Li Fangcai, M.D.

Position:Vice Chair of Orthopedics

Department:Orthopedics

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Clinical study of spinal deformity; basic and clinical studies of spinal degenerative diseases; basic research on spinal cord injury.

Professional Highlights

Zhejiang Scientific and Technological Progress Award, Second Prize, 2013 

Zhejiang Scientific and Technological Progress Award, Third Prize, 2006

Professional Appointments

Chairman, Zhejiang Provincial Spine and Spinal Cord Committee

Deputy Chairman, Orthopedics Branch, Zhejiang Medical Association

Member, Spine Group, Orthopedic Branch, Chinese Medical Association

Member, Spine Deformity Group, Spine Microscopic Committee, Orthopedic Branch, Chinese Medical Doctor Association

Member, Spinal Deformity Group, Chinese Spinal and Spinal Cord Injury Committee

Member, Minimally Invasive Group, Chinese Spinal and Spinal Cord Injury Committee

Member, Basic Group, Chinese Spinal and Spinal Cord Injury Committee

Member, Lumbar Spine Group, Chinese Spinal and Spinal Cord Injury Committee 

Deputy Director, International Education Group, Chinese Medical Education Society 

Member, Chinese Society of Minimally Invasive Spine Surgery, International Society of Orthopedics and Traumatology (SICOT)

Member, International Scoliosis Research Society (SRS)

Communication Editor, China Orthopedics

Editor, Spine (Chinese)

Education Experience

Research Summary

Dr. Li is mainly engaged in clinical and basic research on spinal cord injury, disc degeneration and repair. His research was funded by National Natural Science Foundation of China. The previous study were published in Acta Biomater, FASEB J and Scientific Reports.

Publications

Zhou X(#) ; Wang J; Huang X; Fang W; Tao Y; Zhao T; Liang C; Hua J; Chen Q (*); Li F(*). Injectable decellularized nucleus pulposus-based cell delivery system for differentiation of adipose-derived stem cells and nucleus pulposus regeneration, Acta Biomater, 2018.11.1, 81: 115~128.

Zhou X(#) ; Ma C (#) ; Hu B(#) ; Tao Y; Wang J; Huang X; Zhao T; Han B; Li H;Liang C; Chen Q(*) ; Li F(*). FoxA2 regulates the type II collagen-induced nucleus pulposus-like differentiation of adipose-derived stem cells by activation of the Shh signaling pathway., FASEB J, 2018.6.11. 

Jian Zhu; Yitian Wang; Wei Yu; Kaishun Xia; Yuluan Huang; Junjie Wang; Bing Liu; Huimin Tao (*); Chengzhen Liang (*); Fangcai Li(*). Long Noncoding RNA:Function and Mechanism on Differentiation of Mesenchymal Stem Cells and Embryonic Stem Cells. Current Stem Cell & Therapy.

Jian Zhu(#) ; Kaishun Xia (#) ; Wei Yu; Yitian Wang; Jianming Hua; Bing Liu; Zhe Gong; Junjie Wang; Ankai Xu; Zhengwei You; Qixin Chen; Fangcai Li (*); Huimin Tao(*) ; Chengzhen Liang(*). Sustained Release of GDF5 from a Designed Coacervate Attenuates Disc Degeneration in a Rat Model. Acta biomaterial.

Linwei Chen, Yaosen Wu, Yan Wu, Ye Wang, Liaojun Sun,  Fangcai Li (*). The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/beta-catenin pathway. Scientific Reports, 2016.08.19.

Yaosen Wu, Linwei Chen, Ye Wang, Wanli Li, Yan Lin, Dongsheng Yu, Liang Zhang, Fangcai Li (*), Zhijun Pan(*). Overexpression of Sirtuin 6 suppresses cellular senescence and NF-kappaB mediated inflammatory responses inosteoarthritis development. Scientific reports, 2015.12.07.

Ye, Xiaoyun(#) ; Lou, Danning (#); Ding, Xueping; Xie, Chaoyan; Gao, Jixiang; Lou, Yuting; Cen, Zhidong; Xiao, Yuxiang; Miao, Qianzhuang; Xie, Fei; Zheng, Xiaosheng; Wu, Jianxin; Li, Fangcai (*) ; Luo, Wei(*) . A clinical study of the coronal plane deformity in Parkinson disease. European Spine Journal, 2017.7, 26(7): 1862~1870.

Zhang N, Li H, Xu ZK, Chen WS, Chen QX, Li FC (*).Computer Simulation of Two-level Pedicle Subtraction Osteotomy for Severe Thoracolumbar Kyphosis in Ankylosing Spondylitis. Indian J Orthop0.98Q4. 2017 Nov-Dec;51(6):666-671.


Current Program

The effects and regulatory mechanism of Lnc-NP/FoxA2/Shh in mid-advanced trans-differentiation of adipose stem cells into nucleus pulpous cell. Funding Source: National Natural Science Foundation of China, 2015-2019.

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