Man Xiaoyong, Ph.D.

Position:Chair of Dermatology

Department:Dermatology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Clinical and research of dermatology, especially the research of psoriasis and dermatology and skin surgery.


Professional Highlights

Professional Appointments

Committee Member, Chinese Society of Dermatology, Chinese Medical Association 

Vice-chairman, Committee of Rehabilitation Dermatology, Chinese Association of Rehabilitation Medicine

Education Experience

Research Summary

Publications

Wang Z, Man X. An 18-Year-Old Woman With Recurrent Skin, Nail, and Oral Mucosal Abnormalities. JAMA. 2022 Sep 20;328(11):1100-1101. doi: 10.1001/jama.2022.14460. PMID: 35980713.IF=157.375

Zhou, Y., Xu, F., Chen, X.Y., Yan, B.X., Wang, Z.Y., Chen, S.Q., Zheng, M., and Man, X.Y. (2022). The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry. Cell Mol Immunol 19, 1400-1413. 10.1038/s41423-022-00940-8.IF=22.1

Chen, S.Q., Chen, X.Y., Cui, Y.Z., Yan, B.X., Zhou, Y., Wang, Z.Y., Xu, F., Huang, Y.Z., Zheng, Y.X., and Man, X.Y. (2022a). Cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes. Cell Mol Life Sci 79, 267. 10.1007/s00018-022-04299-x.IF9.234

Zhou Y, Wang P, Chen XY, Yan BX, Landeck L, Wang ZY, Xu F, Zheng M, Man XY. Sprouty1 exerts a preventive effect on the initiation of psoriasis by inhibiting innate immune antimicrobial peptide cathelicidin and immunocytes. Cell Prolif. 2022 Oct;55(10):e13290. doi: 10.1111/cpr.13290. Epub 2022 Jun 18. PMID: 35716036; PMCID: PMC9528767.IF=8.755

Huang, Y.Z., Zheng, Y.X., Zhou, Y., Xu, F., Cui, Y.Z., Chen, X.Y., Wang, Z.Y., Yan, B.X., Zheng, M., and Man, X.Y. (2022). OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1Induced Jak1Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis. J Invest Dermatol 142, 2635-2645 e2639. 10.1016/j.jid.2022.02.018.IF=7.59

Chen, X.Y., Xu, F., Chen, J.Q., Landeck, L., Chen, S.Q., Zhou, Y., Wang, Z., Fu, N.C., Zheng, M., Zhang, X., and Man, X.Y. (2022b). UBE2L3 Reduces TRIM21 Expression and IL-1beta Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin. J Invest Dermatol. 10.1016/j.jid.2022.10.016.IF=7.59

Yan BX, Chen XY, Wang ZY, Cui YZ, Landeck L, Fu NC, Yang XY, Xu F, Zhou Y, Chen JQ, Man XY. Mupirocin blocks imiquimod-induced psoriasis-like skin lesion by inhibiting epidermal isoleucyl-tRNA synthetase. Cell Commun Signal. 2022 Nov 22;20(1):185. doi: 10.1186/s12964-022-00995-0. PMID: 36419191; PMCID: PMC9682813.IF=7.54

Zheng YX, Ye LR, Yan BX, Chen SQ, Cai SQ, Man XY. Biologics for psoriasis patients under 18 years of age: Real-world evidence from the Chinese psoriasis real world evidence research group. Front Med (Lausanne). 2022 Sep 7;9:1009991. doi: 10.3389/fmed.2022.1009991. PMID: 36160145; PMCID: PMC9490006.IF=5.058

Ye, L.R., Yan, B.X., Chen, X.Y., Chen, S.Q., Chen, J.Q., Man, X.Y., and Chinese Psoriasis Real World Evidence Research, G. (2022). Extended dosing intervals of ixekizumab for psoriasis: A single-center, uncontrolled, prospective study. J Am Acad Dermatol 86, 1348-1350. 10.1016/j.jaad.2021.04.093.IF=15.487

Wang ZY, Yan BX, Zhou Y, Chen XY, Zhang J, Cai SQ, Zheng M, Man XY. miRNA Profiling of Extracellular Vesicles Reveals Biomarkers for Psoriasis. J Invest Dermatol. 2021 Jan;141(1):185-189.e4. doi: 10.1016/j.jid.2020.04.021. Epub 2020 May 21. PMID: 32445741.IF=7.59

Yan BX, Chen XY, Ye LR, Chen JQ, Zheng M, Man XY. Cutaneous and Systemic Psoriasis: Classifications and Classification for the Distinction. Front Med (Lausanne). 2021 Oct 13;8:649408. doi: 10.3389/fmed.2021.649408. PMID: 34722555; PMCID: PMC8548430.IF=5.058

Li W, Man X. Gout-like hands. Clin Exp Dermatol. 2022 Jan;47(1):156-157. doi: 10.1111/ced.14855. Epub 2021 Aug 24. PMID: 34289139.IF=4.481

Xin‐Xin Li, Zheng M, Xiao‐Yong Man. A tender sweaty plaque on the foot of an adolescent boy[J]. Pediatric Dermatology, 2019, 36(4).

Chen H#, Zhou Y#, Wang ZY, Yan BX, Zhou WF, Wang TT, Zheng M, Man XY. Exosomal microRNA profiles from serum and cerebrospinal fluid in neurosyphilis. Sexually Transmitted Infections 2019;95:246-250.

Wang P, Zhou Y, Yang JQ, Landeck L, Min M, Chen XB, Chen JQ, Li W, Cai SQ, Zheng M, Man XY. The role of Sprouty1 in the proliferation, differentiation and apoptosis of epidermal keratinocytes[J]. Cell Proliferation, 2018:e12477.

Man, Xiao-Yong, Zheng, Min. Role of Angiogenic and Inflammatory Signal Pathways in Psoriasis. J Investig Dermatol SympProc, 2015.7.01,17(1): 43~45.

Cai SQ, Dou TT, Li W, Li SQ, Chen JQ, Zhou J, Zheng M*, Man XY*. Involvement of pituitary tumor transforming gene 1 in psoriasis, seborrheic keratosis, and skin tumors. Discov Med. 2014;18:289-99.

Cai SQ, Zheng M, Man XY*. Perineal endometriosis: a case report. Int J Clin Exp Med. 2014;7:2939-40.

Zheng M, Bi R, Li W, Landeck L, Chen JQ, Lao LM, Cai SQ, Yao YG,Man XY*. Generalized pure cutaneous Rosai-Dorfman disease: a link between inflammation and cancer not associated with mitochondrial DNA and SLC29A3 gene mutation? Discov Med. 2013;16:193-200.

Man, Xiao-Yong, Zheng, Min (*). Generalized Cutaneous Papules and Nodules in an Asian Man. Journal of the American Medical Association, 2013.7.10, 310(2): 199~200.

Man, Xiao-Yong (#), Li, Wei (#), Chen, Jia-Qi(#) , Zhou, Jiong(#) , Landeck,Lilla, Zhang, Kai-Hong, Mu, Zhen, Li, Chun-Ming, Cai, Sui-Qing, Zheng, Min (*). Impaired nuclear translocation of glucocorticoid receptors: novel findings frompsoriatic epidermal keratinocytes. Cellular and Molecular Life Sciences, 2013.6.01, 70(12): 2205~2220.

Man, Xiao-Yong, Zheng, Min. Papules, Plaques, and Nodules in anImmunocompromised Patient. Journal of the American MedicalAssociation, 2012.1.25, 307(4): 404~405.

Man, Xiao-Yong, Finnson, Kenneth W, Baron, Murray, Philip, Anie. CD109, a TGF-beta co-receptor, attenuates extracellular matrix production inscleroderma skin fibroblasts. Arthritis Research andTherapy, 2012.01.01, 14(3): R144~R144.

Man XY,Finnson KW, Baron M, Philip A*. CD109, a TGF-β co-receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts. Arthritis Res Ther. 2012;14(3):R144.

Li W, Man XY*. Linear psoriasis. CMAJ. 2012;184(7):789.

Man XY, Li W, Chen JQ, Zhou J, Liao YJ, Li CM, Cai SQ, Zheng M*. Huriez syndrome with squamous cell carcinoma. Eur J Dermatol. 2011;21:294-5. 

Man XY, Yang XH, Cai SQ, Bu ZY, Wu XJ, Lu ZF, Zheng M*. Expression and localization of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 in human epidermal appendages: a comparison study by immunofluorescence. Clin Exp Dermatol. 2009;34:396-401.

Man XY,Yang XH, Cai SQ, Bu ZY, Zheng M*. Overexpression of vascular endothelial growth factor (VEGF) receptors on keratinocytes in psoriasis: regulated by calcium independent of VEGF. J Cell Mol Med. 2008;12:649-60. 

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