Liu Xianbao, M.D., Ph.D.

Position:Vice Chair of Cardiology


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Clinical / Research Interests

Coronary artery diseases, valvular heart diseases, hypertension

Professional Highlights

Professional Appointments

Member, Structural Heart Diseases Group, Chinese Society of Cardiology

Education Experience

Research Summary


Ren KD; Pu ZX; Yu L; Gao F; Wang LH; Ng S, Jiang JB; Li HJ; Xu Y; He W; Yan M; Liu XB(*); Wang JA(*). The first two cases of transcatheter mitral valve repair with ARTO system in Asia. World journal of emergency medicine. 2020; 11:33-36.

Wang LH; Pu ZX; Kong MJ; Jiang JB; Ren KD; Gao F; Lin XP; Yu L; He W; Yan M; Liu XB(*); Wang JA (*). The first four cases of successful NeoChord procedure in mainland China. World journal of emergency medicine. 2019; 10:133-137.

Liu X, He Y, Zhu Q, Gao F, He W, Yu L, Zhou Q, Kong M, Wang J. Supra-annular structure assessment for self-expanding transcatheter heart valve size selection in patients with bicuspid aortic valve. Catheter Cardiovasc Interv. 2018 Apr 1;91(5):986-994.

Zhu Q, Liu X, He W, He Y, Tang M, Sun Y, Xu X, Shi K, Kong H, Jiang J, Chen L, Chen J, Hu P, Xu Q, Wang J. Predictors of Thrombocytopenia after Self-Expandable Transcatheter Aortic Valve Replacement: A Single-Center Experience from China. Cardiology. 2018;139(3):151-158.

Lin X, Liu X, Wang L, Jiang J, Sun Y, Zhu Q, Chen Z, He Y, Hu P, Xu Q, Gao F, Lin Y, Jaiswal S, Xiang M, Wang J. Targeted next-generation sequencing identified ADAMTS5 as novel genetic substrate in patients with bicuspid aortic valve. Int J Cardiol. 2018 Feb 1;252:150-155. (Co-first author)

Sun Y, Liu X, Chen Z, Fan J, Jiang J, He Y, Zhu Q, Hu P, Wang L, Xu Q, Lin X, Wang J. Meta-analysis of Predictors of Early Severe Bleeding in Patients Who Underwent Transcatheter Aortic Valve Implantation. Am J Cardiol. 2017 Aug 15;120(4):655-661.

Liu X, Hu D, Zeng Z, Zhu W, Zhang N, Yu H, Chen H, Wang K, Wang Y, Wang L, Zhao J, Zhang L, Wu R, Hu X, Wang J. SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction. Cell Death Dis. 2017 Apr 6;8(4):e2731.

Tang M, Liu X, Lin C, He Y, Cai X, Xu Q, Hu P, Gao F, Jiang J, Lin X, Zhu Q, Wang L, Kong H, Yu Y, Wang J. Meta-Analysis of Outcomes and Evolution of Pulmonary Hypertension Before and After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2017 Jan 1;119(1):91-99.

Sun Y, Liu X, He Y, Tang M, Zhu Q, Xu X, Guo D, Shi K, Hu P, Wang L, Kong H, Jiang J, Lin X, Xu Q, Gao F, Wang J. Meta-Analysis of Impact of Diabetes Mellitus on Outcomes After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2017 Feb 15;119(4):623-629.

Hu P, Liu XB, Liang J, Zhu QF, Pu CX, et al. A hospital-based survey of patients with severe valvular heart disease in China. Int J Cardiol. 2016, 5273(16)32382-8.

Hu DX, Liu XB, Song WC, Wang JA. Roles of SIRT3 in heart failure: from bench to bedside. J Zhejiang Univ Sci B. 2016 Nov.;17(11):821-830.

Tay E, Muda N, Yap J, Muller DW, Santoso T, Walters DL, Liu X, Yamen E, Jansz P, Yip J, Zambahari R, Passage J, Ding ZP, Wang J, Scalia G, Soesanto AM, Yeo KK. The MitraClip Asia-Pacific registry: Differences in outcomes between functional and degenerative mitral regurgitation. Catheter Cardiovasc Interv. 2016 Jun;87(7): E275-81.

Wang Y, Pan X, Fan Y, Hu X, Liu X, Xiang M, Wang J. Dysregulated expression of microRNAs and mRNAs in myocardial infarction. Am J Transl Res. 2015 Nov 15;7(11):2291-304.

Hu P, Tang MY, Song WC, Jiang J, Sun Y, Liu XB, Li CL, Hu XY, Wang JA. Fractional Flow Reserve Guided Percutaneous Coronary Intervention Improves Clinical Outcome with Reduced Cost in Contemporary Clinical Practice. Chin Med J (Engl). 2015 Aug 5;128(15):2000-5.

Hu P, Huang MY, Hu XY, Xie XJ, Xiang MX, Liu XB, Wang JA. Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians. J Zhejiang Univ Sci B. 2015 May;16(5):370-9.

Hu X, Huang X, Yang Q, Wang L, Sun J, Zhan H, Lin J, Pu Z, Jiang J, Sun Y, Xiang M, Liu X, Xie X, Yu X, Chen Z, Tse HF, Zhang J, Wang J. Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial. Int J Cardiol. 2015 Apr 1;184:446-51.

Liu X, Dong L, Jiang J, Zhou Q, He W, Pu Z, Zhou L, Huang Z, Feng Y, Kong M, Hu Y, Sun Y, Jiang J, Fan Y, Dong A, Yan M, Wang J. A case of successful transcatheter aortic valve implantation for severe noncalcified aortic regurgitation. Zhonghua Xin Xue Guan Bing Za Zhi. 2015 Feb;43(2):185-6. Chinese.

Gao F, Hu X, Xie X, Liu X, Wang J.Heat shock protein 90 stimulates rat mesenchymal stem cell migration via PI3K/Akt and ERK1/2 pathways. Cell Biochem Biophys. 2015 Jan;71(1):481-9.

Liu XB, Jiang JB, Zhou QJ, Pu ZX, He W, Dong AQ, Feng Y, Jiang J, Sun Y, Xiang MX, He YX, Fan YQ, Dong L, Wang JA. Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population. J Zhejiang Univ Sci B. 2015 Mar;16(3):208-14.

Yu L, Pu Z, Liu X, Bao X, Huang P, He W, Feng Y, Lin J, You X, Wang J. The value of transesophageal echocardiography to guide the implantation of 2 pieces of MitraClip during transcatheter mitral valve repair operation. Zhonghua Xin Xue Guan Bing Za Zhi. 2015 Apr;43(4):347-51. Chinese.

Liu X, Chen H, Zhu W, Chen H, Hu X, Jiang Z, Xu Y, Zhou Y, Wang K, Wang L, Chen P, Hu H, Wang C, Zhang N, Ma Q, Huang M, Hu D, Zhang L, Wu R, Wang Y, Xu Q, Yu H, Wang J. Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model. J Heart Lung Transplant. 2014 Oct;33(10):1083-1092. 

Zhou Q, Liu X, Dong A, Pu Z, He W, Feng Y, Wang J. Value of preoperative assessment on transcatheter aortic valve implantation procedure with high-pitch dual-source computed tomography angiography. Zhonghua Xin Xue Guan Bing Za Zhi. 2014 Oct;42(10):835-9. Chinese.

Liu X, Wang JA, Ji XY, Yu SP, Wei L. Preconditioning of Bone Marrow Mesenchymal Stem Cells by Prolyl Hydroxylase Inhibition Enhances Cell Survival and Angiogenesis in vitro andafter Transplantation into the Ischemic Heart of Rats. Stem Cell Res Ther. 2014 Sep 25;5(5):111.

Yeo KK, Yap J, Yamen E, Muda N, Tay E, Walters DL, Santoso T, Liu X, Jansz P, Yip J, Zambahari R, Passage J, Koh TH, Wang J, Scalia G, Kuntjoro I, Soesanto AM, Muller D. Percutaneous mitral valve repair with the MitraClip: early results from the MitraClip Asia-Pacific Registry (MARS). EuroIntervention. 2014 Sep;10(5):620-5.

Chen H, Liu X, Zhu W, Chen H, Hu X, Jiang Z, Xu Y, Wang L, Zhou Y, Chen P, Zhang N, Hu D, Zhang L, Wang Y, Xu Q, Wu R, Yu H, Wang J. SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin. Front Aging Neurosci. 2014 Jun 3;6:103. 

Chen H, Liu X, Chen H, Cao J, Zhang L, Hu X, Wang J. Role of SIRT1 and AMPK in mesenchymal stem cells differentiation. Ageing Res Rev. 2014 Jan;13:55-64. 

Hu X, Wu R, Shehadeh LA, Zhou Q, Jiang C, Huang X, Zhang L, Gao F, Liu X, Yu H, Webster KA, Wang J. Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. BMC Genomics. 2014 Apr 23;15(1):303.

Sun Y, Jiang J, Zhu G, Li C, Dong L, Liu X, Lyu L, Hu X, Xiang M, Wang J. Efficacy of intravascular ultrasound guided rotational atherectomy for heavily calcified coronary lesions. Zhonghua Xin Xue Guan Bing Za Zhi. 2014 Jul;42(7):545-50. Chinese.

Liu XB, Wang JA. Update of transcatheter valve treatment. J Zhejiang Univ Sci B. 2013 Aug;14(8):670-5.

Yao YY, Zhu MH, Zhang FJ, Wen CY, Ma LL, Wang WN, Wang CC, Liu XB, Yu LN, Qian LB, Wang JA, Yan M. Activation of Akt and cardioprotection against reperfusion injury are maximal with only five minutes of sevoflurane postconditioning in isolated rat hearts. J Zhejiang Univ Sci B. 2013 Jun;14(6):511-7.

Ma LL, Zhang FJ, Qian LB, Kong FJ, Sun JF, Zhou C, Peng YN, Xu HJ, Wang WN, Wen CY, Zhu MH, Chen G, Yu LN, Liu XB, Wang JA, Yan M. Hypercholesterolemia blocked sevoflurane-induced cardioprotection against ischemia-reperfusion injury by alteration of the MG53/RISK/GSK3β signaling. Int J Cardiol. 2013 Oct 9;168(4):3671-8.

Xu Y, Ma LL, Zhou C, Zhang FJ, Kong FJ, Wang WN, Qian LB, Wang CC, Liu XB, Yan M, Wang JA. Hypercholesterolemic myocardium is vulnerable to ischemia-reperfusion injury and refractory to sevoflurane-induced protection. PLoS One. 2013 Oct 4;8(10):e76652.

Xu Y, Hu X, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J, Wang J. Transplantation of preconditioned bone marrow mononuclear cells by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells. Int J Cardiol. 2013 Oct 9;168(4):4551-4.

Xu Y, Hu X, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J, Jian'an Wang. Preconditioning via angiotensin type 2 receptor activation improves therapeutic efficacy of bone marrow mononuclear cells for cardiac repair. PLoS One. 2013 Dec 10;8(12):e82997.

Liu XB, Chen H, Chen HQ, Zhu MF, Hu XY, Wang YP, Jiang Z, Xu YC, Xiang MX, Wang JA. Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation. J Zhejiang Univ-Sci B (Biomed & Biotechnol). 2012;13(8):616-623.

Jiang J, Sun Y, Xiang MX, Dong L, Liu XB, Hu XY, Feng Y, Wang JA. Complex coronary lesions and rotational atherectomy: one hospital's experience. J Zhejiang Univ Sci B. 2012 Aug;13(8):645-51.

Yang D, Liu X, Xiang M. The correlation between lipids ratio and degree of coronary artery stenosis. High Blood Press Cardiovasc Prev. 2011 Jun 1;18(2):53-6.

Hu XY, Wang WX, Yu MJ, Liu XB, Wu RR, Gao F, Huang X, Cao J, Xie XJ, Wang JA. Tongxinluo promotes mesenchymal stem cell tube formation in vitro. J Zhejiang Univ Sci B. 2011 Aug;12(8):644-51.

Wang Y, Hu X, Xie X, He A, Liu X, Wang JA. Effects of mesenchymal stem cells on matrix metalloproteinase synthesis in cardiac fibroblasts. Exp Biol Med (Maywood). 2011 Oct 1;236(10):1197-204.

Wang WX, Hu XY, Xie XJ, Liu XB, Wu RR, Wang YP, Gao F, Wang JA. Nerve growth factor induces cord formation of mesenchymal stem cell by promoting proliferation and activating the PI3K/Akt signaling pathway. Acta Pharmacol Sin. 2011 Dec;32(12):1483-90.

Gao F, Hu XY, Xie XJ, Xu QY, Wang YP, Liu XB, Xiang MX, Sun Y, Wang JA. Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. J Zhejiang Univ Sci B. 2010 Aug;11(8):608-17.

Liu XB, Wang JA, Ogle M, Wei L. Prolyl hydroxylase inhibitor Dimethyloxalylglycine enhances mesenchymal stem cell survival and its mechanisms. J Cell Biochem. 2009;106(5):903-11. 

Yang D, Xiang M, Liu X, He A. Left ventricular free-wall rupture in acute myocardial infarction: a blow-out type case. High Blood Press Cardiovasc Prev. 2009 Dec;16(4):201-4.

Liu XB, Jiang J, Gui C, Hu XY, Xiang MX, Wang JA. Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathway. Acta Pharmacol Sin. 2008;29(7):815-22.

Liu XB, Wang JA, Yu SP, Keogh CL, Wei L. Therapeutic strategy of erythropoietin in neurological disorders. CNS Neurol Disord Drug Targets. 2008;7(3):227-34. 

Gui C, Wang JA, He AN, Chen TL, Liu XB, Luo RH, Jiang J. Expression of heregulin and ErbB receptors in mesenchymal stem cells. Chin Med J (Engl). 2008 Jan 20;121(2):155-60.

Current Program

Role of TPP1 in anti-senescence and functional optimization of aged mesenchymal stem cells. Funding Source: National Natural Science Foundation of China.

Role of TPP1 in the anti-senescence and function improvement of mesenchymal stem cells from elderly individuals. Funding Source: National Natural Science Foundation of China.

Technique development of SIRT1 targeted functional improvement for mesenchymal stem cells from elderly individuals. Funding Source: "863" Program.

Role of SIRT1 in the anti-senescence and function improvement of mesenchymal stem cells. Funding Source: National Natural Science Foundation of China.

Angiopoietin-1 preconditioning enhances survival and angiogenesis of mesenchymal stem cell. Funding Source: Qianjiang Talents Project of Zhejiang Provincial Department of Science and Technology.

Angiopoietin-1 preconditioning promote the outcome of mesenchymal stem cell transplantation and mechanisms. Funding Source: Natural Science Foundation of Zhejiang.

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