Li Wen, MD, Ph.D

Position:Vice Chair of Respiratory Medicine

Department:Respiratory Medicine

Medical School:Tongji Medical College, Huazhong University of Science and Technology, China

Academic Rank:Professor,Chief Physician 


Clinical / Research Interests

Chronic airway inflammatory disease (asthma and chronic obstructive pulmonary disease, etc.) 

Individualized/precision therapy of lung cancer

Professional Highlights

State Scientific and Technological Progress Award, Second Prize

Scientific and Technological Progress Award of the Ministry of Education of China, First Prize 

Chinese Medical Science and Technology Award, Second Prize

Zhejiang Scientific and Technological Progress Award, First Prize

Zhejiang Scientific and Technological Award, First Prize

Professional Appointments

Chairman-Elect, Zhejiang Society of Respiratory Disease, Zhejiang Medical Association

Vice Chair, Respiratory Physicians Committee, Zhejiang Medical Doctors Association

Member, COPD Group, Chinese Thoracic Society

Member, Lung Cancer Working Committee, Chinese Association of Chest Physicians

Education Experience

Research Summary

Dr. Li has long been committed to the study of the molecular mechanism of the occurrence and development of chronic airway inflammatory disease and lung cancer. In airway inflammatory disease related researches, she with her team focuses on the development, novel function and cell fate of eosinophils in pulmonary inflammation, and biomarkers in the pathogenesis of COPD. 

Besides, she and colleagues explore the molecular mechanisms of both tumor pathogenesis and drug resistant in lung cancer from clinical discoveries.


Li M, Wang HW, Liao HW, Shen JX, Wu YF, Wu YP, Weng QY, Zhu C, Geng XW, Lan F, Xia Y, Zhang B, Zou H, Zhang N, Zhou YZ, Chen ZH, Shen HH*, Ying SM*, Li W*. SETD8C302R Mutation Revealed from Myofibroblastoma-Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity. Adv Sci. 2020, In Press.

Wu YP, Chen HX, Xuan NX, Zhou LR, Wu YF, Zhu C, Li M, Weng QY, Shen JX, Zhang H, Zhang B, Lan F, Xia LX, Xiong XF, Li ZY, Zhao Y, Wu MD, Ying SM, Li W*, Shen HH*, Chen ZH*. Inducing ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation. Thorax. 2020, In Press.

Zhu C, Weng QY, Zhou LR, Cao C, Li F, Wu YF, Wu YP, Li M, Hu Y, Shen JX, Xiong XF, Lan F, Xia LX, Zhang B, Zhang H, Huang M, Ying SM, Shen HH*, Chen ZH*, Li W*. Homeostatic and Early Recruited CD101 - Eosinophils Suppress Endotoxin-induced Acute Lung Injury. Eur Respir J. 2020 Jun 11;1902354. 

Weng QY, Zhu C, Zheng K, Wu YF, Dong LL, Wu YP, Li M, Shen JX, Ying SM, Shen HH, Chen ZH, Li W*. Early Recruited Neutrophils Promote Asthmatic Inflammation Exacerbation by Release of Neutrophil Elastase. Cell Immunol. 2020 Jun; 352:104101.

Yan FG, Wu YF, Liu HW, Wu YP, Shen HH, Li W*. ATF3 Is Positively Involved in Particulate Matter-Induced Airway Inflammation in Vitro and in Vivo. Toxicol Lett. 2018 May 1;287:113-121.

Zhu D, Wu MD, Cao Y, Lin SH, Xuan NX, Zhu C, Li W*, Shen HH*. Heated Humidification Did Not Improve Compliance of Positive Airway Pressure and Subjective Daytime Sleepiness in Obstructive Sleep Apnea Syndrome: A Meta-Analysis. PLoS One. 2018 Dec 5;13(12):e0207994.

Xia Y, Jin R, Li W*, Shen HH*. Magnetic Resonance Imaging of Patients With Airway Stents. J Thorac Dis. 2018 Oct;10(10):5939-5945.

Zhu C, Xia LX, Li F, Zhou LR, Weng QY, Li ZY, Wu YF, Mao YY, Zhang C, Wu YP, Li M, Ying SM, Chen ZH, Shen HH, Li W *. mTOR complexes differentially orchestrates eosinophil development in allergy. Sci Rep, 2018, 8(1):6883. 

Xia Y, Xia LX, Lou LY, Jin R, Shen HH, Li W*. Transient Receptor Potential Channels and Chronic Airway Inflammatory Diseases: A Comprehensive Review. Lung. 2018 Oct;196(5):505-516.

Cao Y, Lin SH, Zhu D, Xu F, Chen ZH, Shen HH*, Li W*. WeChat Public Account Use Improves Clinical Control of Cough-Variant Asthma: A Randomized Controlled Trial. Med Sci Monit. 2018 Mar 14;24:1524-2532.

Zhang Y, Wu Y, Qi H, Xiao J, Gong H, Zhang Y, Xu E, Li S, Ma D, Wang Y*, Li W*, Shen H*. A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma. Sci Rep. 2017 Nov 8;7(1):15038.

Yan FG, Xiao Y, Li MK, Zhang H, Zhang R, Zhou HW, Shen HH, Wang JW, Li W*, Ren LL*. Metagenomic Analysis Identified Human Rhinovirus B91 Infection in an Adult Suffered Severe Pneumonia. Am J Respir Crit Care Med, 2017 Jun 1;195(11):1535-1536. 

Chen ZH,Wu YF,Wang PL,Wu YP,Li ZY,Zhao Y,Zhou JS,Zhu C,Cao C,Mao YY,Xu F,Wang BB,Cormier Stephania A, Ying SM, Li W*, Shen HH*. Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium. Autophagy, 2016, 12(2):297-311. 

Wu YP, Wu YF, Zhang C, Zhou HB, Cao C, Li M, Zhu C, Ying SM, Chen ZH *, Shen HH *, Li W *. Activating Transcription Factor 3 Is Essential for Cigarette Smoke-Induced Mucin Expression via Interaction with Activator Protein-1. Am J Pathol, 2017 Feb;187(2):280-291. 

Wu YP, Cao C, Wu YF, Li M, Lai TW, Zhu C, Wang Y, Ying SM, Chen ZH, Shen HH *, Li W *. Activating transcription factor 3 represses cigarette smoke-induced IL6 and IL8 expression via suppressing NF-κB activation. Toxicology Letters, 2017 Mar 15;270:17-24. 

Cao C#, Li W#, Hua W, Yan FG, Zhang H, Huang HQ, Ying YH, Li N, Lan F, Wang SB, Chen X, Li J, Liu JK, Lai TW, Bao ZQ, Cao Y, Zhao Y, Huang G, Huang LL, Huang YQ, Wu P, Peng C, Chen ZH, Chung KF, Zhong NS *, Ying SM *, Shen HH *. Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma. J Transl Med, 2017, Aug 4;15(1):171. 

Lan F, Cao C, Liu JK, Li W*. Obstructive sleep apnea syndrome susceptible genes in the Chinese population: a meta-analysis of 21 case-control studies. Sleep and Breathing. 2015. 19(4): 1441-1448.

Current Program

The effect and mechanism of targeting eosinophils Ferroptosis in protective airway inflammation of bronchial asthma. Funding Source: General Program of National Natrual Science Fundation of China.

The role and molecular mechanism of eosinophils in regulating pulmonary local immune response. Funding Source: Major Program of National Natrual Science Fundation of China.

The mechanism and intervention of genomic instability in lung injury caused by atmospheric fine particulate matter. Funding Source: National 973 Project.

The regulatory role and molecular mechanism of mTOR signaling pathway in asthma. Funding Source: National Natrual Science Fundation of China.

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