic tremor with epilepsy type 1. Mov Disord, 2020; 35(6): 1012-1020.
Chen Y(#), Cen ZD(#), Chen XH(#), Wang HT, Chen S, Yang DH, Fu F, Wang LB, Liu P, Wu HW, Zheng XS, Xie F, Ouyang ZY, Zhang Y, Zhou YJ, Huang XR, Wang F, Huang GS, An HW, Liang YB, Hong WJ, Wang AL, Huang SL, Chen WH, Yin LL, Yang Y, Huang HY, Zeng RX, Zhao N, Jiang B, Zhang BR, Luo W(*). MYORG mutation heterozygosity is associated with brain calcification. Mov Disord. 2020; 35(4): 679-686.
Cen ZD(#), Chen Y(#), Chen S(#), Wang H(#), Yang DH, Zhang HM, Wu HW, Wang LB, Tang SY, Ye J, Shen J, Wang HT, Fu F, Chen XH, Xie F, Liu P, Xu X, Cao JZ, Cai P, Pan QQ, Li JY, Yang W, Shan PF, Li YZ, Liu JY, Zhang BR, Luo W(*). Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification. Brain. 2020; 143(2): 491-502.
Xie F, Chen S, Cen ZD, Chen Y, Yang DH, Wang HT, Zhang BR, Luo W(*). A novel homozygous SYNJ1 mutation in two siblings with typical Parkinson's disease. Parkinsonism Relat Disord. 2019; 69: 134-137.
Cen ZD(#), Chen Y(#), Yang DH(#), Zhu QC, Chen S, Chen XH, Wang B, Xie F, Ouyang ZY, Jiang ZW, Fu AS, Hu B, Yin HM, Qiu X, Yu F, Du XP, Hao WC, Liu YX, Wang HT, Wang LB, Yu XF, Xiao YC, Liu CY, Xiao JF, Zhou YX, Yang W, Zhang BR, Luo W(*). Intronic (TTTGA)n insertion in SAMD12 also causes familial cortical myoclonic tremor with epilepsy. Mov Disord. 2019; 34(10): 1571-1576.
Gao JX(#), Guan XJ(#), Cen ZD, Chen Y, Ding XP, Lou YT, Wu S, Wang B, Ouyang ZY, Xuan M, Gu QQ, Xu XJ, Huang PY, Zhang MM, Luo W(*). Alteration of Brain Functional Connectivity in Parkinson's Disease Patients with Dysphagia. Dysphagia. 2019; 34(4): 600-607.
Chen S(#), Cen ZD(#), Fu F, Chen Y, Chen XH, Yang DH, Wang HT, Wu HW, Zheng XS, Xie F, Ouyang ZY, Tang WG, Zhang SH, Yin LL, Zhang YQ, Meng PY, Zhu XZ, Zhang HW, Jiang FF, Zhang KY, He JP, Zhang DH, Ming HQ, Song DQ, Zhou ZP, Luo Y, Gu Q, Su YK, Wu XX, Tang HY, Wu CL, Chen WQ, Liu JY, Luo W(*), Chinese PSG. Underestimated disease prevalence and severe phenotypes in patients with biallelic variants: A cohort study of primary familial brain calcification from China. Parkinsonism Relat Disord. 2019; 64: 211-219.
Chen Y(#), Cen ZD(#), Zheng XS, Pan QQ, Chen XH, Zhu LL, Chen S, Wu HW, Xie F, Wang HT, Yang DH, Wang LB, Zhang BR, Luo W(*). LRP10 in autosomal-dominant Parkinson's disease. Mov Disord. 2019; 34(6): 912-916.
Chen Y, Cen ZD, Zheng XS, Xie F, Chen S, Luo W(*). A novel homozygous CAPN1 pathogenic variant in a Chinese patient with pure hereditary spastic paraplegia. J Clin Neurol. 2019; 15(2): 271-2.
Chen Y(#), Fu F(#), Chen S, Cen ZD, Tang HY, Huang JX, Xie F, Zheng XS, Yang DH, Wang HT, Huang XR, Zhang Y, Zhou YJ, Liu JY, Luo W(*). Evaluation of MYORG mutations as a novel cause of primary familial brain calcification. Mov Disord. 2018; 34(2): 291-7.
Cen ZD(#), Jiang ZW(#), Chen Y, Zheng XS, Xie F, Yang XD, Lu XJ, Ouyang ZY, Wu HW, Chen S, Yin HM, Qiu X, Wang S, Ding MP, Tang YL, Yu F, Li CH, Wang T, Ishiura H, Tsuji S, Jiao C, Liu C, Xiao J, Luo W(*). Intronic pentanucleotide TTTCA repeat insertion in the SAMD12 gene causes familial cortical myoclonic tremor with epilepsy type 1. Brain. 2018; 141: 2280-8.
Ding XP, Gao JX, Xie CY, Xiong B, Wu S, Cen ZD, Lou YT, Lou DN, Xie F, Luo W(*). Prevalence and clinical correlation of dysphagia in Parkinson disease: a study on Chinese patients. Eur J Clin Nutr. 2018; 72(1): 82-6.
Li D(#), Huang PY(#), Zang YF, Lou YT, Cen ZD, Gu QQ, Xuan M, Xie F, Ouyang ZY, Wang B, Zhang MM, Luo W(*). Abnormal baseline brain activity in Parkinson's disease with and without REM sleep behavior disorder: A resting-state functional MRI study. J Magn Reson Imaging. 2017; 46(3): 697-703.
Yang XD, Cen ZD, Cheng HP, Shi K, Bai J, Xie F, Wu HW, Li BB, Luo W(*). L-3-n-Butylphthalide Protects HSPB8 K141N Mutation-Induced Oxidative Stress by Modulating the Mitochondrial Apoptotic and Nrf2 Pathways. Front Neurosci. 2017; 11: 402.
Wu HW(#), Zheng XS(#), Cen ZD, Xie F, Chen Y, Lu XJ, Luo W(*). Genetic analysis of the TMEM230 gene in Chinese patients with familial Parkinson disease. Parkinsonism Relat Disord. 2017; 36: 105-6.
Ye XY(#), Lou DN(#), Ding XP, Xie CY, Gao JX, Lou YT, Cen ZD, Xiao YX, Miao QZ, Xie F, Zheng XS, Wu JX, Li FC(*), Luo W(*). A clinical study of the coronal plane deformity in Parkinson disease. Eur Spine J. 2017; 26(7): 1862-70.
Cen ZD(#), Huang CP(#), Yin HM, Ding XP, Xie F, Lu XJ, Ouyang ZY, Lou YT, Qiu X, Wang ZJ, Xiao JF, Ding MP, Luo W(*). Clinical and neurophysiological features of familial cortical myoclonic tremor with epilepsy. Mov Disord. 2016; 31(11): 1704-10.
Wu HW, Lu XJ, Cen ZD, Xie F, Zheng XS, Chen Y, Luo W(*). Genetic analysis of the CHCHD2 gene in Chinese patients with familial essential tremor. Neurosci Lett. 2016; 634: 104-6.
Wu HW(#), Lu XJ(#), Xie F, Cen ZD, Zheng XS, Luo W(*). Genetic analysis of the CHCHD2 gene in a cohort of Chinese patients with Parkinson disease. Neurosci Lett. 2016; 629: 116-8.
Cen ZD(#), Xie F(#), Xiao JF, Luo W(*). Rational search for genes in familial cortical myoclonic tremor with epilepsy, clues from recent advances. Seizure. 2016; 34: 83-9.
Lou YT(#), Huang PY(#), Li D, Cen ZD, Wang B, Gao JX, Xuan M, Yu HL, Zhang MM, Luo W(*). Altered brain network centrality in depressed Parkinson's disease patients. Mov Disord. 2015; 30(13): 1777-84.
Cen ZD(#), Xie F(#), Lou DN, Lu XJ, Ouyang ZY, Liu L, Cao J, Li D, Yin HM, Wang ZJ, Xiao JF, Luo W(*). Fine mapping and whole-exome sequencing of a familial cortical myoclonic tremor with epilepsy family. Am J Med Genet B Neuropsychiatr Genet. 2015; 168(7): 595-9.
Xie F(#), Cen ZD(#), Xiao JF, Luo W(*). Novel compound heterozygous ALS2 mutations in two Chinese siblings with infantile ascending hereditary spastic paralysis. Neurol Sci. 2015; 36(7): 1279-80.
Xie F(#), Cen ZD(#), Ouyang ZY, Wu S, Xiao JF, Luo W(*). Homozygous p.D331Y mutation in PLA2G6 in two patients with pure autosomal-recessive early-onset parkinsonism: further evidence of a fourth phenotype of PLA2G6-associated neurodegeneration. Parkinsonism Relat Disord. 2015; 21(4): 420-2.
Cen ZD(#), Lu XJ(#), Wang ZZ, Ouyang ZY, Xie F, Luo W(*). BSCL2 S90L mutation in a Chinese family with Silver syndrome with a review of the literature. J Clin Neurosci. 2015; 22(2): 429-30.
Identification and functional study of novel genes causing primary familial brain calcification. Funding Source: National Natural Science Foundation of China.
Research on new precision medicine technology for Parkinson's disease and other movement disorders. Funding Source: Key Research and Development Projects of Zhejiang Province.
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