Liu Zhenjie, M.D., Ph.D.

Position:Vice Chair of Vascular Surgery

Department:Vascular Surgery

Medical School:Fudan University, Shanghai Medical College, China

Academic Rank:Associate Chief Physician


Clinical / Research Interests

Aneurysm repair (both open and endovascular)

Carotid stenosis (both carotid endarterctomy and carotid artery stent)

Balloon angioplasty and open surgery of peripheral arteries

Vascular access (fistula, graft) in renal patients

Treatment of vein conditions (varicose vein surgery, sclerotherapy, cockett syndrome)

Adrenal vein sample (primary aldosteronism) 

Mesenteric arterial dissection and mesenteric ischemia (Fraction Flow Reserve Application)

Professional Highlights

 Medical Talents Award of Zhejiang Province, 2017

Professional Appointments

Member, American Heart Association (AHA)

Member, Endovascular Vascular Committee, Chinese Medical Association

Member, Committee of Chinese Microcirculation Society

Member,  Chinese Society of Vascular Surgery, Zhejiang Medical Association

Education Experience

Research Summary

Pathogenesis of abdominal aortic aneurysm

Biomarker of abdominal aortic aneurysm rupture

New models of abdominal aortic aneurysm

Database of abdominal aortic aneurysm

Development of endovascular treatment equipment

3D printed vascular microchannel


Jian Shen#, Yao Xie#, Zhenjie Liu# , Shuning Zhang, Yaping Wang, Liangliang Jia, Yidong Wang, Zhejun Cai, Hong Ma, Meixiang Xiang  Increased Myocardial Stiffness Activates Cardiac Microvascular Endothelial Cell via VEGF Paracrine Signaling in Cardiac Hypertrophy. Journal of Molecular and Cellular Cardiology. 2018. Doi: 10.1016/j.yjmcc. 2018.08.014. 

Weijia Xie, Xiaoxiao Song, Zhenjie Liu. Impact of dipeptidyl-peptidase 4 inhibitors on cardiovascular diseases. Vascul Pharmacol. 2018 S1537-1891(17)30299-9. doi: 10.1016/j.vph. 2018.05.010. 

Xiaojie Huang, Fangfang Xu, Carmel Rebecca Assa, Laigen Shen, Bing Chen, Zhenjie Liu. Recurrent Pulmonary Embolism associated with Deep Venous Thrombosis diagnosed as Protein S Deficiency owing to a novel mutation in PROS1: A case report. Medicine. 2018 May; 97(19):e0714.

Weijia Xie, Zhenjie Liu, Bing Chen. Protein C deficiency resulting from two mutations in PROC presenting with recurrent venous thromboembolism. Journal of Vascular Surgery Cases and Innovative Techniques. 2017;3:254-256. 

Arick C. Park, Noel Phan, Dawiyat Massoudi, Zhenjie Liu, John F. Kernien, Sheila M. Adams, Jeffrey M. Davidson, David E. Birk, Bo Liu, Daniel S. Greenspan Deficits in Col5a2 Expression Result in Novel Skin and Adipose Abnormalities and Predisposition to Aortic Aneurysms and Dissections. American Journal of pathology. 2017;187(10):2300-2311 10.1016/j.ajpath. 2017.06.006.

Jian-Cang Zhou, Nan Zhang2, Zhong-Heng Zhang, Ting-Ting Wang, Yue-Feng Zhu, Hui Kang, Wei-Min Zhang, Dong-Lin Li, Wei-Dong Li, Zhen-Jie Liu, Xi-Min Qian, Ming-You Zhang, Jue Wang, Mi Zhou, Zhi-Tao Yang, Yun-Xian Yu, Hang-Yang Li, Jian Zhang, Yong-Gang Wang, Jian-Ping Gao, Lin Ling, Kong-Han Pan; Intensive blood pressure control in patients with acute type B aortic dissection (RAID): study protocol for randomized controlled trial. Journal of Thoracic Disease. 2017 May;9(5):1369-1374. doi: 10.21037/jtd.2017.03.180.

Yidong Wang, Zhenjie Liu, Jun Ren, Meixiang Xiang. Pharmacological Therapy of Abdominal Aortic Aneurysm: An Update. Curr Vasc Pharmacol. 2017 Apr 13. doi: 10.2174/1570161115666170413145705. 

Yu Liu, Qing Gao, Song Du, Zichen Chen, Jianzhong Fu, Bing Chen, Zhenjie Liu, Yong He. Fabrication of cerebral aneurysm simulator with a desktop 3D printer. Scientific report. 2017;17(7) 44301.

Yuhua Zhang, Zhenjie Liu, Guoliang Shen, Jungang Zhang, Carmel Rebecca Assa, Defei Hong. Treatment of distal splenic artery aneurysm by laparoscopic aneurysmectomy with end-to-end anastomosis. MEDICINE. (2017) 96:19(e6260). 

Qiwei Wang, Ting Zhou, Zhenjie Liu, Jun Ren, Noel Phan, Kartik Gupta, Danielle M. Stewart, Stephanie Morgan, Carmel Assa, K.Craig Kent, Bo Liu. Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Scientific Reports. 2017;7:42159. 

Qing Gao, Zhenjie Liu, Zhiwei Lin, Jingjiang Qiu, Yu Liu, An Liu, Yidong Wang, Meixiang Xiang, Bing Chen, Jianzhong Fu, Yong He. 3D Bioprinting of Vessel-like Structures with Multi-level Fluidic Channels. ACS Biomaterial Science & Engineering. 2017, 3 (3): 399–408.

Jun Ren, Zhenjie Liu, Qiwei Wang, Jasmine Giles, Jason Greenberg, Nader Sheibani, K Craig Kent, Bo Liu. Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression. J Pharmacol Exp Ther. 2016; 356:137-147.

Yuefeng Zhu, Jun Ren, Xiaobo Ma, Mu-Hsun Chen, Yifan Zhou, Mingjuan Jin, Zhenjie Liu. Percutaneous Revascularization for Atherosclerotic Renal Artery Stenosis: A Meta-Analysis of Randomized controlled Trials. Annals of Vascular Surgery. 2015;29(7):1457-1467.

Zhenjie Liu, Stephanie Morgan, Jun Ren, Qiwei Wang,Douglas S Annis, Deane F Mosher, Jing Zhang, Christine M Sorenson, Nader Sheibani, Bo Liu. Thrombospondin-1 (TSP1) Contributes to the Development of Vascular Inflammation by Regulating Monocytic Cell Motility in Mouse Models of Abdominal Aortic Aneurysm. Circulation Research. 2015;117(2):129-41. 

Qiwei Wang, Zhenjie Liu, Jun Ren, Stephanie Morgan, Carmel Assa, Bo Liu. Receptor Interacting Protein Kinase 3 Contributes to Abdominal Aortic Aneurysms via Smooth Muscle Cell Necrosis and Inflammation. Circulation Research. 2015; 116(4):600-11. 

Zhenjie Liu, Qiwei Wang, Jun Ren, Carmel Rebecca Assa, Stephanie Morgan, Jasmine Giles, Qi Han, Bo Liu. Murine Abdominal Aortic Aneurysm Model by Orthotopic Allograft Transplantation of Elastase-treated Abdominal Aorta. J Vasc Surg. 2015;62(6):1607-1614. 

Qiwei Wang, Jun Ren, Stephanie Morgan, Zhenjie Liu, Changlin Dou, Bo Liu Monocyte Chemoattractant Protein-1 (MCP-1) Regulates Macrophage Cytotoxicity in Abdominal Aortic Aneurysm. PLoS ONE. 2014; 9(3):e92053.

Yi Si, Weiguo Fu, Zhenjie Liu, Chen Zuo, Xudong Shi, Yuqi Wang, Daqiao Guo, Qin Xu, Bin Chen. Coverage of the Left Subclavian Artery without Revascularization during Thoracic Endovascular Repair Is Feasible: A Prospective Study. Annals of Vascular Surgery 2014; 28(4):850-9.

Zhenjie Liu, Ning Gao, Laigen Shen, Jin Yang, Yuefeng Zhu, Zhiming Li, Yi Si. Endovascular Treatment for Symptomatic Iliac Vein Compression Syndrome: A Prospective Consecutive Series of 48 Patients. Annals of Vascular Surgery. 2014; 28(3): 695-704. 

Zhenjie Liu, Zhenying Guo, Peng Yu, Yi Si, Mingjuan Jin Reply: Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy in Patients with Graves' Diseases: a Meta-Analysis of Randomized Clinical Trials. Clin Endocrinol 2014; 80(2):316-317

Wenjuan Tang, Zhenjie Liu,Yi Si. Tunica Arterial Adventitia: A New Exploration in Intimal Hyperplasia. Journal of Vascular Medicine & Surgery. 06/2013.

Zhenying Guo, Peng Yu, Zhenjie Liu, Yi Si, Mingjuan Jin Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy in Patients with Graves' Diseases: a Meta-Analysis of Randomized Clinical Trials. Clin Endocrinol. 2013; 79(5): 739-46.

Bin Wang, Zhenying Guo, Zhenjie Liu,Yuan Wang,Yi Si, Mingjuan Jin. Preoperative versus intraoperative endoscopic sphincterotomy in patients with gallbladder and suspected common bile duct stones: system review and meta-analysis. Surg Endosc. 2013; 27(7): 2454-65.

Zhenjie Liu, Zhenying Guo, Yi Si, Xiangman Zhang, Zhenyu Shi, Feng Chen, Weiguo Fu. The research and preparation of a bi-layer biodegradable external sheath with directional drug release profiles for vein graft. Applied Surface Science. 2013, 284(11): 819-825.

Zhenjie Liu, Weiguo Fu, Zhenying Guo, Laigen Shen, Zhenyu Shi, Jiahui Li. Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials Comparing Carotid Artery Stenting and Carotid Endarterectomy in the Treatment of Carotid Stenosis. Annals of Vascualr Surgery. Ann Vasc Surg. 2012; 26(4): 576-90.

Zhang X, Shi Z, Fu W, Liu Z, Fang Z, Lu W, Wang Y, Chen F. In vitro biocompatibility study of electrospun copolymer ethylene carbonate-ε-caprolactone and vascular endothelial growth factor blended nanofibrous scaffolds. Applied Surface Science. 2012; 258: 2301- 2306.

Zhang X, Chen B, Fu W, Fang Z, Liu Z, Lu W, Shi Z, Chen L, Chen T. The research and preparation of a novel nano biodegradable polymer external reinforcement. Applied Surface Science 2011; 258: 196-200.

Gao, B; Fu, WG; Dong, ZH; Fang, ZD; Liu, ZJ; Si, Y; Zhang, XM; Wang, YQ Functional endothelial cells derived from embryonic stem cells labeled with HIV transactivator peptide-conjugated superparamanetic nanoparticles. Chinese Medical Journal. 2011; 124(2): 298-303.

Lu WF, Mo W, Liu Z, Fu WG, Guo da Q, Wang YQ, Song HY. The antithrombotic effect of a novel hirudin derivative after reconstruction of carotid artery in rabbits. Thromb Res. 2010; 126(4): 339-343.

Lu W, Dong Z, Liu Z, Fu W, Peng Y, Chen S, Xiao T, Xie H, Du G, Deng B, Zhang X. Detection of Microvasculature in Rat Hind Limb Using Synchrotron Radiation. J Surg Res. 2010; 164(1): 193-199. 

Liu Z, Shi Z, Wang Y, Chen B, Zhu T, Si Y, Fu W. Carotid Artery Stenting versus Carotid Endarterectomy: A Systematic Review and Meta-Analysis. World J Surg. 2009; 33(3): 586-596.

Current Program

The role of imbalance of TSP1/TSP2 in the inflammatory pahtogenesis of abdominal aortic aneurysm. Funding Source: National Natural Science Foundation of China.

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