Sun Chongran, M.D., Ph.D.

Department:Neurosurgery

Medical School:Capital Medical University, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Surgical treatment of resectable brain tumors

Cellular immunotherapy of gliomas

Tumor treating fields for gilomas

Celluar transplantation for strokes


Professional Highlights

Scientific and Technological Progress Award, Health Commission of Zhejiang Province, Third Prize, 2015 

Scientific and Technological Progress Award, Health Commission of China, Second Prize, 2015 

Zhejiang Scientific and Technological Progress Award, Outstanding Prize, 2014 

Scientific and Technological Progress Award, Zhejiang Provincial Department of Science and Technology, Third Prize, 2010 


Professional Appointments

Youth Committee Member, Gliomas Branch of Chinese Medical Doctor Association 

Committee Member, Pediatric Gliomas Branch of Chinese Medical Doctor Association 

Member, Society for Neuroscience (United States)

Reviewer, Neural Regeneration Research 

Reviewer, Plos One 

Reviewer, Neural Childs Nervous System


Education Experience

Research Summary

Dr. Sun focuses on the cellular treatment of strokes and malignant brain tumors and clinical trials for the treatment of glioblastoma and strokes. He is building a mathematical model to simulate the spatial distribution of the electric field by TTF device to optimize the location of the electric polars, and carrying out a voxel-based retrospect research on the recurrence location of glioblastoma.


Publications

Xiang-Gui Yuan, Yu-Rong Huang, Teng Yu, Yang Xu, Yun Liang, Xiao-Hong Zhang, Chong-Ran Sun, Xiao-Ying Zhao. Primary central nervous system lymphoma in China: a single-center retrospective analysis of 167 cases.[J] .Ann. Hematol., 2020, 99: 93-104.

Si Z, Wang X, Zhang Z, Wang J, Li J, Li J, Li L, Li Y, Peng Y, Sun C, Hui Y, Gao X. Heme Oxygenase 1 Induces Tau Oligomer Formation and Synapse Aberrations in Hippocampal Neurons. J Alzheimers Dis. 2018;65(2):409-419.

Ding X, Wang Z, Chen D, Wang Y, Zhao Z, Sun C, Chen D, Tang C, Xiong J, Chen L, Yao Z, Liu Y, Wang X, Cahill DP, de Groot JF, Jiang T, Yao Y, Zhou L. The prognostic value of maximal surgical resection is attenuated in oligodendroglioma subgroups of adult diffuse glioma: a multicenter retrospective study. J Neurooncol. 2018;140(3):591-603.

Li HY, Sun CR, He M, Yin LC, Du HG, Zhang JM. Correlation between Tumor Location and Clinical Properties of Glioblastomas in Frontal and Temporal Lobes. World Neurosurg. 2018.

Ge J, Hu W, Zhou H, Yu J, Sun C, Chen W, et al. Ubiquitin carboxyl-terminal hydrolase isozyme L5 inhibits human glioma cell migration and invasion via downregulating SNRPF[J]. Oncotarget, 2017, 8(69):113635-113649.

Shi J, Wang YJ, Sun CR, Qin B, Zhang Y, Chen G. Long noncoding RNA lncHERG promotes cell proliferation, migration and invasion in glioblastoma. Oncotarget. 2017;8(64):108031-108041.

Tu M, Zhu P, Hu S, Wang W, Su Z, Guan J, Sun C, Zheng W.Notch1 Signaling Activation Contributes to Adult Hippocampal Neurogenesis Following Traumatic Brain Injury. Med Sci Monit 2017; 23:5480-5487.(co-coresponding) 

Shao F, Jiang W, Gao Q, Li B, Sun C, et al. Frozen tissue preparation for high-resolution multiplex histological analyses of human brain specimens.[J]. Journal of neuro-oncology, 2017:1-8.

Sun C, Lai S, et al. Atypical Radiological Presentation of Neurosyphilis Mimicking Multiple Metastatic Tumors. Journal of Neurosurgery Imaging and Techniques. 2017,2(2): 128-133.

Yang X, Li S, Li B, Wang X, Sun C, Qin H, Sun H.. Netrin‐1 overexpression improves neurobehavioral outcomes and reduces infarct size via inhibition of the notch1 pathway following experimental stroke[J]. Journal of Neuroscience Research, 2017.

Neumann M, Liu W, Sun C, Yang SY, Noble-Haeusslein LJ, Liu J.. Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1, null mice lacking a corpus callosum[J]. Behavioural Brain Research, 2016. (co-first author) 

Sun ZL, Chan AK, Chen LC, Tang C, Zhang ZY, Ding XJ, Wang Y, Sun CR, Ng HK, Yao Y, Zhou LF. TERT promoter mutated WHO grades II and III gliomas are located preferentially in the frontal lobe and avoid the midline[J]. International Journal of Clinical and Experimental Pathology, 2015, 8(9): 11485.

Sun C, Du H, Yin L, He M, Tian Y, Li H.Choice for the removal of bloody cerebrospinal fluid in postcoiling aneurysmal subarachnoid hemorrhage: external ventricular drainage or lumbar drainage? Turk Neurosurg. 2014;24(5):737-44.

Cheng B, Cai W, Sun C, Kang Y, Gong J. 3D bone subtraction CT angiography for the evaluation of intracranial aneurysms: a comparison study with 2D bone subtraction CT angiography and conventional non-subtracted CT angiography.Acta Radiol. 2014 Sep 25. pii: 0284185114549495. [Epub ahead of print]

Sun C, Sun H, Wu S, Lee CC, Akamatsu Y, Wang RK, Kernie SG, Liu J. Conditional  ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway. J Neurosci. 2013,33(44):17314-17325. (IF 5.924)

Sun CR, Chen ZH, Yin SY, Chen S, Hong Y, Yan W, Zhang JM. Brain ischemia induces regeneration of interneurons but not projection neurons. Restor Neurol Neurosci. 2013,31(4):461-72. (IF 2.526)

Cheng B, Sun C, Li S, Gong Q, Lui S. Gelastic epilepsy in combination with hypothalamic hamartoma and partial agenesis of the corpus callosum: A case report and review of the literature. Exp Ther Med. 2013 Dec;6(6):1540-1542.

Shao A, Guo S, Chen S, Sun C, Wu H, Hong Y, Zhang J. Comparison between routine and improved decompressive craniectomy on patients with malignant cerebral artery infarction without traumatic brain injury.J Craniofac Surg. 2013 Nov;24(6):2085-2088.

Zhu G, Sun C, Liu W. Effects of neurotrophin-3 on the differentiation of neural stem cells into neurons and oligodendrocytes. Neural Regen Res. 2012;7(19):1483-1487.

Hong Y, Guo SX, Chen S, Sun CR, Zhang JM Sun XJ.Beneficial Effect of Hydrogen-Rich Saline on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Rats. Journal of Neuroscience Research. 2012,90:1670-1680.

Sun C Zhang H, Li J, Huang H, Cheng H, Wang Y, Li P, An Y. Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke. J Transl Med. 2010 Aug 20;8:77.

Hong Y, Yan W, Chen S, Sun CR, Zhang JM. The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice.Acta Pharmacol Sin. 2010 Nov;31(11):1421-30. Epub 2010 Oct 18.

Sun CR, Zhao XQ, Zhu GW, Yu J, Zhang JM. Underlying pathogenesis and proper treatments of traumatic subdural hygromas. J Trauma. 2008, 65 (4):965-966.

Zhang H, Wei YT, Tsang KS, Sun CR, Li J, Huang H, Cui FZ, An YH.Implantation of neural stem cells embedded in hyaluronic acid and collagen composite conduit promotes regeneration in a rabbit facial nerve injury model. J Transl Med. 2008 Nov 5;6 (1):67. 

Sun CR, Wang CC, Tsang KS, Li J, Zhang H, An YH. Modulation and impact of class I major histocompatibility complex by neural stem cell-derived neurotrophins on neuroregeneration. Med Hypotheses. 2007 68 (1): 176-179.

Li J, Sun CR, Zhang H, Tsang KS, Li JH, Zhang SD, An YH. Induction of functional recovery by co-transplantation of neural stem cells and Schwann cells in a rat spinal cord contusion injury model.Biomed Environ Sci. 2007 Jun;20 (3):242-249.

Xue J, Gao PY, An YH, Sun CR, Li J, Huang H. A Model of Focal Cortical Infarction in Rat:Minimally Invasive Craniotomy. Chinese Journal of Rehabilitation Theory & Practice. 2006,12 (1):11-13.


Current Program

Study of a c-Met Inhibitor PLB1001 in Patients With PTPRZ1-MET Fusion Gene Positive Recurrent High-grade Gliomas.

Intracavitary Injection of hUMSCs in Acute Basal Ganglia Hematoma after Stereotactic Aspiration.

B7-H3-Targeted Chimeric Antigen Receptor (CAR) T Cells in Treating Patients With Recurrent or Refractory Glioblastoma.

Find People

Search by Family Name

Find A Department

Search by Departments