Liang Yun, M.D, Ph.D

Position:Vice Chair of Hematology 

Department:Hematology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Diagnosis and treatment of hematopoietic tumor including multiple myeloma, lymphoma and leukemia

Professional Highlights

Clinical Teaching Award, Zhejiang University


Professional Appointments

Member, Hematology Committee, Zhejiang Anti-Cancer Association, 2018-present

Committee Member, Zhejiang Society of Hematology, 2019-present


Education Experience

Research Summary

The etiology study of lymphoma and myeloma, diagnosis, molecular and genomic advance in the hematology field.

Publications

Yun Liang, Luyin Ding, Xian Li, Weiqin Wang, Xiaohong Zhang.Oculomotor nerve palsy as a preceding symptom of adult sporadic Burkitt lymphoma: A case report and review of the literature.Oncol Lett. 2017;13(3): 1315–1318.

Liang Y, Gao J, Wu D, Li S, Chen H, Ding L, Tong J, Xu Y.Long-Term Remission following Autologous Hematopoietic Cell Transplantation in a Patient with Multiple Nonleukemic Myeloid Sarcoma and a Review of the Literature.Acta Haematol. 2017;137(3):117-122.

Liang Y, He X, Li X, Zhang X, Zhang X, Zhang L, Qiu X, Zhao X, Xu R. 4-Chlorbenzoyl Berbamine, a Novel Derivative of the Natural Product Berbamine, Potently Inhibits the Growth of Human Myeloma Cells by Modulating the NF-κB and JNK Signalling Pathways. Cancer Invest. 2016;34(10):496-505.

Liang Y, Li X, He X, Qiu X, Jin XL, Zhao XY, Xu RZ. Polyphyllin I induces cell cycle arrest and apoptosis in human myeloma cells via modulating β-catenin signaling pathway. Eur J Haematol. 2016;97(4):371-378.

Liang Y, Ding L, Li X, Wang W, Zhang X. Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature. Oncol Lett. 2015;10(6):3789-3792.


Current Program

Molecular mechanisms of berbamine derivatives inhibit proliferation and eliminate cancer stem cells in myeloma via CaMKIIγ kinase. Funding Source: Natural Science Foundation of Zhejiang.

The correlation between APOBEC3B functional complex and TP53 gene mutation in Diffuse large B-cell lymphoma. Funding Source: Natural Science Foundation of Zhejiang.

4-chlorobenzoyl berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in myeloma cells. Funding Source: National Natural Science Foundation of China.

The molecular mechanisms of 4-chlorobenzoyl berbamine targets anti-myeloma through Wnt/β-catenin pathway. Funding Source: Natural Science Foundation of Zhejiang.

The new p53 target genes TMEM endoplasmic reticulum in the cell protective effect of emergency. Funding Resource: National Natural Science Foundation of China.

Identify of APOBEC3B functional complex in hepatocarcinogenesis. Funding Source: National Natural Science Foundation of China.

Effects of calmodulin antagonist berbamine on TGF-β/Smad signaling in human leukemia cells. Funding Source: Natural Science Foundation of Zhejiang.


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