Publications

Feng Lin, Xiaoyu Meng, Yixin Guo, Wenqiang Cao, Wanlu Liu, Qiming Xia, Zhaoyuan Hui, Jian Chen, Shenghui Hong, Xuliang Zhang, Chuan Wu, Di Wang, Jianli Wang, Linrong Lu, Wenbin Qian, Lai Wei, Lie Wang. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019 Oct; 5(10): eaax1608.

Xianbo Huang, Ying Li, Lihong Shou, Li Li, Zhenzhen Chen, Xiujin Ye, Wenbin Qian. The molecular mechanisms underlying BCR/ABL degradation in chronic myeloid leukemia cells promoted by Beclin1-mediated autophagy. Cancer Manag Res. 2019; 11: 5197–5208.

Huang XB, Yang CM, Han QM, Ye XJ, Lei W, Qian WB*. MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells. Acta Pharmacol Sin. 2018 Oct 8. doi: 10.1038/s41401-018-0161-0.

Zhang J, Jin S, Guo X, Qian W*. Targeting the CD47-SIRPα signaling axis: current studies on B-cell lymphoma immunotherapy. J Int Med Res. 2018 Nov;46(11):4418-4426.

Chen Z, You L, Wang L, Huang X, Liu H, Wei JY, Zhu L, Qian W*. Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo. J Exp Clin Cancer Res. 2018 Aug 13;37(1):190.

Jin S, Wei J, You L, Liu H, Qian W*. Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review). Oncol Rep. 2018 Jun;39(6):2473-2481.

Ni F, Huang X, Chen Z, Qian W*, Tong X. Shikonin exerts antitumor activity in Burkitt’s lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin. Sci Rep. 2018 Feb 20;8(1):3317.

You L, Mao L, Wei J, Jin S, Yang C, Liu H, Zhu L, Qian W*. The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses. J Hematol Oncol. 2017 Oct 23;10(1):165.

Li Y, Yang C, Mao L, Wang J, Li C, Qian W* .Clinical characteristics of angioimmunoblastic T-cell lymphoma in China and C-reactive protein as an independent prognostic factor. Medicine (Baltimore). 2017 Sep;96(39):e8091. 

Li L, You LS, Mao LP, Jin SH, Chen XH, Qian W*. Combing oncolytic adenovirus expressing Beclin-1 with chemotherapy agent doxorubicin synergistically enhances cytotoxicity in human CML cells in vitro. Acta Pharmacol Sin. 2017 Sep 14.

Yang C, Huang X, Liu H, Xiao F, Wei J, You L, Qian W*. PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242. Oncotarget. 2017 Jun 13;8(24):39185-39197.

You L, Qian W#, Yang Q, Mao L, Zhu L, Huang X, Jin J, Meng H. ERG11 gene mutations and MDR1 up-regulation confer pan-azole-resistance in Candida tropicalis causing disseminated candidiasis while on posaconazole prophylaxis in an acute lymphoblastic leukemia patient. Antimicrob Agents Chemother. 2017 May 15.

You L, Jin S, Zhu L, Qian W*. Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies. Oncotarget. 2017 Feb 14;8(7):12374-12388.

You L, Liu H, Huang J, Xie W, Wei J, Ye X, Qian W*. The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins. Oncotarget. 2017 Jan 31;8(5):7777-7790.

Lei W, Wang S, Yang C, Huang X, Chen Z, He W, Shen J, Liu X, Qian W*. Combined expression of miR-34a and Smac mediated by oncolytic vaccinia virus synergistically promote anti-tumor effects in Multiple Myeloma. Sci Rep. 2016 Aug 24;6:32174.

He W, Ye X, Huang X, Lel W, You L, Wang L, Chen X, Qian W*. Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells. Int J Oncol. 2016 Feb 8. doi: 10.3892/ijo.2016.3382.

Xiao F, Li Y, Xu W, You L, Yang C, Liu H, Qian W*. Efficacy and safety of homoharringtonine plus cytarabine and aclarubicin for patients with myelodysplastic syndrome-RAEB. Oncol Lett. 2016 Jan;11(1):355-359.

Klionsky DJ, Abdelmohsen K, Abe A,Qian WB, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.

Xu G, Mao L, Liu H, Yang M, Jin J, Qian W*. Sorafenib in combination with low-dose-homoharringtonine as a salvage therapy in primary refractory FLT3-ITD-positive AML: a case report and review of literature. Int J Clin Exp Med. 2015 Nov 15;8(11):19891-4.

Xu G, Wang B, Yang M, Qian W*. A rare case of nasopharyngeal carcinoma in a patient with multiple myeloma after treatment by lenalidomide. Int J Clin Exp Pathol. 2015 Nov 1;8(11):15025-9.

Zhou W, Zhu W, Ma L, Xiao F, Qian W*. Proteasome inhibitor MG-132 enhances histone deacetylase inhibitor SAHA-induced cell death of chronic myeloid leukemia cells by an ROS-mediated mechanism and downregulation of the Bcr-Abl fusion protein. Oncol Lett. 2015 Nov;10(5):2899-2904.

Xu G, Yang M, Qian W*. Long-term disease control in a refractory multiple myeloma patient treated with bortezomib mono-therapy: a case report and review of literature. Int J Clin Exp Med. 2015 Oct 15;8(10):19629-31.

Chen W, Lin J, Cao H, Xu D, Xu B, Xu L, Yue L, Sun C, Wu G, Qian W*. Local and Systemic IKKε and NF-κB Signaling Associated with Sj?gren's Syndrome Immunopathogenesis. J Immunol Res. 2015;2015:534648.

Zhou YH, Feng JY, You LS, Meng HT, Qian WB*. Matrine and CYC116 synergistically inhibit growth and induce apoptosis in multiple myeloma cells. Chin J Integr Med. 2015 Aug;21(8):635-9.

Tong Y, Zhu W, Huang X, You L, Han X, Yang C, Qian W*. PI3K inhibitor LY294002 inhibits activation of the Akt/mTOR pathway induced by an oncolytic adenovirus expressing TRAIL and sensitizes multiple myeloma cells to the oncolytic virus. Oncol Rep. 2014 Apr;31(4):1581-8.

Tong Y, You L, Liu H, Li L, Meng H, Qian Q, Qian W*. Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia. Oncotarget. 2013 Jun;4(6):860-74.

Cao H, Cheng Y, You L, Qian J, Qian W*. Homoharringtonine and SAHA synergistically enhance apoptosis in human acute myeloid leukemia cells through upregulation of TRAIL and death receptors. Mol Med Rep. 2013 Jun;7(6):1838-44.

Meng H, Jin Y, Liu H, You L, Yang C, Yang X, Qian W*. SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt. J Hematol Oncol. 2013 Feb 18;6:18. doi: 10.1186/1756-8722-6-18. 

Wang S, Tan Y, Lei W, Wang Y, Zhou X, Jia X, Zhang K, Chu L, Liu X, Qian W*. Complete eradication of xenograft hepatoma by oncolytic adenovirus ZD55 harboring TRAIL-IETD-Smac gene with broad antitumor effect. Hum Gene Ther. 2012;23(9):992-1002

You L, Wang Y, Jin Y, Qian W*. Down-regulation of Mcl-1 and Bcl-2 synergizes the apoptosis response to combined treatment with cisplatin and a novel fiber chimeric oncolytic adenovirus. Oncol Rep. 2012 Apr;27(4):971-8.

Tong Y, Liu YY, You LS, Qian W*. Perifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro. Acta Pharmacol Sin. 2012 Apr;33(4):542-50.

Meng HT, Zhu L, Ni WM, You LS, Jin J, Qian W*. Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*. Acta Pharmacol Sin. 2011 Apr;32(4):503-11.

Yang C, Tong Y, Ni W, Liu J, Xu W, Li L, Liu X, Meng H, Qian W* Inhibition of autophagy induced by overexpression of MDA/Interleukin-24 using a PI3K inhibitor results in significant enhanced antileukmia activity in vivo. Cancer Gene Ther. 2010; 17(2):109-119.

Xu WL, Jin J, Qian W*. Homoharringtonine in combination with cytarabine and aclarubicin as induction therapy improves remission and survival of patients with higher risk myelodysplastic syndromes. Chin Med J (Engl). 2010;123(1):108-110.

Jin J, Liu H, Yang C, Li G, Liu X, Qian Q, Qian W* .Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation. Mol Cancer Ther. 2009; 8(5):1387-1397.

Wang G, Li G, Liu H, Yang C, Yang X, Jin J, Liu X, Qian Q, Qian W*. E1B 55-kDa deleted, Ad5/F35 fiber chimeric adenovirus, a potential oncolytic agent for B-lymphocytic malignancies. J Gene Med. 2009;11:477-485.

Li GC, Li N, Zhang YH, Li X, Wang YG, Liu XY, Qian W*, Liu XC. Mannose-exposing acute myeloid leukemia cells detected by the sCAR-PPA fusion protein. Int J Hematol. 2009; 89:611-617.

Meng HT, Li L, Liu H, Wang Y, Li GC, Qian W*. Homoharringtonine acts synergistically with SG235-TRAIL, a conditionally replicating adenovirus, in the treatment of leukemia. Acta Pharmacol Sin. 2009; 11:1529-1536. 

Qian W*, Liu J, Tong Y, Yan S, Yang C, Yang M, Liu X. Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis. Leukemia. 2008; 22: 361-369.

Meng H, Yang C, Jin J, Zhou Y, Qian W*. Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Leuk Lymphoma. 2008;49:1954-1962.

Jiao Y, Zhang W, Liu J, Ni W, Xu W, Jin J, Qian W*. Telomere Attrition and Chromosome Instability via Downregulation of TRF2 Contributes to Arsenic Trioxide-Induced Apoptosis of Human T-Cell Leukemia Cell Line Molt-4 Cells. Cancer Biol Ther. 2007;6:1186-1192.

Qian W*, Liu J, Jin J, Ni W, Xu W. Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leuk Res. 2007;31:329-339.

Meng H, Yang C, Ni W, Ding W, Yang X, Qian W*. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. Eur J Haematol. 2007;79:486-493.

Yang X, Yang C, Shao K, Ye X, Meng H, Zhou Y, Qian W*. Refractory multiple myeloma treated with homoharringtonine: report of two cases. Ann Hematol. 2007;86:919-921.