Liu Kaiming, M.D., Ph.D.

Department:Neurology

Medical School:Shandong University, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Headache, migraine, vertigo, cerebrovascular disease


Professional Highlights

Professional Appointments

Vice Chair, Youth Committee of Headache and Sensory Disorders, Chinese Research  Hospital Association

Vice Chair, Pain and Sensory Disorders Group, Zhejiang Society of Neurologist Branch, Zhejiang Medical Association

Vice Chair, Soft Tissue Section, Pain-Relieving Branch, Zhejiang Medical Association


Education Experience

Research Summary

Mitochondria and signaling molecules transfer through tunneling nanotubes in neurovascular unit (pericytes, astrocyte, endothelial cells, and neurons).

Stem cells therapy for central nervous system diseases with mitochondrial dysfunction through tunneling nanotubes.

The clinical characterization, mechanisms, influences and intervention of SARS-CoV-2 invading central nervous system


Publications

Liu K, Pan M, Xiao Z, Xu X. Neurological manifestations of the coronavirus (SARS-CoV-2) pandemic 2019-2020. J Neurol Neurosurg Psychiatry. 2020 Jun;91(6):669-670. 

Liu K, Guo L, Zhou Z, Pan M, Yan C. Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke. Microvasc Res. 2019 May;123:74-80.

Liu K, Zhao H, Ji K, Yan C. MERRF/MELAS overlap syndrome due to the m.3291T>C mutation. Metab Brain Dis. 2014 Mar;29(1):139-44.

Liu K, Ji K, Guo L, Wu W, Lu H, Shan P, Yan C. Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia-reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer. Microvasc Res. 2014 Mar;92:10-8.

Liu K, Chi L, Guo L, Liu X, Luo C, Zhang S, He G. The interactions between brain microvascular endothelial cells and mesenchymal stem cells under hypoxic conditions. Microvasc Res. 2008 Jan;75(1):59-67.


Current Program

Mesenchymal stem cells rescue brain microvascular endothelial cells from cell death in an in vitro ischemia model by transferring mitochondrial directly via tunnelling nanotubes. Funding Resource: National Natural Science Foundation of China.

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