Wang Huiying, M.D., Ph.D.

Position:Excutive Vice Chair of Allergy and Clinical Immunology

Department:Allergy and Clinical Immunology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor, Chief Physician


Appointment

Clinical / Research Interests

Allergic rhinitis\Asthma

Atopic dermatitis

Acute and chronic urticaria

Professional Highlights

Zhejiang Scientific and Technological Progress Award, Frist Prize, 2012

Scientific and Technological Progress Award, Ministry of Education of China, First Prize, 2010

Professional Appointments

Youth Committee Member, Chinese Society of Allergology, Chinese Medicial Association

Youth Committee Member, Chinese Society of Allergology, Chinese Association of Integrative Medicine

Editorial Member, World Respiratory Journal

Translator and Proofreading Expert, Up to Date Chinese Version

Editorial Member, Allergy Chinese Version

Invited Reviewer, Chinese Journal of Clinicians (Electronic Edition)

Invited Reviewer, National Natural Science Foundation of China

Education Experience

Research Summary

Molicular immunologic mechanism of allergic diseases including the roles of eosinophils and multiple regulatory surface molecule CD69 in allergic asthma.

Publications

Gao Z, Fu WY, Sun Y, Gao B, Wang HY, et al. Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization. Allergy 2019 Feb;74(2):284-293.

Fang ZY, Zhang HT, Lu C, Lu QM, Yu CH, Wang HY#. Association between allergic diseases and irritable bowel syndrome: a retrospective study. Int Arch Allergy Immunol. 2018;177(2):153-159. (Corresponding author)

Xin-Jiang Lu, Qiang Chen, Ye-Jing Rong, Guan-Jun Yang, Chang-Hong Li, Ning-Yi Xu, Chao-Hui Yu, Hui-Ying Wang, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nature Communications. 2016;7:12719.

Gao ZS, Zhou X, Yang ZW, Versteeg SA, Gao L, Fu WY, Wang HY, et al. IgE-binding potencies of three peach Pru p 1 isoforms.Mol Nutr Food Res. 2016 Nov;60(11):2457-2466.

Lu XJ, Chen Q, Rong YJ, Yang GJ, Li CH, Xu NY, Yu CH, Wang HY, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016 Sep 6;7:12719. 

Wang HY, Gao ZS, Zhou X, et al. Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients. Int Arch Allergy Immunol. 2015;167(3):203-10. 

Gao ZS, Ma YT, Zhou X, Yang ZW, Jia HJ, Gao L, Wu SD, Han LY, Yi XY, Wang HY*, et al. Quantification of peach fruit allergen lipid transfer protein by a double monoclonal antibody-based sandwich ELISA. Food Anal Methods. 2015, DOI 10.1007/s12161-015-0272-x

Zhang S, Pan C, Zhou F, Yuan Z, Wang H,et al. Hydrogen sulfide as a potential therapeutic target in fibrosis. Oxid Med Cell Longev. 2015;593407. doi: 10.1155/2015/593407.

Wang HY*, Dai Y, Wang JL, Yang XY, Jiang XG.Anti-CD69 monoclonal antibody treatment inhibits airway inflammation in a mouse model of asthma. J Zhejiang Univ Sci B. 2015;16(7):622-31. (corresponding author)

Wang HY, Shen YH, Yang XY, Tang LF, Zhou JY; Zhejiang Provincial Academy of Allergy.Diagnosis and treatment of allergic diseases in Zhejiang Province: a cross-sectional survey. J Zhejiang Univ Sci B. 2015; 16(7):640-50. 

Wang H*, Zhou N, and Yang X. Update on Diagnosis and Treatment of Pulmonary Alveolar Microlithiasis. WRJ. 2014; 4(3):26-30. (corresponding author)

Yang X,  Gao Y, Wang H,  Zhao X, Gong X, Wang Q, Zhang X. Increased urinary interleukin 22 binding protein levels correlate with lupus nephritis activity. J Rheumatol. 2014;41(9):1793-800.

Wang H*, Yin X, Wu D, and Jiang X. SLC34A2 gene compound heterozygous mutation identification in a patient with pulmonary alveolar microlithiasis and computational 3D protein structure prediction. GeneMeta. 2014; 2:557-564. (corresponding author)

Wang H, Shen H, and Luo F. An adult case of isolated unilateral pulmonary agenesis under general anesthesia. [Chin Med J (Engl)]. 2014; 127(4):789-790 (First author)

Ma Y, Zhou X, Gao Z, Li X, Jia H, Wu H, Xie R, Wang Z, Yu M, Cao K, Chen S, Li Y, Wang H, Ree R. The PpLTP1 primary allergen gene is highly conserved in peach and has small variations in other prunus species. Plant Mol Biol Rep. 2013 Nov.DOI 10.1007/s11105-013-0678-9

Yang XY, Wang HY, Zhao XY, et al. Th22, but not Th17 might be a good index to predict the issue involvement of systemic lupus erythematosus. J Clin Immunol. 2013; 33:767-774. 

Chen CG, Wang HY*, et al. Tripterygium polyglycosid attenuates the established airway inflammation in asthmatic mice. Chin J Integr Med. 2013; 19(4):282-288. (corresponding author)

Gao ZS, Yang YW, Wu SD, Wang HY, et al. Peach allergy in China: a dominant role for mugwort pollen lipid transfer protein as a primary sensitizer, JACI. 2013;131 (1):224-226.

Yin X, Wang H*, Wu D, Zhao G, Shao J, Dai Y. SLC34A2 Gene mutation of pulmonary alveolar microlithiasis: report of four cases and review of literatures. Respir Med. 2013;107(2):217-22. (Corresponding author) 

Wang HY, Gao ZS, Yang ZW, Shao JX, Zhao XZ, Dai Y, Van Ree R.  Anaphylaxis and generalized urticaria from eating Chinese bayberry fruit. J Zhejiang Univ Sci B. 2012;13(10):851-854. 

Wang H*, Wu D, Xiang H, Chen A, Liu J. Pulmonary non-Hodgkin's lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis. Rheumatol Int. 2012;32 (11):3639-42. (corresponding author)

Xia JY, Chen XY, Xu F, Yang Y, Wang HY, Xue J. A case report of systemic lupus erythematosus combined with Castleman's disease and literature review. Rheumatology International. Rheumatol Int. 2012 ;32(7):2189-93. 

Wang H*, Yin X, Wu D. Novel human pathological mutations. SLC34A2. Disease: pulmonary alveolar microlithiasis. Hum Genet. 2010; 127(4):471. (corresponding author)

Ding L, Li W, Wang K, Chen H, Xu H, Wang H, Shen H. Primary tracheobronchial amyloidosis in China: Analysis of 64 aases and a review of literature. J Huazhong Univ Sci Technol. 2010; 30(5): 599-603.

Zhang H, Wu D, Wang Z, Xu J, Wang H*. Primary fibrosarcoma of the diaphragm with pleural effusion.Clin Respir J. 2010 Apr;4(2):127-8. (corresponding author)

Xu F, Yang Y, Xia JY, Chen XY, Wang HY, Shen HH. Clinical profiles of pulmonary lymphangioleiomyomatosis in the mainland of China. Chin Med J (Engl).2009;122(12): 1473-1476. 

Xu Z, Jing J, Wang H*, Ren E, Xu F, Wang J. Progress of pulmonary alveolar proteinosis in China: systemic review of 241 cases. Respirology. 2009;14(5):761-766. (corresponding author)

Xue J, Wang H*, Wu H, Jin Q. Wegener’s granulomatosis complicated by central diabetes insipidus and peripheral neutrophy with normal pituitary in a patient case report. Rheumatology International. 2009; 29(10):1213-7. (corresponding author)

Ochkur SI, Jacobsen EA, Protheroe CA, Biechele TL, Pero RS, McGarry MP, Wang H, et al Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma. J Immunol. 2007 Jun 15; 178(12): 7879-7889.

Wang HY, Shen HH, Lee JJ, and Lee NA. CD69 expression on airway eosinophils and airway inflammation in a murine model of asthma. Chin Med J (Engl) 2006; 119(23): 1983-1990. 

Wang H, Shen H, Jiang Z. Pulmonary Alveolar Microlithiasis: A familial report of 4 cases, CMJ. 2004; 117(6):950-952. 

Wang H, Ochkur SI, McGarry MP, O'Neill KR, Colbert DC, Cormier SA, Lee NA, Shen HH, Lee JJ. CD69 expression on eosinophils is a marker of activation in the lung following allergen provocation. JACI.2004;113(2): s118-s118.

Shen HH, Ochkur SI, McGarry MP, Crosby JR, Hines EM, Borchers MT, Wang H, et al. A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. J Immunol. 2003 Mar 15; 170(6):3296-305. 


Current Program

National key clinical project of allergy.Funding Source: National Key Clinical Project of Health Commission of China.

Variablity of the main peach allergen Pru p 3 among different cultivars and a genome-wide association analysis. Funding Source:  National Natural Science Foundation of China.

Building of CD69 transgenic mouse model and its application in bronchial asthma. Funding Source: Zhejiang Provincial Science and Technology Project.

Study on expression of CD69 on airway eosinophils in mice and the mechanism of the induced apoptosis. Funding Source: National Natural Science Foundation of China.

The investigation and application of the diagnostic technique in the early stage of connective tissue disease related interstitial lung diseases. Funding Source: Zhejiang Provincial Science and Technology Project.

Study on the mechanism of airway remodeling and drug prevention in mouse model of chronic obstructive pulmonary disease. Funding Source: Zhejiang Provincial Science and Technology Project.

Mechanism of CD69-induced apoptosis of eosinophils. Funding Source: Zhejiang Provincial Research Project of Educational Department.


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