Liu Bing, M.D.

Department:Orthopedics

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

Bone and soft tissue tumors; fracture of the extremities

Professional Highlights

Professional Appointments

Education Experience

Research Summary

COX-2/PGE2 induces osteosarcoma stem cells and immune evasion


Publications

Liu B, Qu L, Zhu J, Yang Z, Yan S.Histoplasmosis mimicking metastatic spinal tumour. J Int Med Res. 2017 Aug;45(4):1440-1446.

Liu B, Yan S, Qu L, Zhu J.Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway.Cancer Cell International. 2017 Jan 3;17:1. 

Liu B, Qu L, Yan S. Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity. Cancer Cell Int. 2015 Nov 5;15:106. 

Qu L, Liu B(corresponding author). Cyclooxygeanse-2 promotes metastasis in osteosarcoma. Cancer Cell Int. 2015 Jul 4;15:69. 

Zhao Z, Tao L, Shen C, Liu B, Yang Z, Tao H. Silencing of Barkor/ATG14 sensitizes osteosarcoma cells to cisplatin-induced apoptosis. Int J Mol Med. 2014 Feb;33(2):271-6. 

Tao LJ, Zhou XD, Shen CC, Liang CZ, Liu B, Tao Y, Tao HM. Tetrandrine induces apoptosis and triggers a caspase cascade in U2-OS and MG-63 cells through the intrinsic and extrinsic pathways. Mol Med Rep. 2014 Jan;9(1):345-9. 

Shen C, Wang W, Tao L, Liu B, Yang Z, Tao H. Chloroquine blocks the autophagic process in cisplatin-resistant osteosarcoma cells by regulating the expression of p62/SQSTM1. Int J Mol Med. 2013 Aug;32(2):448-56. 

Liang C, Li H, Shen C, Lai J, Shi Z, Liu B, Tao HM. Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-KB pathway. Anticancer Agents Med Chem. 2012 Jun;12(5):554-63. 

Liang CZ, Zhang JK, Shi Z, Liu B, Shen CQ, Tao HM. Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Cancer Chemother Pharmacol. 2012 Feb;69(2):317-31. 

Liu B#, Qu L#, Yang Z, Tao H. Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. Med Hypotheses. 2012 Jul;79(1):98-100. 

Wu Y, Liu B, Qu L, Tao H.Extracranial skeletal metastasis in anaplastic ligodendroglioma: case report and review of the literature.J Int Med Res. 2011;39(3):960-7.

Zhang B, Shi ZL, Liu B, Yan XB, Feng J, Tao HM. Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-kappaB. Anticancer Drugs. 2010 Mar;21(3):288-96. 

Shi Z, Huang X, Liu B, Tao H, Cai Y, Tang R. Biological response of osteosarcoma cells to size-controlled nanostructured hydroxyapatite. J Biomater Appl. 2010 Jul;25(1):19-37. 

Liu B#, Qu L#, Tao H. Cyclo-oxygenase 2 up-regulates the effect of multidrug resistance. Cell Biol Int. 2009 Dec 16;34(1):21-5. 

Liu B, Shi ZL, Feng J, Tao HM. Celecoxib, a cyclooxygenase-2 inhibitor,induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt. Cell Biol Int. 2008 May;32(5):494-501.

Liu B, Shi ZL, Feng J, Tao HM. Celecoxib, a cyclooxygenase-2 inhibitor,induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt. Cell Biol Int. 2008 May;32(5):494-501.


Current Program

COX-2/PGE2 induces osteosarcoma stem cells and immune evasion. Funding Source: National Natural Science Foundation of China.


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